Aliases for MRGBP Gene
External Ids for MRGBP Gene
Previous HGNC Symbols for MRGBP Gene
Previous GeneCards Identifiers for MRGBP Gene
GeneCards Summary for MRGBP Gene
MRGBP (MRG Domain Binding Protein) is a Protein Coding gene. Among its related pathways are Chromatin organization.
UniProtKB/Swiss-Prot for MRGBP Gene
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.