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Aliases for MPRIP Gene
Aliases for MPRIP Gene
External Ids for MPRIP Gene
- HGNC: 30321
- NCBI Entrez Gene: 23164
- Ensembl: ENSG00000133030
- OMIM®: 612935
- UniProtKB/Swiss-Prot: Q6WCQ1
Previous GeneCards Identifiers for MPRIP Gene
- GC17P016888
- GC17P016946
- GC17P016701
Summaries for MPRIP Gene
GeneCards Summary for MPRIP Gene
MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Diseases associated with MPRIP include Congenital Mesoblastic Nephroma and Pediatric Fibrosarcoma. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.
UniProtKB/Swiss-Prot Summary for MPRIP Gene
-
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Additional gene information for MPRIP Gene
- HGNC (30321)
- NCBI Entrez Gene (23164)
- Ensembl (ENSG00000133030)
- OMIM® (612935)
- UniProtKB/Swiss-Prot (Q6WCQ1)
- Open Targets Platform(ENSG00000133030)
- Search for MPRIP at DataMed
- Search for MPRIP at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPRIP Gene
Genomics for MPRIP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MPRIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MPRIP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPRIP
- Top Transcription factor binding sites by QIAGEN in the MPRIP gene promoter:
-
- AML1a
- AREB6
- c-Myb
- FOXI1
- HFH-3
- LCR-F1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Nkx2-5
Genomic Locations for MPRIP Gene
Latest Assembly
- chr17:17,042,455-17,217,679
- (GRCh38/hg38)
- Size:
- 175,225 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:16,945,771-17,095,957
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 150,187 bases
- Orientation:
- Plus strand
- chr17:16,945,859-17,120,993
- (GRCh37/hg19 by Ensembl)
- Size:
- 175,135 bases
- Orientation:
- Plus strand
Genomic View for MPRIP Gene
Genes around MPRIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
MPRIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MPRIP Gene
Proteins for MPRIP Gene
-
Protein details for MPRIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6WCQ1-MPRIP_HUMAN
- Recommended name:
- Myosin phosphatase Rho-interacting protein
- Protein Accession:
- Q6WCQ1
- Q3KQZ5
- Q5FB94
- Q6DHW2
- Q7Z5Y2
- Q8N390
- Q96G40
Protein attributes for MPRIP Gene
- Size:
- 1025 amino acids
- Molecular mass:
- 116533 Da
- Quaternary structure:
-
- Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.
Protein Expression for MPRIP Gene
Post-translational modifications for MPRIP Gene
Other Protein References for MPRIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MPRIP / RIP3 Antibody
- G Biosciences Immunotag™ MRIP Antibody
-
Custom Antibody ServicesOriGene Antibodies for MPRIP
- Novus Biologicals Antibodies for MPRIP
- Invitrogen Antibodies for MPRIP (AFLGC-MPRIP)
-
Biorbyt antibodies for MPRIP
-
Santa Cruz Biotechnology (SCBT) Antibodies for MPRIP
Protein products for research
-
OriGene Purified Proteins for MPRIP
- Search Origene for MassSpec and Protein Over-expression Lysates for MPRIP
- Origene Custom Protein Services for MPRIP
- Novus Biologicals proteins for MPRIP
Assay products for research
No data available for DME Specific Peptides for MPRIP Gene
Domains & Families for MPRIP Gene
Gene Families for MPRIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MPRIP Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
- ProtoNet:
Suggested Antigen Peptide Sequences for MPRIP Gene
- GenScript: Design optimal peptide antigens:
-
- Myosin phosphatase-Rho interacting protein (A8CGI0_HUMAN)
- Myosin phosphatase-Rho interacting protein (A8CGI1_HUMAN)
- Myosin phosphatase Rho interacting protein (B9EGI2_HUMAN)
- p116Rip (MPRIP_HUMAN)
- Myosin phosphatase-Rho interacting protein (Q5ZEZ6_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MPRIP Gene
Function for MPRIP Gene
Molecular function for MPRIP Gene
- UniProtKB/Swiss-Prot Function:
- Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Phenotypes From GWAS Catalog for MPRIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
| GO:0051015 | actin filament binding | IBA | 21873635 |
Phenotypes for MPRIP Gene
