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This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways... See more...
Aliases for MRAS Gene
Aliases for MRAS Gene
External Ids for MRAS Gene
- HGNC: 7227
- NCBI Entrez Gene: 22808
- Ensembl: ENSG00000158186
- OMIM®: 608435
- UniProtKB/Swiss-Prot: O14807
Previous GeneCards Identifiers for MRAS Gene
- GC03P135051
- GC03P138859
- GC03P139348
- GC03P139388
- GC03P139387
- GC03P139549
- GC03P138066
- GC03P135441
Summaries for MRAS Gene
-
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for MRAS Gene
MRAS (Muscle RAS Oncogene Homolog) is a Protein Coding gene. Diseases associated with MRAS include Noonan Syndrome 11 and Noonan Syndrome 1. Among its related pathways are G-protein signaling M-RAS regulation pathway and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-dependent protein binding. An important paralog of this gene is RRAS2.
UniProtKB/Swiss-Prot Summary for MRAS Gene
-
Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
Additional gene information for MRAS Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MRAS Gene
Genomics for MRAS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MRAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MRAS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MRAS
- Top Transcription factor binding sites by QIAGEN in the MRAS gene promoter:
-
- CREB
- deltaCREB
- HEN1
- HOXA9
- HOXA9B
Genomic Locations for MRAS Gene
Latest Assembly
- chr3:138,347,648-138,405,535
- (GRCh38/hg38)
- Size:
- 57,888 bases
- Orientation:
- Plus strand
Previous Assembly
- chr3:138,066,490-138,124,377
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 57,888 bases
- Orientation:
- Plus strand
Genomic View for MRAS Gene
Genes around MRAS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.3 by HGNC
- 3q22.3 by Entrez Gene
- 3q22.3 by Ensembl
MRAS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRAS Gene
Proteins for MRAS Gene
-
Protein details for MRAS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14807-RASM_HUMAN
- Recommended name:
- Ras-related protein M-Ras
- Protein Accession:
- O14807
- B4DIK0
- Q86WX8
Protein attributes for MRAS Gene
- Size:
- 208 amino acids
- Molecular mass:
- 23846 Da
- Quaternary structure:
-
- Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).
Protein Expression for MRAS Gene
Post-translational modifications for MRAS Gene
Other Protein References for MRAS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for MRAS
-
Abcam antibodies for MRAS
- Invitrogen Antibodies for MRAS (AFLGC-MRAS)
-
Custom Antibody ServicesProSci Antibodies for MRAS
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for MRAS
- Origene Custom Protein Services for MRAS
- ProSpec Recombinant Proteins for MRAS
- antibodies-online: Show 10 available MRAS Proteins ranked by validation data
- Compare Top MRAS Proteins
-
Quality Products:
-
Abcam proteins for MRAS
Assay products for research
- antibodies-online: Show 4 available MRAS Elisa Kits ranked by validation data
- Compare Top MRAS Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MRAS Gene
Domains & Families for MRAS Gene
Gene Families for MRAS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MRAS Gene
- InterPro:
- Blocks:
-
- Transforming protein P21 RAS signature
- Ras small GTPase, Ras type
Suggested Antigen Peptide Sequences for MRAS Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ78970, highly similar to Ras-related protein M-Ras (B4DIK0_HUMAN)
- cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras (Q6FGP0_HUMAN)
- Ras-related protein R-Ras3 (RASM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14807- Family:
-
- Belongs to the small GTPase superfamily. Ras family.
Function for MRAS Gene
Molecular function for MRAS Gene
- UniProtKB/Swiss-Prot Function:
- Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P01116};.
- UniProtKB/Swiss-Prot Induction:
- By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.
