Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 and Nijmegen Breakage Syndrome-Like Disorder. Among its related pathways are DNA Double-Strand Break Repair and Cellular Senescence (REACTOME).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000014 | single-stranded DNA endodeoxyribonuclease activity | IDA | 9705271 |
GO:0003677 | contributes_to DNA binding | IDA | 15790808 |
GO:0003678 | contributes_to DNA helicase activity | IMP | 15790808 |
GO:0003690 | double-stranded DNA binding | TAS | 10802669 |
GO:0004003 | ATP-dependent DNA helicase activity | IMP | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000781 | colocalizes_with chromosome, telomeric region | IDA | 15149599 |
GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | ISS,IBA | -- |
GO:0005634 | nucleus | TAS,IEA | 10802669 |
GO:0005654 | nucleoplasm | TAS,IDA | -- |
GO:0005657 | replication fork | IDA | 29290612 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000019 | regulation of mitotic recombination | TAS | 8530104 |
GO:0000723 | telomere maintenance | IBA | 21873635 |
GO:0000724 | double-strand break repair via homologous recombination | TAS | -- |
GO:0000729 | DNA double-strand break processing | TAS | -- |
GO:0006260 | DNA replication | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Manganese | Approved | Nutra | 48 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MRE11A 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MRE11A 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | MRE11A 33 |
|
OneToOne | |
GPR83 32 |
|
||||
platypus (Ornithorhynchus anatinus) |
Mammalia | MRE11A 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | MRE11A 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mre11a 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Mre11a 32 |
|
||
chicken (Gallus gallus) |
Aves | MRE11A 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | MRE11A 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | mre11a 32 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | mre11-A-prov 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | mre11a 32 |
|
||
wufc38f05 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | mre11 33 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006797 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | mre-11 33 32 |
|
OneToOne | |
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C06930g 32 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MRE11 35 33 32 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR553C 32 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | MRE11 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os04g0635900 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne | |
Cin.4753 32 |
|
||||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rad32 32 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU08730 32 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4753 32 |
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001831519 | likely-benign, Hereditary cancer-predisposing syndrome | 94,464,153(-) | A/G | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs1025272236 | uncertain-significance, Hereditary cancer-predisposing syndrome | 94,485,924(-) | T/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
rs1028566396 | uncertain-significance, Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia-like disorder 1 | 94,445,877(-) | C/A | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
rs1047206353 | likely-benign, Hereditary cancer-predisposing syndrome | 94,471,588(-) | T/C | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs104895004 | not-provided, uncertain-significance, not provided, Ataxia-telangiectasia-like disorder 1 | 94,418,192(-) | C/A/T | 3_prime_UTR_variant, non_coding_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
ataxia-telangiectasia-like disorder 1 |
|
|
nijmegen breakage syndrome-like disorder |
|
|
tumor predisposition syndrome |
|
|
ovarian cancer |
|
|
inherited cancer-predisposing syndrome |
|