Free for academic non-profit institutions. Other users need a Commercial license
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohal... See more...
Aliases for MPO Gene
External Ids for MPO Gene
- HGNC: 7218
- Entrez Gene: 4353
- Ensembl: ENSG00000005381
- OMIM: 606989
- UniProtKB: P05164
Previous GeneCards Identifiers for MPO Gene
- GC17M056091
- GC17M058828
- GC17M056689
- GC17M056821
- GC17M053702
- GC17M056347
- GC17M051708
Summaries for MPO Gene
-
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
GeneCards Summary for MPO Gene
MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include Myeloperoxidase Deficiency and Alzheimer Disease. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.
UniProtKB/Swiss-Prot Summary for MPO Gene
-
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Additional gene information for MPO Gene
- HGNC(7218)
- Entrez Gene(4353)
- Ensembl(ENSG00000005381)
- OMIM(606989)
- UniProtKB(P05164)
- Open Targets Platform(ENSG00000005381)
- Monarch Initiative
- Search for MPO at DataMed
- Search for MPO at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPO Gene
Genomics for MPO Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MPO Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J058281 | Enhancer | 0.7 | FANTOM5 ENCODE | 626.3 | -0.9 | -865 | 0.6 | SPI1 GABPA POLR2A IKZF1 MAX GABPB1 ZNF579 | MPO TSPOAP1 HSALNG0117702 | |
| GH17J058280 | Promoter | 0.5 | EPDnew | 600.7 | 0.0 | -20 | 0.1 | REST POLR2A | MPO HSALNG0117702 TSPOAP1 | |
| GH17J058284 | Promoter/Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 11.6 | -3.9 | -3865 | 0.8 | CEBPG ATF7 JUND POLR2A CEBPB ZFHX2 SPI1 ATF4 REST ATF3 | TSPOAP1 MPO MKS1 LPO RNF43 SUPT4H1 SRSF1 HSALNG0117702 | |
| GH17J058328 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 3.5 | -56.6 | -56582 | 21 | ARHGAP35 CEBPG SP1 HNRNPL CREB1 CTCF PRDM10 ZNF512 RFX1 LEF1 | TSPOAP1 MN297491 MIR4736 TSPOAP1-AS1 SRSF1 MKS1 SMG8 SUPT4H1 VEZF1 TRIM37 | |
| GH17J057573 | Enhancer | 0.7 | Ensembl dbSUPER | 4.9 | +706.6 | 706634 | 1.4 | PRDM10 ZNF629 PATZ1 KLF7 OSR2 RBM22 ZNF189 GLIS1 ZNF2 ZBTB6 | MPO RF00017-2458 LOC107984993 CCDC182 MSI2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MPO on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPO
- Top Transcription factor binding sites by QIAGEN in the MPO gene promoter:
-
- AML1a
- ITF-2
- Msx-1
- NRF-2
- Sp1
- Tal-1beta
Genomic Locations for MPO Gene
Genomic Locations for MPO Gene
- chr17:58,269,855-58,280,935
- (GRCh38/hg38)
- Size:
- 11,081 bases
- Orientation:
- Minus strand
- chr17:56,347,217-56,358,296
- (GRCh37/hg19)
- Size:
- 11,080 bases
- Orientation:
- Minus strand
Genomic View for MPO Gene
Genes around MPO on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
MPO Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MPO Gene
Proteins for MPO Gene
-
Protein details for MPO Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05164-PERM_HUMAN
- Recommended name:
- Myeloperoxidase
- Protein Accession:
- P05164
- A1L4B8
- Q14862
- Q4PJH5
- Q9UCL7
Protein attributes for MPO Gene
- Size:
- 745 amino acids
- Molecular mass:
- 83869 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=heme b; Xref=ChEBI:CHEBI:60344;
- Quaternary structure:
-
- Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.
