Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
MRGPRX3 (MAS Related GPR Family Member X3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MRGPRX1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J018105 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 12.8 | -15.4 | -15354 | 2.4 | SP1 GATAD2A CTCF HNRNPL ZNF629 TFE3 NFKBIZ KDM1A ZNF692 POLR2A | SAAL1 HIGD1AP5 lnc-MRGPRX3-1 GTF2H1 SPTY2D1 MRGPRX3 ENSG00000256282 TSG101 ENSG00000256361 TPH1 | |
GH11J018101 | Enhancer | 0.4 | FANTOM5 | 26.6 | -19.6 | -19579 | 0.2 | ZNF184 MZF1 | MRGPRX3 SAAL1 HPS5 TSG101 GTF2H1 UEVLD lnc-TPH1-1 TPH1 | |
GH11J018143 | Enhancer | 0.4 | ENCODE | 11.2 | +23.3 | 23335 | 1.4 | CTCF JUND BHLHE40 | ENSG00000285562 MRGPRX3 TPH1 MRGPRX12P lnc-MRGPRX3-2 MRGPRX4 ENSG00000255470 | |
GH11J018189 | Promoter | 0.3 | Ensembl | 8.3 | +68.2 | 68246 | 0.4 | GLTPP1 lnc-MRGPRX4-2 MRGPRX3 ENSG00000255470 MRGPRX4 SAA4 | ||
GH11J018133 | Enhancer | 0.2 | Ensembl | 16.5 | +12.1 | 12146 | 0.6 | MRGPRX3 MRGPRX13P SLC25A51P4 GLTPP1 ENSG00000255470 ENSG00000285562 piR-57195-048 MRGPRX4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ML 382 |
|
1646499-97-9 |
|
|
Compound | Action | Cas Number |
---|---|---|
BAM (8-22) | Selective agonist for the sensory neuron specific receptor (SNSR) | 412961-36-5 |
ML 382 | MrgX1 (SNSR4) positive allosteric modulator | 1646499-97-9 |
Compound | Action | Cas Number |
---|---|---|
BAM 22P | Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); | 76622-26-9 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRGPRX3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrgprx3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mrgpra1 30 17 |
|
||
Mrgprx1 31 |
|
ManyToMany | |||
Mrgprb4 31 |
|
ManyToMany | |||
Mrgprx2 31 |
|
ManyToMany | |||
Mrgprb2 31 |
|
ManyToMany | |||
Mrgprb5 31 |
|
ManyToMany | |||
Mrgprb3 31 |
|
ManyToMany | |||
Mrgprb1 31 |
|
ManyToMany | |||
Mrgprb8 31 |
|
ManyToMany | |||
Mrgpra2a 17 |
|
||||
Mrgpra2b 17 |
|
||||
Mrgpra9 17 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | MRGPRX2 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
768430 | Benign: not provided | 18,137,795(+) | T/G | MISSENSE_VARIANT | |
rs12291017 | - | p.Cys82Arg | |||
rs4274188 | - | p.Asn169Asp |
No disorders were found for MRGPRX3 Gene.