Enzyme Numbers (IUBMB) for MRAS Gene
Phenotypes From GWAS Catalog for MRAS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IMP | 28289718 |
| GO:0005515 | protein binding | IPI | 25137548 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for MRAS Gene
- MGI mutant phenotypes for MRAS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRAS:
Animal Models for research
-
Taconic Biosciences Mouse Models for MRAS
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MRAS - Starting at $85 >
- * MRAS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRAS
miRNA for MRAS Gene
- miRTarBase miRNAs that target MRAS
-
- hsa-miR-652-3p (MIRT039529)
- hsa-miR-192-3p (MIRT443651)
- hsa-miR-95-5p (MIRT443652)
- hsa-miR-548c-3p (MIRT443653)
- hsa-miR-6778-5p (MIRT473037)
- hsa-miR-1233-5p (MIRT473038)
- hsa-miR-5192 (MIRT473039)
- hsa-miR-6069 (MIRT473040)
- hsa-miR-4644 (MIRT473041)
- hsa-miR-4306 (MIRT473042)
- hsa-miR-185-5p (MIRT473043)
- hsa-miR-3605-5p (MIRT473044)
- hsa-miR-2392 (MIRT473045)
- hsa-miR-1185-5p (MIRT761210)
- hsa-miR-1265 (MIRT761738)
- hsa-miR-3679-5p (MIRT766736)
- hsa-miR-4681 (MIRT770934)
- hsa-miR-7-5p (MIRT781776)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRAS
- Browse OriGene Inhibitory RNA Products For MRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS
Clone products for research
- Applied Biological Materials (abm): Clones for MRAS - Starting at $45 >
- * MRAS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202224
- MR202224
- MR202224L3
- MR202224L4
- RC212259
- RC212259L3
- RC212259L4
- RC218272
- RC218272L3
- RC218272L4
- RC231758
- RC231759
- RC231760
- RC233439
- RG212259
- RG218272
- RG231758
- RG231759
- RG231760
- RG233439
- RR213801
- RR213801L3
- RR213801L4
- MR202224L3V
- MR202224L4V
- RC212259L3V
- RC212259L4V
- RC218272L3V
- RC218272L4V
- RR213801L3V
- RR213801L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRAS
- Addgene plasmids for MRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRAS
Cell Lines for research
-
Horizon Cell Lines for MRAS
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MRAS Gene
Localization for MRAS Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRAS Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for MRAS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
|
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
|
| 2 | fMLP Pathway |
CCR3 Pathway in Eosinophils
.44
VEGF and S-1P Signaling
.44
fMLP Pathway
.43
|
CXCR4 Pathway
.39
Alpha-Adrenergic Signaling
.38
Internalin Pathway
.31
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
|
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
|
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
|
| 5 | CNTF Signaling |
CNTF Signaling
.50
FLT3 Signaling
.50
IL-3 Pathway
.46
|
OSM Pathway
.46
Nur77-Induced AICD in Macrophage
.45
|
Pathways by source for MRAS Gene
2 BioSystems pathways for MRAS Gene
3 PharmGKB pathways for MRAS Gene
11 KEGG pathways for MRAS Gene
6 GeneGo (Thomson Reuters) pathways for MRAS Gene
- Development G-Proteins mediated regulation MARK-ERK signaling
- G-protein signaling G-Protein alpha-12 signaling pathway
- G-protein signaling M-RAS regulation pathway
- G-protein signaling_Cross-talk between Ras-family GTPases
- G-protein signaling_Rap1A regulation pathway
2 R&D Systems pathways for MRAS Gene
108 Qiagen pathways for MRAS Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Agrin Interactions at Neuromuscular Junction
- Akt Signaling
1 Cell Signaling Technology pathway for MRAS Gene
Interacting Proteins for MRAS Gene
GPS-Prot Interaction Network for MRAS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007265 | Ras protein signal transduction | IBA,IMP | 28289718 |
| GO:0007275 | multicellular organism development | TAS | 10446149 |
| GO:0007517 | muscle organ development | TAS | -- |
| GO:0030036 | actin cytoskeleton organization | TAS | -- |
Transcripts for MRAS Gene
mRNA/cDNA for MRAS Gene
- 6 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000289104 4538 nts (view in UCSC)
- ENST00000423968 4098 nts (view in UCSC)
- ENST00000461114 973 nts (view in UCSC)
- ENST00000464896 1534 nts (view in UCSC)
- ENST00000474559 856 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MRAS - Starting at $85 >
- * MRAS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MRAS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MRAS
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRAS
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRAS
- Browse OriGene Inhibitory RNA Products For MRAS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MRAS
Clone products for research
- Applied Biological Materials (abm): Clones for MRAS - Starting at $45 >
- * MRAS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202224
- MR202224
- MR202224L3
- MR202224L4
- RC212259
- RC212259L3
- RC212259L4
- RC218272
- RC218272L3
- RC218272L4
- RC231758
- RC231759
- RC231760
- RC233439
- RG212259
- RG218272
- RG231758
- RG231759
- RG231760
- RG233439
- RR213801
- RR213801L3
- RR213801L4
- MR202224L3V
- MR202224L4V
- RC212259L3V
- RC212259L4V
- RC218272L3V
- RC218272L4V
- RR213801L3V
- RR213801L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MRAS
- Addgene plasmids for MRAS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MRAS
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for MRAS Gene
- GeneLoc Exon Structure for
- MRAS
Expression for MRAS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (14.9), Spinal cord (7.3), Frontal cortex (6.7), Retina (6.2), and Nasopharynx (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRAS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MRAS
SOURCE GeneReport for Unigene cluster for MRAS Gene:
Hs.527021mRNA Expression by UniProt/SwissProt for MRAS Gene:
O14807-RASM_HUMAN
Tissue specificity:
Expression highly restricted to the brain and heart.
