Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohal... See more...

Aliases for MPO Gene

Aliases for MPO Gene

  • Myeloperoxidase 2 3 4 5
  • EC 1.11.1.7 51
  • EC 1.11.2.2 4
  • EC 1.11.1 51
  • MPO 5

External Ids for MPO Gene

Previous GeneCards Identifiers for MPO Gene

  • GC17M056091
  • GC17M058828
  • GC17M056689
  • GC17M056821
  • GC17M053702
  • GC17M056347
  • GC17M051708

Summaries for MPO Gene

Entrez Gene Summary for MPO Gene

  • Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

GeneCards Summary for MPO Gene

MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include Myeloperoxidase Deficiency and Alzheimer Disease. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.

UniProtKB/Swiss-Prot Summary for MPO Gene

  • Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Gene Wiki entry for MPO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPO Gene

Genomics for MPO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MPO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058281 Enhancer 0.7 FANTOM5 ENCODE 626.3 -0.9 -865 0.6 SPI1 GABPA POLR2A IKZF1 MAX GABPB1 ZNF579 MPO TSPOAP1 HSALNG0117702
GH17J058280 Promoter 0.5 EPDnew 600.7 0.0 -20 0.1 REST POLR2A MPO HSALNG0117702 TSPOAP1
GH17J058284 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.6 -3.9 -3865 0.8 CEBPG ATF7 JUND POLR2A CEBPB ZFHX2 SPI1 ATF4 REST ATF3 TSPOAP1 MPO MKS1 LPO RNF43 SUPT4H1 SRSF1 HSALNG0117702
GH17J058328 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.5 -56.6 -56582 21 ARHGAP35 CEBPG SP1 HNRNPL CREB1 CTCF PRDM10 ZNF512 RFX1 LEF1 TSPOAP1 MN297491 MIR4736 TSPOAP1-AS1 SRSF1 MKS1 SMG8 SUPT4H1 VEZF1 TRIM37
GH17J057573 Enhancer 0.7 Ensembl dbSUPER 4.9 +706.6 706634 1.4 PRDM10 ZNF629 PATZ1 KLF7 OSR2 RBM22 ZNF189 GLIS1 ZNF2 ZBTB6 MPO RF00017-2458 LOC107984993 CCDC182 MSI2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPO

Top Transcription factor binding sites by QIAGEN in the MPO gene promoter:
  • AML1a
  • ITF-2
  • Msx-1
  • NRF-2
  • Sp1
  • Tal-1beta

Genomic Locations for MPO Gene

Genomic Locations for MPO Gene
chr17:58,269,855-58,280,935
(GRCh38/hg38)
Size:
11,081 bases
Orientation:
Minus strand
chr17:56,347,217-56,358,296
(GRCh37/hg19)
Size:
11,080 bases
Orientation:
Minus strand

Genomic View for MPO Gene

Genes around MPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPO Gene

Proteins for MPO Gene

  • Protein details for MPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05164-PERM_HUMAN
    Recommended name:
    Myeloperoxidase
    Protein Accession:
    P05164
    Secondary Accessions:
    • A1L4B8
    • Q14862
    • Q4PJH5
    • Q9UCL7

    Protein attributes for MPO Gene

    Size:
    745 amino acids
    Molecular mass:
    83869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Quaternary structure:
    • Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.

    Three dimensional structures from OCA and Proteopedia for MPO Gene

    Alternative splice isoforms for MPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPO Gene

Selected DME Specific Peptides for MPO Gene

P05164:
  • RDGDRFW
  • LTSMHTL
  • EGGIDPILRGL
  • PCFLAGD
  • LMFMQWGQ
  • RDHGLPGYN
  • RFQDNGRAL

Post-translational modifications for MPO Gene

  • Glycosylation at Asn139, Asn323, Asn355, Asn391, Asn483, and Asn729
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PERM_HUMAN (428)

Other Protein References for MPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MPO Gene

Gene Families for MPO Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for MPO Gene

InterPro:
Blocks:
  • Animal haem peroxidase signature
  • Haem peroxidase
ProtoNet:

Suggested Antigen Peptide Sequences for MPO Gene

GenScript: Design optimal peptide antigens:
  • Myeloperoxidase (PERM_HUMAN)
  • Peroxidase (Myeloperoxidase) (Q16771_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05164

