Aliases for MRAS Gene
External Ids for MRAS Gene
Previous GeneCards Identifiers for MRAS Gene
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for MRAS Gene
MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Noonan Syndrome 11 and Noonan Syndrome 1. Among its related pathways are CCR5 Pathway in Macrophages and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is RRAS2.
UniProtKB/Swiss-Prot Summary for MRAS Gene
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.