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The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind hi... See more...
Aliases for MRC1 Gene
Aliases for MRC1 Gene
External Ids for MRC1 Gene
- HGNC: 7228
- Entrez Gene: 4360
- Ensembl: ENSG00000260314
- OMIM: 153618
- UniProtKB: P22897
Previous HGNC Symbols for MRC1 Gene
- MRC1L1
Previous GeneCards Identifiers for MRC1 Gene
- GC10P017833
- GC10P018248
- GC10P018102
- GC10P018138
- GC10P018098
Summaries for MRC1 Gene
-
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
GeneCards Summary for MRC1 Gene
MRC1 (Mannose Receptor C-Type 1) is a Protein Coding gene. Diseases associated with MRC1 include Dengue Virus and Hepatitis B. Among its related pathways are Tuberculosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is MRC2.
UniProtKB/Swiss-Prot Summary for MRC1 Gene
-
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
-
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
-
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
-
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Additional gene information for MRC1 Gene
- HGNC(7228)
- Entrez Gene(4360)
- Ensembl(ENSG00000260314)
- OMIM(153618)
- UniProtKB(P22897)
- Open Targets Platform(ENSG00000260314)
- Monarch Initiative
- Search for MRC1 at DataMed
- Search for MRC1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRC1 Gene
Genomics for MRC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MRC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J017809 | Promoter | 0.7 | EPDnew Ensembl | 600.7 | +1.1 | 1053 | 3.2 | MRC1 RF00017-606 SLC39A12 | ||
| GH10J017770 | Promoter | 0.3 | EPDnew | 600.3 | -38.1 | -38070 | 0.1 | MRC1 LOC107984212 HSALNG0076476 TMEM236 | ||
| GH10J017984 | Enhancer | 0.9 | Ensembl ENCODE | 15.4 | +175.1 | 175053 | 1.6 | BACH1 IKZF2 PKNOX1 EED CEBPB DPF2 RELB JUND RUNX3 CBFB | MRC1 SLC39A12 SLC39A12-AS1 CACNB2 | |
| GH10J017950 | Enhancer | 0.4 | FANTOM5 | 28.7 | +141.2 | 141210 | 0.3 | ZNF316 NFATC3 EMSY MAFK | SLC39A12 piR-33730-012 MRC1 | |
| GH10J017980 | Enhancer | 0.7 | Ensembl ENCODE | 15.8 | +172.6 | 172628 | 2 | JUND CEBPB JUN FOS EP300 FOSL2 MAFK ZMYM3 BACH1 NFE2L2 | MRC1 SLC39A12 SLC39A12-AS1 CACNB2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRC1
- Top Transcription factor binding sites by QIAGEN in the MRC1 gene promoter:
-
- aMEF-2
- AREB6
- C/EBPalpha
- HSF2
- MEF-2
- MEF-2A
- Olf-1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for MRC1 Gene
Genomic Locations for MRC1 Gene
- chr10:17,809,348-17,911,164
- (GRCh38/hg38)
- Size:
- 101,817 bases
- Orientation:
- Plus strand
- chr10:18,098,352-18,200,091
- (GRCh37/hg19)
- Size:
- 101,740 bases
- Orientation:
- Plus strand
Genomic View for MRC1 Gene
Genes around MRC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.33 by HGNC
- 10p12.33 by Entrez Gene
- 10p12.33 by Ensembl
MRC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRC1 Gene
Proteins for MRC1 Gene
-
Protein details for MRC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22897-MRC1_HUMAN
- Recommended name:
- Macrophage mannose receptor 1
- Protein Accession:
- P22897
- A5PKW3
- Q5VSJ2
- Q5VSK2
Protein attributes for MRC1 Gene
- Size:
- 1456 amino acids
- Molecular mass:
- 166012 Da
- Quaternary structure:
-
- (Microbial infection) Interacts with Dengue virus.
- (Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.
