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Aliases for MPRIP Gene

Aliases for MPRIP Gene

  • Myosin Phosphatase Rho Interacting Protein 2 3 5
  • Rho Interacting Protein 3 2 3
  • P116Rip 3 4
  • RHOIP3 3 4
  • M-RIP 3 4
  • MRIP 3 4
  • RIP3 3 4
  • Myosin Phosphatase Rho-Interacting Protein 3
  • Rho-Interacting Protein 3 4
  • KIAA0864 4

External Ids for MPRIP Gene

Previous GeneCards Identifiers for MPRIP Gene

  • GC17P016888
  • GC17P016946
  • GC17P016701

Summaries for MPRIP Gene

GeneCards Summary for MPRIP Gene

MPRIP (Myosin Phosphatase Rho Interacting Protein) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TRIOBP.

UniProtKB/Swiss-Prot for MPRIP Gene

  • Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Gene Wiki entry for MPRIP Gene

Additional gene information for MPRIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPRIP Gene

Genomics for MPRIP Gene

GeneHancer (GH) Regulatory Elements for MPRIP Gene

Promoters and enhancers for MPRIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I017040 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 574.8 +1.4 1396 6.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MPRIP GC17P017043 GC17P017048 PIR46780 PIR43427 MPRIP-AS1 FLCN PIGL PLD6 NCOR1
GH17I017590 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.2 +549.5 549501 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PEMT ENSG00000264666 USP32P2 SMCR5 MPRIP DRG2 SMCR8 LOC644422 MPRIP-AS1 ENSG00000265511
GH17I016406 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.6 -634.8 -634757 2.2 HDGF SMAD1 ZFP64 SIN3A FEZF1 YBX1 IRF4 ZNF213 ZNF207 ZNF548 PIGL PPIAP53 ENSG00000266538 NCOR1 TVP23C MPRIP-AS1 ZNF286A LOC644422 UPF3AP1 MPRIP
GH17I017014 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -23.4 -23435 10 PKNOX1 NFIB SIN3A BATF RAD21 ZNF335 GLIS2 ELK1 EGR1 SCRT2 MPRIP FLCN MPRIP-AS1 PLD6 COPS3 ENSG00000260328 SREBF1 LRRC75A
GH17I018037 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13 +996.8 996758 3.9 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143 GID4 ATPAF2 FAM106A LOC100419436 TOM1L2 ZNF286B ENSG00000273018 ENSG00000264885 MPRIP-AS1 MPRIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MPRIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MPRIP gene promoter:

Genomic Locations for MPRIP Gene

Genomic Locations for MPRIP Gene
chr17:17,042,468-17,217,679
(GRCh38/hg38)
Size:
175,212 bases
Orientation:
Plus strand
chr17:16,945,859-17,120,993
(GRCh37/hg19)

Genomic View for MPRIP Gene

Genes around MPRIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPRIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPRIP Gene

Proteins for MPRIP Gene

  • Protein details for MPRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WCQ1-MPRIP_HUMAN
    Recommended name:
    Myosin phosphatase Rho-interacting protein
    Protein Accession:
    Q6WCQ1
    Secondary Accessions:
    • Q3KQZ5
    • Q5FB94
    • Q6DHW2
    • Q7Z5Y2
    • Q8N390
    • Q96G40

    Protein attributes for MPRIP Gene

    Size:
    1025 amino acids
    Molecular mass:
    116533 Da
    Quaternary structure:
    • Binds F-actin through its N-terminus. Interacts with MYZAP (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

    Alternative splice isoforms for MPRIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPRIP Gene

Post-translational modifications for MPRIP Gene

  • Ubiquitination at Lys396
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MPRIP Gene

Domains & Families for MPRIP Gene

Gene Families for MPRIP Gene

Protein Domains for MPRIP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MPRIP: view

No data available for UniProtKB/Swiss-Prot for MPRIP Gene

Function for MPRIP Gene

Molecular function for MPRIP Gene

UniProtKB/Swiss-Prot Function:
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Phenotypes From GWAS Catalog for MPRIP Gene

Gene Ontology (GO) - Molecular Function for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 15545284
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with MPRIP: view
genes like me logo Genes that share phenotypes with MPRIP: view

Animal Model Products

miRNA for MPRIP Gene

miRTarBase miRNAs that target MPRIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPRIP Gene

Localization for MPRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPRIP Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPRIP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion HDA,IDA 21423176
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MPRIP: view

