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Aliases for MRAS Gene

Aliases for MRAS Gene

  • Muscle RAS Oncogene Homolog 2 3 5
  • Ras-Related Protein R-Ras3 3 4
  • RRAS3 3 4
  • Muscle And Microspikes RAS 3
  • Ras-Related Protein M-Ras 3
  • R-RAS3 3
  • M-RAs 3

External Ids for MRAS Gene

Previous GeneCards Identifiers for MRAS Gene

  • GC03P135051
  • GC03P138859
  • GC03P139348
  • GC03P139388
  • GC03P139387
  • GC03P139549
  • GC03P138066
  • GC03P135441

Summaries for MRAS Gene

Entrez Gene Summary for MRAS Gene

  • This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MRAS Gene

MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Vertebral Artery Occlusion and Causalgia. Among its related pathways are Akt Signaling and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is RRAS2.

UniProtKB/Swiss-Prot for MRAS Gene

  • May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.

Gene Wiki entry for MRAS Gene

Additional gene information for MRAS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRAS Gene

Genomics for MRAS Gene

GeneHancer (GH) Regulatory Elements for MRAS Gene

Promoters and enhancers for MRAS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138347 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 661.6 +1.8 1815 4.7 ATF1 SIN3A FEZF1 ZNF48 ZNF121 ZFP91 ATF7 SP5 ZSCAN16 CTCF MRAS GC03M138344 PIR43849 DZIP1L PRR23C
GH03J138381 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +34.6 34559 1.8 ELF3 DMAP1 RARA YY1 ZNF614 THAP11 NFKBIZ RXRA CEBPB MXD4 MRAS NME9 ESYT3 GC03P138407 GC03M138344
GH03J138389 Enhancer 1.1 Ensembl ENCODE dbSUPER 36.2 +42.5 42511 2.2 PKNOX1 JUN ZSCAN4 MAX ZIC2 HIC1 ZFHX2 ZNF366 POLR2A RCOR1 MRAS NME9 GC03P138407 GC03M138344
GH03J138373 Enhancer 0.8 dbSUPER 40 +28.8 28830 5.2 HDAC1 PKNOX1 ZNF213 SCRT2 ZNF680 ZBTB11 ZC3H11A REST ZNF623 ZNF518A MRAS DBR1 DZIP1L ENSG00000272656 NME9 GC03M138344 GC03P138407
GH03J138398 Enhancer 1 ENCODE dbSUPER 25.2 +51.8 51755 1.2 FOXA2 ARID4B THRB RARA CREM MIXL1 HMG20B RXRA SREBF1 NFIL3 MRAS NME9 GC03P138407 GC03M138344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MRAS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRAS gene promoter:
  • deltaCREB
  • CREB
  • HEN1
  • HOXA9
  • HOXA9B

Genomic Locations for MRAS Gene

Genomic Locations for MRAS Gene
chr3:138,347,648-138,405,535
(GRCh38/hg38)
Size:
57,888 bases
Orientation:
Plus strand
chr3:138,066,539-138,124,377
(GRCh37/hg19)
Size:
57,839 bases
Orientation:
Plus strand

Genomic View for MRAS Gene

Genes around MRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRAS Gene

Proteins for MRAS Gene

  • Protein details for MRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14807-RASM_HUMAN
    Recommended name:
    Ras-related protein M-Ras
    Protein Accession:
    O14807
    Secondary Accessions:
    • B4DIK0
    • Q86WX8

    Protein attributes for MRAS Gene

    Size:
    208 amino acids
    Molecular mass:
    23846 Da
    Quaternary structure:
    • Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).

    Alternative splice isoforms for MRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRAS Gene

Post-translational modifications for MRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRAS Gene

Domains & Families for MRAS Gene

Gene Families for MRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O14807

UniProtKB/Swiss-Prot:

RASM_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with MRAS: view

Function for MRAS Gene

Molecular function for MRAS Gene

UniProtKB/Swiss-Prot Function:
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
UniProtKB/Swiss-Prot Induction:
By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.

