Aliases for MRGPRX2 Gene

Aliases for MRGPRX2 Gene

  • MAS Related GPR Family Member X2 2 3 5
  • MRGX2 2 3 4
  • Mas-Related G-Protein Coupled Receptor Member X2 3 4
  • MAS-Related GPR, Member X2 2 3
  • Mas-Related G Protein-Coupled Receptor G3 3
  • G Protein-Coupled Receptor MRGX2 3
  • MRGPRX2 5
  • MGRG3 3

External Ids for MRGPRX2 Gene

Previous GeneCards Identifiers for MRGPRX2 Gene

  • GC11M019033
  • GC11M018759

Summaries for MRGPRX2 Gene

GeneCards Summary for MRGPRX2 Gene

MRGPRX2 (MAS Related GPR Family Member X2) is a Protein Coding gene. Diseases associated with MRGPRX2 include Ceftazidime Allergy and Cephalosporin Allergy. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and mast cell secretagogue receptor activity. An important paralog of this gene is MRGPRX1.

UniProtKB/Swiss-Prot Summary for MRGPRX2 Gene

  • Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Gene Wiki entry for MRGPRX2 Gene

Additional gene information for MRGPRX2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRGPRX2 Gene

Genomics for MRGPRX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRGPRX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J019060 Promoter/Enhancer 0.5 EPDnew Ensembl 600.7 -0.5 -483 1.2 MRGPRX2 ZDHHC13
GH11J019059 Enhancer 0.2 FANTOM5 612.3 +0.7 669 0.2 MRGPRX2 ZDHHC13 piR-61101-093 MRGPRX1
GH11J019025 Enhancer 0.5 FANTOM5 Ensembl 37.2 +34.5 34469 0.7 CHD2 MRGPRX2 MRGPRX9P lnc-MRGPRX2-1 piR-53029-011 MRGPRX1
GH11J019027 Enhancer 0.7 Ensembl ENCODE 11.6 +32.3 32319 1.3 ZNF629 FOXA2 JUND ZNF335 SMAD4 JUN RARA FOS ZNF362 MRGPRX2 MRGPRX9P lnc-MRGPRX2-1 piR-53029-011 MRGPRX1
GH11J019028 Enhancer 0.2 Ensembl 11.6 +33.3 33316 0.4 MRGPRX2 MRGPRX9P lnc-MRGPRX2-1 piR-53029-011 MRGPRX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRGPRX2

Top Transcription factor binding sites by QIAGEN in the MRGPRX2 gene promoter:
  • E47
  • HEN1
  • HNF-3beta
  • Ik-3
  • p53
  • Tal-1
  • Tal-1beta

Genomic Locations for MRGPRX2 Gene

Genomic Locations for MRGPRX2 Gene
chr11:19,054,455-19,060,717
(GRCh38/hg38)
Size:
6,263 bases
Orientation:
Minus strand
chr11:19,076,002-19,082,228
(GRCh37/hg19)
Size:
6,227 bases
Orientation:
Minus strand

Genomic View for MRGPRX2 Gene

Genes around MRGPRX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX2 Gene

Proteins for MRGPRX2 Gene

  • Protein details for MRGPRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB1-MRGX2_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X2
    Protein Accession:
    Q96LB1
    Secondary Accessions:
    • B5B0C7
    • Q4QXW4
    • Q4QXW7
    • Q4QXX0
    • Q4QXX2
    • Q4QXX3
    • Q4QXX4
    • Q4QXX6
    • Q4QXX7
    • W8W3L5

    Protein attributes for MRGPRX2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX2 Gene

Post-translational modifications for MRGPRX2 Gene

No Post-translational modifications

Other Protein References for MRGPRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX2 Gene

Domains & Families for MRGPRX2 Gene

Gene Families for MRGPRX2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRX2 Gene

Suggested Antigen Peptide Sequences for MRGPRX2 Gene

GenScript: Design optimal peptide antigens:
  • Mas-related G-protein coupled receptor member X2 (MRGX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LB1

UniProtKB/Swiss-Prot:

MRGX2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX2: view

Function for MRGPRX2 Gene

Molecular function for MRGPRX2 Gene

UniProtKB/Swiss-Prot Function:
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Gene Ontology (GO) - Molecular Function for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,IDA 12915402
GO:0042923 neuropeptide binding IPI 12915402
GO:1990595 mast cell secretagogue receptor activity ISS --
genes like me logo Genes that share ontologies with MRGPRX2: view
genes like me logo Genes that share phenotypes with MRGPRX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRX2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRX2 Gene

Localization for MRGPRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRX2 gene
Compartment Confidence
plasma membrane 4
lysosome 3
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 12915402
GO:0042629 mast cell granule IEA --
genes like me logo Genes that share ontologies with MRGPRX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRX2 Gene

Pathways & Interactions for MRGPRX2 Gene

PathCards logo

SuperPathways for MRGPRX2 Gene

No Data Available

Interacting Proteins for MRGPRX2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000333800 Q96LB1-MRGX2_HUMAN for MRGPRX2 Gene via STRING IID

