Aliases for MRC1 Gene
Aliases for MRC1 Gene
External Ids for MRC1 Gene
- HGNC: 7228
- Entrez Gene: 4360
- Ensembl: ENSG00000260314
- OMIM: 153618
- UniProtKB: P22897
Previous HGNC Symbols for MRC1 Gene
- MRC1L1
Previous GeneCards Identifiers for MRC1 Gene
- GC10P017833
- GC10P018248
- GC10P018102
- GC10P018138
- GC10P018098
Summaries for MRC1 Gene
-
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
GeneCards Summary for MRC1 Gene
MRC1 (Mannose Receptor C-Type 1) is a Protein Coding gene. Diseases associated with MRC1 include Dengue Virus and Gastroparesis. Among its related pathways are Innate Immune System and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is MRC2.
UniProtKB/Swiss-Prot for MRC1 Gene
-
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
-
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
-
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
-
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Additional gene information for MRC1 Gene
- Monarch Initiative
- Search for MRC1 at DataMed
- Search for MRC1 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRC1 Gene
Genomics for MRC1 Gene
GeneHancer (GH) Regulatory Elements for MRC1 Gene
Promoters and enhancers for MRC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J017809 | Promoter | 1 | EPDnew Ensembl | 605.6 | +2.4 | 2358 | 5.8 | MRC1 TMEM236 GC10M017832 | ||
| GH10J017770 | Promoter | 0.5 | EPDnew | 600.3 | -38.1 | -38065 | 0.1 | MRC1 GC10P017764 TMEM236 PIR51894 | ||
| GH10J017984 | Enhancer | 0.9 | Ensembl ENCODE | 15.4 | +175.3 | 175258 | 1.6 | CREM ZBED1 IKZF1 PKNOX1 BACH1 IKZF2 CEBPB CBFB JUN DPF2 | MRC1 SLC39A12 SLC39A12-AS1 | |
| GH10J017950 | Enhancer | 0.5 | FANTOM5 | 28.7 | +141.2 | 141215 | 0.3 | MAFK ZNF316 EMSY | SLC39A12 MRC1 GC10P017900 | |
| GH10J017980 | Enhancer | 0.8 | Ensembl ENCODE | 10.3 | +172.6 | 172558 | 1.9 | MAFK CEBPB JUN JUND FOS EP300 FOSL2 ZMYM3 BACH1 | SLC39A12 MRC1 SLC39A12-AS1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MRC1 gene promoter:
-
- aMEF-2
- AREB6
- C/EBPalpha
- HSF2
- MEF-2
- MEF-2A
- Olf-1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for MRC1 Gene
Genomic Locations for MRC1 Gene
- chr10:17,809,343-17,911,164
- (GRCh38/hg38)
- Size:
- 101,822 bases
- Orientation:
- Plus strand
- chr10:18,098,352-18,200,091
- (GRCh37/hg19)
- Size:
- 101,740 bases
- Orientation:
- Plus strand
Genomic View for MRC1 Gene
Genes around MRC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.33 by HGNC
- 10p12.33 by Entrez Gene
- 10p12.33 by Ensembl
MRC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRC1 Gene
Proteins for MRC1 Gene
-
Protein details for MRC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22897-MRC1_HUMAN
- Recommended name:
- Macrophage mannose receptor 1
- Protein Accession:
- P22897
- A5PKW3
- Q5VSJ2
- Q5VSK2
Protein attributes for MRC1 Gene
- Size:
- 1456 amino acids
- Molecular mass:
- 166012 Da
- Quaternary structure:
-
- (Microbial infection) Interacts with Dengue virus.
- (Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.
