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This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DN... See more...
Aliases for MRE11 Gene
Aliases for MRE11 Gene
- MRE11 Homolog, Double Strand Break Repair Nuclease 2 3 5
- MRE11 Homolog A, Double Strand Break Repair Nuclease 2 3
- Double-Strand Break Repair Protein MRE11A 3 4
- Double-Strand Break Repair Protein MRE11 3 4
- Meiotic Recombination 11 Homolog 1 3 4
- Meiotic Recombination 11 Homolog A 3 4
- AT-Like Disease 2 3
- MRE11 Homolog 1 3 4
- MRE11A 3 4
- HNGS1 3 4
- ATLD 2 3
- MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) 2
- MRE11 Homolog, Double Strand Break Repair Nuclease A 3
- MRE11 Meiotic Recombination 11-Like Protein A 3
- MRE11 Double Strand Break Repair Nuclease A 3
- MRE11 Meiotic Recombination 11 Homolog A 3
- DNA Recombination And Repair Protein 3
- Endo/Exonuclease Mre11 3
- MRE11 Homolog A 4
- EC 3.1.-.- 4
- MRE11B 3
- MRE11 5
External Ids for MRE11 Gene
- HGNC: 7230
- Entrez Gene: 4361
- Ensembl: ENSG00000020922
- OMIM: 600814
- UniProtKB: P49959
Previous HGNC Symbols for MRE11 Gene
- MRE11A
Previous GeneCards Identifiers for MRE11 Gene
- GC11M094416
- GC11M094529
Summaries for MRE11 Gene
-
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRE11 Gene
MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 and Nijmegen Breakage Syndrome-Like Disorder. Among its related pathways are ATM Pathway and Homologous DNA Pairing and Strand Exchange.
UniProtKB/Swiss-Prot Summary for MRE11 Gene
-
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Additional gene information for MRE11 Gene
- HGNC(7230)
- Entrez Gene(4361)
- Ensembl(ENSG00000020922)
- OMIM(600814)
- UniProtKB(P49959)
- Open Targets Platform(ENSG00000020922)
- Monarch Initiative
- Search for MRE11 at DataMed
- Search for MRE11 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRE11 Gene
Genomics for MRE11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MRE11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRE11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRE11
Genomic Locations for MRE11 Gene
Genomic Locations for MRE11 Gene
- chr11:94,415,570-94,512,701
- (GRCh38/hg38)
- Size:
- 97,132 bases
- Orientation:
- Minus strand
- chr11:94,150,466-94,227,074
- (GRCh37/hg19)
- Size:
- 76,609 bases
- Orientation:
- Minus strand
Genomic View for MRE11 Gene
Genes around MRE11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q21 by HGNC
- 11q21 by Entrez Gene
- 11q21 by Ensembl
MRE11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRE11 Gene
Proteins for MRE11 Gene
-
Protein details for MRE11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49959-MRE11_HUMAN
- Recommended name:
- Double-strand break repair protein MRE11
- Protein Accession:
- P49959
- B3KTC7
- O43475
Protein attributes for MRE11 Gene
- Size:
- 708 amino acids
- Molecular mass:
- 80593 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:10839544, PubMed:26215093). As part of the MRN complex, interacts with MCM9; the interaction recruits the complex to DNA repair sites (PubMed:26215093). Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (PubMed:10783165). Found in a complex with TERF2 (PubMed:10888888). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo (PubMed:15456891, PubMed:15723659, PubMed:18469862). Interacts with ATF2 (PubMed:15916964). Interacts with EXD2 (PubMed:26807646). Interacts with MRNIP (PubMed:27568553). Interacts with SAMHD1; leading to stimulate 3'-5' exonuclease activity (PubMed:28834754, PubMed:29670289). Interacts (when ubiquitinated) with UBQLN4 (via its UBA domain) (PubMed:30612738).
- (Microbial infection) Interacts with herpes simplex virus 1 protein UL12 (PubMed:20943970).
- Miscellaneous:
-
- In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.
