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This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
MRFAP1 (Morf4 Family Associated Protein 1) is a Protein Coding gene. An important paralog of this gene is MRFAP1L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11500496 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | MRFAP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRFAP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mrfap1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mrfap1 30 17 31 |
|
OneToMany | |
Gm5814 31 |
|
OneToMany |
No disorders were found for MRFAP1 Gene.