Aliases for MRGPRX3 Gene
Aliases for MRGPRX3 Gene
External Ids for MRGPRX3 Gene
- HGNC: 17980
- Entrez Gene: 117195
- Ensembl: ENSG00000179826
- OMIM: 607229
- UniProtKB: Q96LB0
Previous GeneCards Identifiers for MRGPRX3 Gene
- GC11P018100
- GC11P018142
- GC11P017825
- GC11P018121
Summaries for MRGPRX3 Gene
-
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
GeneCards Summary for MRGPRX3 Gene
MRGPRX3 (MAS Related GPR Family Member X3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX1.
UniProtKB/Swiss-Prot for MRGPRX3 Gene
-
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
Additional gene information for MRGPRX3 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX3 Gene
Genomics for MRGPRX3 Gene
GeneHancer (GH) Regulatory Elements for MRGPRX3 Gene
Promoters and enhancers for MRGPRX3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I018126 | Promoter | 0.5 | EPDnew | 550.3 | +22.6 | 22613 | 0.1 | MRGPRX3 GC11P018120 LOC645297 | ||
| GH11I018105 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 13.2 | +2.2 | 2210 | 1.7 | HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B | SAAL1 HIGD1AP5 SPTY2D1 ENSG00000256361 TSG101 GTF2H1 MRGPRX3 ENSG00000256588 LOC100129966 TPH1 | |
| GH11I018101 | Enhancer | 0.4 | FANTOM5 | 27 | -2.3 | -2276 | 0.2 | ZNF184 MZF1 | MRGPRX3 SAAL1 HPS5 TSG101 GTF2H1 UEVLD GC11P018102 | |
| GH11I018143 | Enhancer | 0.4 | ENCODE | 11.1 | +40.6 | 40638 | 1.4 | CTCF JUND | MRGPRX3 TPH1 LOC645297 GC11P018120 ENSG00000255470 | |
| GH11I017821 | Enhancer | 0.5 | Ensembl ENCODE | 4.9 | -281.4 | -281373 | 1.1 | NFE2 | MRGPRX3 SPTY2D1OS GC11P017794 GC11M017875 KCNC1 SERGEF |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MRGPRX3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MRGPRX3 Gene
Genomic Locations for MRGPRX3 Gene
- chr11:18,103,652-18,138,491
- (GRCh38/hg38)
- Size:
- 34,840 bases
- Orientation:
- Plus strand
- chr11:18,142,502-18,160,027
- (GRCh37/hg19)
Genomic View for MRGPRX3 Gene
Genes around MRGPRX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.1 by Ensembl
- 11p15.1 by Entrez Gene
- 11p15.1 by HGNC
MRGPRX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRGPRX3 Gene
Proteins for MRGPRX3 Gene
-
Protein details for MRGPRX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96LB0-MRGX3_HUMAN
- Recommended name:
- Mas-related G-protein coupled receptor member X3
- Protein Accession:
- Q96LB0
- B0M0L1
- Q8TDE0
- Q8TDE1
Protein attributes for MRGPRX3 Gene
- Size:
- 322 amino acids
- Molecular mass:
- 36483 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for MRGPRX3 Gene
No Post-translational modifications
Other Protein References for MRGPRX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MRGPRX3
-
Abcam antibodies for MRGPRX3
- Invitrogen Antibodies for MRGPRX3
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-
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Protein Products
-
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-
Quality Products:
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-
Abcam proteins for MRGPRX3
Assay Products
No data available for DME Specific Peptides for MRGPRX3 Gene
Domains & Families for MRGPRX3 Gene
Gene Families for MRGPRX3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for MRGPRX3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRGPRX3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96LB0UniProtKB/Swiss-Prot:
MRGX3_HUMAN :- Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Function for MRGPRX3 Gene
Molecular function for MRGPRX3 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IBA | -- |
Phenotypes for MRGPRX3 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
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miRNA for MRGPRX3 Gene
- miRTarBase miRNAs that target MRGPRX3
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MRGPRX3
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX3 Gene
Localization for MRGPRX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX3 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRX3 Gene
Pathways & Interactions for MRGPRX3 Gene
No Data Available
Interacting Proteins for MRGPRX3 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| ITCH |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MRGPRX3 Gene
Drugs & Compounds for MRGPRX3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ML 382 |
|
1646499-97-9 |
|
|