Three dimensional structures from OCA and Proteopedia for MPO Gene
Protein Expression for MPO Gene
Selected DME Specific Peptides for MPO Gene
- P05164:
-
- RDGDRFW
- LTSMHTL
- EGGIDPILRGL
- PCFLAGD
- LMFMQWGQ
- RDHGLPGYN
- RFQDNGRAL
Post-translational modifications for MPO Gene
Other Protein References for MPO Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences MPO / Myeloperoxidase Antibody (LS-B4741) and MPO / Myeloperoxidase Antibody (LS-B6699)
- NSJ Bioreagents MPO Antibody Myeloperoxidase
- Creative Diagnostics Anti-Myeloperoxidase monoclonal antibody, clone 60B6
-
Custom Antibody ServicesOriGene Antibodies for MPO
- 4M43-16E3
- 4M43-17G2
- 4M43-18B7
- 4M43-19G8
- 4M43-4A4
- 4M43-4B3
- AM05455PU-N
- AM05456PU-N
- AM26163BT-N
- AM26163FC-N
- AM26163PU-N
- AM26227BT-N
- AM26227PU-N
- AM26325BT-N
- AM26325FC-N
- AM26325PU-N
- AM26774FC-N
- AM26774PU-N
- AM32277PU-N
- AM39035FC-N
- AM39035PU-N
- AP02121SU-N
- AP02121SU-S
- AP07604SU-N
- AP23272PU-N
- AP23566PU-N
- AP31673PU-N
- AP32134PU-N
- AP52737PU-N
- AP52788PU-N
- BP2067
- R1537P
- SM1475F
- SM1475P
- SM1475PT
- SM1475R
- TA318973
- TA319305
- TA327707
- TA343091
- TA349402
- Novus Biologicals Antibodies for MPO
-
Abcam antibodies for MPO
- Invitrogen Antibodies for MPO (AFLGC-MPO)
- antibodies-online: Show 206 available Myeloperoxidase Antibodies ranked by validation data
- Compare Top Myeloperoxidase Antibodies
-
Recommended
- 344 WB Antibodies (anti-human)
- 47 FACS Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 59 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 4 IHC (fro) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 3 IA Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 43 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 IF Antibodies (anti-rat)
- 5 IHC (fro) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MPO
- Sino Biological Antibodies for MPO
Protein Products
- G Biosciences Human Myeloperoxidase/MPO, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for MPO
- Origene Custom Protein Services for MPO
- Sino Biological Recombinant Proteins for MPO
- Sino Biological Cell Lysates for MPO
- ProSpec Recombinant Proteins for MPO
-
Abcam proteins for MPO
Assay Products
- Novus Biologicals ELISA Kits for MPO
- antibodies-online: Show 128 available Myeloperoxidase Elisa Kits ranked by validation data
- Compare Top Myeloperoxidase Elisa Kits
-
Quality Products:
- ABIN411400
- ABIN414471
- ABIN366561
- ABIN492079
- ABIN455939
- ABIN2685015
- ABIN1029344
- ABIN1380041
- ABIN5564581
- ABIN1305167
- ABIN6574172
- ABIN1672855
- ABIN415435
- ABIN2506963
- ABIN367676
- ABIN1979442
- ABIN5521261
- ABIN492080
- ABIN1116079
- ABIN3198471
- ABIN416157
- ABIN368087
- ABIN1571313
- ABIN1116081
- ABIN5521262
- ABIN627285
- ABIN492081
- ABIN5592411
- ABIN5657063
- ABIN577535
- ABIN628448
- ABIN2092945
-
Abcam assays for MPO
Domains & Families for MPO Gene
Gene Families for MPO Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MPO Gene
- InterPro:
- Blocks:
-
- Animal haem peroxidase signature
- Haem peroxidase
- ProtoNet:
Suggested Antigen Peptide Sequences for MPO Gene
- GenScript: Design optimal peptide antigens:
-
- Myeloperoxidase (PERM_HUMAN)
- Peroxidase (Myeloperoxidase) (Q16771_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05164- Family:
-
- Belongs to the peroxidase family. XPO subfamily.