- Miscellaneous:
-
- CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
- SequenceCaution:
-
- Sequence=CAH70733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MRC1 Gene
Protein Expression for MRC1 Gene
Post-translational modifications for MRC1 Gene
Other Protein References for MRC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-MRC1 Antibody (HPA004114), Anti-MRC1 Antibody (AMAb90746), and Anti-MRC1 Antibody (HPA045134)
-
BioLegend
- CD206 (MMR) Antibody (321113)
- CD206 (MMR) Antibody (321114)
- CD206 (MMR) Antibody (321108)
- CD206 (MMR) Antibody (321105)
- CD206 (MMR) Antibody (321101)
- CD206 (MMR) Antibody (321102)
- CD206 (MMR) Antibody (321109)
- CD206 (MMR) Antibody (321112)
- CD206 (MMR) Antibody (321110)
- CD206 (MMR) Antibody (321104)
- CD206 (MMR) Antibody (321116)
- CD206 (MMR) Antibody (321103)
- CD206 (MMR) Antibody (321111)
- CD206 (MMR) Antibody (321106)
- CD206 (MMR) Antibody (321118)
- APC/Cyanine7 CD206 (MMR) Antibody (321119)
- APC/Cyanine7 CD206 (MMR) Antibody (321120)
- PerCP/Cyanine5.5 CD206 (MMR) Antibody (321121)
- CD206 (MMR) Antibody (321123)
- PerCP/Cyanine5.5 CD206 (MMR) Antibody (321122)
- CD206 (MMR) Antibody (321124)
- CD206 (MMR) Antibody (321125)
- CD206 (MMR) (MaxPar(R) Ready) Antibody
- CD206 (MMR) Antibody (321126)
- CD206 (MMR) Antibody (321131)
- CD206 (MMR) Antibody (321130)
- CD206 (MMR) Antibody (321132)
- CD206 (MMR) Antibody (321129)
- CD206 (MMR) Antibody (321136)
- APC/Fire(TM) 750 CD206 (MMR) Antibody (321134)
- CD206 (MMR) Antibody (321135)
- APC/Fire(TM) 750 CD206 (MMR) Antibody (321133)
- CD206 (MMR) Antibody (321137)
- CD206 (MMR) Antibody (321138)
- CD206 (MMR) Antibody (321141)
- CD206 (MMR) Antibody (321142)
- CD206 (MMR) Antibody (321140)
- CD206 (MMR) Antibody (321139)
- TotalSeq(TM)-A0205 CD206 (MMR) Antibody
-
Custom Antibody ServicesOriGene Antibodies for MRC1
- Novus Biologicals Antibodies for MRC1
-
Abcam antibodies for MRC1
- Invitrogen Antibodies for MRC1 (AFLGC-MRC1)
-
Boster Bio Antibodies for MRC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MRC1
Protein Products
- Atlas Antibodies PrEST Antigen MRC1 (APrEST86249) and PrEST Antigen MRC1 (APrEST86248)
-
OriGene Purified Proteins for MRC1
- Search Origene for MassSpec and Protein Over-expression Lysates for MRC1
- Origene Custom Protein Services for MRC1
- Novus Biologicals proteins for MRC1
-
Abcam proteins for MRC1
No data available for DME Specific Peptides for MRC1 Gene
Domains & Families for MRC1 Gene
Gene Families for MRC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted membrane proteins
Protein Domains for MRC1 Gene
Suggested Antigen Peptide Sequences for MRC1 Gene
- GenScript: Design optimal peptide antigens:
-
- Mannose receptor, C type 1-like 1 (B9EJA8_HUMAN)
- Macrophage mannose receptor 1-like protein 1 (MRC1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MRC1 Gene
Function for MRC1 Gene
Molecular function for MRC1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Interacts with Hepatitis B virus envelope protein.
- GENATLAS Biochemistry:
- mannose receptor C,type 1,expressed in macrophage,endothelial cells,binding oligosaccharides
Phenotypes From GWAS Catalog for MRC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0004888 | transmembrane signaling receptor activity | IBA,IEA | 21873635 |
| GO:0005515 | protein binding | IPI | 11222859 |
| GO:0005537 | mannose binding | TAS,IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for MRC1 Gene
- MGI mutant phenotypes for MRC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MRC1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRC1
-
CRISPR Products
-
OriGene CRISPR knockouts for MRC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRC1
- Applied Biological Materials (abm): CRISPR Clones for MRC1 - Now 50% OFF >
- * MRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MRC1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRC1
miRNA for MRC1 Gene
- miRTarBase miRNAs that target MRC1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MRC1
- Browse OriGene Inhibitory RNA Products For MRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1
Clone Products
-
- MG222935
- MR222935
- MR222935L1
- MR222935L1V
- MR222935L2
- MR222935L2V
- MR222935L3
- MR222935L3V
- MR222935L4
- MR222935L4V
- RC219343
- RC219343L1
- RC219343L1V
- RC219343L2
- RC219343L2V
- RC219343L3
- RC219343L3V
- RC219343L4
- RC219343L4V
- RC223814
- RC223814L1
- RC223814L1V
- RC223814L2
- RC223814L2V
- RC223814L3
- RC223814L3V
- RC223814L4
- RC223814L4V
- RG219343
- RG223814
- RR203299
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRC1
- genomics-online: cdna clones - Search results for 97 available Macrophage Mannose Receptor 1 gene related products
- Overview of 97 available Macrophage Mannose Receptor 1 gene related products
- orf clones - Search results for 97 available Macrophage Mannose Receptor 1 gene related products
- Overview of 97 available Macrophage Mannose Receptor 1 gene related products
- Applied Biological Materials (abm): Clones for MRC1 - Now 50% OFF >
- * MRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MRC1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for MRC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRC1 Gene
Localization for MRC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRC1 Gene
- Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| extracellular | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005886 | plasma membrane | IDA,IEA | 20035344 |
| GO:0005887 | integral component of plasma membrane | TAS | 1294118 |
| GO:0009986 | cell surface | IEA | -- |
| GO:0010008 | endosome membrane | IEA,IDA | 20035344 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRC1 Gene
Pathways & Interactions for MRC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Phagosome | ||
| 3 | Tuberculosis | ||
| 4 | Microglia Activation During Neuroinflammation: Microglia Polarization | ||
| 5 | Phagocytosis of Microbes | ||
Pathways by source for MRC1 Gene
5 Reactome pathways for MRC1 Gene
2 KEGG pathways for MRC1 Gene
1 R&D Systems pathway for MRC1 Gene
1 Qiagen pathway for MRC1 Gene
Interacting Proteins for MRC1 Gene
