Aliases for MRC1 Gene
External Ids for MRC1 Gene
Previous HGNC Symbols for MRC1 Gene
Previous GeneCards Identifiers for MRC1 Gene
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
GeneCards Summary for MRC1 Gene
MRC1 (Mannose Receptor C-Type 1) is a Protein Coding gene. Diseases associated with MRC1 include Dengue Virus and Gaucher's Disease. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include receptor activity and mannose binding. An important paralog of this gene is MRC2.
UniProtKB/Swiss-Prot for MRC1 Gene
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778).