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Aliases for MRGBP Gene

Aliases for MRGBP Gene

  • MRG Domain Binding Protein 2 3 5
  • Up-Regulated In Colon Cancer 4 3 4
  • MRG/MORF4L Binding Protein 2 3
  • MRG-Binding Protein 3 4
  • C20orf20 3 4
  • URCC4 3 4
  • Chromosome 20 Open Reading Frame 20 2
  • MRG/MORF4L-Binding Protein 3
  • MRG15BP 3
  • Eaf7 3

External Ids for MRGBP Gene

Previous HGNC Symbols for MRGBP Gene

  • C20orf20

Previous GeneCards Identifiers for MRGBP Gene

  • GC20P061428
  • GC20P062797
  • GC20P062798
  • GC20P062808

Summaries for MRGBP Gene

GeneCards Summary for MRGBP Gene

MRGBP (MRG Domain Binding Protein) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for MRGBP Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Additional gene information for MRGBP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGBP Gene

Genomics for MRGBP Gene

GeneHancer (GH) Regulatory Elements for MRGBP Gene

Promoters and enhancers for MRGBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062793 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.8 -0.6 -627 5 HDGF CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B MRGBP LOC105372716 OGFR DIDO1 YTHDF1 RPS21 LSM14B LAMA5 RTEL1 SS18L1
GH20I062300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.9 -492.7 -492663 5.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ADRM1 DIDO1 TAF4 MRGBP ENSG00000226332 RPS21 LAMA5 GID8 LAMA5-AS1 CABLES2
GH20I063625 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.8 +831.4 831362 4.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GMEB2 GC20P063629 MHENCR DIDO1 CICP4 MRGBP GID8 RTEL1 MIR647 UCKL1
GH20I062140 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.4 -653.5 -653548 4.3 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF207 SS18L1 PIR42263 PSMA7 MRGBP TAF4 DIDO1 ADRM1 MTG2
GH20I062236 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.4 -558.1 -558132 4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 OSBPL2 TAF4 MRGBP DIDO1 MTG2 ADRM1 LAMA5-AS1 CABLES2 GATA5 GC20M062290
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRGBP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MRGBP Gene

Genomic Locations for MRGBP Gene
chr20:62,796,453-62,801,738
(GRCh38/hg38)
Size:
5,286 bases
Orientation:
Plus strand
chr20:61,427,805-61,431,945
(GRCh37/hg19)

Genomic View for MRGBP Gene

Genes around MRGBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGBP Gene

Proteins for MRGBP Gene

  • Protein details for MRGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV56-MRGBP_HUMAN
    Recommended name:
    MRG/MORF4L-binding protein
    Protein Accession:
    Q9NV56
    Secondary Accessions:
    • A8C4L5

    Protein attributes for MRGBP Gene

    Size:
    204 amino acids
    Molecular mass:
    22417 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.

    Three dimensional structures from OCA and Proteopedia for MRGBP Gene

neXtProt entry for MRGBP Gene

Post-translational modifications for MRGBP Gene

No Post-translational modifications

Other Protein References for MRGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGBP Gene

Domains & Families for MRGBP Gene

Gene Families for MRGBP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MRGBP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRGBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV56

UniProtKB/Swiss-Prot:

MRGBP_HUMAN :
  • Belongs to the EAF7 family.
Family:
  • Belongs to the EAF7 family.
genes like me logo Genes that share domains with MRGBP: view

Function for MRGBP Gene

Molecular function for MRGBP Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Phenotypes From GWAS Catalog for MRGBP Gene

Gene Ontology (GO) - Molecular Function for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963728
genes like me logo Genes that share ontologies with MRGBP: view
genes like me logo Genes that share phenotypes with MRGBP: view

Clone Products

  • Addgene plasmids for MRGBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGBP Gene

Localization for MRGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGBP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGBP gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
GO:0043189 H4/H2A histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with MRGBP: view

Pathways & Interactions for MRGBP Gene

genes like me logo Genes that share pathways with MRGBP: view

Pathways by source for MRGBP Gene

Gene Ontology (GO) - Biological Process for MRGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0016569 covalent chromatin modification IEA --
GO:0016573 histone acetylation IBA --
genes like me logo Genes that share ontologies with MRGBP: view

No data available for SIGNOR curated interactions for MRGBP Gene

Drugs & Compounds for MRGBP Gene

No Compound Related Data Available

Transcripts for MRGBP Gene

mRNA/cDNA for MRGBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(184) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGBP Gene

MRG/MORF4L binding protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for MRGBP

Alternative Splicing Database (ASD) splice patterns (SP) for MRGBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for MRGBP Gene

GeneLoc Exon Structure for
MRGBP
ECgene alternative splicing isoforms for
MRGBP

Expression for MRGBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGBP Gene

mRNA differential expression in normal tissues according to GTEx for MRGBP Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for MRGBP Gene

This gene is overexpressed in Breast (35.0), Peripheral blood mononuclear cells (9.0), and Testis (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRGBP Gene



Protein tissue co-expression partners for MRGBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRGBP Gene:

MRGBP

SOURCE GeneReport for Unigene cluster for MRGBP Gene:

Hs.590870

Evidence on tissue expression from TISSUES for MRGBP Gene

  • Liver(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with MRGBP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGBP Gene

Orthologs for MRGBP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRGBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGBP 33 34
  • 94.95 (n)
cow
(Bos Taurus)
Mammalia C13H20orf20 33 34
  • 91.94 (n)
mouse
(Mus musculus)
Mammalia Mrgbp 33 16 34
  • 91.4 (n)
dog
(Canis familiaris)
Mammalia MRGBP 33 34
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910098 33
  • 90.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRGBP 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20ORF20 33
  • 79.37 (n)
MRGBP 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRGBP 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3953 33
zebrafish
(Danio rerio)
Actinopterygii mrgbp 33 34
  • 67.4 (n)
zgc73167 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012361 33
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta MrgBP 33 34
  • 48.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for MRGBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRGBP Gene

ENSEMBL:
Gene Tree for MRGBP (if available)
TreeFam:
Gene Tree for MRGBP (if available)

Paralogs for MRGBP Gene

No data available for Paralogs for MRGBP Gene

Variants for MRGBP Gene

Sequence variations from dbSNP and Humsavar for MRGBP Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000031625 -- 62,802,126(+) C/G downstream_transcript_variant
rs1000078923 -- 62,795,571(+) G/A upstream_transcript_variant
rs1000325278 -- 62,797,301(+) G/T intron_variant
rs1001401289 -- 62,794,730(+) G/A upstream_transcript_variant
rs1002384446 -- 62,796,845(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRGBP Gene

Variant ID Type Subtype PubMed ID
nsv1072133 CNV deletion 25765185
nsv1136334 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv828792 CNV loss 20364138
nsv828793 CNV gain 20364138
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for MRGBP Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRGBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGBP Gene

Disorders for MRGBP Gene

Additional Disease Information for MRGBP

No disorders were found for MRGBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGBP Gene

Publications for MRGBP Gene

  1. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y … Conaway JW (The Journal of biological chemistry 2003) 2 3 4 58
  2. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman BR … Quiocho FA (Structure (London, England : 1993) 2006) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for MRGBP Gene

  • Addgene plasmids for MRGBP

Sources for MRGBP Gene

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