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Aliases for MRGPRG Gene

Aliases for MRGPRG Gene

  • MAS Related GPR Family Member G 2 3 5
  • G Protein-Coupled Receptor 169 2 3
  • GPR169 3 4
  • MRGG 3 4
  • Mas-Related G-Protein Coupled Receptor Member G 3
  • G Protein-Coupled Receptor MRGG 3
  • G-Protein Coupled Receptor 169 4
  • MAS-Related GPR, Member G 2

External Ids for MRGPRG Gene

Previous HGNC Symbols for MRGPRG Gene

  • GPR169

Previous GeneCards Identifiers for MRGPRG Gene

  • GC11U900565
  • GC11M003195
  • GC11M003029

Summaries for MRGPRG Gene

GeneCards Summary for MRGPRG Gene

MRGPRG (MAS Related GPR Family Member G) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRF.

UniProtKB/Swiss-Prot for MRGPRG Gene

  • Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Gene Wiki entry for MRGPRG Gene

Additional gene information for MRGPRG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRG Gene

Genomics for MRGPRG Gene

GeneHancer (GH) Regulatory Elements for MRGPRG Gene

Promoters and enhancers for MRGPRG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003217 Enhancer 0.9 ENCODE 650.7 +1.4 1354 0.7 HDAC1 PKNOX1 RB1 KLF17 KLF14 ZNF2 RAD21 GLIS2 ARID2 ZNF143 GC11M003218 MRGPRG MRGPRG-AS1 ENSG00000234791
GH11J003000 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 9.9 +217.8 217785 2.1 ZBTB6 NFIB ZIC2 GATA3 POLR2A ZBTB48 RCOR1 ZNF600 CHD2 ZBTB20 NAP1L4 CARS-AS1 CARS SNORA54 RNU1-91P ENSG00000224513 PHLDA2 SLC22A18 MRGPRG MRGPRG-AS1
GH11J003339 Enhancer 0.8 ENCODE 10.9 -121.4 -121379 1.6 HDAC1 ATF1 ARNT NFRKB FOS ATF7 CREM NCOA1 ZEB2 ZNF592 ZNF195 TSSC2 ENSG00000224513 MRGPRG MRGPRG-AS1 RNU1-91P NAP1L4 SNORA54 ART1 ART5
GH11J003110 Enhancer 0.7 ENCODE 11.3 +108.5 108497 0.2 BCOR CTCF RB1 TEAD4 RAD21 CC2D1A CTBP1 ARID2 ZNF143 SMC3 CARS MRGPRG MRGPRG-AS1 ENSG00000224513 RNU1-91P NAP1L4 ENSG00000236710 GC11P003163 OSBPL5
GH11J003137 Enhancer 0.7 ENCODE dbSUPER 10.9 +80.3 80327 1.2 GLIS1 VEZF1 MAX MNT ZIC2 MYC OSBPL5 MRGPRG-AS1 MRGPRG ENSG00000224513 GC11P003163 ENSG00000236710
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRGPRG gene promoter:
  • SEF-1 (1)
  • MyoD
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • LyF-1
  • Arnt
  • AhR
  • Tal-1beta

Genomic Locations for MRGPRG Gene

Genomic Locations for MRGPRG Gene
870 bases
Minus strand
870 bases
Minus strand

Genomic View for MRGPRG Gene

Genes around MRGPRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRG Gene

Proteins for MRGPRG Gene

  • Protein details for MRGPRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member G
    Protein Accession:

    Protein attributes for MRGPRG Gene

    289 amino acids
    Molecular mass:
    31518 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRG Gene

Post-translational modifications for MRGPRG Gene

No Post-translational modifications

Other Protein References for MRGPRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRG Gene

Domains & Families for MRGPRG Gene

Gene Families for MRGPRG Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRG Gene

Suggested Antigen Peptide Sequences for MRGPRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRG: view