- MGI mutant phenotypes for MPRIP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MPRIP:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- shRNA abundance <= 25%
- Increased Salmonella enterica Typhimurium invasion
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased Akt phosphorylation after EGF stimulation
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MPRIP - Starting at $85 >
- * MPRIP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MPRIP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPRIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPRIP
miRNA for MPRIP Gene
- miRTarBase miRNAs that target MPRIP
-
- hsa-miR-31-5p (MIRT004977)
- mmu-miR-758-3p (MIRT007590)
- mmu-miR-301b-3p (MIRT007718)
- mmu-miR-425-5p (MIRT008432)
- hsa-miR-124-3p (MIRT023094)
- hsa-miR-1-3p (MIRT023650)
- hsa-miR-1909-3p (MIRT035803)
- hsa-miR-1296-5p (MIRT036110)
- hsa-miR-324-3p (MIRT042870)
- hsa-miR-542-5p (MIRT196090)
- hsa-miR-2113 (MIRT196091)
- hsa-miR-1290 (MIRT196093)
- hsa-miR-4450 (MIRT196095)
- hsa-miR-4696 (MIRT196096)
- hsa-miR-218-5p (MIRT196099)
- hsa-miR-568 (MIRT196100)
- hsa-miR-595 (MIRT196101)
- hsa-miR-636 (MIRT196102)
- hsa-miR-643 (MIRT196103)
- hsa-miR-648 (MIRT196104)
- hsa-miR-1252-5p (MIRT196105)
- hsa-miR-3185 (MIRT196106)
- hsa-miR-4271 (MIRT196107)
- hsa-miR-4533 (MIRT196109)
- hsa-miR-4725-3p (MIRT196110)
- hsa-miR-4747-5p (MIRT196111)
- hsa-miR-5196-5p (MIRT196113)
- hsa-miR-6783-5p (MIRT196114)
- hsa-miR-6780b-5p (MIRT196115)
- hsa-miR-3120-3p (MIRT285872)
- hsa-miR-3942-5p (MIRT285873)
- hsa-miR-4703-5p (MIRT285874)
- hsa-miR-183-5p (MIRT344312)
- hsa-miR-593-5p (MIRT344313)
- hsa-miR-4786-3p (MIRT473046)
- hsa-miR-8076 (MIRT473047)
- hsa-miR-549a (MIRT547381)
- hsa-miR-3529-3p (MIRT547382)
- hsa-miR-5010-3p (MIRT556076)
- hsa-miR-128-2-5p (MIRT556077)
- hsa-miR-128-1-5p (MIRT556078)
- hsa-miR-6781-5p (MIRT556079)
- hsa-miR-19a-3p (MIRT556080)
- hsa-miR-19b-3p (MIRT556081)
- hsa-miR-495-3p (MIRT556082)
- hsa-miR-5688 (MIRT556083)
- hsa-miR-548m (MIRT556085)
- hsa-miR-5011-3p (MIRT569621)
- hsa-miR-6877-5p (MIRT569622)
- hsa-miR-6845-3p (MIRT569623)
- hsa-miR-1976 (MIRT569624)
- hsa-miR-3653-5p (MIRT569625)
- mmu-miR-1896 (MIRT582402)
- mmu-miR-129-1-3p (MIRT582403)
- mmu-miR-129-2-3p (MIRT582404)
- mmu-miR-3064-5p (MIRT582405)
- mmu-miR-3085-3p (MIRT582406)
- mmu-miR-3110-5p (MIRT600627)
- mmu-miR-5125 (MIRT600628)
- mmu-miR-1186a (MIRT604851)
- hsa-miR-2681-5p (MIRT626143)
- hsa-miR-27b-3p (MIRT626144)
- hsa-miR-27a-3p (MIRT626145)
- hsa-miR-4328 (MIRT626146)
- hsa-miR-3681-3p (MIRT626147)
- hsa-miR-216a-3p (MIRT626148)
- hsa-miR-128-3p (MIRT626149)
- hsa-miR-4659b-3p (MIRT642036)
- hsa-miR-4659a-3p (MIRT642037)
- hsa-miR-6875-3p (MIRT642038)
- hsa-miR-3160-5p (MIRT642039)
- hsa-miR-3691-3p (MIRT642040)
- hsa-miR-6814-5p (MIRT642041)
- hsa-miR-7977 (MIRT656178)
- hsa-miR-4530 (MIRT656179)
- hsa-miR-646 (MIRT656180)
- hsa-miR-3613-3p (MIRT723107)
- hsa-miR-122-5p (MIRT761341)
- hsa-miR-3135b (MIRT764936)
- hsa-miR-3136-5p (MIRT764967)
- hsa-miR-3652 (MIRT766295)
- hsa-miR-4430 (MIRT768930)
- hsa-miR-4439 (MIRT769145)
- hsa-miR-4462 (MIRT769403)
- hsa-miR-4513 (MIRT769898)
- hsa-miR-504-3p (MIRT773060)
- hsa-miR-5190 (MIRT773606)
- hsa-miR-5698 (MIRT775156)
- hsa-miR-6855-3p (MIRT780473)
- hsa-miR-6857-3p (MIRT780502)
- hsa-miR-7156-3p (MIRT781552)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPRIP
- Browse OriGene Inhibitory RNA Products For MPRIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPRIP
Clone products for research
- Applied Biological Materials (abm): Clones for MPRIP - Starting at $45 >
- * MPRIP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211499
- MG224193
- MR211499
- MR211499L3
- MR211499L4
- MR224193
- MR224193L3
- MR224193L4
- RC211386
- RC211386L3
- RC211386L4
- RC224291
- RC224291L3
- RC224291L4
- RG211386
- RG224291
- RR200230
- RR200230L3
- RR200230L4
- RR200231
- RR200231L3
- RR200231L4
- MR211499L3V
- MR211499L4V
- MR224193L3V
- MR224193L4V
- RC211386L3V
- RC211386L4V
- RC224291L3V
- RC224291L4V
- RR200230L3V
- RR200230L4V