Post-translational modifications for MRE11 Gene
- Ubiquitinated following DNA damage. Ubiquitination triggers interaction with UBQLN4, leading to MRE11 removal from chromatin and degradation by the proteasome.
-
Ubiquitination at Lys393, Lys416, Lys434, Lys442, Lys475, and Lys673
- NX_P49959 (NX_P49959-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MRE11 Gene
Antibody Products
- NSJ Bioreagents MRE11 Antibody
- GeneTex Anti-Mre11 antibody [12D7] and Anti-Mre11 antibody
-
Custom Antibody ServicesOriGene Antibodies for MRE11
- Novus Biologicals Antibodies for MRE11
-
Abcam antibodies for MRE11
- Invitrogen Antibodies for MRE11 (AFLGC-Mre11)
- antibodies-online: Show 44 available MRE11A Antibodies ranked by validation data
- Compare Top MRE11A Antibodies
-
Recommended
- 106 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 162 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 72 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for MRE11
-
Custom Antibody ServicesProSci Antibodies for MRE11
- Sino Biological Antibodies for MRE11
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MRE11
- Origene Custom Protein Services for MRE11
-
Signalway Proteins for MRE11
-
Abcam proteins for MRE11
Assay Products
- antibodies-online: Show 3 available MRE11A Elisa Kits ranked by validation data
- Compare Top MRE11A Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MRE11
No data available for DME Specific Peptides for MRE11 Gene
Domains & Families for MRE11 Gene
Gene Families for MRE11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MRE11 Gene
- InterPro:
- Blocks:
-
- Mre11 DNA-binding presumed domain
- ProtoNet:
Suggested Antigen Peptide Sequences for MRE11 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ38069 fis, clone CTONG2015434, highly similar to DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11A (B3KTC7_HUMAN)
- Meiotic recombination 11 homolog A (MRE11_HUMAN)
- MRE11A protein (Q05D78_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49959- Family:
-
- Belongs to the MRE11/RAD32 family.
Function for MRE11 Gene
Molecular function for MRE11 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Interaction with SAMHD1 stimulates the double-strand-specific 3'-5' exonuclease activity.
Enzyme Numbers (IUBMB) for MRE11 Gene
Phenotypes From GWAS Catalog for MRE11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000014 | single-stranded DNA endodeoxyribonuclease activity | IDA | 9705271 |
| GO:0003677 | contributes_to DNA binding | IDA | 15790808 |
| GO:0003678 | contributes_to DNA helicase activity | IMP | 15790808 |
| GO:0003690 | double-stranded DNA binding | TAS | -- |
| GO:0004518 | nuclease activity | IEA,TAS | 15790808 |
Phenotypes for MRE11 Gene
- MGI mutant phenotypes for MRE11:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for MRE11:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased viability
- Decreased viability after Maraba virus infection
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased HIV-1 infection
- Increased Sindbis virus (SINV) infection
- Decreased and increased HIV-LTR-beta-galactosidase protein expression
Animal Models for MRE11 Gene
- MGI Knock Outs for MRE11:
-
- Mre11a Mre11a<tm2.2Dof>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRE11 - Select products 50% OFF >
- * MRE11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MRE11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRE11
miRNA for MRE11 Gene
- miRTarBase miRNAs that target MRE11
-
- hsa-miR-210-3p (MIRT003916)
- hsa-miR-373-3p (MIRT003919)
- hsa-miR-375 (MIRT019709)
- hsa-miR-1-3p (MIRT023658)
- hsa-miR-34a-5p (MIRT025337)
- hsa-miR-30a-5p (MIRT028405)
- hsa-miR-2110 (MIRT489518)
- hsa-miR-491-5p (MIRT489519)
- hsa-miR-6887-5p (MIRT489520)
- hsa-miR-6795-5p (MIRT489521)
- hsa-miR-6870-5p (MIRT489522)
- hsa-miR-7111-5p (MIRT489523)
- hsa-miR-5698 (MIRT489524)
- hsa-miR-4723-5p (MIRT489525)
- hsa-miR-3175 (MIRT489526)
- hsa-miR-6780b-5p (MIRT489527)
- hsa-miR-4725-3p (MIRT489528)
- hsa-miR-4271 (MIRT489529)
- hsa-miR-8085 (MIRT489530)
