Aliases for MPP2 Gene
External Ids for MPP2 Gene
Previous HGNC Symbols for MPP2 Gene
Previous GeneCards Identifiers for MPP2 Gene
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
GeneCards Summary for MPP2 Gene
MPP2 (Membrane Palmitoylated Protein 2) is a Protein Coding gene. Diseases associated with MPP2 include Danon Disease and Tetanus. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and guanylate kinase activity. An important paralog of this gene is MPP6.
UniProtKB/Swiss-Prot Summary for MPP2 Gene
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).