Aliases for MRI1 Gene
- Methylthioribose-1-Phosphate Isomerase 1 2 3 5
- Mediator Of RhoA-Dependent Invasion 2 3 4
- MRDI 2 3 4
- Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein 3 4
- S-Methyl-5-Thioribose-1-Phosphate Isomerase 1 2 3
- Methylthioribose-1-Phosphate Isomerase 3 4
- MTR-1-P Isomerase 3 4
- EC 220.127.116.11 4 51
External Ids for MRI1 Gene
Previous GeneCards Identifiers for MRI1 Gene
This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]
GeneCards Summary for MRI1 Gene
MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. Diseases associated with MRI1 include Spinal Cord Melanoma and Intermittent Squint. Among its related pathways are S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include identical protein binding and S-methyl-5-thioribose-1-phosphate isomerase activity. An important paralog of this gene is EIF2B4.
UniProtKB/Swiss-Prot Summary for MRI1 Gene
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.