- hsa-miR-6731-5p (MIRT489531)
- hsa-miR-1292-5p (MIRT489532)
- hsa-miR-4644 (MIRT489533)
- hsa-miR-4306 (MIRT489534)
- hsa-miR-185-5p (MIRT489535)
- hsa-miR-6133 (MIRT489536)
- hsa-miR-6130 (MIRT489537)
- hsa-miR-6129 (MIRT489538)
- hsa-miR-6127 (MIRT489539)
- hsa-miR-4510 (MIRT489540)
- hsa-miR-4419a (MIRT489541)
- hsa-miR-1296-3p (MIRT489542)
- hsa-miR-6873-5p (MIRT489543)
- hsa-miR-6760-5p (MIRT489544)
- hsa-miR-6077 (MIRT499678)
- hsa-miR-4745-5p (MIRT499679)
- hsa-miR-4481 (MIRT499680)
- hsa-miR-3925-5p (MIRT499681)
- hsa-miR-665 (MIRT551327)
- hsa-miR-6874-5p (MIRT551328)
- hsa-miR-6500-5p (MIRT551329)
- hsa-miR-7160-5p (MIRT551330)
- hsa-miR-4633-3p (MIRT551331)
- hsa-miR-4722-5p (MIRT551332)
- hsa-miR-6884-5p (MIRT551333)
- hsa-miR-485-5p (MIRT551334)
- hsa-miR-1827 (MIRT551335)
- hsa-miR-4649-3p (MIRT551336)
- hsa-miR-4768-3p (MIRT551337)
- hsa-miR-4478 (MIRT551338)
- hsa-miR-4419b (MIRT551339)
- hsa-miR-3929 (MIRT551340)
- hsa-miR-940 (MIRT551341)
- hsa-miR-6893-5p (MIRT551342)
- hsa-miR-6808-5p (MIRT551343)
- hsa-miR-498 (MIRT672172)
- hsa-miR-4279 (MIRT672173)
- hsa-miR-6869-5p (MIRT672174)
- hsa-miR-1200 (MIRT672175)
- hsa-miR-23b-5p (MIRT672176)
- hsa-miR-23a-5p (MIRT672177)
- hsa-miR-6791-3p (MIRT672178)
- hsa-miR-6829-3p (MIRT672179)
- hsa-miR-1976 (MIRT672180)
- hsa-miR-6747-3p (MIRT672181)
- hsa-miR-6727-3p (MIRT672182)
- hsa-miR-4722-3p (MIRT672183)
- hsa-miR-544b (MIRT672184)
- hsa-miR-4324 (MIRT672185)
- hsa-miR-660-3p (MIRT672186)
- hsa-miR-3653-5p (MIRT680138)
- hsa-miR-4446-5p (MIRT714204)
- hsa-miR-5006-3p (MIRT714205)
- hsa-miR-4755-5p (MIRT714206)
- hsa-miR-642a-5p (MIRT714207)
- hsa-miR-3124-3p (MIRT714208)
- hsa-miR-130b-5p (MIRT714209)
- hsa-miR-6796-3p (MIRT714210)
- hsa-miR-99b-3p (MIRT714211)
- hsa-miR-99a-3p (MIRT714212)
- hsa-miR-21-3p (MIRT763828)
- hsa-miR-3591-3p (MIRT765838)
- hsa-miR-6512-5p (MIRT776975)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRE11
- Browse OriGene Inhibitory RNA Products For MRE11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRE11
Clone Products
- Applied Biological Materials (abm): Clones for MRE11 - Select products 50% OFF >
- * MRE11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210160
- MR210160
- MR210160L3
- MR210160L4
- RC209414
- RC209414L1
- RC209414L2
- RC209414L3
- RC209414L4
- RC213729
- RC213729L1
- RC213729L2
- RC213729L3
- RC213729L4
- RG209414
- RG213729
- RR209143
- RR209143L3
- RR209143L4
- MR210160L3V
- MR210160L4V
- RC209414L1V
- RC209414L2V
- RC209414L3V
- RC209414L4V
- RC213729L1V
- RC213729L2V
- RC213729L3V
- RC213729L4V
- RR209143L3V
- RR209143L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRE11
- Addgene plasmids for MRE11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRE11
Cell Line Products
-
Horizon Cell Lines for MRE11
No data available for Transcription Factor Targets and HOMER Transcription for MRE11 Gene
Localization for MRE11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRE11 Gene
- Nucleus. Chromosome, telomere. Chromosome. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269 PubMed:10783165, ECO:0000269 PubMed:26215093, ECO:0000269 PubMed:30612738}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000781 | colocalizes_with chromosome, telomeric region | IDA | 15149599 |
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IBA,ISS | -- |
| GO:0005634 | nucleus | IEA,TAS | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005657 | replication fork | IDA | 29290612 |
Pathways & Interactions for MRE11 Gene
Pathways by source for MRE11 Gene
11 BioSystems pathways for MRE11 Gene
36 Reactome pathways for MRE11 Gene
3 KEGG pathways for MRE11 Gene
2 GeneGo (Thomson Reuters) pathways for MRE11 Gene
- DNA damage_NHEJ mechanisms of DSBs repair
- DNA damage_Role of Brca1 and Brca2 in DNA repair
6 Qiagen pathways for MRE11 Gene
- ATM Pathway
- BRCA1 Pathway
- Chks in Checkpoint Regulation
- DNA Repair Mechanisms
- Fanconi's Anaemia Pathway
1 Cell Signaling Technology pathway for MRE11 Gene
1 GeneTex pathway for MRE11 Gene
Interacting Proteins for MRE11 Gene
