Aliases for MRFAP1 Gene
Aliases for MRFAP1 Gene
External Ids for MRFAP1 Gene
- HGNC: 24549
- Entrez Gene: 93621
- Ensembl: ENSG00000179010
- OMIM: 616905
- UniProtKB: Q9Y605
Previous GeneCards Identifiers for MRFAP1 Gene
- GC04P006761
- GC04P006692
- GC04P006643
- GC04P006573
Summaries for MRFAP1 Gene
-
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for MRFAP1 Gene
MRFAP1 (Morf4 Family Associated Protein 1) is a Protein Coding gene. An important paralog of this gene is MRFAP1L1.
Additional gene information for MRFAP1 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRFAP1 Gene
Genomics for MRFAP1 Gene
GeneHancer (GH) Regulatory Elements for MRFAP1 Gene
Promoters and enhancers for MRFAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MRFAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MRFAP1 gene promoter:
Regulatory Element Products
Genomic Locations for MRFAP1 Gene
Genomic Locations for MRFAP1 Gene
- chr4:6,640,091-6,642,745
- (GRCh38/hg38)
- Size:
- 2,655 bases
- Orientation:
- Plus strand
- chr4:6,641,818-6,644,472
- (GRCh37/hg19)
Genomic View for MRFAP1 Gene
Genes around MRFAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Ensembl
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
MRFAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRFAP1 Gene
Proteins for MRFAP1 Gene
-
Protein details for MRFAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y605-MOFA1_HUMAN
- Recommended name:
- MORF4 family-associated protein 1
- Protein Accession:
- Q9Y605
- B3KVT2
- D3DVT3
Protein attributes for MRFAP1 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14650 Da
- Quaternary structure:
-
- Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.
Protein Expression for MRFAP1 Gene
Post-translational modifications for MRFAP1 Gene
Other Protein References for MRFAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MRFAP1
- Novus Biologicals Antibodies for MRFAP1
- Invitrogen Antibodies for MRFAP1
- Search GeneTex for Antibodies for MRFAP1
Protein Products
-
OriGene Purified Proteins for MRFAP1
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- antibodies-online: Search results for 5 available MRFAP1 Proteins ranked by validation data
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-
Quality Products:
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Assay Products
- antibodies-online: Search results for 4 available MRFAP1 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for MRFAP1 Gene
Domains & Families for MRFAP1 Gene
Gene Families for MRFAP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for MRFAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y605- Family:
-
- Belongs to the MORF4 family-associated protein family.
Function for MRFAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11500496 |
Phenotypes for MRFAP1 Gene
- MGI mutant phenotypes for MRFAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRFAP1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability after ionizing radiation
Animal Models for MRFAP1 Gene
- MGI Knock Outs for MRFAP1:
-
- Mrfap1 tm1Kto
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRFAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MRFAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRFAP1 gene
- Search ViGene Biosciences for MRFAP1
CRISPR Products
-
OriGene CRISPR knockouts for MRFAP1
- genomics-online: gRNA clones - Search results for available MRFAP1 gene related products
- Applied Biological Materials CRISPR for MRFAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRFAP1
- GenScript: Design CRISPR guide RNA sequences for MRFAP1
miRNA for MRFAP1 Gene
- miRTarBase miRNAs that target MRFAP1
-
- hsa-mir-1-3p (MIRT023865)
- hsa-mir-16-5p (MIRT031820)
- hsa-mir-615-3p (MIRT039701)
- hsa-mir-423-3p (MIRT042574)
- hsa-mir-328-3p (MIRT043774)
- hsa-mir-186-5p (MIRT045034)
- hsa-mir-142-3p (MIRT440218)
- hsa-mir-552-5p (MIRT556070)
- hsa-mir-302c-5p (MIRT556071)
- hsa-mir-4477a (MIRT556072)
- hsa-mir-3143 (MIRT556073)
- hsa-mir-8068 (MIRT556074)
- hsa-mir-5003-3p (MIRT556075)
miRNA Products
- Search ViGene Biosciences for MRFAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRFAP1
- Browse OriGene Inhibitory RNA Products For MRFAP1
- genomics-online: shRNA clones - Search results for available MRFAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRFAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for MRFAP1
- VectorBuilder custom plasmid, inducible vectors for MRFAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRFAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRFAP1 gene related products
- orf clones - Search results for available MRFAP1 gene related products
- Applied Biological Materials Clones for MRFAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MRFAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for MRFAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MRFAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRFAP1 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRFAP1 Gene
Localization for MRFAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRFAP1 Gene
- Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000269 PubMed:11500496, ECO:0000269 PubMed:12397079}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for MRFAP1 Gene
No Data Available
Interacting Proteins for MRFAP1 Gene
Selected Interacting proteins:
Q9Y605-MOFA1_HUMAN
ENSP00000318352
for MRFAP1 Gene via
IID
STRING
