This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009] See more...

Aliases for MRGPRX3 Gene

Aliases for MRGPRX3 Gene

  • MAS Related GPR Family Member X3 2 3 5
  • MRGX3 2 3 4
  • Sensory Neuron-Specific G-Protein Coupled Receptor 1/2 3 4
  • Mas-Related G-Protein Coupled Receptor Member X3 3 4
  • MAS-Related GPR, Member X3 2 3
  • SNSR1 3 4
  • SNSR2 3 4
  • G Protein-Coupled Receptor MRGX3 3
  • G Protein-Coupled Receptor SNSR1 3
  • G Protein-Coupled Receptor SNSR2 3
  • Mas-Related GPCR Member X3 3
  • MRGPRX3 5
  • GPCR 3

External Ids for MRGPRX3 Gene

Previous GeneCards Identifiers for MRGPRX3 Gene

  • GC11P018100
  • GC11P018142
  • GC11P017825
  • GC11P018121
  • GC11P018103

Summaries for MRGPRX3 Gene

Entrez Gene Summary for MRGPRX3 Gene

  • This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

GeneCards Summary for MRGPRX3 Gene

MRGPRX3 (MAS Related GPR Family Member X3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MRGPRX1.

UniProtKB/Swiss-Prot Summary for MRGPRX3 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX3 Gene

Additional gene information for MRGPRX3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRGPRX3 Gene

Genomics for MRGPRX3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRGPRX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018105 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.8 -15.4 -15354 2.4 SP1 GATAD2A CTCF HNRNPL ZNF629 TFE3 NFKBIZ KDM1A ZNF692 POLR2A SAAL1 HIGD1AP5 lnc-MRGPRX3-1 GTF2H1 SPTY2D1 MRGPRX3 ENSG00000256282 TSG101 ENSG00000256361 TPH1
GH11J018101 Enhancer 0.4 FANTOM5 26.6 -19.6 -19579 0.2 ZNF184 MZF1 MRGPRX3 SAAL1 HPS5 TSG101 GTF2H1 UEVLD lnc-TPH1-1 TPH1
GH11J018143 Enhancer 0.4 ENCODE 11.2 +23.3 23335 1.4 CTCF JUND BHLHE40 ENSG00000285562 MRGPRX3 TPH1 MRGPRX12P lnc-MRGPRX3-2 MRGPRX4 ENSG00000255470
GH11J018189 Promoter 0.3 Ensembl 8.3 +68.2 68246 0.4 GLTPP1 lnc-MRGPRX4-2 MRGPRX3 ENSG00000255470 MRGPRX4 SAA4
GH11J018133 Enhancer 0.2 Ensembl 16.5 +12.1 12146 0.6 MRGPRX3 MRGPRX13P SLC25A51P4 GLTPP1 ENSG00000255470 ENSG00000285562 piR-57195-048 MRGPRX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRX3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRGPRX3

Top Transcription factor binding sites by QIAGEN in the MRGPRX3 gene promoter:
  • c-Myc
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA5
  • Max1
  • POU2F1
  • POU2F1a
  • POU2F1c
  • TBP

Genomic Locations for MRGPRX3 Gene

Genomic Locations for MRGPRX3 Gene
chr11:18,120,955-18,138,488
(GRCh38/hg38)
Size:
17,534 bases
Orientation:
Plus strand
chr11:18,142,502-18,160,027
(GRCh37/hg19)
Size:
17,526 bases
Orientation:
Plus strand

Genomic View for MRGPRX3 Gene

Genes around MRGPRX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX3 Gene

Proteins for MRGPRX3 Gene

  • Protein details for MRGPRX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB0-MRGX3_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X3
    Protein Accession:
    Q96LB0
    Secondary Accessions:
    • B0M0L1
    • Q8TDE0
    • Q8TDE1

    Protein attributes for MRGPRX3 Gene

    Size:
    322 amino acids
    Molecular mass:
    36483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX3 Gene

Post-translational modifications for MRGPRX3 Gene

No Post-translational modifications

Other Protein References for MRGPRX3 Gene

Antibody Products

  • Abcam antibodies for MRGPRX3
  • Boster Bio Antibodies for MRGPRX3
  • Santa Cruz Biotechnology (SCBT) Antibodies for MRGPRX3

No data available for DME Specific Peptides for MRGPRX3 Gene

Domains & Families for MRGPRX3 Gene

Gene Families for MRGPRX3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRX3 Gene

Suggested Antigen Peptide Sequences for MRGPRX3 Gene

GenScript: Design optimal peptide antigens:
  • Sensory neuron-specific G-protein coupled receptor 1/2 (MRGX3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LB0

UniProtKB/Swiss-Prot:

MRGX3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX3: view

Function for MRGPRX3 Gene

Molecular function for MRGPRX3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Phenotypes From GWAS Catalog for MRGPRX3 Gene

Gene Ontology (GO) - Molecular Function for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
genes like me logo Genes that share ontologies with MRGPRX3: view
genes like me logo Genes that share phenotypes with MRGPRX3: view

Animal Model Products

CRISPR Products

miRNA for MRGPRX3 Gene

miRTarBase miRNAs that target MRGPRX3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRX3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX3 Gene

Localization for MRGPRX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRX3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRX3 Gene

Pathways & Interactions for MRGPRX3 Gene

PathCards logo

SuperPathways for MRGPRX3 Gene

No Data Available

Interacting Proteins for MRGPRX3 Gene

Gene Ontology (GO) - Biological Process for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with MRGPRX3: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRX3 Gene

Drugs & Compounds for MRGPRX3 Gene

(2) Drugs for MRGPRX3 Gene - From: ApexBio and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAM 22P Pharma Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 0
BAM (8-22) Pharma Selective agonist for the sensory neuron specific receptor (SNSR) 0

(1) Additional Compounds for MRGPRX3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ML 382
1646499-97-9

(2) Tocris Compounds for MRGPRX3 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
ML 382 MrgX1 (SNSR4) positive allosteric modulator 1646499-97-9

(1) ApexBio Compounds for MRGPRX3 Gene

Compound Action Cas Number
BAM 22P Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 76622-26-9
genes like me logo Genes that share compounds with MRGPRX3: view

Drug Products

Transcripts for MRGPRX3 Gene

mRNA/cDNA for MRGPRX3 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRX3

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX3 Gene

No ASD Table

Relevant External Links for MRGPRX3 Gene

GeneLoc Exon Structure for
MRGPRX3

Expression for MRGPRX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRGPRX3 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX3 Gene

This gene is overexpressed in Minor Salivary Gland (x26.2), Esophagus - Mucosa (x14.0), and Breast - Mammary Tissue (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRGPRX3

SOURCE GeneReport for Unigene cluster for MRGPRX3 Gene:

Hs.380177

mRNA Expression by UniProt/SwissProt for MRGPRX3 Gene:

Q96LB0-MRGX3_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Evidence on tissue expression from TISSUES for MRGPRX3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MRGPRX3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRX3 Gene

Orthologs for MRGPRX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRGPRX3 30 31
  • 97.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrgprx3 30
  • 67.89 (n)
Mouse
(Mus musculus)
Mammalia Mrgpra1 30 17
  • 66.79 (n)
Mrgprx1 31
  • 51 (a)
ManyToMany
Mrgprb4 31
  • 46 (a)
ManyToMany
Mrgprx2 31
  • 46 (a)
ManyToMany
Mrgprb2 31
  • 46 (a)
ManyToMany
Mrgprb5 31
  • 45 (a)
ManyToMany
Mrgprb3 31
  • 44 (a)
ManyToMany
Mrgprb1 31
  • 43 (a)
ManyToMany
Mrgprb8 31
  • 39 (a)
ManyToMany
Mrgpra2a 17
Mrgpra2b 17
Mrgpra9 17
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MRGPRX2 31
  • 51 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 36 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
Species where no ortholog for MRGPRX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRGPRX3 Gene

ENSEMBL:
Gene Tree for MRGPRX3 (if available)
TreeFam:
Gene Tree for MRGPRX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRGPRX3: view image

Paralogs for MRGPRX3 Gene

Paralogs for MRGPRX3 Gene

(9) SIMAP similar genes for MRGPRX3 Gene using alignment to 2 proteins:

  • MRGX3_HUMAN
  • E9PPY5_HUMAN

Pseudogenes.org Pseudogenes for MRGPRX3 Gene

genes like me logo Genes that share paralogs with MRGPRX3: view

Variants for MRGPRX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRGPRX3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768430 Benign: not provided 18,137,795(+) T/G MISSENSE_VARIANT
rs12291017 - p.Cys82Arg
rs4274188 - p.Asn169Asp

Additional dbSNP identifiers (rs#s) for MRGPRX3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX3 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV gain 19812545
esv2744166 CNV deletion 23290073
nsv971990 CNV duplication 23825009

Variation tolerance for MRGPRX3 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRX3 Gene

Human Gene Mutation Database (HGMD)
MRGPRX3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Disorders for MRGPRX3 Gene

No disorders were found for MRGPRX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX3 Gene

Publications for MRGPRX3 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. (PMID: 11850634) Lembo PM … Ahmad S (Nature neuroscience 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. (PMID: 29408502) Schmid CD … Koch PS (Biochemical and biophysical research communications 2018) 3

Products for MRGPRX3 Gene

Sources for MRGPRX3 Gene