Aliases for MRC2 Gene
External Ids for MRC2 Gene
Previous GeneCards Identifiers for MRC2 Gene
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
GeneCards Summary for MRC2 Gene
MRC2 (Mannose Receptor C Type 2) is a Protein Coding gene. Diseases associated with MRC2 include Primary Bone Cancer and Bone Cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and collagen binding. An important paralog of this gene is PLA2R1.
UniProtKB/Swiss-Prot for MRC2 Gene
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).