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Aliases for MRGPRF Gene

Aliases for MRGPRF Gene

  • MAS Related GPR Family Member F 2 3 5
  • G-Protein Coupled Receptor 140 3 4
  • G-Protein Coupled Receptor 168 3 4
  • Mas-Related Gene F Protein 3 4
  • MAS-Related GPR, Member F 2 3
  • GPR140 3 4
  • GPR168 3 4
  • MRGF 3 4
  • Mas-Related G-Protein Coupled Receptor Member F 3
  • Seven Transmembrane Helix Receptor 3
  • Mas-Related G Protein-Coupled MRGF 3
  • G Protein-Coupled Receptor MrgF 3
  • G Protein-Coupled Receptor 168 2
  • G Protein-Coupled Receptor 140 2
  • RTA 3

External Ids for MRGPRF Gene

Previous HGNC Symbols for MRGPRF Gene

  • GPR168
  • GPR140

Previous GeneCards Identifiers for MRGPRF Gene

  • GC11M068548
  • GC11M068528
  • GC11M068771
  • GC11M065111

Summaries for MRGPRF Gene

GeneCards Summary for MRGPRF Gene

MRGPRF (MAS Related GPR Family Member F) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRD.

UniProtKB/Swiss-Prot for MRGPRF Gene

  • Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Additional gene information for MRGPRF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRF Gene

Genomics for MRGPRF Gene

GeneHancer (GH) Regulatory Elements for MRGPRF Gene

Promoters and enhancers for MRGPRF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I069006 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.8 +1.9 1927 9 PKNOX1 ATF1 FOXA2 SIN3A RAD21 YY1 EGR1 ZNF143 RCOR1 ATF7 MRGPRF MRGPRF-AS1 IGHMBP2 ENSG00000261625 MRPL21 PPP6R3 GAL ORAOV1 ENSG00000261276
GH11I068098 Enhancer 1.4 Ensembl ENCODE dbSUPER 60.2 +912.4 912367 4.7 FOXA2 SMAD1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF213 SP5 KMT5B PPP6R3 MRGPRF-AS1 ENSG00000260808 MRGPRF ENSG00000261625 TPCN2 RAD9A KDM2A SSH3
GH11I068902 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 +109.1 109083 2.7 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 ZC3H11A ZFP41 ZNF610 IGHMBP2 MRPL21 ORAOV1 KMT5B MRGPRF-AS1 MRGPRF LOC105369364 PPP6R3 ENSG00000260808 ENSG00000261625
GH11I068836 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.3 +172.7 172665 8.1 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 CPT1A IGHMBP2 PPP6R3 MRGPRF-AS1 KMT5B ENSG00000261625 ORAOV1 MRGPRF ENSG00000260808 TPCN2
GH11I069048 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -37.5 -37479 5.7 HDGF ATF1 ZFP64 ARID4B SIN3A ZBTB7B ZNF48 YY1 POLR2B GLIS2 TPCN2 MRGPRF MRGPRF-AS1 IGHMBP2 MRPL21 MRGPRD PIR48560
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRGPRF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRGPRF gene promoter:

Genomic Locations for MRGPRF Gene

Genomic Locations for MRGPRF Gene
9,016 bases
Minus strand

Genomic View for MRGPRF Gene

Genes around MRGPRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRF Gene

Proteins for MRGPRF Gene

  • Protein details for MRGPRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member F
    Protein Accession:
    Secondary Accessions:
    • B3KV43
    • Q8NBK8

    Protein attributes for MRGPRF Gene

    343 amino acids
    Molecular mass:
    38171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRF Gene

Post-translational modifications for MRGPRF Gene

  • Glycosylation at isoforms=4
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRF Gene

No data available for DME Specific Peptides for MRGPRF Gene

Domains & Families for MRGPRF Gene

Gene Families for MRGPRF Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for MRGPRF Gene

Suggested Antigen Peptide Sequences for MRGPRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRF: view

Function for MRGPRF Gene

Molecular function for MRGPRF Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

Phenotypes From GWAS Catalog for MRGPRF Gene

Gene Ontology (GO) - Molecular Function for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRF: view
genes like me logo Genes that share phenotypes with MRGPRF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRF Gene

Localization for MRGPRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRF Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRF gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with MRGPRF: view

Pathways & Interactions for MRGPRF Gene

SuperPathways for MRGPRF Gene

No Data Available

Interacting Proteins for MRGPRF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000309782 for MRGPRF Gene via STRING

Gene Ontology (GO) - Biological Process for MRGPRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRF: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRF Gene

Drugs & Compounds for MRGPRF Gene

No Compound Related Data Available

Transcripts for MRGPRF Gene


(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRF Gene

MAS-related GPR, member F:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - - -
SP3: -

Relevant External Links for MRGPRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRGPRF Gene

This gene is overexpressed in Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Uterus (x4.1).

Protein differential expression in normal tissues from HIPED for MRGPRF Gene

This gene is overexpressed in Gallbladder (14.8), Colon (11.8), and Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRGPRF Gene

Protein tissue co-expression partners for MRGPRF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRGPRF Gene:


SOURCE GeneReport for Unigene cluster for MRGPRF Gene:


Evidence on tissue expression from TISSUES for MRGPRF Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MRGPRF: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRF Gene

Orthologs for MRGPRF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRGPRF 33 34
  • 99.71 (n)
(Bos Taurus)
Mammalia MRGPRF 33 34
  • 89.99 (n)
(Canis familiaris)
Mammalia MRGPRF 34 33
  • 89.6 (n)
(Mus musculus)
Mammalia Mrgprf 33 16 34
  • 83.97 (n)
(Rattus norvegicus)
Mammalia Mrgprf 33
  • 83.67 (n)
(Monodelphis domestica)
Mammalia MRGPRF 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRGPRF 34
  • 33 (a)
(Gallus gallus)
Aves -- 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 27 (a)
-- 34
  • 26 (a)
-- 34
  • 25 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
-- 34
  • 22 (a)
-- 34
  • 21 (a)
Species where no ortholog for MRGPRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRF Gene

Gene Tree for MRGPRF (if available)
Gene Tree for MRGPRF (if available)

Paralogs for MRGPRF Gene

Paralogs for MRGPRF Gene

(8) SIMAP similar genes for MRGPRF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRGPRF: view

Variants for MRGPRF Gene

Sequence variations from dbSNP and Humsavar for MRGPRF Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000005074 -- 69,014,742(-) G/A/T upstream_transcript_variant
rs1000439978 -- 69,015,004(-) A/G upstream_transcript_variant
rs1000737094 -- 69,012,962(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000849518 -- 69,011,059(-) G/C 5_prime_UTR_variant, intron_variant
rs1001530743 -- 69,008,675(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRF Gene

Variant ID Type Subtype PubMed ID
nsv468619 CNV loss 19166990
nsv527120 CNV loss 19592680
nsv555299 CNV loss 21841781
nsv832196 CNV loss 17160897

Variation tolerance for MRGPRF Gene

Gene Damage Index Score: 8.94; 87.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRF Gene

Disorders for MRGPRF Gene

Additional Disease Information for MRGPRF

No disorders were found for MRGPRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRF Gene

Publications for MRGPRF Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M (Gene 2014) 3 58

Products for MRGPRF Gene

Sources for MRGPRF Gene

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