SIGNOR curated interactions for MRGPRX2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MRGPRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0019233 sensory perception of pain NAS 12915402
GO:0030431 sleep NAS 12915402
GO:0032467 positive regulation of cytokinesis IMP 22888021
genes like me logo Genes that share ontologies with MRGPRX2: view

No data available for Pathways by source for MRGPRX2 Gene

Drugs & Compounds for MRGPRX2 Gene

(5) Drugs for MRGPRX2 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
compound 2 [PMID:19230660] Pharma Agonist, Full agonist 0
PAMP-12 (human) Pharma Agonist, Full agonist 0
PAMP-20 Pharma Agonist, Full agonist 0
CORTISTATIN-14 Pharma 0
genes like me logo Genes that share compounds with MRGPRX2: view

Transcripts for MRGPRX2 Gene

mRNA/cDNA for MRGPRX2 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRX2

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX2 Gene

No ASD Table

Relevant External Links for MRGPRX2 Gene

GeneLoc Exon Structure for
MRGPRX2

Expression for MRGPRX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRGPRX2 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.3), Skin - Not Sun Exposed (Suprapubic) (x7.7), and Adipose - Subcutaneous (x5.9).

Protein differential expression in normal tissues from HIPED for MRGPRX2 Gene

This gene is overexpressed in Liver, secretome (48.4) and Heart (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRGPRX2 Gene



Protein tissue co-expression partners for MRGPRX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRGPRX2

SOURCE GeneReport for Unigene cluster for MRGPRX2 Gene:

Hs.350566

mRNA Expression by UniProt/SwissProt for MRGPRX2 Gene:

Q96LB1-MRGX2_HUMAN
Tissue specificity: Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).

Evidence on tissue expression from TISSUES for MRGPRX2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MRGPRX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRX2 Gene

Orthologs for MRGPRX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRGPRX2 30 31
  • 98.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRGPRX2 30
  • 75.18 (n)
-- 31
  • 62 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia MRGPRX2 30 31
  • 73.09 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mrgprx2 30
  • 69.38 (n)
Mouse
(Mus musculus)
Mammalia Mrgprx2 30 17 31
  • 66.87 (n)
ManyToMany
Mrgprx3-ps 31
  • 53 (a)
ManyToMany
Mrgprx1 31
  • 50 (a)
ManyToMany
Mrgpra3 31
  • 50 (a)
ManyToMany
Mrgpra4 31
  • 50 (a)
ManyToMany
Mrgpra6 31
  • 50 (a)
ManyToMany
Mrgprb2 31
  • 50 (a)
ManyToMany
Mrgpra1 31
  • 50 (a)
ManyToMany
Mrgprb1 17 31
  • 49 (a)
ManyToMany
Mrgprb4 31
  • 49 (a)
ManyToMany
Mrgprb5 31
  • 48 (a)
ManyToMany
Mrgpra2b 31
  • 47 (a)
ManyToMany
Mrgpra2a 31
  • 46 (a)
ManyToMany
Mrgprb3 31
  • 43 (a)
ManyToMany
Mrgprb8 31
  • 41 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 38 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 37 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 23 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for MRGPRX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRGPRX2 Gene

ENSEMBL:
Gene Tree for MRGPRX2 (if available)
TreeFam:
Gene Tree for MRGPRX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRGPRX2: view image

Paralogs for MRGPRX2 Gene

Paralogs for MRGPRX2 Gene

(9) SIMAP similar genes for MRGPRX2 Gene using alignment to 1 proteins:

  • MRGX2_HUMAN

Pseudogenes.org Pseudogenes for MRGPRX2 Gene

genes like me logo Genes that share paralogs with MRGPRX2: view

Variants for MRGPRX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRGPRX2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10833049 - p.Asn62Ser
rs11024970 - p.Asn16His
rs11823569 - p.Val43Ile
rs79763999 - p.Phe78Leu

Additional dbSNP identifiers (rs#s) for MRGPRX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX2 Gene

Variant ID Type Subtype PubMed ID
esv2759806 CNV gain+loss 17122850
nsv428250 CNV gain 18775914
nsv975890 CNV duplication 23825009

Variation tolerance for MRGPRX2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.71; 89.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX2 Gene

Disorders for MRGPRX2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MRGPRX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ceftazidime allergy
  • fortaz allergy
cephalosporin allergy
mastocytosis, cutaneous
  • mastc
corticosteroid allergy
drug allergy
  • allergy drug
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MRGPRX2

genes like me logo Genes that share disorders with MRGPRX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRGPRX2 Gene

Publications for MRGPRX2 Gene

  1. Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. (PMID: 15862286) Yang S … Su B (Gene 2005) 3 4 23
  2. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3 4
  3. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. (PMID: 25517090) McNeil BD … Dong X (Nature 2015) 3 4
  4. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M (Gene 2014) 3 4
  5. β-Defensins activate human mast cells via Mas-related gene X2. (PMID: 23698749) Subramanian H … Ali H (Journal of immunology (Baltimore, Md. : 1950) 2013) 3 4

Products for MRGPRX2 Gene

  • Biorbyt antibodies for MRGPRX2

Sources for MRGPRX2 Gene