Aliases for MPRIP Gene
External Ids for MPRIP Gene
Previous GeneCards Identifiers for MPRIP Gene
GeneCards Summary for MPRIP Gene
MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Diseases associated with MPRIP include Congenital Mesoblastic Nephroma and Pediatric Fibrosarcoma. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.
UniProtKB/Swiss-Prot Summary for MPRIP Gene
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.