Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRLN Gene

Aliases for MRLN Gene

  • Myoregulin 2 3 3 5
  • Long Intergenic Non-Protein Coding RNA 948 2 3
  • Muscle Enriched RNA 1 2 3
  • Muscle Specific 1 2 3
  • MLN 3 4
  • LINC00948 3
  • Linc-RAM 3
  • MUSER1 3
  • M1 3

External Ids for MRLN Gene

Previous HGNC Symbols for MRLN Gene

  • LINC00948

Summaries for MRLN Gene

Entrez Gene Summary for MRLN Gene

  • This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]

GeneCards Summary for MRLN Gene

MRLN (Myoregulin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity.

UniProtKB/Swiss-Prot for MRLN Gene

  • Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.

Additional gene information for MRLN Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRLN Gene

Genomics for MRLN Gene

GeneHancer (GH) Regulatory Elements for MRLN Gene

Promoters and enhancers for MRLN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J059752 Promoter/Enhancer 0.8 EPDnew ENCODE 650.7 +2.8 2825 1.6 ZNF768 MRLN SLC16A9
GH10J059897 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.1 -147.5 -147507 11.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 ZNF610 CCDC6 MRLN
GH10J059809 Enhancer 0.9 ENCODE dbSUPER 0.2 -53.7 -53701 0.7 CTCF USF1 SIN3A RAD21 TEAD3 POLR2A ZNF143 SMC3 FOSL2 ZNF444 CCDC6 MRLN
GH10J059831 Enhancer 0.9 ENCODE dbSUPER 0.2 -75.7 -75706 1.5 HDAC1 CTCF MEIS2 PKNOX1 TEAD4 TAL1 ZBTB40 GATA3 NCOR1 SMARCE1 CCDC6 MRLN
GH10J059748 Enhancer 0.4 ENCODE 0.4 +7.0 6963 0.9 JUNB REST BATF SLC16A9 MRLN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRLN on UCSC Golden Path with GeneCards custom track

Genomic Locations for MRLN Gene

Genomic Locations for MRLN Gene
chr10:59,736,692-59,756,041
(GRCh38/hg38)
Size:
19,350 bases
Orientation:
Minus strand
chr10:61,496,748-61,513,203
(GRCh37/hg19)
Size:
16,456 bases
Orientation:
Minus strand

Genomic View for MRLN Gene

Genes around MRLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRLN Gene

Proteins for MRLN Gene

  • Protein details for MRLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMT0-MLN_HUMAN
    Recommended name:
    Myoregulin
    Protein Accession:
    P0DMT0

    Protein attributes for MRLN Gene

    Size:
    46 amino acids
    Molecular mass:
    5194 Da
    Quaternary structure:
    • Interacts with ATP2A1/SERCA1.

neXtProt entry for MRLN Gene

Post-translational modifications for MRLN Gene

No Post-translational modifications

Other Protein References for MRLN Gene

No data available for DME Specific Peptides for MRLN Gene

Domains & Families for MRLN Gene

Gene Families for MRLN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for MRLN Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRLN: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MRLN Gene

Function for MRLN Gene

Molecular function for MRLN Gene

UniProtKB/Swiss-Prot Function:
Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.

Phenotypes From GWAS Catalog for MRLN Gene

Gene Ontology (GO) - Molecular Function for MRLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
genes like me logo Genes that share ontologies with MRLN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRLN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRLN Gene

Localization for MRLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRLN Gene

Sarcoplasmic reticulum membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MRLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
GO:0033017 sarcoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with MRLN: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MRLN Gene

Pathways & Interactions for MRLN Gene

No Data Available

Interacting Proteins for MRLN Gene

Gene Ontology (GO) - Biological Process for MRLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009611 response to wounding IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:1902081 negative regulation of calcium ion import into sarcoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with MRLN: view

No data available for Pathways by source and SIGNOR curated interactions for MRLN Gene

Drugs & Compounds for MRLN Gene

No Compound Related Data Available

Transcripts for MRLN Gene

mRNA/cDNA for MRLN Gene

(2) REFSEQ mRNAs :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRLN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRLN Gene

No ASD Table

Relevant External Links for MRLN Gene

GeneLoc Exon Structure for
MRLN
ECgene alternative splicing isoforms for
MRLN

Expression for MRLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRLN Gene

NURSA nuclear receptor signaling pathways regulating expression of MRLN Gene:

MRLN
genes like me logo Genes that share expression patterns with MRLN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRLN Gene

Orthologs for MRLN Gene

Evolution for MRLN Gene

ENSEMBL:
Gene Tree for MRLN (if available)
TreeFam:
Gene Tree for MRLN (if available)

No data available for Orthologs for MRLN Gene

Paralogs for MRLN Gene

No data available for Paralogs for MRLN Gene

Variants for MRLN Gene

Sequence variations from dbSNP and Humsavar for MRLN Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000340176 -- 59,737,275(-) T/G intron_variant
rs1000406158 -- 59,737,539(-) A/G intron_variant
rs1000776962 -- 59,743,270(-) C/T intron_variant
rs1000839565 -- 59,744,044(-) C/T intron_variant
rs1000902463 -- 59,748,221(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRLN Gene

Variant ID Type Subtype PubMed ID
esv2677045 CNV deletion 23128226

Additional Variant Information for MRLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRLN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MRLN Gene

Disorders for MRLN Gene

Additional Disease Information for MRLN

No disorders were found for MRLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRLN Gene

Publications for MRLN Gene

  1. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. (PMID: 25640239) Anderson DM … Olson EN (Cell 2015) 2 3 4 58
  2. Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD. (PMID: 28091529) Yu X … Zhu D (Nature communications 2017) 2 3 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3 58

Products for MRLN Gene

Sources for MRLN Gene

Content
Loading form....