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Aliases for MRGPRD Gene

Aliases for MRGPRD Gene

  • MAS Related GPR Family Member D 2 3 5
  • G-Protein Coupled Receptor TGR7 3 4
  • MAS-Related GPR, Member D 2 3
  • Beta-Alanine Receptor 3 4
  • MRGD 3 4
  • Mas-Related G-Protein Coupled Receptor Member D 3
  • Mas-Related G Protein-Coupled MRGD 3
  • TGR7 3

External Ids for MRGPRD Gene

Previous GeneCards Identifiers for MRGPRD Gene

  • GC11M068523
  • GC11M068504
  • GC11M068747
  • GC11M065086

Summaries for MRGPRD Gene

GeneCards Summary for MRGPRD Gene

MRGPRD (MAS Related GPR Family Member D) is a Protein Coding gene. Among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX1.

UniProtKB/Swiss-Prot for MRGPRD Gene

  • May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

Gene Wiki entry for MRGPRD Gene

Additional gene information for MRGPRD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRD Gene

Genomics for MRGPRD Gene

GeneHancer (GH) Regulatory Elements for MRGPRD Gene

Promoters and enhancers for MRGPRD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J069040 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -59.9 -59939 1.6 USF1 RFX1 MAX FOSL1 MITF ZNF692 CBFA2T2 FOS MYC MRGPRF MRGPRF-AS1 MRGPRD IGHMBP2 TPCN2 MRPL21
GH11J069027 Enhancer 0.9 Ensembl dbSUPER 12 -47.0 -46993 0.8 FOXA2 RXRA FOXA3 MAX CEBPB CEBPG ETV5 RAD21 ZNF7 NR2F2 MRGPRD ENSG00000261625 IGHMBP2 MRGPRF TPCN2
GH11J069030 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 11.4 -49.5 -49515 0.2 ATF4 ZNF512 CEBPG PRDM1 MRGPRD TPCN2 MRGPRF
GH11J068997 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.7 -20.8 -20812 7.7 NFIB ZSCAN4 ARID4B SIN3A BATF IRF4 RAD21 YY1 ZNF335 EGR1 ENSG00000261625 IGHMBP2 MRPL21 GAL LTO1 MRGPRF-AS1 MRGPRD ENSG00000261276 MRGPRF
GH11J069034 Enhancer 0.5 Ensembl ENCODE 11.2 -54.5 -54455 2.3 ADNP ENSG00000261625 MRGPRF MRGPRF-AS1 MRGPRD IGHMBP2 TPCN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRGPRD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRGPRD gene promoter:
  • AML1a
  • COMP1
  • Pax-6

Genomic Locations for MRGPRD Gene

Genomic Locations for MRGPRD Gene
chr11:68,980,021-68,980,986
(GRCh38/hg38)
Size:
966 bases
Orientation:
Minus strand
chr11:68,747,490-68,748,455
(GRCh37/hg19)
Size:
966 bases
Orientation:
Minus strand

Genomic View for MRGPRD Gene

Genes around MRGPRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRD Gene

Proteins for MRGPRD Gene

  • Protein details for MRGPRD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDS7-MRGRD_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member D
    Protein Accession:
    Q8TDS7
    Secondary Accessions:
    • Q8NGK7

    Protein attributes for MRGPRD Gene

    Size:
    321 amino acids
    Molecular mass:
    36118 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MRGPRD Gene

Post-translational modifications for MRGPRD Gene

  • Glycosylation at isoforms=92, isoforms=16, Asn6, and isoforms=2
  • Modification sites at PhosphoSitePlus

Other Protein References for MRGPRD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRD Gene

Domains & Families for MRGPRD Gene

Gene Families for MRGPRD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRD Gene

Suggested Antigen Peptide Sequences for MRGPRD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDS7

UniProtKB/Swiss-Prot:

MRGRD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRD: view

Function for MRGPRD Gene

Molecular function for MRGPRD Gene

UniProtKB/Swiss-Prot Function:
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

Phenotypes From GWAS Catalog for MRGPRD Gene

Gene Ontology (GO) - Molecular Function for MRGPRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRD: view
genes like me logo Genes that share phenotypes with MRGPRD: view

