Aliases for MPST Gene
External Ids for MPST Gene
Previous GeneCards Identifiers for MPST Gene
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MPST Gene
MPST (Mercaptopyruvate Sulfurtransferase) is a Protein Coding gene. Diseases associated with MPST include Mercaptolactate-Cysteine Disulfiduria and Cyanide Poisoning. Among its related pathways are Sulfur relay system and Sulfur amino acid metabolism. Gene Ontology (GO) annotations related to this gene include thiosulfate sulfurtransferase activity and 3-mercaptopyruvate sulfurtransferase activity. An important paralog of this gene is TST.
UniProtKB/Swiss-Prot Summary for MPST Gene
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.