UniProtKB/Swiss-Prot:

PERM_HUMAN :
  • Belongs to the peroxidase family. XPO subfamily.
Family:
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with MPO: view

Function for MPO Gene

Molecular function for MPO Gene

UniProtKB/Swiss-Prot Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=chloride + H(+) + H2O2 = H2O + hypochlorous acid; Xref=Rhea:RHEA:28218, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:17996, ChEBI:CHEBI:24757; EC=1.11.2.2; Evidence={ECO:0000269|PubMed:9922160};.
GENATLAS Biochemistry:
myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of monocytes,involved in oxygen dependent mechanism of phagocytosis

Enzyme Numbers (IUBMB) for MPO Gene

Phenotypes From GWAS Catalog for MPO Gene

Gene Ontology (GO) - Molecular Function for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 2829220
GO:0004601 peroxidase activity IEA,IDA 10772654
GO:0005515 protein binding IPI 24355864
GO:0008201 heparin binding IDA 11907569
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MPO: view
genes like me logo Genes that share phenotypes with MPO: view

Human Phenotype Ontology for MPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MPO Gene

MGI Knock Outs for MPO:
  • Mpo Mpo<tm1Lus>
  • Mpo Mpo<tm1Mae>

CRISPR Products

miRNA for MPO Gene

miRTarBase miRNAs that target MPO

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPO

No data available for Transcription Factor Targets and HOMER Transcription for MPO Gene

Localization for MPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPO Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPO gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
plasma membrane 3
cytoskeleton 3
mitochondrion 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 10772654
GO:0005623 cell IEA --
GO:0005634 nucleus TAS,HDA 21630459
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MPO: view

Pathways & Interactions for MPO Gene

genes like me logo Genes that share pathways with MPO: view

SIGNOR curated interactions for MPO Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0002149 hypochlorous acid biosynthetic process IEA --
GO:0002679 respiratory burst involved in defense response IEA --
GO:0006952 defense response IEA,TAS 8621627
GO:0006979 response to oxidative stress IEA,TAS 2903767
genes like me logo Genes that share ontologies with MPO: view

Drugs & Compounds for MPO Gene

(107) Drugs for MPO Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propylthiouracil Approved, Investigational Pharma Enzyme, inhibitor 11
Aminosalicylic Acid Approved Pharma Enzyme, inhibitor 37
Calcipotriol Approved Pharma Agonist, Enzyme, inhibitor Vitamin D3 analog,regulates cell differentiation and proliferation 0
Cefaclor Approved Pharma Enzyme, inducer 5
Cefdinir Approved Pharma Target, inhibitor 29

(85) Additional Compounds for MPO Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hypothiocyanite
  • Cyanosulfoxylate
  • N,6-didehydro-3,6-dihydro-3-Methyl-adenosine
  • OSCN-hypothiocyanite ion
  • Hypothiocyanite ion
63296-34-4
2-Phenylacetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • Benzeneacetamide
  • Phenyl-beta-acetylamine
  • Phenylacetamide
103-81-1
7-Hydroxyticlopidine
  • Hydroxyticlopidine
  • M1
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
methanol
  • Carbinol
  • CH3OH
  • MeOH
  • Methyl alcohol
  • Methylalkohol
67-56-1
genes like me logo Genes that share compounds with MPO: view

Transcripts for MPO Gene

mRNA/cDNA for MPO Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPO

Alternative Splicing Database (ASD) splice patterns (SP) for MPO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

Relevant External Links for MPO Gene

GeneLoc Exon Structure for
MPO

Expression for MPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPO Gene

This gene is overexpressed in Whole Blood (x38.6) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for MPO Gene

This gene is overexpressed in Neutrophil (37.9), Monocytes (10.5), and Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MPO Gene



Protein tissue co-expression partners for MPO Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPO

SOURCE GeneReport for Unigene cluster for MPO Gene:

