The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind hi... See more...

Aliases for MRC1 Gene

Aliases for MRC1 Gene

  • Mannose Receptor C-Type 1 2 3 5
  • CLEC13DL 2 3 4
  • CLEC13D 2 3 4
  • Macrophage Mannose Receptor 1-Like Protein 1 3 4
  • C-Type Lectin Domain Family 13 Member D 3 4
  • Mannose Receptor, C Type 1-Like 1 2 3
  • Macrophage Mannose Receptor 1 3 4
  • Human Mannose Receptor 3 4
  • BA541I19.1 2 3
  • MRC1L1 3 4
  • CD206 2 3
  • MMR 3 4
  • HMR 3 4
  • C-Type Lectin Domain Family 13 Member D-Like 4
  • Macrophage Mannose Receptor 2
  • Mannose Receptor, C Type 1 2
  • CD206 Antigen 4
  • MRC1 5

External Ids for MRC1 Gene

Previous HGNC Symbols for MRC1 Gene

  • MRC1L1

Previous GeneCards Identifiers for MRC1 Gene

  • GC10P017833
  • GC10P018248
  • GC10P018102
  • GC10P018138
  • GC10P018098

Summaries for MRC1 Gene

Entrez Gene Summary for MRC1 Gene

  • The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

GeneCards Summary for MRC1 Gene

MRC1 (Mannose Receptor C-Type 1) is a Protein Coding gene. Diseases associated with MRC1 include Dengue Virus and Hepatitis B. Among its related pathways are Tuberculosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is MRC2.

UniProtKB/Swiss-Prot Summary for MRC1 Gene

  • Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
  • (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
  • (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
  • (Microbial infection) Interacts with Hepatitis B virus envelope protein.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRC1 Gene

Genomics for MRC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MRC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J017809 Promoter 0.7 EPDnew Ensembl 600.7 +1.1 1053 3.2 MRC1 RF00017-606 SLC39A12
GH10J017770 Promoter 0.3 EPDnew 600.3 -38.1 -38070 0.1 MRC1 LOC107984212 HSALNG0076476 TMEM236
GH10J017984 Enhancer 0.9 Ensembl ENCODE 15.4 +175.1 175053 1.6 BACH1 IKZF2 PKNOX1 EED CEBPB DPF2 RELB JUND RUNX3 CBFB MRC1 SLC39A12 SLC39A12-AS1 CACNB2
GH10J017950 Enhancer 0.4 FANTOM5 28.7 +141.2 141210 0.3 ZNF316 NFATC3 EMSY MAFK SLC39A12 piR-33730-012 MRC1
GH10J017980 Enhancer 0.7 Ensembl ENCODE 15.8 +172.6 172628 2 JUND CEBPB JUN FOS EP300 FOSL2 MAFK ZMYM3 BACH1 NFE2L2 MRC1 SLC39A12 SLC39A12-AS1 CACNB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRC1

Top Transcription factor binding sites by QIAGEN in the MRC1 gene promoter:
  • aMEF-2
  • AREB6
  • C/EBPalpha
  • HSF2
  • MEF-2
  • MEF-2A
  • Olf-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for MRC1 Gene

Genomic Locations for MRC1 Gene
chr10:17,809,348-17,911,164
(GRCh38/hg38)
Size:
101,817 bases
Orientation:
Plus strand
chr10:18,098,352-18,200,091
(GRCh37/hg19)
Size:
101,740 bases
Orientation:
Plus strand

Genomic View for MRC1 Gene

Genes around MRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRC1 Gene

Proteins for MRC1 Gene

  • Protein details for MRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22897-MRC1_HUMAN
    Recommended name:
    Macrophage mannose receptor 1
    Protein Accession:
    P22897
    Secondary Accessions:
    • A5PKW3
    • Q5VSJ2
    • Q5VSK2

    Protein attributes for MRC1 Gene

    Size:
    1456 amino acids
    Molecular mass:
    166012 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Dengue virus.
    • (Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.
    SequenceCaution:
    • Sequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.

    Three dimensional structures from OCA and Proteopedia for MRC1 Gene

    Alternative splice isoforms for MRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRC1 Gene

Post-translational modifications for MRC1 Gene

  • Glycosylation at Asn104, Asn147, Asn344, Asn529, Asn926, Asn930, Asn1160, and Asn1205
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for MRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRC1 Gene

Domains & Families for MRC1 Gene

Gene Families for MRC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for MRC1 Gene

InterPro:
Blocks:
  • Type II fibronectin collagen-binding domain
  • Ricin B lectin domain
ProtoNet:

Suggested Antigen Peptide Sequences for MRC1 Gene

GenScript: Design optimal peptide antigens:
  • Mannose receptor, C type 1-like 1 (B9EJA8_HUMAN)
  • Macrophage mannose receptor 1-like protein 1 (MRC1_HUMAN)
genes like me logo Genes that share domains with MRC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MRC1 Gene

Function for MRC1 Gene

Molecular function for MRC1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
GENATLAS Biochemistry:
mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides

Phenotypes From GWAS Catalog for MRC1 Gene

Gene Ontology (GO) - Molecular Function for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 11222859
GO:0005537 mannose binding TAS,IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MRC1: view
genes like me logo Genes that share phenotypes with MRC1: view