Selected Interacting proteins:
P49959-MRE11_HUMAN
ENSP00000325863
for MRE11 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MRE11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000019 | regulation of mitotic recombination | TAS | 8530104 |
| GO:0000723 | telomere maintenance | IBA | 21873635 |
| GO:0000724 | double-strand break repair via homologous recombination | TAS | -- |
| GO:0000729 | DNA double-strand break processing | TAS | -- |
| GO:0006260 | DNA replication | TAS | -- |
Drugs & Compounds for MRE11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | 56 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MRE11 Gene
mRNA/cDNA for MRE11 Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000323929 6841 nts (view in UCSC)
- ENST00000323977 2588 nts (view in UCSC)
- ENST00000393241 2604 nts (view in UCSC)
- ENST00000407439 2684 nts (view in UCSC)
- ENST00000535120 234 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRE11 - Select products 50% OFF >
- * MRE11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MRE11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRE11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRE11
- Browse OriGene Inhibitory RNA Products For MRE11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRE11
Clone Products
- Applied Biological Materials (abm): Clones for MRE11 - Select products 50% OFF >
- * MRE11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210160
- MR210160
- MR210160L3
- MR210160L4
- RC209414
- RC209414L1
- RC209414L2
- RC209414L3
- RC209414L4
- RC213729
- RC213729L1
- RC213729L2
- RC213729L3
- RC213729L4
- RG209414
- RG213729
- RR209143
- RR209143L3
- RR209143L4
- MR210160L3V
- MR210160L4V
- RC209414L1V
- RC209414L2V
- RC209414L3V
- RC209414L4V
- RC213729L1V
- RC213729L2V
- RC213729L3V
- RC213729L4V
- RR209143L3V
- RR209143L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRE11
- Addgene plasmids for MRE11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRE11
Relevant External Links for MRE11 Gene
- GeneLoc Exon Structure for
- MRE11
Expression for MRE11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRE11
Evidence on tissue expression from TISSUES for MRE11 Gene
- Nervous system(4.5)
- Liver(4.4)
- Intestine(2.8)
- Blood(2.8)
- Skin(2.5)
- Lung(2.5)
- Kidney(2.4)
- Lymph node(2.3)
- Bone marrow(2.3)
- Pancreas(2.3)
- Stomach(2.2)
- Thyroid gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MRE11 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- head
Thorax:
- breast
Limb:
- hand
- lower limb
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MRE11
-
OriGene qPCR primer pairs and template standards for MRE11
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MRE11 Gene
Orthologs for MRE11 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MRE11A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MRE11A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MRE11A 31 |
|
OneToOne | |
| GPR83 30 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MRE11A 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MRE11A 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mre11a 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mre11a 30 |
|
||
| Chicken (Gallus gallus) |
Aves | MRE11A 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MRE11A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mre11a 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | mre11-A-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mre11a 30 |
|
||
| wufc38f05 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | mre11 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006797 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mre-11 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C06930g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MRE11 30 31 33 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR553C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MRE11 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0635900 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rad32 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08730 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4753 30 |
