Aliases for MRGPRX2 Gene
External Ids for MRGPRX2 Gene
Previous GeneCards Identifiers for MRGPRX2 Gene
GeneCards Summary for MRGPRX2 Gene
MRGPRX2 (MAS Related GPR Family Member X2) is a Protein Coding gene. Diseases associated with MRGPRX2 include Ceftazidime Allergy and Chronic Urticaria. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and mast cell secretagogue receptor activity. An important paralog of this gene is MRGPRX1.
UniProtKB/Swiss-Prot Summary for MRGPRX2 Gene
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.