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Aliases for MRNIP Gene

Aliases for MRNIP Gene

  • MRN Complex Interacting Protein 2 3 5
  • MRN-Interacting Protein 2 3 4
  • C5orf45 3 4
  • Chromosome 5 Open Reading Frame 45 2
  • Truncated Calcium Binding Protein 2
  • MRN Complex-Interacting Protein 3
  • UPF0544 Protein C5orf45 3

External Ids for MRNIP Gene

Previous HGNC Symbols for MRNIP Gene

  • C5orf45

Previous GeneCards Identifiers for MRNIP Gene

  • GC05M179840
  • GC05M179843
  • GC05M179845

Summaries for MRNIP Gene

GeneCards Summary for MRNIP Gene

MRNIP (MRN Complex Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRNIP Gene

  • Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

Additional gene information for MRNIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRNIP Gene

Genomics for MRNIP Gene

GeneHancer (GH) Regulatory Elements for MRNIP Gene

Promoters and enhancers for MRNIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I179857 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563 +3.0 2998 2.9 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MRNIP LOC100996419 HNRNPH1 MAML1 TBC1D9B RUFY1 ZNF354B CNOT6
GH05I179619 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 73.9 +239.9 239900 6.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 HNRNPH1 MAML1 MRNIP ZNF879 RUFY1 ZFP2 GRM6 ZNF354C LOC100996419 ENSG00000254035
GH05I180069 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.4 -208.8 -208806 3.6 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B RNF130 ZFP62 MRNIP HNRNPH1 MAML1 LOC100996419 RN7SKP150 CNOT6 RUFY1 TBC1D9B
GH05I179817 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.7 +41.6 41614 6.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SQSTM1 MRNIP HNRNPH1 MAML1 ZNF354C TBC1D9B RUFY1 RNF130 LOC105377763 ZNF879
GH05I180493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.8 -633.2 -633193 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 CNOT6 HNRNPH1 MAML1 MRNIP ENSG00000233937 TRIM52 ZFP62 RUFY1 RACK1 LOC100996419
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRNIP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MRNIP Gene

Genomic Locations for MRNIP Gene
chr5:179,835,133-179,862,173
(GRCh38/hg38)
Size:
27,041 bases
Orientation:
Minus strand
chr5:179,261,436-179,289,173
(GRCh37/hg19)

Genomic View for MRNIP Gene

Genes around MRNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRNIP Gene

Proteins for MRNIP Gene

  • Protein details for MRNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTE8-MRNIP_HUMAN
    Recommended name:
    MRN complex-interacting protein
    Protein Accession:
    Q6NTE8
    Secondary Accessions:
    • B5MD09
    • E9PAK6
    • Q7Z3D8
    • Q9BUC1
    • Q9UN54

    Protein attributes for MRNIP Gene

    Size:
    343 amino acids
    Molecular mass:
    37743 Da
    Quaternary structure:
    • Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive (PubMed:27568553). Interacts with MRE11 (PubMed:27568553). Interacts with NBN (PubMed:27568553). Interacts with RAD50 (PubMed:27568553).
    SequenceCaution:
    • Sequence=AAD51611.1; Type=Frameshift; Positions=191; Evidence={ECO:0000305}; Sequence=CAD97932.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRNIP Gene

Post-translational modifications for MRNIP Gene

  • Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRNIP Gene

Domains & Families for MRNIP Gene

Gene Families for MRNIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRNIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRNIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NTE8

UniProtKB/Swiss-Prot:

MRNIP_HUMAN :
  • Belongs to the MRNIP family.
Family:
  • Belongs to the MRNIP family.
genes like me logo Genes that share domains with MRNIP: view

Function for MRNIP Gene

Molecular function for MRNIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

Phenotypes From GWAS Catalog for MRNIP Gene

Gene Ontology (GO) - Molecular Function for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 27568553
GO:0005515 protein binding IPI 27568553
genes like me logo Genes that share ontologies with MRNIP: view
genes like me logo Genes that share phenotypes with MRNIP: view

