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The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
MRC1 (Mannose Receptor C-Type 1) is a Protein Coding gene. Diseases associated with MRC1 include Dengue Virus and Hepatitis B. Among its related pathways are Tuberculosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is MRC2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J017809 | Promoter | 0.7 | EPDnew Ensembl | 600.7 | +1.1 | 1053 | 3.2 | MRC1 RF00017-606 SLC39A12 | ||
GH10J017770 | Promoter | 0.3 | EPDnew | 600.3 | -38.1 | -38070 | 0.1 | MRC1 LOC107984212 HSALNG0076476 TMEM236 | ||
GH10J017984 | Enhancer | 0.9 | Ensembl ENCODE | 15.4 | +175.1 | 175053 | 1.6 | BACH1 IKZF2 PKNOX1 EED CEBPB DPF2 RELB JUND RUNX3 CBFB | MRC1 SLC39A12 SLC39A12-AS1 CACNB2 | |
GH10J017950 | Enhancer | 0.4 | FANTOM5 | 28.7 | +141.2 | 141210 | 0.3 | ZNF316 NFATC3 EMSY MAFK | SLC39A12 piR-33730-012 MRC1 | |
GH10J017980 | Enhancer | 0.7 | Ensembl ENCODE | 15.8 | +172.6 | 172628 | 2 | JUND CEBPB JUN FOS EP300 FOSL2 MAFK ZMYM3 BACH1 NFE2L2 | MRC1 SLC39A12 SLC39A12-AS1 CACNB2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 11222859 |
GO:0005537 | mannose binding | TAS,IEA | -- |
GO:0030246 | carbohydrate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005768 | endosome | IEA | -- |
GO:0005886 | plasma membrane | IBA,IDA | 20035344 |
GO:0005887 | integral component of plasma membrane | TAS | 1294118 |
GO:0009986 | cell surface | IEA | -- |
GO:0010008 | endosome membrane | IEA,IDA | 20035344 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Phagosome | ||
3 | Tuberculosis | ||
4 | Phagocytosis of Microbes |
Phagocytosis of Microbes
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5 | Antigen processing-Cross presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0006898 | receptor-mediated endocytosis | IDA | 20035344 |
GO:0016032 | viral process | IEA | -- |
GO:0046718 | viral entry into host cell | IEA | -- |
GO:0071222 | cellular response to lipopolysaccharide | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Technetium Tc-99m tilmanocept | Approved, Investigational | Pharma | Target, ligand | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRC1 30 |
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Dog (Canis familiaris) |
Mammalia | MRC1 30 |
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Cow (Bos Taurus) |
Mammalia | MRC1 30 |
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||
Mouse (Mus musculus) |
Mammalia | Mrc1 30 17 |
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Rat (Rattus norvegicus) |
Mammalia | Mrc1 30 |
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||
Chicken (Gallus gallus) |
Aves | LOC420516 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mrc1 30 |
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||
Zebrafish (Danio rerio) |
Actinopterygii | mrc1a 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs606231248 | Risk Factor: Multibacillary leprosy | 17,849,701(+) | G/A | MISSENSE_VARIANT | |
rs1926736 | - | p.Gly396Ser | |||
rs2296414 | - | p.Thr167Ile | |||
rs2437257 | - | p.Leu407Phe | |||
rs71497223 | - | p.Thr399Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv188e212 | CNV | loss | 25503493 |
dgv189e212 | CNV | loss | 25503493 |
esv2851568 | CNV | deletion | 24192839 |
esv29303 | CNV | loss | 19812545 |
esv33746 | CNV | gain | 17666407 |
esv3578673 | CNV | loss | 25503493 |
esv3578698 | CNV | loss | 25503493 |
esv3578701 | CNV | loss | 25503493 |
nsv971903 | OTHER | complex | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dengue virus |
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hepatitis b |
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hepatitis |
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gastroparesis |
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idiopathic gastroparesis |
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