Hs.458272

Evidence on tissue expression from TISSUES for MPO Gene

  • Blood(5)
  • Bone marrow(4.8)
  • Liver(4.7)
  • Saliva(4.4)
  • Nervous system(4.3)
  • Intestine(3.6)
  • Heart(3.3)
  • Lung(3.3)
  • Kidney(3.1)
  • Spleen(3.1)
  • Lymph node(2.9)
  • Skin(2.9)
  • Muscle(2.7)
  • Pancreas(2.6)
  • Urine(2.6)
  • Eye(2.4)
  • Stomach(2.3)
  • Bone(2.2)
  • Adrenal gland(2.2)
  • Gall bladder(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MPO Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
Regions:
Thorax:
  • thymus
Abdomen:
  • liver
  • spleen
General:
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with MPO: view

No data available for mRNA Expression by UniProt/SwissProt for MPO Gene

Orthologs for MPO Gene

This gene was present in the common ancestor of animals.

Orthologs for MPO Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MPO 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MPO 30 31
  • 87.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MPO 30 31
  • 87.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mpo 30 17 31
  • 85.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MPO 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MPO 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MPO 30
  • 64.96 (n)
-- 31
  • 60 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496213 30
  • 60.9 (n)
Str.11704 30
African clawed frog
(Xenopus laevis)
Amphibia mpo-A 30
Zebrafish
(Danio rerio)
Actinopterygii mpx 31
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5873 32
  • 34 (a)
CG10211 32
  • 33 (a)
CG6969 32
  • 33 (a)
CG6879 32
  • 32 (a)
pxt 32
  • 29 (a)
CG4009 32
  • 29 (a)
Pxd 31
  • 28 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea C46A5.4 32
  • 36 (a)
ZK430.8 32
  • 35 (a)
F09F3.5 32
  • 32 (a)
R08F11.7 32
  • 31 (a)
mlt-7 31
  • 30 (a)
ManyToMany
K10B4.1 32
  • 30 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
ManyToMany
Species where no ortholog for MPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MPO Gene

ENSEMBL:
Gene Tree for MPO (if available)
TreeFam:
Gene Tree for MPO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPO: view image

Paralogs for MPO Gene

Paralogs for MPO Gene

(5) SIMAP similar genes for MPO Gene using alignment to 3 proteins:

  • PERM_HUMAN
  • J3QSF7_HUMAN
  • Q16771_HUMAN
genes like me logo Genes that share paralogs with MPO: view

Variants for MPO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPO Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
710279 Benign: not provided 58,270,761(-) G/A SYNONYMOUS_VARIANT
714561 Likely Benign: not provided 58,279,948(-) C/T SYNONYMOUS_VARIANT
718104 Likely Benign: not provided 58,273,656(-) C/T MISSENSE_VARIANT
726909 Likely Benign: not provided 58,275,535(-) G/A INTRON_VARIANT
727047 Likely Benign: not provided 58,271,875(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MPO Gene

Structural Variations from Database of Genomic Variants (DGV) for MPO Gene

Variant ID Type Subtype PubMed ID
nsv2109 CNV deletion 18451855
nsv509663 CNV insertion 20534489
nsv517229 CNV gain+loss 19592680

Variation tolerance for MPO Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPO Gene

Human Gene Mutation Database (HGMD)
MPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPO Gene

Disorders for MPO Gene

MalaCards: The human disease database

(169) MalaCards diseases for MPO Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MPO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PERM_HUMAN
  • Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269 PubMed:7904599, ECO:0000269 PubMed:8142659, ECO:0000269 PubMed:8621627, ECO:0000269 PubMed:9354683, ECO:0000269 PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for MPO Gene

infections,recurrent,with disseminated candidiasis

Additional Disease Information for MPO

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MPO: view

Publications for MPO Gene

  1. Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. (PMID: 19651119) Wainstein RV … Polanczyk CA (Clinical biochemistry 2010) 3 23 41
  2. Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. (PMID: 19897513) Wenten M … Gilliland FD (American journal of epidemiology 2009) 3 23 41
  3. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. (PMID: 19731237) Nahon P … Beaugrand M (Hepatology (Baltimore, Md.) 2009) 3 23 41
  4. Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. (PMID: 19255063) Li Y … Hong CC (Carcinogenesis 2009) 3 23 41
  5. A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function. (PMID: 19735726) Rudolph V … Baldus S (Free radical biology & medicine 2009) 3 23 41

Products for MPO Gene

  • Addgene plasmids for MPO

Sources for MPO Gene