Phenotypes From GWAS Catalog for MRAS Gene

Gene Ontology (GO) - Molecular Function for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005515 protein binding IPI 10446149
GO:0005525 GTP binding IEA --
GO:0030742 GTP-dependent protein binding IPI 10934204
genes like me logo Genes that share ontologies with MRAS: view
genes like me logo Genes that share phenotypes with MRAS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRAS

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS

Clone Products

  • Addgene plasmids for MRAS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRAS Gene

Localization for MRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRAS gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with MRAS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRAS Gene

Pathways & Interactions for MRAS Gene

genes like me logo Genes that share pathways with MRAS: view

SIGNOR curated interactions for MRAS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction TAS 10446149
GO:0007275 multicellular organism development TAS 10446149
GO:0007517 muscle organ development TAS 9395237
GO:0030036 actin cytoskeleton organization TAS 9395237
genes like me logo Genes that share ontologies with MRAS: view

Drugs & Compounds for MRAS Gene

(1) Additional Compounds for MRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRAS: view

Transcripts for MRAS Gene

Unigene Clusters for MRAS Gene

Muscle RAS oncogene homolog:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS

Clone Products

  • Addgene plasmids for MRAS

Alternative Splicing Database (ASD) splice patterns (SP) for MRAS Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - -
SP6: - -
SP7:

Relevant External Links for MRAS Gene

GeneLoc Exon Structure for
MRAS
ECgene alternative splicing isoforms for
MRAS

Expression for MRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRAS Gene

This gene is overexpressed in Brain (14.9), Spinal cord (7.3), Frontal cortex (6.7), Retina (6.2), and Nasopharynx (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRAS Gene



Protein tissue co-expression partners for MRAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRAS Gene:

MRAS

SOURCE GeneReport for Unigene cluster for MRAS Gene:

Hs.527021

mRNA Expression by UniProt/SwissProt for MRAS Gene:

O14807-RASM_HUMAN
Tissue specificity: Expression highly restricted to the brain and heart.

Evidence on tissue expression from TISSUES for MRAS Gene

  • Nervous system(4.9)
  • Lung(4.2)
  • Spleen(4.2)
  • Pancreas(4.1)
  • Heart(2.7)
  • Muscle(2.6)
  • Kidney(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with MRAS: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRAS Gene

Orthologs for MRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRAS 34 33
  • 99.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRAS 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRAS 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRAS 34 33
  • 94.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRAS 34 33
  • 93.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mras 33
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Mras 16 34 33
  • 89.42 (n)
chicken
(Gallus gallus)
Aves MRAS 34 33
  • 83.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRAS 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496446 33
  • 79.81 (n)
zebrafish
(Danio rerio)
Actinopterygii MRAS 34
  • 86 (a)
OneToOne
LOC100536317 33
  • 77.24 (n)
worm
(Caenorhabditis elegans)
Secernentea ras-2 34 35 33
  • 60.59 (n)
OneToOne
ras-1 35
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 34
  • 32 (a)
ManyToMany
RAS2 34
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2555 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2555 33
Species where no ortholog for MRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRAS Gene

ENSEMBL:
Gene Tree for MRAS (if available)
TreeFam:
Gene Tree for MRAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MRAS: view image

Paralogs for MRAS Gene

Pseudogenes.org Pseudogenes for MRAS Gene

genes like me logo Genes that share paralogs with MRAS: view

Variants for MRAS Gene

Sequence variations from dbSNP and Humsavar for MRAS Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000009406 -- 138,391,040(+) G/T intron_variant
rs1000031948 -- 138,369,736(+) G/C intron_variant
rs1000065097 -- 138,379,034(+) T/C intron_variant
rs1000083950 -- 138,369,438(+) T/A intron_variant
rs1000101212 -- 138,354,036(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRAS Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV gain+loss 18775914
nsv526089 CNV gain 19592680
nsv528349 CNV loss 19592680
nsv591853 CNV loss 21841781

Variation tolerance for MRAS Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRAS Gene

Human Gene Mutation Database (HGMD)
MRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRAS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRAS Gene

Disorders for MRAS Gene

MalaCards: The human disease database

(3) MalaCards diseases for MRAS Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
causalgia
  • complex regional pain syndrome, type ii
cerebral arterial disease
  • cerebral arterial diseases
- elite association - COSMIC cancer census association via MalaCards
Search MRAS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MRAS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRAS Gene

Publications for MRAS Gene

  1. Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PMID: 9400994) Kimmelman A … Chan AM (Oncogene 1997) 2 3 4 22 58
  2. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P … McCormick F (Molecular cell 2006) 3 4 22 58
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 44 58
  4. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) Lluís-Ganella C … Elosua R (Revista espanola de cardiologia 2010) 3 44 58
  5. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S … Kathiresan S (Lancet (London, England) 2010) 3 44 58

Products for MRAS Gene

  • Addgene plasmids for MRAS

Sources for MRAS Gene

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