- RR200231L3V
- RR200231L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MPRIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPRIP
Cell Lines for research
-
Horizon Cell Lines for MPRIP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPRIP Gene
Localization for MPRIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MPRIP Gene
- Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
- Actin filaments (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0015629 | actin cytoskeleton | IDA | -- |
Pathways & Interactions for MPRIP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.45
|
|
| 2 | Oncogenic MAPK signaling | ||
| 3 | Cytoskeletal Signaling | ||
Pathways by source for MPRIP Gene
4 Reactome pathways for MPRIP Gene
1 Cell Signaling Technology pathway for MPRIP Gene
Interacting Proteins for MPRIP Gene
Selected Interacting proteins:
Q6WCQ1-MPRIP_HUMAN
ENSP00000379156
for MPRIP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MPRIP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007015 | actin filament organization | IBA | 21873635 |
Transcripts for MPRIP Gene
mRNA/cDNA for MPRIP Gene
- 3 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313485 6050 nts (view in UCSC)
- ENST00000341712 3846 nts (view in UCSC)
- ENST00000395806 527 nts (view in UCSC)
- ENST00000395807 926 nts (view in UCSC)
- ENST00000395811 10960 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MPRIP - Starting at $85 >
- * MPRIP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MPRIP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPRIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPRIP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPRIP
- Browse OriGene Inhibitory RNA Products For MPRIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPRIP
Clone products for research
- Applied Biological Materials (abm): Clones for MPRIP - Starting at $45 >
- * MPRIP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211499
- MG224193
- MR211499
- MR211499L3
- MR211499L4
- MR224193
- MR224193L3
- MR224193L4
- RC211386
- RC211386L3
- RC211386L4
- RC224291
- RC224291L3
- RC224291L4
- RG211386
- RG224291
- RR200230
- RR200230L3
- RR200230L4
- RR200231
- RR200231L3
- RR200231L4
- MR211499L3V
- MR211499L4V
- MR224193L3V
- MR224193L4V
- RC211386L3V
- RC211386L4V
- RC224291L3V
- RC224291L4V
- RR200230L3V
- RR200230L4V
- RR200231L3V
- RR200231L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MPRIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPRIP
Relevant External Links for MPRIP Gene
- GeneLoc Exon Structure for
- MPRIP
Expression for MPRIP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (36.2) and Bone marrow stromal cell (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPRIP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPRIP
SOURCE GeneReport for Unigene cluster for MPRIP Gene:
Hs.462341Evidence on tissue expression from TISSUES for MPRIP Gene
- Nervous system(4.5)
- Liver(4.4)
- Lung(3.5)
- Skin(3.1)
- Intestine(2.9)
- Eye(2.9)
- Muscle(2.7)
- Kidney(2.5)
- Heart(2.5)
- Lymph node(2.1)
- Stomach(2.1)
- Blood(2)
- Adrenal gland(2)
Primer products for research
-
OriGene qPCR primer pairs for MPRIP
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPRIP Gene
Orthologs for MPRIP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MPRIP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC479530 30 |
|
||
| MPRIP 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | MPRIP 30 |
|
||
| M-RIP 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Mprip 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mprip 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | MPRIP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MPRIP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MPRIP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mprip 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch73-103b11.2 30 |
|
||
| MPRIP (1 of 4) 31 |
|
OneToMany | |||
| MPRIP (4 of 4) 31 |
|
OneToMany | |||
| MPRIP (2 of 4) 31 |
|
OneToMany | |||
