This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways... See more...

Aliases for MRAS Gene

Aliases for MRAS Gene

  • Muscle RAS Oncogene Homolog 2 3 5
  • Ras-Related Protein R-Ras3 3 4
  • Ras-Related Protein M-Ras 3 4
  • RRAS3 3 4
  • Muscle And Microspikes RAS 3
  • R-RAS3 3
  • M-RAs 3
  • NS11 3

External Ids for MRAS Gene

Previous GeneCards Identifiers for MRAS Gene

  • GC03P135051
  • GC03P138859
  • GC03P139348
  • GC03P139388
  • GC03P139387
  • GC03P139549
  • GC03P138066
  • GC03P135441

Summaries for MRAS Gene

Entrez Gene Summary for MRAS Gene

  • This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MRAS Gene

MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Noonan Syndrome 11 and Noonan Syndrome 1. Among its related pathways are CCR5 Pathway in Macrophages and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is RRAS2.

UniProtKB/Swiss-Prot Summary for MRAS Gene

  • May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.

Gene Wiki entry for MRAS Gene

Additional gene information for MRAS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRAS Gene

Genomics for MRAS Gene

GeneHancer (GH) Regulatory Elements for MRAS Gene

Promoters and enhancers for MRAS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138347 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.5 +1.6 1615 4.3 ZNF217 EP300 CTCF PHF8 ZFX POLR2A ZBTB26 MYC CTBP1 ZBTB7A MRAS lnc-ARMC8-2 piR-32850 DZIP1L PRR23C
GH03J138381 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 38.2 +41.9 41853 17.8 JUND FOS ZIC2 CTBP1 TEAD1 NR2F2 NCOR1 CTCF CREB1 CEBPB MRAS NME9 ESYT3 AB372650-002 piR-32850
GH03J138363 Enhancer 1.1 Ensembl ENCODE dbSUPER 40.4 +21.1 21052 9.4 RFX1 RELA MEF2C RCOR1 RBM25 BCL11A CBFB MEF2B NR2F2 BATF MRAS NME9 PRR23C DZIP1L piR-32850 AB372650-002
GH03J138374 Enhancer 0.8 Ensembl dbSUPER 35.9 +28.1 28053 2.2 NFIC NCOR1 PBX2 NR2F2 TAL1 MEIS2 HLF ARID1B KDM1A IKZF1 MRAS AB372650-002 piR-32850
GH03J138373 Enhancer 0.7 dbSUPER 40 +26.5 26533 0.6 ZNF623 ZNF510 ZNF266 ZBTB11 ZNF426 ZNF213 ZNF664 ZNF34 ZC3H11A ZNF781 MRAS DZIP1L DBR1 AB372650-002 piR-32850
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRAS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRAS

Top Transcription factor binding sites by QIAGEN in the MRAS gene promoter:
  • CREB
  • deltaCREB
  • HEN1
  • HOXA9
  • HOXA9B

Genomic Locations for MRAS Gene

Genomic Locations for MRAS Gene
chr3:138,347,648-138,405,535
(GRCh38/hg38)
Size:
57,888 bases
Orientation:
Plus strand
chr3:138,066,539-138,124,377
(GRCh37/hg19)
Size:
57,839 bases
Orientation:
Plus strand

Genomic View for MRAS Gene

Genes around MRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRAS Gene

Proteins for MRAS Gene

  • Protein details for MRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14807-RASM_HUMAN
    Recommended name:
    Ras-related protein M-Ras
    Protein Accession:
    O14807
    Secondary Accessions:
    • B4DIK0
    • Q86WX8

    Protein attributes for MRAS Gene

    Size:
    208 amino acids
    Molecular mass:
    23846 Da
    Quaternary structure:
    • Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).

    Alternative splice isoforms for MRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRAS Gene

Post-translational modifications for MRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRAS Gene

Domains & Families for MRAS Gene

Gene Families for MRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRAS Gene

Blocks:
  • Ras small GTPase, Ras type
  • Transforming protein P21 RAS signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRAS Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78970, highly similar to Ras-related protein M-Ras (B4DIK0_HUMAN)
  • cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras (Q6FGP0_HUMAN)
  • Ras-related protein R-Ras3 (RASM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14807

UniProtKB/Swiss-Prot:

RASM_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with MRAS: view

Function for MRAS Gene

Molecular function for MRAS Gene

UniProtKB/Swiss-Prot Function:
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
UniProtKB/Swiss-Prot Induction:
By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.

Phenotypes From GWAS Catalog for MRAS Gene

Gene Ontology (GO) - Molecular Function for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA,TAS 21873635
GO:0005515 protein binding IPI 25137548
GO:0005525 GTP binding IBA 21873635
GO:0019003 GDP binding IBA 21873635
GO:0030742 GTP-dependent protein binding IPI 10934204
genes like me logo Genes that share ontologies with MRAS: view
genes like me logo Genes that share phenotypes with MRAS: view

Human Phenotype Ontology for MRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MRAS

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS

Clone Products

  • Addgene plasmids for MRAS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRAS Gene

Localization for MRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRAS gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MRAS: view

