Aliases for MPV17L Gene

Aliases for MPV17L Gene

  • MPV17 Mitochondrial Inner Membrane Protein Like 2 3 5
  • Mpv17-Like Protein 3 4
  • M-LP Homolog 3 4
  • MPV17L1 2 3
  • M-LPH 3 4
  • MLPH1 2 3
  • MLPH2 2 3
  • MPV17 Mitochondrial Membrane Protein-Like 3
  • Mpv17-Like Protein Type 1 3
  • Mpv17-Like Protein Type 2 3
  • FLJ39599 2
  • MPV17L 5

External Ids for MPV17L Gene

Previous GeneCards Identifiers for MPV17L Gene

  • GC16P014882

Summaries for MPV17L Gene

GeneCards Summary for MPV17L Gene

MPV17L (MPV17 Mitochondrial Inner Membrane Protein Like) is a Protein Coding gene. Among its related pathways are Peroxisome. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is MPV17.

UniProtKB/Swiss-Prot Summary for MPV17L Gene

  • Isoform 1 participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.

Additional gene information for MPV17L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPV17L Gene

Genomics for MPV17L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MPV17L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015395 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 623.7 +1.9 1881 4.2 GATAD2A ATF7 REST TFE3 SOX13 NFKBIZ RCOR2 RBFOX2 RXRB IRF2 MPV17L PDXDC1 LOC100505915 piR-32559-154 BMERB1
GH16J015403 Enhancer 0.8 FANTOM5 ENCODE 29.8 +9.1 9126 1.8 SP1 CEBPA NR3C1 FOXA2 RBM22 NR2F2 GATA3 HNF4A RXRA RARA MPV17L RRN3 piR-32559-154 BMERB1
GH16J015427 Enhancer 1 Ensembl ENCODE 21.9 +32.5 32492 1.1 CTCF PRDM10 ZNF692 PKNOX1 REST RAD21 TRIM22 HDAC1 MGA CBX3 MPV17L BMERB1 lnc-MPV17L-1
GH16J015414 Enhancer 0.6 Ensembl ENCODE 26 +20.0 20006 1.7 CREB1 JUND ZNF664 MAFK MPV17L RRN3 NPIPA2 lnc-MPV17L-1 BMERB1
GH16J015649 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 5.7 +255.0 255049 2.5 SP1 PRDM10 RFX1 IKZF1 KDM1A POLR2A BACH1 LARP7 PRDM1 MTA2 piR-50444-143 NDE1 ENSG00000263335 LOC100505915 MPV17L BMERB1 piR-42491-079 MYH11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPV17L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPV17L

Top Transcription factor binding sites by QIAGEN in the MPV17L gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • MEF-2A
  • Pax-5
  • TBP
  • TFIID

Genomic Locations for MPV17L Gene

Genomic Locations for MPV17L Gene
chr16:15,395,569-15,413,271
(GRCh38/hg38)
Size:
17,703 bases
Orientation:
Plus strand
chr16:15,489,611-15,507,125
(GRCh37/hg19)
Size:
17,515 bases
Orientation:
Plus strand

Genomic View for MPV17L Gene

Genes around MPV17L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPV17L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPV17L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPV17L Gene

Proteins for MPV17L Gene

  • Protein details for MPV17L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2QL34-MP17L_HUMAN
    Recommended name:
    Mpv17-like protein
    Protein Accession:
    Q2QL34
    Secondary Accessions:
    • B4DDY1
    • Q6P7T6
    • Q8N8E9

    Protein attributes for MPV17L Gene

    Size:
    196 amino acids
    Molecular mass:
    22116 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPV17L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPV17L Gene

Post-translational modifications for MPV17L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MPV17L Gene

No data available for DME Specific Peptides for MPV17L Gene

Domains & Families for MPV17L Gene

Gene Families for MPV17L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MPV17L Gene

InterPro:
Blocks:
  • Mpv17/PMP22
ProtoNet:

Suggested Antigen Peptide Sequences for MPV17L Gene

GenScript: Design optimal peptide antigens:
  • M-LP homolog (MP17L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2QL34

UniProtKB/Swiss-Prot:

MP17L_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with MPV17L: view

Function for MPV17L Gene

Molecular function for MPV17L Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.