GPS-Prot Interaction Network for MRC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | IDA | 20035344 |
| GO:0016032 | viral process | IEA | -- |
| GO:0046718 | viral entry into host cell | IEA | -- |
| GO:0071222 | cellular response to lipopolysaccharide | IEA | -- |
Drugs & Compounds for MRC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Technetium Tc-99m tilmanocept | Approved, Investigational | Pharma | Target, ligand | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen MRC1 (APrEST86249) and PrEST Antigen MRC1 (APrEST86248)
Transcripts for MRC1 Gene
mRNA/cDNA for MRC1 Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000569591 5188 bps (ENST00000569591.2)
Unigene Clusters for MRC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRC1
- Applied Biological Materials (abm): CRISPR Clones for MRC1 - Now 50% OFF >
- * MRC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MRC1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRC1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MRC1
- Browse OriGene Inhibitory RNA Products For MRC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRC1
Clone Products
-
- MG222935
- MR222935
- MR222935L1
- MR222935L1V
- MR222935L2
- MR222935L2V
- MR222935L3
- MR222935L3V
- MR222935L4
- MR222935L4V
- RC219343
- RC219343L1
- RC219343L1V
- RC219343L2
- RC219343L2V
- RC219343L3
- RC219343L3V
- RC219343L4
- RC219343L4V
- RC223814
- RC223814L1
- RC223814L1V
- RC223814L2
- RC223814L2V
- RC223814L3
- RC223814L3V
- RC223814L4
- RC223814L4V
- RG219343
- RG223814
- RR203299
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRC1
- genomics-online: cdna clones - Search results for 97 available Macrophage Mannose Receptor 1 gene related products
- Overview of 97 available Macrophage Mannose Receptor 1 gene related products
- orf clones - Search results for 97 available Macrophage Mannose Receptor 1 gene related products
- Overview of 97 available Macrophage Mannose Receptor 1 gene related products
- Applied Biological Materials (abm): Clones for MRC1 - Now 50% OFF >
- * MRC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MRC1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MRC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
-
Lung (Respiratory System)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for MRC1 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9) and Lung (x6.5).
This gene is overexpressed in Milk (20.0) and Serum (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MRC1 Gene:
MRC1SOURCE GeneReport for Unigene cluster for MRC1 Gene:
Hs.75182Evidence on tissue expression from TISSUES for MRC1 Gene
- Liver(4.6)
- Lung(3.4)
- Spleen(2.9)
- Lymph node(2.5)
- Blood(2.4)
- Intestine(2.4)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for MRC1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRC1 Gene
Orthologs for MRC1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRC1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MRC1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MRC1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrc1 17 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mrc1 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC420516 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mrc1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mrc1a 34 |
|
- Species where no ortholog for MRC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MRC1 Gene
- ENSEMBL:
- Gene Tree for MRC1 (if available)
- TreeFam:
- Gene Tree for MRC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRC1: view image
Paralogs for MRC1 Gene
Variants for MRC1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MRC1 Gene
- MRC1_HUMAN-P22897
- Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs606231248 | risk-factor, Multibacillary leprosy | 17,849,701(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000021646 | -- | 17,825,121(+) | C/T | intron_variant | |
| rs1000023384 | -- | 17,864,656(+) | C/T | intron_variant | |
| rs1000047075 | -- | 17,879,569(+) | G/A/T | intron_variant | |
| rs1000121320 | -- | 17,910,096(+) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv188e212 | CNV | loss | 25503493 |
| dgv189e212 | CNV | loss | 25503493 |
| esv2851568 | CNV | deletion | 24192839 |
| esv29303 | CNV | loss | 19812545 |
| esv33746 | CNV | gain | 17666407 |
| esv3578673 | CNV | loss | 25503493 |
| esv3578698 | CNV | loss | 25503493 |
| esv3578701 | CNV | loss | 25503493 |
| nsv971903 | OTHER | complex | 23825009 |
Gene Damage Index Score:
11.81;
93.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRC1 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for MRC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dengue virus |
|
|
| gastroparesis |
|
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| calcific tendinitis |
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| mycobacterium tuberculosis 1 |
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Search MRC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MRC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MRC1 Gene
Publications for MRC1 Gene
- Organization of the gene encoding the human macrophage mannose receptor (MRC1). (PMID: 1294118) Kim SJ … Drickamer K (Genomics 1992) 2 3 4 23 58
- Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. (PMID: 20035344) Alter A … Schurr E (Human genetics 2010) 3 4 45 58
- Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. (PMID: 10779515) Feinberg H … Weis WI (The Journal of biological chemistry 2000) 3 4 23 58
- Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. (PMID: 1730714) Taylor ME … Drickamer K (The Journal of biological chemistry 1992) 3 4 23 58
- Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. (PMID: 2258707) Ezekowitz RA … Warner A (The Journal of experimental medicine 1990) 3 4 23 58
ExternalLinks
Products for MRC1 Gene
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- antibodies-online: Search results for 173 available Macrophage Mannose Receptor 1 Antibodies ranked by validation data
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Sources for MRC1 Gene
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