Aliases for MRM3 Gene
External Ids for MRM3 Gene
Previous HGNC Symbols for MRM3 Gene
Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for MRM3 Gene
MRM3 (Mitochondrial RRNA Methyltransferase 3) is a Protein Coding gene. Among its related pathways are rRNA processing in the mitochondrion and Gene Expression. An important paralog of this gene is TARBP1.
UniProtKB/Swiss-Prot Summary for MRM3 Gene
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.