Pathways & Interactions for MPRIP Gene

genes like me logo Genes that share pathways with MPRIP: view

Pathways by source for MPRIP Gene

1 Cell Signaling Technology pathway for MPRIP Gene

SIGNOR curated interactions for MPRIP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MPRIP Gene

None

Drugs & Compounds for MPRIP Gene

No Compound Related Data Available

Transcripts for MPRIP Gene

Unigene Clusters for MPRIP Gene

Myosin phosphatase Rho interacting protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPRIP Gene

No ASD Table

Relevant External Links for MPRIP Gene

GeneLoc Exon Structure for
MPRIP
ECgene alternative splicing isoforms for
MPRIP

Expression for MPRIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPRIP Gene

Protein differential expression in normal tissues from HIPED for MPRIP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (36.2) and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPRIP Gene



Protein tissue co-expression partners for MPRIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MPRIP Gene:

MPRIP

SOURCE GeneReport for Unigene cluster for MPRIP Gene:

Hs.462341

Evidence on tissue expression from TISSUES for MPRIP Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Lung(3.3)
  • Skin(2.6)
  • Eye(2.5)
  • Muscle(2.5)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with MPRIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPRIP Gene

Orthologs for MPRIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MPRIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPRIP 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia LOC479530 33
  • 88.77 (n)
MPRIP 34
  • 18 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPRIP 33
  • 87.85 (n)
M-RIP 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mprip 33 16 34
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Mprip 33
  • 85.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MPRIP 34
  • 16 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPRIP 33 34
  • 70.48 (n)
lizard
(Anolis carolinensis)
Reptilia MPRIP 34
  • 18 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mprip 33
  • 73.59 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-103b11.2 33
  • 66.43 (n)
MPRIP (1 of 4) 34
  • 57 (a)
OneToMany
MPRIP (4 of 4) 34
  • 51 (a)
OneToMany
MPRIP (2 of 4) 34
  • 20 (a)
OneToMany
MPRIP (3 of 4) 34
  • 12 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta osp 34
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10G8.8 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for MPRIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPRIP Gene

ENSEMBL:
Gene Tree for MPRIP (if available)
TreeFam:
Gene Tree for MPRIP (if available)

Paralogs for MPRIP Gene

Paralogs for MPRIP Gene

Pseudogenes.org Pseudogenes for MPRIP Gene

genes like me logo Genes that share paralogs with MPRIP: view

Variants for MPRIP Gene

Sequence variations from dbSNP and Humsavar for MPRIP Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000019674 -- 17,050,782(+) G/A intron_variant
rs1000040759 -- 17,093,064(+) T/C intron_variant
rs1000054640 -- 17,110,431(+) T/G intron_variant
rs1000075510 -- 17,070,790(+) T/A intron_variant
rs1000086848 -- 17,110,205(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MPRIP Gene

Variant ID Type Subtype PubMed ID
esv2299362 CNV deletion 18987734
esv2676412 CNV deletion 23128226
esv3306277 CNV mobile element insertion 20981092
esv3346710 CNV insertion 20981092
esv3414266 CNV insertion 20981092
esv3554213 CNV deletion 23714750
esv3640122 CNV loss 21293372
esv3640123 CNV loss 21293372
nsv1070816 CNV deletion 25765185
nsv1131131 CNV deletion 24896259
nsv155 OTHER inversion 15895083
nsv1995 CNV insertion 18451855
nsv1996 CNV insertion 18451855
nsv474958 CNV novel sequence insertion 20440878
nsv478946 CNV novel sequence insertion 20440878
nsv499114 OTHER inversion 21111241
nsv524958 CNV loss 19592680
nsv833380 CNV loss 17160897
nsv962272 CNV duplication 23825009

Variation tolerance for MPRIP Gene

Residual Variation Intolerance Score: 2.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPRIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPRIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPRIP Gene

Disorders for MPRIP Gene

Additional Disease Information for MPRIP

No disorders were found for MPRIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPRIP Gene

Publications for MPRIP Gene

  1. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. (PMID: 15545284) Koga Y … Ikebe M (The Journal of biological chemistry 2005) 3 4 22 58
  2. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. (PMID: 16257966) Surks HK … Ohtani K (The Journal of biological chemistry 2005) 3 4 22 58
  3. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. (PMID: 14506264) Surks HK … Mendelsohn ME (The Journal of biological chemistry 2003) 3 4 22 58
  4. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PMID: 18636174) Ono R … Matsushita M (International journal of molecular medicine 2008) 3 22 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for MPRIP Gene

Sources for MPRIP Gene

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