Function for MRGPRG Gene

Molecular function for MRGPRG Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Phenotypes From GWAS Catalog for MRGPRG Gene

Gene Ontology (GO) - Molecular Function for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRG: view

Phenotypes for MRGPRG Gene

genes like me logo Genes that share phenotypes with MRGPRG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRG Gene

Localization for MRGPRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRG Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRG gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRG Gene

Pathways & Interactions for MRGPRG Gene

SuperPathways for MRGPRG Gene

No Data Available

Interacting Proteins for MRGPRG Gene

Gene Ontology (GO) - Biological Process for MRGPRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRG: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRG Gene

Drugs & Compounds for MRGPRG Gene

No Compound Related Data Available

Transcripts for MRGPRG Gene


(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRG Gene

MAS-related GPR, member G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRG Gene

No ASD Table

Relevant External Links for MRGPRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRG Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRG Gene

This gene is overexpressed in Testis (x42.9) and Cervix - Endocervix (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of MRGPRG Gene:


SOURCE GeneReport for Unigene cluster for MRGPRG Gene:

genes like me logo Genes that share expression patterns with MRGPRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRG Gene

Orthologs for MRGPRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRGPRG 34 33
  • 98.15 (n)
(Canis familiaris)
Mammalia MRGPRG 34 33
  • 78.55 (n)
(Bos Taurus)
Mammalia LOC618771 33
  • 77.82 (n)
  • 66 (a)
(Mus musculus)
Mammalia Mrgprg 16 34 33
  • 69.36 (n)
(Rattus norvegicus)
Mammalia Mrgprg 33
  • 69.11 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
-- 34
  • 32 (a)
-- 34
  • 30 (a)
(Gallus gallus)
Aves -- 34
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
-- 34
  • 27 (a)
-- 34
  • 25 (a)
-- 34
  • 25 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
-- 34
  • 23 (a)
-- 34
  • 23 (a)
-- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 21 (a)
-- 34
  • 21 (a)
-- 34
  • 19 (a)
-- 34
  • 17 (a)
Species where no ortholog for MRGPRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRG Gene

Gene Tree for MRGPRG (if available)
Gene Tree for MRGPRG (if available)
Evolutionary constrained regions (ECRs) for MRGPRG: view image

Paralogs for MRGPRG Gene

Paralogs for MRGPRG Gene

(7) SIMAP similar genes for MRGPRG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRGPRG: view

Variants for MRGPRG Gene

Sequence variations from dbSNP and Humsavar for MRGPRG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000180807 -- 3,219,204(-) T/C upstream_transcript_variant
rs1000262710 -- 3,220,431(-) A/G upstream_transcript_variant
rs1000554484 -- 3,218,968(-) C/T upstream_transcript_variant
rs1000621812 -- 3,219,174(-) A/C upstream_transcript_variant
rs1000922769 -- 3,220,437(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRG Gene

Variant ID Type Subtype PubMed ID
dgv176e214 CNV gain 21293372
dgv19e180 CNV loss 20482838
dgv574n106 CNV deletion 24896259
esv2678047 CNV deletion 23128226
esv27427 CNV loss 19812545
esv2744033 CNV deletion 23290073
esv2759796 CNV gain+loss 17122850
esv3259052 CNV deletion 24192839
esv3547230 CNV deletion 23714750
esv3625135 CNV loss 21293372
esv992308 CNV deletion 20482838
nsv428245 CNV gain 18775914
nsv469931 CNV loss 18288195
nsv524468 CNV loss 19592680
nsv7649 CNV deletion 18451855
nsv951295 CNV deletion 24416366

Variation tolerance for MRGPRG Gene

Gene Damage Index Score: 3.57; 56.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRG Gene

Disorders for MRGPRG Gene

Additional Disease Information for MRGPRG

No disorders were found for MRGPRG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRG Gene

Publications for MRGPRG Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for MRGPRG Gene

Sources for MRGPRG Gene

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