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This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Noonan Syndrome 11 and Noonan Syndrome 1. Among its related pathways are NGF Pathway and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is RRAS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | TAS,IMP | 28289718 |
GO:0005515 | protein binding | IPI | 25137548 |
GO:0005525 | GTP binding | IBA | 21873635 |
GO:0019003 | GDP binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
4 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
|
5 | CNTF Signaling |
CNTF Signaling
.50
FLT3 Signaling
.50
IL-3 Pathway
.46
|
OSM Pathway
.46
Nur77-Induced AICD in Macrophage
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007265 | Ras protein signal transduction | IBA,IMP | 28289718 |
GO:0007275 | multicellular organism development | TAS | 10446149 |
GO:0007517 | muscle organ development | TAS | -- |
GO:0030036 | actin cytoskeleton organization | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MRAS 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MRAS 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MRAS 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MRAS 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRAS 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mras 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mras 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MRAS 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MRAS 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496446 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | MRAS 31 |
|
OneToOne | |
LOC100536317 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | ras-2 30 31 32 |
|
OneToOne | |
ras-1 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 31 |
|
ManyToMany | |
RAS2 31 |
|
ManyToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2555 30 |
|
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
635781 | Pathogenic: NOONAN SYNDROME 11 | 138,372,951(+) | G/T | MISSENSE_VARIANT,INTRON_VARIANT | |
635782 | Likely Pathogenic: NOONAN SYNDROME 11; not provided | 138,397,333(+) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
635783 | Pathogenic: NOONAN SYNDROME 11 | 138,397,342(+) | A/G | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
rs138905383 | Benign: not provided | 138,397,436(+) | C/T | SYNONYMOUS_VARIANT | |
rs149904534 | Benign: not provided | 138,400,539(+) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome 11 |
|
|
noonan syndrome 1 |
|
|
rasopathy |
|
|
tuberculum sellae meningioma |
|
|
sella turcica neoplasm |
|
|