Animal Models for MRGPRD Gene

MGI Knock Outs for MRGPRD:

Animal Model Products

  • Taconic Biosciences Mouse Models for MRGPRD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRD Gene

Localization for MRGPRD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRD Gene

Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRD gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for MRGPRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRD Gene

Pathways & Interactions for MRGPRD Gene

genes like me logo Genes that share pathways with MRGPRD: view

Pathways by source for MRGPRD Gene

1 KEGG pathway for MRGPRD Gene

Interacting Proteins for MRGPRD Gene

Gene Ontology (GO) - Biological Process for MRGPRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRD: view

No data available for SIGNOR curated interactions for MRGPRD Gene

Drugs & Compounds for MRGPRD Gene

(4) Drugs for MRGPRD Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
beta-Alanine Experimental Pharma Full agonist, Agonist Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 0
cyclic amp Experimental Pharma 0
Β-ALANINE Pharma 0

(1) Additional Compounds for MRGPRD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRGPRD: view

Transcripts for MRGPRD Gene

mRNA/cDNA for MRGPRD Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRD Gene

MAS-related GPR, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRD Gene

No ASD Table

Relevant External Links for MRGPRD Gene

GeneLoc Exon Structure for
MRGPRD
ECgene alternative splicing isoforms for
MRGPRD

Expression for MRGPRD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRGPRD Gene

This gene is overexpressed in Brain - Cerebellum (x4.6), Colon - Sigmoid (x4.6), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for MRGPRD Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRGPRD Gene



Protein tissue co-expression partners for MRGPRD Gene

NURSA nuclear receptor signaling pathways regulating expression of MRGPRD Gene:

MRGPRD

SOURCE GeneReport for Unigene cluster for MRGPRD Gene:

Hs.527802

Evidence on tissue expression from TISSUES for MRGPRD Gene

  • Liver(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with MRGPRD: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRD Gene

Orthologs for MRGPRD Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRD 34 33
  • 98.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRGPRD 33
  • 77.03 (n)
rat
(Rattus norvegicus)
Mammalia Mrgprd 33
  • 73.59 (n)
cow
(Bos Taurus)
Mammalia MRGPRD 33
  • 69.76 (n)
-- 34
  • 52 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrgprd 16 34 33
  • 69.62 (n)
oppossum
(Monodelphis domestica)
Mammalia MRGPRD 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for MRGPRD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRD Gene

ENSEMBL:
Gene Tree for MRGPRD (if available)
TreeFam:
Gene Tree for MRGPRD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRGPRD: view image

Paralogs for MRGPRD Gene

Paralogs for MRGPRD Gene

(9) SIMAP similar genes for MRGPRD Gene using alignment to 1 proteins:

  • MRGRD_HUMAN
genes like me logo Genes that share paralogs with MRGPRD: view

Variants for MRGPRD Gene

Sequence variations from dbSNP and Humsavar for MRGPRD Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000957464 -- 68,982,497(-) G/A upstream_transcript_variant
rs1001869825 -- 68,981,885(-) C/G upstream_transcript_variant
rs1002300932 -- 68,981,643(-) G/C upstream_transcript_variant
rs1002960083 -- 68,979,858(-) T/C downstream_transcript_variant
rs1003568580 -- 68,980,507(-) G/A coding_sequence_variant, synonymous_variant

Variation tolerance for MRGPRD Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGPRD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRGPRD Gene

Disorders for MRGPRD Gene

Additional Disease Information for MRGPRD

No disorders were found for MRGPRD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRD Gene

Publications for MRGPRD Gene

  1. Identification of a G protein-coupled receptor specifically responsive to beta-alanine. (PMID: 15037633) Shinohara T … Hinuma S (The Journal of biological chemistry 2004) 3 4 22 58
  2. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. (PMID: 12909716) Zylka MJ … Anderson DJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  3. Angiotensin metabolites can stimulate receptors of the Mas-related genes family. (PMID: 18636314) Gembardt F … Walther T (Molecular and cellular biochemistry 2008) 3 22 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3 58

Products for MRGPRD Gene

Sources for MRGPRD Gene

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