Aliases for MRGPRE Gene

Aliases for MRGPRE Gene

  • MAS Related GPR Family Member E 2 3 5
  • Mas-Related G-Protein Coupled Receptor Member E 3 4
  • G-Protein Coupled Receptor 167 3 4
  • MAS-Related GPR, Member E 2 3
  • GPR167 3 4
  • MRGE 3 4
  • Mas-Related G Protein-Coupled Receptor F 3
  • Mas-Related G Protein-Coupled MRGE 3
  • G Protein-Coupled Receptor 167 2
  • MRGPRE 5
  • MGRF 3
  • MrgE 2

External Ids for MRGPRE Gene

Previous HGNC Symbols for MRGPRE Gene

  • GPR167

Previous GeneCards Identifiers for MRGPRE Gene

  • GC11M003214
  • GC11M003206

Summaries for MRGPRE Gene

GeneCards Summary for MRGPRE Gene

MRGPRE (MAS Related GPR Family Member E) is a Protein Coding gene. Diseases associated with MRGPRE include Mixed Sleep Apnea and Isolated Growth Hormone Deficiency, Type Ib. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MRGPRX2.

UniProtKB/Swiss-Prot Summary for MRGPRE Gene

  • Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Gene Wiki entry for MRGPRE Gene

Additional gene information for MRGPRE Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRGPRE Gene

Genomics for MRGPRE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRGPRE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J003232 Enhancer 0.8 Ensembl 600.7 +0.3 310 1.4 MTA2 ZIC2 SOX6 TCF12 EP300 CTBP1 ZBTB11 TBL1XR1 TRIM24 NCOR1 MRGPRE CARS1 MRGPRG-AS1 ENSG00000224513 MRGPRG
GH11J003227 Enhancer 0.5 Ensembl 11.4 +5.3 5316 3 REST BHLHE40 SPI1 GABPA POLR2A MYC CTCF MAX ENSG00000224513 MRGPRG-AS1 MRGPRE RNU1-91P MRGPRG
GH11J003222 Enhancer 0.4 Ensembl 0.4 +9.2 9181 0.9 ZBTB33 POLR2A MAX piR-54723 ENSG00000224513 MRGPRG MRGPRG-AS1 MRGPRE
GH11J003223 Enhancer 0.4 Ensembl 0.4 +8.0 8016 1.2 KLF17 ZNF143 CTCF ENSG00000224513 piR-54723 MRGPRG-AS1 TSSC2 MRGPRE MRGPRG
GH11J003262 Enhancer 0.5 Ensembl 0.3 -30.3 -30298 0.6 IKZF1 NCOR1 ZNF592 TAL1 TCF12 CBFA2T2 CBFA2T3 ARID1B piR-37972-066 MRGPRE ZNF195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRGPRE

Top Transcription factor binding sites by QIAGEN in the MRGPRE gene promoter:
  • AhR
  • Arnt
  • E47
  • LyF-1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • SEF-1 (1)
  • Tal-1beta

Genomic Locations for MRGPRE Gene

Genomic Locations for MRGPRE Gene
chr11:3,225,030-3,232,417
(GRCh38/hg38)
Size:
7,388 bases
Orientation:
Minus strand
chr11:3,248,928-3,253,616
(GRCh37/hg19)
Size:
4,689 bases
Orientation:
Minus strand

Genomic View for MRGPRE Gene

Genes around MRGPRE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRE Gene

Proteins for MRGPRE Gene

  • Protein details for MRGPRE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SM8-MRGRE_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member E
    Protein Accession:
    Q86SM8
    Secondary Accessions:
    • Q2M1V7

    Protein attributes for MRGPRE Gene

    Size:
    312 amino acids
    Molecular mass:
    34286 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI12204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for MRGPRE Gene

Post-translational modifications for MRGPRE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRGPRE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRE Gene

Domains & Families for MRGPRE Gene

Gene Families for MRGPRE Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRE Gene

Suggested Antigen Peptide Sequences for MRGPRE Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 167 (MRGRE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SM8

UniProtKB/Swiss-Prot:

MRGRE_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRE: view

Function for MRGPRE Gene

Molecular function for MRGPRE Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Phenotypes From GWAS Catalog for MRGPRE Gene

Gene Ontology (GO) - Molecular Function for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
genes like me logo Genes that share ontologies with MRGPRE: view
genes like me logo Genes that share phenotypes with MRGPRE: view

Animal Models for MRGPRE Gene

MGI Knock Outs for MRGPRE:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRE

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRGPRE Gene

Localization for MRGPRE Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRE Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRE gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRE Gene

Pathways & Interactions for MRGPRE Gene

PathCards logo

SuperPathways for MRGPRE Gene

No Data Available

Interacting Proteins for MRGPRE Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000374482 for MRGPRE Gene via STRING

Gene Ontology (GO) - Biological Process for MRGPRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with MRGPRE: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRE Gene

Drugs & Compounds for MRGPRE Gene

No Compound Related Data Available

Transcripts for MRGPRE Gene

mRNA/cDNA for MRGPRE Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRGPRE

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRE Gene

No ASD Table

Relevant External Links for MRGPRE Gene

GeneLoc Exon Structure for
MRGPRE

Expression for MRGPRE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRGPRE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRGPRE

SOURCE GeneReport for Unigene cluster for MRGPRE Gene:

Hs.745512

Evidence on tissue expression from TISSUES for MRGPRE Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with MRGPRE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRE Gene

Orthologs for MRGPRE Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRGPRE 30 31
  • 99.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mrgpre 30 17 31
  • 80.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrgpre 30
  • 80.13 (n)
Oppossum
(Monodelphis domestica)
Mammalia MRGPRE 31
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 30 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 29 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 24 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
Species where no ortholog for MRGPRE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRGPRE Gene

ENSEMBL:
Gene Tree for MRGPRE (if available)
TreeFam:
Gene Tree for MRGPRE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRGPRE: view image

Paralogs for MRGPRE Gene

(9) SIMAP similar genes for MRGPRE Gene using alignment to 3 proteins:

  • MRGRE_HUMAN
  • L8E724_HUMAN
  • W4VSQ4_HUMAN
genes like me logo Genes that share paralogs with MRGPRE: view

Variants for MRGPRE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRGPRE Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12295710 - p.Gly16Ser
rs4391795 - p.Gly160Ser

Additional dbSNP identifiers (rs#s) for MRGPRE Gene

Structural Variations from Database of Genomic Variants (DGV) for MRGPRE Gene

Variant ID Type Subtype PubMed ID
dgv176e214 CNV gain 21293372
esv2759796 CNV gain+loss 17122850
esv3891908 CNV loss 25118596
nsv428245 CNV gain 18775914
nsv523703 CNV loss 19592680
nsv7649 CNV deletion 18451855
nsv951295 CNV deletion 24416366

Variation tolerance for MRGPRE Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRE Gene

Disorders for MRGPRE Gene

MalaCards: The human disease database

(2) MalaCards diseases for MRGPRE Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed sleep apnea
  • complex sleep apnea
isolated growth hormone deficiency, type ib
  • pituitary dwarfism i
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MRGPRE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRGPRE Gene

Publications for MRGPRE Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  3. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3
  4. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. (PMID: 24583173) Premzl M (Gene 2014) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3

Products for MRGPRE Gene

Sources for MRGPRE Gene