| MPRIP (3 of 4) 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | osp 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F10G8.8 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MPRIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MPRIP Gene
- ENSEMBL:
- Gene Tree for MPRIP (if available)
- TreeFam:
- Gene Tree for MPRIP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MPRIP: view image
Paralogs for MPRIP Gene
(4) SIMAP similar genes for MPRIP Gene using alignment to 13 proteins:
- MPRIP_HUMAN
- A8MZF8_HUMAN
- B9EGI2_HUMAN
- H0Y2S9_HUMAN
- H0Y7E2_HUMAN
- H7C3G6_HUMAN
- J3KSK7_HUMAN
- J3KSW8_HUMAN
- J3QL44_HUMAN
- J3QRL2_HUMAN
- K7EJ14_HUMAN
- K7EL39_HUMAN
- Q96EE5_HUMAN
Pseudogenes.org Pseudogenes for MPRIP Gene
Variants for MPRIP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPRIP Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11551186 | Benign: not provided | 17,174,006(+) |
G/A NM_015134.4(MPRIP):c.2520G>A (p.Ala840=) |
SYNONYMOUS | |
| rs7212131 | Benign: not provided | 17,143,603(+) |
T/A NM_015134.4(MPRIP):c.1083T>A (p.Ala361=) |
SYNONYMOUS | |
| rs73279632 | Benign: not provided | 17,146,026(+) |
C/T NM_015134.4(MPRIP):c.1150-10C>T |
INTRON | |
| rs3744137 | - |
p.Pro327Gln |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2299362 | CNV | deletion | 18987734 |
| esv2676412 | CNV | deletion | 23128226 |
| esv3306277 | CNV | mobile element insertion | 20981092 |
| esv3346710 | CNV | insertion | 20981092 |
| esv3414266 | CNV | insertion | 20981092 |
| esv3554213 | CNV | deletion | 23714750 |
| esv3640122 | CNV | loss | 21293372 |
| esv3640123 | CNV | loss | 21293372 |
| nsv1070816 | CNV | deletion | 25765185 |
| nsv1131131 | CNV | deletion | 24896259 |
| nsv155 | OTHER | inversion | 15895083 |
| nsv1995 | CNV | insertion | 18451855 |
| nsv1996 | CNV | insertion | 18451855 |
| nsv474958 | CNV | novel sequence insertion | 20440878 |
| nsv478946 | CNV | novel sequence insertion | 20440878 |
| nsv499114 | OTHER | inversion | 21111241 |
| nsv524958 | CNV | loss | 19592680 |
| nsv833380 | CNV | loss | 17160897 |
| nsv962272 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
2.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MPRIP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MPRIP
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPRIP Gene
Disorders for MPRIP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital mesoblastic nephroma |
|
|
| pediatric fibrosarcoma |
|
|
| retinitis pigmentosa 20 |
|
|
Search MPRIP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MPRIP
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MPRIP Gene
Publications for MPRIP Gene
- p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PMID: 15545284) Koga Y … Ikebe M (The Journal of biological chemistry 2005) 3 4 23
- M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PMID: 16257966) Surks HK … Ohtani K (The Journal of biological chemistry 2005) 3 4 23
- Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PMID: 14506264) Surks HK … Mendelsohn ME (The Journal of biological chemistry 2003) 3 4 23
- M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PMID: 18636174) Ono R … Matsushita M (International journal of molecular medicine 2008) 3 23
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
ExternalLinks
Products for MPRIP Gene
- Custom Antibody ServicesOriGene Antibodies for MPRIP
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MPRIP
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- Novus Biologicals proteins for MPRIP
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- Invitrogen Antibodies for MPRIP (AFLGC-MPRIP)
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- antibodies-online: Show 29 available MPRIP Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MPRIP
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- Horizon Cell Lines for MPRIP
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for MPRIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPRIP
- Biorbyt antibodies for MPRIP
Sources for MPRIP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
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