Animal Models for MRNIP Gene

MGI Knock Outs for MRNIP:

miRNA for MRNIP Gene

miRTarBase miRNAs that target MRNIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRNIP Gene

Localization for MRNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRNIP Gene

Nucleus. Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553). {ECO:0000269 PubMed:27568553}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRNIP gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 27568553
GO:0005654 nucleoplasm IEA,IDA 27568553
GO:0030870 colocalizes_with Mre11 complex IDA 27568553
genes like me logo Genes that share ontologies with MRNIP: view

Pathways & Interactions for MRNIP Gene

SuperPathways for MRNIP Gene

No Data Available

Interacting Proteins for MRNIP Gene

Selected Interacting proteins: Q6NTE8-MRNIP_HUMAN for MRNIP Gene via IID

Symbol External ID(s) Details
LRRK2

Gene Ontology (GO) - Biological Process for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 27568553
GO:0007095 mitotic G2 DNA damage checkpoint IMP 27568553
GO:0010212 response to ionizing radiation IMP 27568553
GO:0045860 positive regulation of protein kinase activity IMP 27568553
genes like me logo Genes that share ontologies with MRNIP: view

No data available for Pathways by source and SIGNOR curated interactions for MRNIP Gene

Drugs & Compounds for MRNIP Gene

No Compound Related Data Available

Transcripts for MRNIP Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRNIP Gene

No ASD Table

Relevant External Links for MRNIP Gene

GeneLoc Exon Structure for
MRNIP
ECgene alternative splicing isoforms for
MRNIP

Expression for MRNIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MRNIP Gene:

MRNIP

Evidence on tissue expression from TISSUES for MRNIP Gene

  • Lung(4.2)
  • Nervous system(3.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRNIP Gene

Orthologs for MRNIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf45 33
  • 99.13 (n)
C5orf45 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5orf45 34
  • 83 (a)
OneToOne
C11H5orf45 33
  • 71.26 (n)
cow
(Bos Taurus)
Mammalia C7H5orf45 33 34
  • 72.07 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564036 33
  • 67.94 (n)
mouse
(Mus musculus)
Mammalia 3010026O09Rik 33 34
  • 67.57 (n)
Mrnip 16
lizard
(Anolis carolinensis)
Reptilia C5orf45 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C14H5orf45 34
  • 21 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43295 34
  • 27 (a)
OneToOne
Species where no ortholog for MRNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRNIP Gene

ENSEMBL:
Gene Tree for MRNIP (if available)
TreeFam:
Gene Tree for MRNIP (if available)

Paralogs for MRNIP Gene

No data available for Paralogs for MRNIP Gene

Variants for MRNIP Gene

Sequence variations from dbSNP and Humsavar for MRNIP Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs10277 likely-benign, Paget disease of bone 179,837,731(-) T/C coding_sequence_variant, missense_variant
rs1060271 likely-benign, Paget disease of bone 179,837,132(-) T/G downstream_transcript_variant
rs1065154 likely-benign, Paget disease of bone 179,837,915(-) G/T intron_variant
rs10688915 likely-benign, Paget disease of bone 179,836,768(-) TGTGTGTGTGTGTG/TGTGTGTGTGTG/TGTGTGTGTGTGTGTG downstream_transcript_variant
rs11548631 likely-benign, Paget disease of bone 179,836,872(-) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRNIP Gene

Variant ID Type Subtype PubMed ID
esv2667626 CNV deletion 23128226
esv2731309 CNV deletion 23290073
esv2731310 CNV deletion 23290073
esv2731311 CNV deletion 23290073
esv3567108 CNV deletion 23714750
esv3607755 CNV loss 21293372
nsv1109752 CNV deletion 24896259
nsv469579 CNV loss 16826518

Variation tolerance for MRNIP Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRNIP Gene

Disorders for MRNIP Gene

No disorders were found for MRNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRNIP Gene

Publications for MRNIP Gene

  1. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. (PMID: 27568553) Staples CJ … Collis SJ (Cell reports 2016) 2 3 4 58
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A … Wiemann S (Nucleic acids research 2006) 3 58

Products for MRNIP Gene

Sources for MRNIP Gene

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