|
- Species where no ortholog for MRE11 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MRE11 Gene
- ENSEMBL:
- Gene Tree for MRE11 (if available)
- TreeFam:
- Gene Tree for MRE11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRE11: view image
Paralogs for MRE11 Gene
Pseudogenes.org Pseudogenes for MRE11 Gene
No data available for Paralogs for MRE11 Gene
Variants for MRE11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRE11 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 638600 | Likely Pathogenic: Ataxia-telangiectasia-like disorder 1 | 94,455,248(-) | GTCTCCTCATTTATAA | SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT | |
| 641005 | Uncertain Significance: Ataxia-telangiectasia-like disorder | 94,467,824(-) | C/T | MISSENSE_VARIANT | |
| 642476 | Uncertain Significance: Hereditary cancer-predisposing syndrome; Ataxia-telangiectasia-like disorder | 94,445,843(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 643735 | Uncertain Significance: Ataxia-telangiectasia-like disorder | 94,470,518(-) | C/G | MISSENSE_VARIANT | |
| 647222 | Uncertain Significance: Ataxia-telangiectasia-like disorder | 94,420,135(-) | T/C | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.11;
51.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRE11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRE11 Gene
Disorders for MRE11 Gene
(27) MalaCards diseases for MRE11 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ataxia-telangiectasia-like disorder 1 |
|
|
| nijmegen breakage syndrome-like disorder |
|
|
| ovarian cancer |
|
|
| inherited cancer-predisposing syndrome |
|
|
| ataxia-telangiectasia |
|
Search MRE11 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MRE11_HUMAN- Ataxia-telangiectasia-like disorder 1 (ATLD1) [MIM:604391]: A rare disorder characterized by progressive cerebellar ataxia, dysarthria, abnormal eye movements, and absence of telangiectasia. ATLD patients show normal levels of total IgG, IgA and IgM, although there may be reduced levels of specific functional antibodies. At the cellular level, ATLD exhibits hypersensitivity to ionizing radiation and radioresistant DNA synthesis. {ECO:0000269 PubMed:10612394}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Defects in MRE11 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11 has been found in patients with cerebellar vermis hypoplasia, ataxia and dysarthria. {ECO:0000269 PubMed:22863007}.
Additional Disease Information for MRE11
No data available for Genatlas for MRE11 Gene
Publications for MRE11 Gene
- Isolation and characterization of the human MRE11 homologue. (PMID: 8530104) Petrini JH … Weaver DT (Genomics 1995) 2 3 4 23
- Alterations of the double-strand break repair gene MRE11 in cancer. (PMID: 11196167) Fukuda T … Miyagawa K (Cancer research 2001) 3 4 23
- Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. (PMID: 10888888) Zhu XD … de Lange T (Nature genetics 2000) 3 4 23
- Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. (PMID: 9705271) Trujillo KM … Sung P (The Journal of biological chemistry 1998) 3 4 23
- The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. (PMID: 9651580) Paull TT … Gellert M (Molecular cell 1998) 3 4 23
ExternalLinks
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- 1 IHC Antibody (anti-rat)
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Sources for MRE11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (22) IntAct
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- (24) PharmGKB
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
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- (50) miRBase
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- (53) PubMed
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (84) COMPARTMENTS
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- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (104) diseasecard
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