Pathways & Interactions for MRAS Gene

PathCards logo

SuperPathways for MRAS Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.59
.59
.54
.51
.49
.48
.47
.44
.43
.36
.35
.34
2 fMLP Pathway
.44
.44
.43
.39
.38
.31
3 GPCR Pathway
.73
.73
.62
.58
.55
.38
4 Apoptotic Pathways in Synovial Fibroblasts
.66
.65
.64
.61
.60
.57
5 CNTF Signaling
.50
.50
.46
.46
.45
genes like me logo Genes that share pathways with MRAS: view

Pathways by source for MRAS Gene

2 BioSystems pathways for MRAS Gene
6 GeneGo (Thomson Reuters) pathways for MRAS Gene
  • Development G-Proteins mediated regulation MARK-ERK signaling
  • G-protein signaling G-Protein alpha-12 signaling pathway
  • G-protein signaling M-RAS regulation pathway
  • G-protein signaling_Cross-talk between Ras-family GTPases
  • G-protein signaling_Rap1A regulation pathway
108 Qiagen pathways for MRAS Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
1 Cell Signaling Technology pathway for MRAS Gene

SIGNOR curated interactions for MRAS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction IBA 21873635
GO:0007275 multicellular organism development TAS 10446149
GO:0007517 muscle organ development TAS 9395237
GO:0030036 actin cytoskeleton organization TAS 9395237
genes like me logo Genes that share ontologies with MRAS: view

Drugs & Compounds for MRAS Gene

(1) Additional Compounds for MRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRAS: view

Transcripts for MRAS Gene

mRNA/cDNA for MRAS Gene

6 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS

Clone Products

  • Addgene plasmids for MRAS

Alternative Splicing Database (ASD) splice patterns (SP) for MRAS Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for MRAS Gene

GeneLoc Exon Structure for
MRAS

Expression for MRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRAS Gene

This gene is overexpressed in Brain (14.9), Spinal cord (7.3), Frontal cortex (6.7), Retina (6.2), and Nasopharynx (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRAS Gene



Protein tissue co-expression partners for MRAS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRAS

SOURCE GeneReport for Unigene cluster for MRAS Gene:

Hs.527021

mRNA Expression by UniProt/SwissProt for MRAS Gene:

O14807-RASM_HUMAN
Tissue specificity: Expression highly restricted to the brain and heart.

Evidence on tissue expression from TISSUES for MRAS Gene

  • Nervous system(4.9)
  • Lung(4.2)
  • Spleen(4.2)
  • Pancreas(4.1)
  • Heart(2.7)
  • Muscle(2.6)
  • Kidney(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with MRAS: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRAS Gene

Orthologs for MRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRAS 31 30
  • 99.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRAS 31
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRAS 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRAS 31 30
  • 94.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRAS 31 30
  • 93.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mras 30
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Mras 17 31 30
  • 89.42 (n)
chicken
(Gallus gallus)
Aves MRAS 31 30
  • 83.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRAS 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496446 30
  • 79.81 (n)
zebrafish
(Danio rerio)
Actinopterygii MRAS 31
  • 86 (a)
OneToOne
LOC100536317 30
  • 77.24 (n)
worm
(Caenorhabditis elegans)
Secernentea ras-2 31 32 30
  • 60.59 (n)
OneToOne
ras-1 32
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 31
  • 32 (a)
ManyToMany
RAS2 31
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2555 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2555 30
Species where no ortholog for MRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRAS Gene

ENSEMBL:
Gene Tree for MRAS (if available)
TreeFam:
Gene Tree for MRAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRAS: view image

Paralogs for MRAS Gene

Pseudogenes.org Pseudogenes for MRAS Gene

genes like me logo Genes that share paralogs with MRAS: view

Variants for MRAS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRAS Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
635781 Pathogenic: NOONAN SYNDROME 11 138,372,951(+) G/T MISSENSE_VARIANT,INTRON_VARIANT
635782 Pathogenic: NOONAN SYNDROME 11 138,397,333(+) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
635783 Pathogenic: NOONAN SYNDROME 11 138,397,342(+) A/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
rs138905383 Benign: not provided 138,397,436(+) C/T SYNONYMOUS_VARIANT
rs149904534 Benign: not provided 138,400,539(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MRAS Gene

Structural Variations from Database of Genomic Variants (DGV) for MRAS Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV gain+loss 18775914
nsv526089 CNV gain 19592680
nsv528349 CNV loss 19592680
nsv591853 CNV loss 21841781

Variation tolerance for MRAS Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRAS Gene

Human Gene Mutation Database (HGMD)
MRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRAS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRAS Gene

Disorders for MRAS Gene

MalaCards: The human disease database

(10) MalaCards diseases for MRAS Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
noonan syndrome 11
  • ns11
noonan syndrome 1
  • ns1
rasopathy
tuberculum sellae meningioma
  • meningioma of the tuberculum sellae
sella turcica neoplasm
  • tumor of sella turcica
- elite association - COSMIC cancer census association via MalaCards
Search MRAS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRAS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRAS Gene

Publications for MRAS Gene

  1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PMID: 9400994) Kimmelman A … Chan AM (Oncogene 1997) 2 3 4 23 54
  2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P … McCormick F (Molecular cell 2006) 3 4 23 54
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 41 54
  4. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S … Kathiresan S (Lancet (London, England) 2010) 3 41 54
  5. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) Lluís-Ganella C … Elosua R (Revista espanola de cardiologia 2010) 3 41 54

Products for MRAS Gene

Sources for MRAS Gene