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Aliases for MROH2A Gene

Aliases for MROH2A Gene

  • Maestro Heat Like Repeat Family Member 2A 2 3 5
  • HEAT Repeat Containing 7B1 2 3
  • HEATR7B1 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 2A 3
  • Maestro Heat-Like Repeat Family Member 2A 2
  • HEAT Repeat-Containing Protein 7B1 4

External Ids for MROH2A Gene

Previous HGNC Symbols for MROH2A Gene

  • HEATR7B1

Previous GeneCards Identifiers for MROH2A Gene

  • GC02P234689
  • GC02P234698
  • GC02P234702

Summaries for MROH2A Gene

Entrez Gene Summary for MROH2A Gene

  • This gene encodes a HEAT-domain-containing protein. The function of the encoded protein has not been characterized. [provided by RefSeq, Aug 2016]

GeneCards Summary for MROH2A Gene

MROH2A (Maestro Heat Like Repeat Family Member 2A) is a Protein Coding gene. Diseases associated with MROH2A include Crigler-Najjar Syndrome, Type Ii. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is MROH2B.

Additional gene information for MROH2A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH2A Gene

Genomics for MROH2A Gene

GeneHancer (GH) Regulatory Elements for MROH2A Gene

Promoters and enhancers for MROH2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233828 Promoter 0.5 EPDnew 650.2 +53.0 52952 0.1 PIR47187 MROH2A
GH02J233816 Enhancer 0.6 ENCODE 18.5 +41.8 41769 2 SP1 ZFHX2 RXRA MAX FEZF1 HNF4A KDM1A RAD21 YY1 MROH2A MSL3P1 PIR47187
GH02J233832 Enhancer 0.9 Ensembl ENCODE 10.9 +57.1 57137 0.8 CTCF ZNF654 USF1 MAX USF2 SIN3A ELF1 EBF1 RAD21 SP1 MROH2A HJURP MSL3P1 PIR47187
GH02J233759 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE 6.4 -14.8 -14760 2.5 FOXA2 TAF1 MAX RAD21 YY1 ZNF316 EGR1 HNF4G MAFK RXRA UGT1A1 UGT1A6 MROH2A UGT1A3 UGT1A4 UGT1A5 UGT1A7 UGT1A9 UGT1A10 UGT1A8
GH02J233688 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 5.1 -84.7 -84661 4.1 NFIB JUN YY1 GATA3 RCOR1 FOSL2 FOS NFE2L2 SMARCE1 RXRA UGT1A6 UGT1A1 USP40 UGT1A4 MROH2A UGT1A7 UGT1A9 UGT1A10 UGT1A8 UGT1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MROH2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MROH2A Gene

Genomic Locations for MROH2A Gene
chr2:233,775,662-233,833,423
(GRCh38/hg38)
Size:
57,762 bases
Orientation:
Plus strand
chr2:234,684,370-234,742,069
(GRCh37/hg19)
Size:
57,700 bases
Orientation:
Plus strand

Genomic View for MROH2A Gene

Genes around MROH2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH2A Gene

Proteins for MROH2A Gene

  • Protein details for MROH2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NES4-MRO2A_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 2A
    Protein Accession:
    A6NES4
    Secondary Accessions:
    • F8VUA0

    Protein attributes for MROH2A Gene

    Size:
    1674 amino acids
    Molecular mass:
    189561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH2A Gene

Post-translational modifications for MROH2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MROH2A Gene

Domains & Families for MROH2A Gene

Gene Families for MROH2A Gene

Protein Domains for MROH2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH2A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH2A: view

No data available for UniProtKB/Swiss-Prot for MROH2A Gene

Function for MROH2A Gene

Phenotypes From GWAS Catalog for MROH2A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH2A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH2A Gene

Localization for MROH2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH2A gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MROH2A Gene

Pathways & Interactions for MROH2A Gene

SuperPathways for MROH2A Gene

No Data Available

Interacting Proteins for MROH2A Gene

Gene Ontology (GO) - Biological Process for MROH2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH2A Gene

Drugs & Compounds for MROH2A Gene

No Compound Related Data Available

Transcripts for MROH2A Gene

mRNA/cDNA for MROH2A Gene

(14) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH2A Gene

Maestro heat-like repeat family member 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MROH2A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH2A Gene

No ASD Table

Relevant External Links for MROH2A Gene

GeneLoc Exon Structure for
MROH2A
ECgene alternative splicing isoforms for
MROH2A

Expression for MROH2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MROH2A Gene

mRNA differential expression in normal tissues according to GTEx for MROH2A Gene

This gene is overexpressed in Testis (x14.8), Liver (x10.7), Thyroid (x8.1), Kidney - Cortex (x4.8), and Stomach (x4.7).

