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Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include Myeloperoxidase Deficiency and Alzheimer Disease. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J058281 | Enhancer | 0.7 | FANTOM5 ENCODE | 626.3 | -0.9 | -865 | 0.6 | SPI1 GABPA POLR2A IKZF1 MAX GABPB1 ZNF579 | MPO TSPOAP1 HSALNG0117702 | |
GH17J058280 | Promoter | 0.5 | EPDnew | 600.7 | 0.0 | -20 | 0.1 | REST POLR2A | MPO HSALNG0117702 TSPOAP1 | |
GH17J058284 | Promoter/Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 11.6 | -3.9 | -3865 | 0.8 | CEBPG ATF7 JUND POLR2A CEBPB ZFHX2 SPI1 ATF4 REST ATF3 | TSPOAP1 MPO MKS1 LPO RNF43 SUPT4H1 SRSF1 HSALNG0117702 | |
GH17J058328 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 3.5 | -56.6 | -56582 | 21 | ARHGAP35 CEBPG SP1 HNRNPL CREB1 CTCF PRDM10 ZNF512 RFX1 LEF1 | TSPOAP1 MN297491 MIR4736 TSPOAP1-AS1 SRSF1 MKS1 SMG8 SUPT4H1 VEZF1 TRIM37 | |
GH17J057573 | Enhancer | 0.7 | Ensembl dbSUPER | 4.9 | +706.6 | 706634 | 1.4 | PRDM10 ZNF629 PATZ1 KLF7 OSR2 RBM22 ZNF189 GLIS1 ZNF2 ZBTB6 | MPO RF00017-2458 LOC107984993 CCDC182 MSI2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | TAS | 2829220 |
GO:0004601 | peroxidase activity | IEA,IDA | 10772654 |
GO:0005515 | protein binding | IPI | 24355864 |
GO:0008201 | heparin binding | IDA | 11907569 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 10772654 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | TAS,HDA | 21630459 |
GO:0005654 | nucleoplasm | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
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2 | Folate Metabolism | ||
3 | NF-kappaB Signaling | ||
4 | Endometrial cancer | ||
5 | Drug metabolism - cytochrome P450 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001878 | response to yeast | IEA | -- |
GO:0002149 | hypochlorous acid biosynthetic process | IEA | -- |
GO:0002679 | respiratory burst involved in defense response | IEA | -- |
GO:0006952 | defense response | IEA,TAS | 8621627 |
GO:0006979 | response to oxidative stress | IEA,TAS | 2903767 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Propylthiouracil | Approved, Investigational | Pharma | Enzyme, inhibitor | 11 | ||
Aminosalicylic Acid | Approved | Pharma | Enzyme, inhibitor | 37 | ||
Calcipotriol | Approved | Pharma | Agonist, Enzyme, inhibitor | Vitamin D3 analog,regulates cell differentiation and proliferation | 0 | |
Cefaclor | Approved | Pharma | Enzyme, inducer | 5 | ||
Cefdinir | Approved | Pharma | Target, inhibitor | 29 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Hypothiocyanite |
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63296-34-4 | ||||
2-Phenylacetamide |
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103-81-1 |
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7-Hydroxyticlopidine |
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Hydrogen Ion |
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methanol |
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67-56-1 |
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ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MPO 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MPO 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MPO 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mpo 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MPO 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MPO 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MPO 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496213 30 |
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Str.11704 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | mpo-A 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | mpx 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5873 32 |
|
|
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CG10211 32 |
|
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CG6969 32 |
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CG6879 32 |
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pxt 32 |
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CG4009 32 |
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Pxd 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | C46A5.4 32 |
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ZK430.8 32 |
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F09F3.5 32 |
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R08F11.7 32 |
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mlt-7 31 |
|
ManyToMany | |||
K10B4.1 32 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710279 | Benign: not provided | 58,270,761(-) | G/A | SYNONYMOUS_VARIANT | |
714561 | Likely Benign: not provided | 58,279,948(-) | C/T | SYNONYMOUS_VARIANT | |
718104 | Likely Benign: not provided | 58,273,656(-) | C/T | MISSENSE_VARIANT | |
726909 | Likely Benign: not provided | 58,275,535(-) | G/A | INTRON_VARIANT | |
727047 | Likely Benign: not provided | 58,271,875(-) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
myeloperoxidase deficiency |
|
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alzheimer disease |
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myeloid sarcoma |
|
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churg-strauss syndrome |
|
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rapidly progressive glomerulonephritis |
|