Aliases for MRC2 Gene
External Ids for MRC2 Gene
Previous GeneCards Identifiers for MRC2 Gene
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
GeneCards Summary for MRC2 Gene
MRC2 (Mannose Receptor C Type 2) is a Protein Coding gene. Diseases associated with MRC2 include Mental Retardation, Autosomal Dominant 57 and Primary Bone Cancer. Among its related pathways are Phagocytosis of Microbes and Phagosome. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and collagen binding. An important paralog of this gene is PLA2R1.
UniProtKB/Swiss-Prot Summary for MRC2 Gene
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).