(2) Tocris Compounds for MRGPRX3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAM (8-22) | Selective agonist for the sensory neuron specific receptor (SNSR) | 412961-36-5 |
| ML 382 | MrgX1 (SNSR4) positive allosteric modulator | 1646499-97-9 |
(1) ApexBio Compounds for MRGPRX3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAM 22P | Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); | 76622-26-9 |
Transcripts for MRGPRX3 Gene
mRNA/cDNA for MRGPRX3 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRGPRX3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRGPRX3
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for MRGPRX3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MRGPRX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRGPRX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MRGPRX3
- genomics-online: cdna clones - Search results for available MRGPRX3 gene related products
- orf clones - Search results for available MRGPRX3 gene related products
- Applied Biological Materials Clones for MRGPRX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Expression for MRGPRX3 Gene
mRNA differential expression in normal tissues according to GTEx for MRGPRX3 Gene
This gene is overexpressed in Minor Salivary Gland (x26.2), Esophagus - Mucosa (x14.0), and Breast - Mammary Tissue (x5.0).
NURSA nuclear receptor signaling pathways regulating expression of MRGPRX3 Gene:
MRGPRX3SOURCE GeneReport for Unigene cluster for MRGPRX3 Gene:
Hs.380177mRNA Expression by UniProt/SwissProt for MRGPRX3 Gene:
Q96LB0-MRGX3_HUMAN
Tissue specificity:
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Evidence on tissue expression from TISSUES for MRGPRX3 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for MRGPRX3
-
OriGene qPCR primer pairs and template standards for MRGPRX3
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRX3 Gene
Orthologs for MRGPRX3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRGPRX3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mrgprx3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrgpra1 33 |
|
||
| Mrgprx1 34 |
|
ManyToMany | |||
| Mrgprb2 34 |
|
ManyToMany | |||
| Mrgprb4 34 |
|
ManyToMany | |||
| Mrgprx2 34 |
|
ManyToMany | |||
| Mrgprb5 34 |
|
ManyToMany | |||
| Mrgprb3 34 |
|
ManyToMany | |||
| Mrgprb1 34 |
|
ManyToMany | |||
| Mrgprb8 34 |
|
ManyToMany | |||
| Mrgpra9 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | MRGPRX2 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for MRGPRX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MRGPRX3 Gene
Paralogs for MRGPRX3 Gene
(9) SIMAP similar genes for MRGPRX3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for MRGPRX3 Gene
Variants for MRGPRX3 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034070 | -- | 18,124,905(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000076297 | -- | 18,135,603(+) | G/A/T | intron_variant | |
| rs1000122906 | -- | 18,124,360(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000239421 | -- | 18,124,172(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000414119 | -- | 18,122,019(+) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.77;
58.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRGPRX3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRGPRX3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX3 Gene
Disorders for MRGPRX3 Gene
Additional Disease Information for MRGPRX3
No disorders were found for MRGPRX3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX3 Gene
Publications for MRGPRX3 Gene
- A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. (PMID: 11850634) Lembo PM … Ahmad S (Nature neuroscience 2002) 3 4 58
- Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. (PMID: 28189739) Franco R … Zamarbide M (Progress in neurobiology 2017) 3 58
- Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PMID: 16284629) Burstein ES … Nash NR (British journal of pharmacology 2006) 3 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MRGPRX3
- antibodies-online: Search results for 49 available MRGPRX3 Antibodies ranked by validation data
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- antibodies-online: Search results for available MRGPRX3 related products ranked by validation data
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- Quality Products:
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Sources for MRGPRX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
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