MINT
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for MRFAP1 Gene
Transcripts for MRFAP1 Gene
mRNA/cDNA for MRFAP1 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (602) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRFAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRFAP1
- genomics-online: gRNA clones - Search results for available MRFAP1 gene related products
- Applied Biological Materials CRISPR for MRFAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRFAP1
- GenScript: Design CRISPR guide RNA sequences for MRFAP1
miRNA Products
- Search ViGene Biosciences for MRFAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRFAP1
- Browse OriGene Inhibitory RNA Products For MRFAP1
- genomics-online: shRNA clones - Search results for available MRFAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRFAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for MRFAP1
- VectorBuilder custom plasmid, inducible vectors for MRFAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRFAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRFAP1 gene related products
- orf clones - Search results for available MRFAP1 gene related products
- Applied Biological Materials Clones for MRFAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: |
Expression for MRFAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Fetal ovary (13.8), Bone (12.2), Ovary (9.8), and Prostate (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRFAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MRFAP1 Gene:
MRFAP1SOURCE GeneReport for Unigene cluster for MRFAP1 Gene:
Hs.406590Evidence on tissue expression from TISSUES for MRFAP1 Gene
- Nervous system(5)
- Lung(3.5)
- Liver(3.1)
- Intestine(2.9)
- Heart(2.8)
- Spleen(2.8)
- Kidney(2.7)
- Muscle(2.7)
- Eye(2.6)
- Stomach(2.5)
- Adrenal gland(2.2)
- Gall bladder(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for MRFAP1
-
OriGene qPCR primer pairs and template standards for MRFAP1
- genomics-online: primer clones - Search results for available MRFAP1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRFAP1 Gene
Orthologs for MRFAP1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MRFAP1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MRFAP1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mrfap1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrfap1 16 34 33 |
|
||
| Gm5814 34 |
|
OneToMany |
- Species where no ortholog for MRFAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MRFAP1 Gene
(1) SIMAP similar genes for MRFAP1 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for MRFAP1 Gene
Variants for MRFAP1 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000091111 | -- | 6,642,241(+) | G/C | 3_prime_UTR_variant | |
| rs1000253392 | -- | 6,642,517(+) | G/T | 3_prime_UTR_variant | |
| rs1000575974 | -- | 6,639,954(+) | A/C/G | upstream_transcript_variant | |
| rs1001320778 | -- | 6,642,819(+) | G/A | downstream_transcript_variant | |
| rs1001413469 | -- | 6,643,054(+) | A/G | downstream_transcript_variant |
Residual Variation Intolerance Score:
36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRFAP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRFAP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRFAP1 Gene
Disorders for MRFAP1 Gene
Additional Disease Information for MRFAP1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MRFAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRFAP1 Gene
Publications for MRFAP1 Gene
- The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PMID: 17008723) Zhang P … Ding J (Protein science : a publication of the Protein Society 2006) 3 4 58
- PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. (PMID: 15367658) Tominaga K … Pereira-Smith OM (Molecular and cellular biology 2004) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PMID: 14506250) Tominaga K … Pereira-Smith OM (The Journal of biological chemistry 2003) 3 4 58
- MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PMID: 12397079) Pardo PS … Pereira-Smith OM (The Journal of biological chemistry 2002) 3 4 58
Products for MRFAP1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MRFAP1
- VectorBuilder custom plasmid, inducible vectors for MRFAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRFAP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available MRFAP1 Antibodies ranked by validation data
- Compare Top MRFAP1 Antibodies
- antibodies-online: Search results for 4 available MRFAP1 Elisa Kits ranked by validation data
- Compare Top MRFAP1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 5 available MRFAP1 Proteins ranked by validation data
- Compare Top MRFAP1 Proteins
- Quality Products:
- Search GeneTex for Antibodies for MRFAP1
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- ViGene Biosciences adenoviral particle packaged cDNA for MRFAP1 gene
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- Horizon Cell Lines for MRFAP1
- genomics-online: cdna clones - Search results for available MRFAP1 gene related products
- orf clones - Search results for available MRFAP1 gene related products
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- genomics-online: primer clones - Search results for available MRFAP1 gene related products
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Sources for MRFAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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