Evidence on tissue expression from TISSUES for MRAS Gene
- Nervous system(4.9)
- Lung(4.3)
- Spleen(4.3)
- Pancreas(4.2)
- Muscle(2.7)
- Heart(2.6)
- Adrenal gland(2.3)
- Kidney(2.1)
- Liver(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MRAS
-
OriGene qPCR primer pairs and template standards for MRAS
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRAS Gene
Orthologs for MRAS Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MRAS 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MRAS 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MRAS 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MRAS 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MRAS 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mras 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mras 29 16 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MRAS 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MRAS 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496446 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | MRAS 30 |
|
OneToOne | |
| LOC100536317 29 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | ras-2 29 30 31 |
|
OneToOne | |
| ras-1 31 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAS1 30 |
|
ManyToMany | |
| RAS2 30 |
|
ManyToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2555 29 |
|
- Species where no ortholog for MRAS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MRAS Gene
- ENSEMBL:
- Gene Tree for MRAS (if available)
- TreeFam:
- Gene Tree for MRAS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MRAS: view image
- Alliance of Genome Resources:
- Additional Orthologs for MRAS
Paralogs for MRAS Gene
Paralogs for MRAS Gene
(77) SIMAP similar genes for MRAS Gene using alignment to 4 proteins:
- RASM_HUMAN
- C9J601_HUMAN
- C9J8Q6_HUMAN
- Q6FGP0_HUMAN
- RRAS2
- c-bas/has
- RAP1B
- RRAS
- RAP1A
- RAP2A
- RALB
- RIT2
- KRAS
- RALA
- RAP2C
- RAP2B
- DKFZp547A0616
- RIT1
- RERG
- HRAS
- NRAS
- RAB30
- NKIRAS2
- RAB7A
- RAB28
- RAB13
- RAB15
- RASL12
- RAB9A
- RAB7B
- RAB3C
- RAB27A
- DIRAS1
- RASL11B
- RAB9B
- RAB6A
- RAB3A
- RAB39B
- RAB26
- RAB23
- RAB1A
- RAB12
- GEM
- RAB37
- RAB17
- RHEBL1
- RAB2B
- RAB22A
- RAB1C
- RAB1B
- DKFZp313C1541
- DIRAS2
- RAB8B
- RAB11B
- RAB2A
- RAB6B
- RHEB
- REM2
- RAB43
- RAB11A
- RAB10
- REM1
- RAB8A
- RAB40C
- RAB39A
- RAB18
- RAB14
- ERAS
- RAB33B
- RASEF
- RASD2
- RASD1
- RAB44
- RAB27B
- RERGL
- RASL11A
- RAB35
- DIRAS3
- RRAD
- RHOG
- ARHG
Pseudogenes.org Pseudogenes for MRAS Gene
Variants for MRAS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MRAS Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 917547 | Likely Benign: not specified | 138,402,192(+) |
CAGA/C NM_001085049.3(MRAS):c.552_554GAA[4] (p.Lys189del) |
INFRAME_DELETION | |
| 928788 | Benign: not specified | 138,397,382(+) |
G/A NM_001085049.3(MRAS):c.252G>A (p.Thr84=) |
SYNONYMOUS | |
| 929025 | Benign: not specified | 138,397,421(+) |
G/A NM_001085049.3(MRAS):c.291G>A (p.Lys97=) |
SYNONYMOUS | |
| 981089 | Uncertain Significance: not specified | 138,402,190(+) |
G/A NM_001085049.3(MRAS):c.548G>A (p.Ser183Asn) |
MISSENSE | |
| 985724 | Uncertain Significance: Inborn genetic diseases | 138,397,327(+) |
T/A NM_001085049.3(MRAS):c.197T>A (p.Leu66Gln) |
MISSENSE_VARIANT,FIVE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.02;
20.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRAS Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRAS Gene
Disorders for MRAS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noonan syndrome 11 |
|
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| noonan syndrome 1 |
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| rasopathy |
|
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| juvenile myelomonocytic leukemia |
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| cardiofaciocutaneous syndrome 1 |
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UniProtKB/Swiss-Prot
RASM_HUMAN- Noonan syndrome 11 (NS11) [MIM:618499]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS11 inheritance is autosomal dominant. {ECO:0000269 PubMed:28289718, ECO:0000269 PubMed:31173466}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for MRAS
- Human Genome Epidemiology Navigator
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No data available for Genatlas for MRAS Gene
Publications for MRAS Gene
- Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution. (PMID: 9400994) Kimmelman A … Chan AM (Oncogene 1997) 2 3 4 22
- Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers. (PMID: 31173466) Suzuki H … Kosaki K (American journal of medical genetics. Part A 2019) 3 4 72
- Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. (PMID: 28289718) Higgins EM … Ackerman MJ (JCI insight 2017) 3 4 72
- A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P … McCormick F (Molecular cell 2006) 3 4 22
- Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 40
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