- SequenceCaution:
-
- Sequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
- Miscellaneous:
-
- CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
Three dimensional structures from OCA and Proteopedia for MRC1 Gene
Protein Expression for MRC1 Gene
Post-translational modifications for MRC1 Gene
Other Protein References for MRC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MRC1 Antibody
-
BioLegend
- CD206 (MMR) Antibody (321113)
- CD206 (MMR) Antibody (321114)
- CD206 (MMR) Antibody (321108)
- CD206 (MMR) Antibody (321105)
- CD206 (MMR) Antibody (321101)
- CD206 (MMR) Antibody (321102)
- CD206 (MMR) Antibody (321109)
- CD206 (MMR) Antibody (321110)
- CD206 (MMR) Antibody (321104)
- CD206 (MMR) Antibody (321116)
- CD206 (MMR) Antibody (321103)
- CD206 (MMR) Antibody (321106)
- CD206 (MMR) Antibody (321118)
- APC/Cyanine7 CD206 (MMR) Antibody (321119)
- APC/Cyanine7 CD206 (MMR) Antibody (321120)
- PerCP/Cyanine5.5 CD206 (MMR) Antibody (321121)
- CD206 (MMR) Antibody (321123)
- PerCP/Cyanine5.5 CD206 (MMR) Antibody (321122)
- CD206 (MMR) Antibody (321124)
- CD206 (MMR) Antibody (321125)
- CD206 (MMR) (MaxPar(R) Ready) Antibody
- CD206 (MMR) Antibody (321126)
- CD206 (MMR) Antibody (321131)
- CD206 (MMR) Antibody (321130)
- CD206 (MMR) Antibody (321132)
- CD206 (MMR) Antibody (321129)
- CD206 (MMR) Antibody (321136)
- APC/Fire(TM) 750 CD206 (MMR) Antibody (321134)
- CD206 (MMR) Antibody (321135)
- APC/Fire(TM) 750 CD206 (MMR) Antibody (321133)
- CD206 (MMR) Antibody (321137)
- CD206 (MMR) Antibody (321138)
- CD206 (MMR) Antibody (321141)
- CD206 (MMR) Antibody (321142)
- CD206 (MMR) Antibody (321140)
- CD206 (MMR) Antibody (321139)
- TotalSeq(TM)-A0205 CD206 (MMR) Antibody
- Novus Biologicals Antibodies for MRC1
-
Abcam antibodies for MRC1
- Invitrogen Antibodies for MRC1 (AFLGC-Mrc1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MRC1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MRC1
- Origene Custom Protein Services for MRC1
- Novus Biologicals proteins for MRC1
-
Abcam proteins for MRC1
No data available for DME Specific Peptides for MRC1 Gene
Domains & Families for MRC1 Gene
Gene Families for MRC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
Protein Domains for MRC1 Gene
- InterPro:
- Blocks:
-
- Type II fibronectin collagen-binding domain
- Ricin B lectin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for MRC1 Gene
- GenScript: Design optimal peptide antigens:
-
- Mannose receptor, C type 1-like 1 (B9EJA8_HUMAN)
- Macrophage mannose receptor 1-like protein 1 (MRC1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MRC1 Gene
Function for MRC1 Gene
Molecular function for MRC1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Interacts with Hepatitis B virus envelope protein.
- GENATLAS Biochemistry:
- mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides
Phenotypes From GWAS Catalog for MRC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 11222859 |
| GO:0005537 | mannose binding | TAS,IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for MRC1 Gene
- MGI mutant phenotypes for MRC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MRC1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRC1 - Select products 50% OFF >
- * MRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRC1
miRNA for MRC1 Gene
- miRTarBase miRNAs that target MRC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRC1
- Browse OriGene Inhibitory RNA Products For MRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1
Clone Products
- Applied Biological Materials (abm): Clones for MRC1 - Select products 50% OFF >
- * MRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRC1
Cell Line Products
-
Horizon Cell Lines for MRC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRC1 Gene
Localization for MRC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRC1 Gene
- Endosome membrane. Single-pass type I membrane protein. Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| extracellular | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | IBA,IDA | 20035344 |
| GO:0005887 | integral component of plasma membrane | TAS | 1294118 |
| GO:0009986 | cell surface | IEA | -- |
| GO:0010008 | endosome membrane | IEA,IDA | 20035344 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRC1 Gene
Pathways & Interactions for MRC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Phagosome | ||
| 3 | Tuberculosis | ||
| 4 | Phagocytosis of Microbes |
Phagocytosis of Microbes
-
|
|
| 5 | Antigen processing-Cross presentation | ||
Pathways by source for MRC1 Gene
5 Reactome pathways for MRC1 Gene
2 KEGG pathways for MRC1 Gene
1 Qiagen pathway for MRC1 Gene
- Phagocytosis of Microbes
Interacting Proteins for MRC1 Gene
GPS-Prot Interaction Network for MRC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | IDA | 20035344 |
| GO:0016032 | viral process | IEA | -- |
| GO:0046718 | viral entry into host cell | IEA | -- |
| GO:0071222 | cellular response to lipopolysaccharide | IEA | -- |
Drugs & Compounds for MRC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Technetium Tc-99m tilmanocept | Approved, Investigational | Pharma | Target, ligand | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MRC1 Gene
mRNA/cDNA for MRC1 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000569591 5188 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MRC1 - Select products 50% OFF >
- * MRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRC1
- Browse OriGene Inhibitory RNA Products For MRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1
Clone Products
- Applied Biological Materials (abm): Clones for MRC1 - Select products 50% OFF >
- * MRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRC1
Relevant External Links for MRC1 Gene
- GeneLoc Exon Structure for
- MRC1
Expression for MRC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
-
Lung (Respiratory System)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for MRC1 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9) and Lung (x6.5).
