Aliases for MRGPRG Gene

Aliases for MRGPRG Gene

  • MAS Related GPR Family Member G 2 3 5
  • Mas-Related G-Protein Coupled Receptor Member G 3 4
  • G Protein-Coupled Receptor 169 2 3
  • GPR169 3 4
  • MRGG 3 4
  • G Protein-Coupled Receptor MRGG 3
  • G-Protein Coupled Receptor 169 4
  • MAS-Related GPR, Member G 2
  • MRGPRG 5
  • MrgG 2

External Ids for MRGPRG Gene

Previous HGNC Symbols for MRGPRG Gene

  • GPR169

Previous GeneCards Identifiers for MRGPRG Gene

  • GC11U900565
  • GC11M003195
  • GC11M003029

Summaries for MRGPRG Gene

GeneCards Summary for MRGPRG Gene

MRGPRG (MAS Related GPR Family Member G) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MRGPRE.

UniProtKB/Swiss-Prot Summary for MRGPRG Gene

  • Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Gene Wiki entry for MRGPRG Gene

Additional gene information for MRGPRG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRGPRG Gene

Genomics for MRGPRG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRGPRG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003217 Enhancer 1 Ensembl ENCODE 600.7 +1.4 1417 0.8 CTCF ZNF512 ZNF692 MTA2 PKNOX1 MTA1 PATZ1 REST RAD21 HDAC1 MG828482 MRGPRG MRGPRG-AS1 OSBPL5
GH11J003218 Promoter 0.3 EPDnew 600.7 +0.5 455 0.1 MRGPRG MRGPRG-AS1 OSBPL5
GH11J003000 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +217.8 217812 2.4 FOXA1 ZIC2 POLR2A ZNF600 ZNF341 ZBTB44 ZBTB20 ESR1 ZBTB48 ZNF217 NAP1L4 CARS1-AS1 CARS1 SNORA54 RNU1-91P ENSG00000224513 PHLDA2 SLC22A18 MRGPRG MRGPRG-AS1
GH11J003136 Enhancer 1 Ensembl ENCODE dbSUPER 10.9 +81.9 81949 7.9 CTCF PRDM10 KDM1A ZIC2 SCRT2 MNT ZNF316 BCOR SPI1 GABPA OSBPL5 MRGPRG MRGPRG-AS1 ENSG00000224513 MN309223 lnc-CARS-3 lnc-SLC22A18-7 LOC107987158 CARS1
GH11J003339 Enhancer 1 Ensembl ENCODE 10.9 -121.4 -121379 1.6 IKZF1 JUND BRD9 ZNF24 DPF2 HDAC1 SOX6 EP300 NRF1 MGA piR-31474-001 ZNF195 TSSC2 ENSG00000224513 MRGPRG MRGPRG-AS1 RNU1-91P NAP1L4 SNORA54 ART1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRGPRG

Top Transcription factor binding sites by QIAGEN in the MRGPRG gene promoter:
  • AhR
  • Arnt
  • LyF-1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • SEF-1 (1)
  • Tal-1beta

Genomic Locations for MRGPRG Gene

Genomic Locations for MRGPRG Gene
chr11:3,217,944-3,218,813
(GRCh38/hg38)
Size:
870 bases
Orientation:
Minus strand
chr11:3,239,174-3,240,043
(GRCh37/hg19)
Size:
870 bases
Orientation:
Minus strand

Genomic View for MRGPRG Gene

Genes around MRGPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRG Gene

Proteins for MRGPRG Gene

  • Protein details for MRGPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SM5-MRGRG_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member G
    Protein Accession:
    Q86SM5

    Protein attributes for MRGPRG Gene

    Size:
    289 amino acids
    Molecular mass:
    31518 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRG Gene

Post-translational modifications for MRGPRG Gene

No Post-translational modifications

Other Protein References for MRGPRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRG Gene

Domains & Families for MRGPRG Gene

Gene Families for MRGPRG Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRG Gene

Suggested Antigen Peptide Sequences for MRGPRG Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 169 (MRGRG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SM5

UniProtKB/Swiss-Prot:

MRGRG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRG: view

Function for MRGPRG Gene

Molecular function for MRGPRG Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Phenotypes From GWAS Catalog for MRGPRG Gene

Gene Ontology (GO) - Molecular Function for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
genes like me logo Genes that share ontologies with MRGPRG: view

Phenotypes for MRGPRG Gene

genes like me logo Genes that share phenotypes with MRGPRG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRG Gene

Localization for MRGPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRG Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRG gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRG Gene

Pathways & Interactions for MRGPRG Gene

PathCards logo

SuperPathways for MRGPRG Gene

No Data Available

Interacting Proteins for MRGPRG Gene

Gene Ontology (GO) - Biological Process for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with MRGPRG: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRG Gene

Drugs & Compounds for MRGPRG Gene

No Compound Related Data Available

Transcripts for MRGPRG Gene

mRNA/cDNA for MRGPRG Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRG

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRG Gene

No ASD Table

Relevant External Links for MRGPRG Gene

GeneLoc Exon Structure for
MRGPRG

Expression for MRGPRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRGPRG Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRG Gene

This gene is overexpressed in Testis (x42.9) and Cervix - Endocervix (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRGPRG

SOURCE GeneReport for Unigene cluster for MRGPRG Gene:

Hs.730306
genes like me logo Genes that share expression patterns with MRGPRG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRG Gene

Orthologs for MRGPRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRGPRG 30 31
  • 98.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRGPRG 30 31
  • 78.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC618771 30
  • 77.82 (n)
MRGPRG 31
  • 66 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrgprg 30 17 31
  • 69.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrgprg 30
  • 69.11 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 36 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 21 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 17 (a)
ManyToMany
Species where no ortholog for MRGPRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRGPRG Gene

ENSEMBL:
Gene Tree for MRGPRG (if available)
TreeFam:
Gene Tree for MRGPRG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRGPRG: view image

Paralogs for MRGPRG Gene

(7) SIMAP similar genes for MRGPRG Gene using alignment to 1 proteins:

  • MRGRG_HUMAN
genes like me logo Genes that share paralogs with MRGPRG: view

Variants for MRGPRG Gene

Additional dbSNP identifiers (rs#s) for MRGPRG Gene

Structural Variations from Database of Genomic Variants (DGV) for MRGPRG Gene

Variant ID Type Subtype PubMed ID
dgv176e214 CNV gain 21293372
dgv19e180 CNV loss 20482838
dgv574n106 CNV deletion 24896259
esv2678047 CNV deletion 23128226
esv27427 CNV loss 19812545
esv2744033 CNV deletion 23290073
esv2759796 CNV gain+loss 17122850
esv3259052 CNV deletion 24192839
esv3547230 CNV deletion 23714750
esv3625135 CNV loss 21293372
esv992308 CNV deletion 20482838
nsv428245 CNV gain 18775914
nsv469931 CNV loss 18288195
nsv524468 CNV loss 19592680
nsv7649 CNV deletion 18451855
nsv951295 CNV deletion 24416366

Variation tolerance for MRGPRG Gene

Gene Damage Index Score: 3.57; 56.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRGPRG Gene

Disorders for MRGPRG Gene

Additional Disease Information for MRGPRG

No disorders were found for MRGPRG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRG Gene

Publications for MRGPRG Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for MRGPRG Gene

Sources for MRGPRG Gene