Protein differential expression in normal tissues from HIPED for MROH2A Gene

This gene is overexpressed in Plasma (56.0) and Brain (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH2A Gene



Protein tissue co-expression partners for MROH2A Gene

NURSA nuclear receptor signaling pathways regulating expression of MROH2A Gene:

MROH2A

SOURCE GeneReport for Unigene cluster for MROH2A Gene:

Hs.361778
genes like me logo Genes that share expression patterns with MROH2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH2A Gene

Orthologs for MROH2A Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEATR7B1 33
  • 98.04 (n)
dog
(Canis familiaris)
Mammalia MROH2A 34 33
  • 85.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HEATR7B1 33
  • 85.07 (n)
MROH2A 34
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mroh2a 16 34 33
  • 82.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MROH2A 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta c11.1 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-27 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for MROH2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MROH2A Gene

ENSEMBL:
Gene Tree for MROH2A (if available)
TreeFam:
Gene Tree for MROH2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MROH2A: view image

Paralogs for MROH2A Gene

Paralogs for MROH2A Gene

(5) SIMAP similar genes for MROH2A Gene using alignment to 3 proteins:

  • MRO2A_HUMAN
  • C9IYW5_HUMAN
  • F8VUA0_HUMAN
genes like me logo Genes that share paralogs with MROH2A: view

Variants for MROH2A Gene

Sequence variations from dbSNP and Humsavar for MROH2A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1042640 benign, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, Gilbert's syndrome 233,772,898(+) G/C/T upstream_transcript_variant
rs10929303 benign, Gilbert's syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome 233,772,770(+) T/C upstream_transcript_variant
rs202172337 uncertain-significance, Gilbert's syndrome, Lucey-Driscoll syndrome, Crigler-Najjar syndrome 233,772,279(+) T/A/C/G upstream_transcript_variant
rs34993780 pathogenic, Lucey-Driscoll syndrome, Crigler-Najjar syndrome, type II, Hyperbilirubinemia 233,772,413(+) T/A/C/G upstream_transcript_variant
rs541532523 uncertain-significance, Lucey-Driscoll syndrome, Gilbert's syndrome, Crigler-Najjar syndrome 233,772,760(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MROH2A Gene

Variant ID Type Subtype PubMed ID
esv2332178 CNV deletion 18987734
esv24508 CNV gain 19812545
esv25607 CNV gain 19812545
esv2721670 CNV deletion 23290073
esv3561179 CNV deletion 23714750
esv3584375 CNV loss 25503493
nsv1008316 CNV gain 25217958
nsv1013712 CNV loss 25217958
nsv1114182 CNV deletion 24896259
nsv1131559 CNV deletion 24896259
nsv1132894 CNV insertion 24896259
nsv460137 CNV loss 19166990
nsv470523 CNV loss 18288195
nsv527330 CNV loss 19592680
nsv584706 CNV loss 21841781
nsv584707 CNV gain 21841781
nsv584708 CNV loss 21841781

Variation tolerance for MROH2A Gene

Gene Damage Index Score: 15.34; 97.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MROH2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH2A Gene

Disorders for MROH2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MROH2A Gene - From: GeneCards

Disorder Aliases PubMed IDs
crigler-najjar syndrome, type ii
  • hyperbilirubinemia, crigler-najjar type ii; hblrcn2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MROH2A

genes like me logo Genes that share disorders with MROH2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MROH2A Gene

Publications for MROH2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski SJ … Chute CG (Mayo Clinic proceedings 2011) 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F … Reymond A (Genome research 2007) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for MROH2A Gene

Sources for MROH2A Gene

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