Aliases for MRAP2 Gene
External Ids for MRAP2 Gene
Previous HGNC Symbols for MRAP2 Gene
Previous GeneCards Identifiers for MRAP2 Gene
This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]
GeneCards Summary for MRAP2 Gene
MRAP2 (Melanocortin 2 Receptor Accessory Protein 2) is a Protein Coding gene. Diseases associated with MRAP2 include Body Mass Index Quantitative Trait Locus 18 and Familial Glucocorticoid Deficiency. Gene Ontology (GO) annotations related to this gene include identical protein binding and type 4 melanocortin receptor binding.
UniProtKB/Swiss-Prot for MRAP2 Gene
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.