Animal Models for MRC1 Gene

MGI Knock Outs for MRC1:

Animal Model Products

CRISPR Products

miRNA for MRC1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRC1 Gene

Localization for MRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRC1 Gene

Endosome membrane. Single-pass type I membrane protein. Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRC1 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 3
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IBA,IDA 20035344
GO:0005887 integral component of plasma membrane TAS 1294118
GO:0009986 cell surface IEA --
GO:0010008 endosome membrane IEA,IDA 20035344
genes like me logo Genes that share ontologies with MRC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRC1 Gene

Pathways & Interactions for MRC1 Gene

genes like me logo Genes that share pathways with MRC1: view

Pathways by source for MRC1 Gene

SIGNOR curated interactions for MRC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IDA 20035344
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with MRC1: view

Drugs & Compounds for MRC1 Gene

(5) Drugs for MRC1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Technetium Tc-99m tilmanocept Approved, Investigational Pharma Target, ligand 0

(5) Additional Compounds for MRC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRC1: view

Transcripts for MRC1 Gene

mRNA/cDNA for MRC1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1

Alternative Splicing Database (ASD) splice patterns (SP) for MRC1 Gene

No ASD Table

Relevant External Links for MRC1 Gene

GeneLoc Exon Structure for
MRC1

Expression for MRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRC1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9) and Lung (x6.5).

Protein differential expression in normal tissues from HIPED for MRC1 Gene

This gene is overexpressed in Milk (20.0) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRC1 Gene



Protein tissue co-expression partners for MRC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRC1

SOURCE GeneReport for Unigene cluster for MRC1 Gene:

Hs.75182

Evidence on tissue expression from TISSUES for MRC1 Gene

  • Liver(4.7)
  • Lung(3.7)
  • Spleen(3.4)
  • Intestine(3.2)
  • Lymph node(3.2)
  • Blood(3.2)
  • Heart(3)
  • Nervous system(2.9)
  • Pancreas(2.9)
  • Bone marrow(2.8)
  • Kidney(2.7)
  • Muscle(2.7)
  • Skin(2.7)
  • Adrenal gland(2.6)
  • Bone(2.3)
  • Eye(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with MRC1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRC1 Gene

Orthologs for MRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MRC1 30
  • 99.04 (n)
Dog
(Canis familiaris)
Mammalia MRC1 30
  • 87.89 (n)
Cow
(Bos Taurus)
Mammalia MRC1 30
  • 87.18 (n)
Mouse
(Mus musculus)
Mammalia Mrc1 30 17
  • 82.25 (n)
Rat
(Rattus norvegicus)
Mammalia Mrc1 30
  • 81.7 (n)
Chicken
(Gallus gallus)
Aves LOC420516 30
  • 67.59 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mrc1 30
  • 62.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii mrc1a 30
  • 57.18 (n)
Species where no ortholog for MRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MRC1 Gene

ENSEMBL:
Gene Tree for MRC1 (if available)
TreeFam:
Gene Tree for MRC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRC1: view image

Paralogs for MRC1 Gene

Paralogs for MRC1 Gene

(4) SIMAP similar genes for MRC1 Gene using alignment to 2 proteins:

  • MRC1_HUMAN
  • L8E7Q9_HUMAN
genes like me logo Genes that share paralogs with MRC1: view

Variants for MRC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MRC1 Gene

MRC1_HUMAN-P22897
Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRC1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs606231248 Risk Factor: Multibacillary leprosy 17,849,701(+) G/A MISSENSE_VARIANT
rs1926736 - p.Gly396Ser
rs2296414 - p.Thr167Ile
rs2437257 - p.Leu407Phe
rs71497223 - p.Thr399Ala

Additional dbSNP identifiers (rs#s) for MRC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRC1 Gene

Variant ID Type Subtype PubMed ID
dgv188e212 CNV loss 25503493
dgv189e212 CNV loss 25503493
esv2851568 CNV deletion 24192839
esv29303 CNV loss 19812545
esv33746 CNV gain 17666407
esv3578673 CNV loss 25503493
esv3578698 CNV loss 25503493
esv3578701 CNV loss 25503493
nsv971903 OTHER complex 23825009

Variation tolerance for MRC1 Gene

Gene Damage Index Score: 11.81; 93.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRC1 Gene

Human Gene Mutation Database (HGMD)
MRC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRC1

SNP Genotyping and Copy Number Assay Products

Disorders for MRC1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MRC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dengue virus
  • dengue virus, susceptibility to
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
gastroparesis
  • gastric atonia
idiopathic gastroparesis
- elite association - COSMIC cancer census association via MalaCards
Search MRC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MRC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRC1 Gene

Publications for MRC1 Gene

  1. Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PMID: 1294118) Kim SJ … Drickamer K (Genomics 1992) 2 3 4 23
  2. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PMID: 20035344) Alter A … Schurr E (Human genetics 2010) 3 4 41
  3. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PMID: 10779515) Feinberg H … Weis WI (The Journal of biological chemistry 2000) 3 4 23
  4. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PMID: 1730714) Taylor ME … Drickamer K (The Journal of biological chemistry 1992) 3 4 23
  5. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PMID: 2258707) Ezekowitz RA … Warner A (The Journal of experimental medicine 1990) 3 4 23

Products for MRC1 Gene

Sources for MRC1 Gene