Phenotypes From GWAS Catalog for MPV17L Gene

Gene Ontology (GO) - Molecular Function for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MPV17L: view
genes like me logo Genes that share phenotypes with MPV17L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPV17L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPV17L Gene

Localization for MPV17L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPV17L Gene

[Isoform 1]: Peroxisome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPV17L gene
Compartment Confidence
peroxisome 5
mitochondrion 4
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
plasma membrane 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MPV17L: view

Pathways & Interactions for MPV17L Gene

PathCards logo

SuperPathways for MPV17L Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with MPV17L: view

Pathways by source for MPV17L Gene

1 KEGG pathway for MPV17L Gene

Interacting Proteins for MPV17L Gene

Gene Ontology (GO) - Biological Process for MPV17L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process IDA 22306510
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA 22306510
genes like me logo Genes that share ontologies with MPV17L: view

No data available for SIGNOR curated interactions for MPV17L Gene

Drugs & Compounds for MPV17L Gene

No Compound Related Data Available

Transcripts for MPV17L Gene

mRNA/cDNA for MPV17L Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPV17L

Alternative Splicing Database (ASD) splice patterns (SP) for MPV17L Gene

No ASD Table

Relevant External Links for MPV17L Gene

GeneLoc Exon Structure for
MPV17L

Expression for MPV17L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPV17L Gene

mRNA differential expression in normal tissues according to GTEx for MPV17L Gene

This gene is overexpressed in Pancreas (x5.2) and Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for MPV17L Gene

This gene is overexpressed in Kidney (55.5) and Islet of Langerhans (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPV17L Gene



Protein tissue co-expression partners for MPV17L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPV17L

SOURCE GeneReport for Unigene cluster for MPV17L Gene:

Hs.720673

mRNA Expression by UniProt/SwissProt for MPV17L Gene:

Q2QL34-MP17L_HUMAN
Tissue specificity: Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle.

Evidence on tissue expression from TISSUES for MPV17L Gene

  • Kidney(2.2)
genes like me logo Genes that share expression patterns with MPV17L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPV17L Gene

Orthologs for MPV17L Gene

This gene was present in the common ancestor of animals.

Orthologs for MPV17L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Mpv17l 30 17 31
  • 79.04 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC100362572 30
  • 78.87 (n)
Cow
(Bos Taurus)
Mammalia MPV17L 30
  • 78.23 (n)
-- 31
  • 70 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 53 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493944 30
  • 56.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC563178 30
  • 56.77 (n)
MPV17L 31
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012390 30
  • 44.44 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12355 30 31
  • 43.95 (n)
ManyToMany
CG14777 31
  • 27 (a)
ManyToMany
CG14778 31
  • 23 (a)
ManyToMany
CG2022 31
  • 21 (a)
ManyToMany
Species where no ortholog for MPV17L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MPV17L Gene

ENSEMBL:
Gene Tree for MPV17L (if available)
TreeFam:
Gene Tree for MPV17L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPV17L: view image

Paralogs for MPV17L Gene

Paralogs for MPV17L Gene

(2) SIMAP similar genes for MPV17L Gene using alignment to 2 proteins:

  • MP17L_HUMAN
  • H3BT45_HUMAN

Pseudogenes.org Pseudogenes for MPV17L Gene

genes like me logo Genes that share paralogs with MPV17L: view

Variants for MPV17L Gene

Additional dbSNP identifiers (rs#s) for MPV17L Gene

Structural Variations from Database of Genomic Variants (DGV) for MPV17L Gene

Variant ID Type Subtype PubMed ID
dgv2755n100 CNV gain 25217958
dgv4924n54 CNV gain 21841781
esv2664596 CNV deletion 23128226
esv2714015 CNV deletion 23290073
esv3638030 CNV loss 21293372
nsv1035393 CNV gain 25217958
nsv1038151 CNV loss 25217958
nsv1040547 CNV gain 25217958
nsv1045440 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv1127473 CNV deletion 24896259
nsv1741 CNV insertion 18451855
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv833145 CNV gain 17160897
nsv833146 CNV gain 17160897
nsv974763 CNV duplication 23825009
nsv977121 CNV duplication 23825009

Variation tolerance for MPV17L Gene

Gene Damage Index Score: 0.03; 0.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPV17L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPV17L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPV17L Gene

Disorders for MPV17L Gene

No disorders were found for MPV17L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPV17L Gene

Publications for MPV17L Gene

  1. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. (PMID: 16631601) Iida R … Kishi K (Biochemical and biophysical research communications 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Identification of interacting partners of Human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage. (PMID: 26165189) Iida R … Yasuda T (Free radical biology & medicine 2015) 3
  4. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. (PMID: 22306510) Iida R … Yasuda T (Free radical biology & medicine 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3

Products for MPV17L Gene

  • Signalway ELISA kits for MPV17L

Sources for MPV17L Gene