This gene is overexpressed in Milk (20.0) and Serum (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRC1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRC1
SOURCE GeneReport for Unigene cluster for MRC1 Gene:
Hs.75182Evidence on tissue expression from TISSUES for MRC1 Gene
- Liver(4.7)
- Lung(3.7)
- Spleen(3.4)
- Intestine(3.2)
- Lymph node(3.2)
- Blood(3.2)
- Heart(3)
- Nervous system(2.9)
- Pancreas(2.9)
- Bone marrow(2.8)
- Kidney(2.7)
- Muscle(2.7)
- Skin(2.7)
- Adrenal gland(2.6)
- Bone(2.3)
- Eye(2.1)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for MRC1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRC1 Gene
Orthologs for MRC1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MRC1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | MRC1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | MRC1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mrc1 30 17 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Mrc1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | LOC420516 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrc1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mrc1a 30 |
|
- Species where no ortholog for MRC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MRC1 Gene
- ENSEMBL:
- Gene Tree for MRC1 (if available)
- TreeFam:
- Gene Tree for MRC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRC1: view image
Paralogs for MRC1 Gene
Variants for MRC1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MRC1 Gene
- MRC1_HUMAN-P22897
- Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRC1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs606231248 | Risk Factor: Multibacillary leprosy | 17,849,701(+) | G/A | MISSENSE_VARIANT | |
| rs1926736 | - | p.Gly396Ser | |||
| rs2296414 | - | p.Thr167Ile | |||
| rs2437257 | - | p.Leu407Phe | |||
| rs71497223 | - | p.Thr399Ala |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv188e212 | CNV | loss | 25503493 |
| dgv189e212 | CNV | loss | 25503493 |
| esv2851568 | CNV | deletion | 24192839 |
| esv29303 | CNV | loss | 19812545 |
| esv33746 | CNV | gain | 17666407 |
| esv3578673 | CNV | loss | 25503493 |
| esv3578698 | CNV | loss | 25503493 |
| esv3578701 | CNV | loss | 25503493 |
| nsv971903 | OTHER | complex | 23825009 |
Gene Damage Index Score:
11.81;
93.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRC1 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for MRC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dengue virus |
|
|
| hepatitis b |
|
|
| hepatitis |
|
|
| gastroparesis |
|
|
| idiopathic gastroparesis |
|
|
Search MRC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MRC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MRC1 Gene
Publications for MRC1 Gene
- Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PMID: 1294118) Kim SJ … Drickamer K (Genomics 1992) 2 3 4 23
- Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PMID: 20035344) Alter A … Schurr E (Human genetics 2010) 3 4 41
- Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PMID: 10779515) Feinberg H … Weis WI (The Journal of biological chemistry 2000) 3 4 23
- Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PMID: 1730714) Taylor ME … Drickamer K (The Journal of biological chemistry 1992) 3 4 23
- Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PMID: 2258707) Ezekowitz RA … Warner A (The Journal of experimental medicine 1990) 3 4 23
ExternalLinks
Products for MRC1 Gene
- View all 31 R&D Systems MRC1 (MMR/CD206) Products
- View all R&D Systems MRC1 (MMR/CD206) Proteins and Enzymes
- View all 29 R&D Systems MRC1 (MMR/CD206) Primary Antibodies
- View all R&D Systems MRC1 (MMR/CD206) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom MRC1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MRC1
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MRC1
- Origene Custom Protein Services for MRC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRC1
- Browse OriGene Inhibitory RNA Products For MRC1
- OriGene qPCR primer pairs for MRC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for MRC1
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- High-throughput Antibody Production Service
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- Novus Biologicals Antibodies for MRC1
- Novus Biologicals proteins for MRC1
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- Invitrogen Antibodies for MRC1 (AFLGC-Mrc1)
- VectorBuilder Custom and pre-made DNA vectors for MRC1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MRC1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MRC1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MRC1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MRC1
- antibodies-online: Show 25 available Macrophage Mannose Receptor 1 Antibodies ranked by validation data
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- antibodies-online: Show 11 available Macrophage Mannose Receptor 1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MRC1
- Search Santa Cruz Biotechnology (SCBT) for MRC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MRC1
- Horizon Cell Lines for MRC1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRC1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1
Sources for MRC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB