This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] See more...

Aliases for MRFAP1 Gene

Aliases for MRFAP1 Gene

  • Morf4 Family Associated Protein 1 2 3 5
  • PAM14 2 3 4
  • PGR1 2 3 4
  • Protein Associated With MRG Of 14 KDa 3 4
  • MORF4 Family-Associated Protein 1 3 4
  • Mof4 Family Associated Protein 1 3
  • T-Cell Activation Protein 3
  • Protein PGR1 4
  • MRFAP1 5

External Ids for MRFAP1 Gene

Previous GeneCards Identifiers for MRFAP1 Gene

  • GC04P006761
  • GC04P006692
  • GC04P006643
  • GC04P006573

Summaries for MRFAP1 Gene

Entrez Gene Summary for MRFAP1 Gene

  • This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for MRFAP1 Gene

MRFAP1 (Morf4 Family Associated Protein 1) is a Protein Coding gene. An important paralog of this gene is MRFAP1L1.

Gene Wiki entry for MRFAP1 Gene

Additional gene information for MRFAP1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRFAP1 Gene

Genomics for MRFAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRFAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRFAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRFAP1

Top Transcription factor binding sites by QIAGEN in the MRFAP1 gene promoter:
  • CBF(2)
  • CBF-A
  • HFH-1
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRF
  • SRF (504 AA)

Genomic Locations for MRFAP1 Gene

Genomic Locations for MRFAP1 Gene
chr4:6,640,091-6,642,745
(GRCh38/hg38)
Size:
2,655 bases
Orientation:
Plus strand
chr4:6,641,818-6,644,472
(GRCh37/hg19)
Size:
2,655 bases
Orientation:
Plus strand

Genomic View for MRFAP1 Gene

Genes around MRFAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRFAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRFAP1 Gene

Proteins for MRFAP1 Gene

  • Protein details for MRFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y605-MOFA1_HUMAN
    Recommended name:
    MORF4 family-associated protein 1
    Protein Accession:
    Q9Y605
    Secondary Accessions:
    • B3KVT2
    • D3DVT3

    Protein attributes for MRFAP1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14650 Da
    Quaternary structure:
    • Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.

neXtProt entry for MRFAP1 Gene

Post-translational modifications for MRFAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRFAP1 Gene

No data available for DME Specific Peptides for MRFAP1 Gene

Domains & Families for MRFAP1 Gene

Gene Families for MRFAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRFAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRFAP1 Gene

GenScript: Design optimal peptide antigens:
  • Protein associated with MRG of 14 kDa (MOFA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y605

UniProtKB/Swiss-Prot:

MOFA1_HUMAN :
  • Belongs to the MORF4 family-associated protein family.
Family:
  • Belongs to the MORF4 family-associated protein family.
genes like me logo Genes that share domains with MRFAP1: view

Function for MRFAP1 Gene

Phenotypes From GWAS Catalog for MRFAP1 Gene

Gene Ontology (GO) - Molecular Function for MRFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11500496
genes like me logo Genes that share ontologies with MRFAP1: view
genes like me logo Genes that share phenotypes with MRFAP1: view

Animal Models for MRFAP1 Gene

MGI Knock Outs for MRFAP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRFAP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRFAP1 Gene

Localization for MRFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRFAP1 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000269 PubMed:11500496, ECO:0000269 PubMed:12397079}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRFAP1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MRFAP1: view

Pathways & Interactions for MRFAP1 Gene

PathCards logo

SuperPathways for MRFAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRFAP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MRFAP1 Gene

Drugs & Compounds for MRFAP1 Gene

No Compound Related Data Available

Transcripts for MRFAP1 Gene

mRNA/cDNA for MRFAP1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRFAP1

Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2:
SP3:
SP4: - -
SP5:
SP6:

Relevant External Links for MRFAP1 Gene

GeneLoc Exon Structure for
MRFAP1

Expression for MRFAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRFAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRFAP1 Gene

This gene is overexpressed in Fetal ovary (13.8), Bone (12.2), Ovary (9.8), and Prostate (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRFAP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRFAP1

SOURCE GeneReport for Unigene cluster for MRFAP1 Gene:

Hs.406590

Evidence on tissue expression from TISSUES for MRFAP1 Gene

  • Nervous system(5)
  • Lung(3.5)
  • Liver(3.1)
  • Intestine(2.9)
  • Heart(2.8)
  • Spleen(2.8)
  • Kidney(2.7)
  • Muscle(2.7)
  • Skin(2.6)
  • Eye(2.6)
  • Stomach(2.5)
  • Adrenal gland(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MRFAP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRFAP1 Gene

Orthologs for MRFAP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia MRFAP1 30 31
  • 91.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MRFAP1 30 31
  • 90.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mrfap1 30
  • 86.93 (n)
Mouse
(Mus musculus)
Mammalia Mrfap1 30 17 31
  • 86.4 (n)
OneToMany
Gm5814 31
  • 83 (a)
OneToMany
Species where no ortholog for MRFAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MRFAP1 Gene

ENSEMBL:
Gene Tree for MRFAP1 (if available)
TreeFam:
Gene Tree for MRFAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRFAP1: view image

Paralogs for MRFAP1 Gene

Paralogs for MRFAP1 Gene

(1) SIMAP similar genes for MRFAP1 Gene using alignment to 1 proteins:

  • MOFA1_HUMAN

Pseudogenes.org Pseudogenes for MRFAP1 Gene

genes like me logo Genes that share paralogs with MRFAP1: view

Variants for MRFAP1 Gene

Additional dbSNP identifiers (rs#s) for MRFAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRFAP1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER inversion 12058347
nsv4215 CNV deletion 18451855
nsv829849 CNV loss 17160897

Variation tolerance for MRFAP1 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRFAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRFAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRFAP1 Gene

Disorders for MRFAP1 Gene

Additional Disease Information for MRFAP1

No disorders were found for MRFAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRFAP1 Gene

Publications for MRFAP1 Gene

  1. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PMID: 17008723) Zhang P … Ding J (Protein science : a publication of the Protein Society 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. (PMID: 15367658) Tominaga K … Pereira-Smith OM (Molecular and cellular biology 2004) 2 3
  4. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PMID: 14506250) Tominaga K … Pereira-Smith OM (The Journal of biological chemistry 2003) 3 4
  5. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PMID: 12397079) Pardo PS … Pereira-Smith OM (The Journal of biological chemistry 2002) 3 4

Products for MRFAP1 Gene

Sources for MRFAP1 Gene