Function for MPO Gene
Molecular function for MPO Gene
- UniProtKB/Swiss-Prot Function:
- Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=chloride + H(+) + H2O2 = H2O + hypochlorous acid; Xref=Rhea:RHEA:28218, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:17996, ChEBI:CHEBI:24757; EC=1.11.2.2; Evidence={ECO:0000269|PubMed:9922160};.
- GENATLAS Biochemistry:
- myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of monocytes,involved in oxygen dependent mechanism of phagocytosis
Enzyme Numbers (IUBMB) for MPO Gene
Phenotypes From GWAS Catalog for MPO Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | TAS | 2829220 |
| GO:0004601 | peroxidase activity | IEA,IDA | 10772654 |
| GO:0005515 | protein binding | IPI | 24355864 |
| GO:0008201 | heparin binding | IDA | 11907569 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for MPO Gene
- MGI mutant phenotypes for MPO:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MPO:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability ratio
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased viability with MLN4924 (a NAE inhibitor)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MPO - Select products 50% OFF >
- * MPO CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MPO
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPO
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPO
miRNA for MPO Gene
- miRTarBase miRNAs that target MPO
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPO
- Browse OriGene Inhibitory RNA Products For MPO
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPO
Clone Products
- Applied Biological Materials (abm): Clones for MPO - Select products 50% OFF >
- * MPO as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MPO
- Addgene plasmids for MPO
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPO
Cell Line Products
-
Horizon Cell Lines for MPO
No data available for Transcription Factor Targets and HOMER Transcription for MPO Gene
Localization for MPO Gene
Subcellular locations from UniProtKB/Swiss-Prot for MPO Gene
- Lysosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| cytosol | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 1 |
- Vesicles (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 10772654 |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | TAS,HDA | 21630459 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for MPO Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Folate Metabolism | ||
| 3 | NF-kappaB Signaling | ||
| 4 | Endometrial cancer | ||
| 5 | Drug metabolism - cytochrome P450 | ||
Pathways by source for MPO Gene
7 BioSystems pathways for MPO Gene
3 Reactome pathways for MPO Gene
3 PharmGKB pathways for MPO Gene
4 KEGG pathways for MPO Gene
1 R&D Systems pathway for MPO Gene
1 Qiagen pathway for MPO Gene
- LDL Oxidation in Atherogenesis
1 Cell Signaling Technology pathway for MPO Gene
Interacting Proteins for MPO Gene
Selected Interacting proteins:
P05164-PERM_HUMAN
ENSP00000225275
for MPO Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MPO
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001878 | response to yeast | IEA | -- |
| GO:0002149 | hypochlorous acid biosynthetic process | IEA | -- |
| GO:0002679 | respiratory burst involved in defense response | IEA | -- |
| GO:0006952 | defense response | IEA,TAS | 8621627 |
| GO:0006979 | response to oxidative stress | IEA,TAS | 2903767 |
Drugs & Compounds for MPO Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Propylthiouracil | Approved, Investigational | Pharma | Enzyme, inhibitor | 11 | ||
| Aminosalicylic Acid | Approved | Pharma | Enzyme, inhibitor | 37 | ||
| Calcipotriol | Approved | Pharma | Agonist, Enzyme, inhibitor | Vitamin D3 analog,regulates cell differentiation and proliferation | 0 | |
| Cefaclor | Approved | Pharma | Enzyme, inducer | 5 | ||
| Cefdinir | Approved | Pharma | Target, inhibitor | 29 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Hypothiocyanite |
|
63296-34-4 | ||||
| 2-Phenylacetamide |
|
103-81-1 |
|
|||
| 7-Hydroxyticlopidine |
|
|||||
| Hydrogen Ion |
|
|
||||
| methanol |
|
67-56-1 |
|
Transcripts for MPO Gene
mRNA/cDNA for MPO Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225275 3216 nts (view in UCSC)
- ENST00000577220 260 nts (view in UCSC)
- ENST00000578493 483 nts (view in UCSC)
- ENST00000580005 398 nts (view in UCSC)
- ENST00000581022 481 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MPO - Select products 50% OFF >
- * MPO CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MPO
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPO
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPO
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPO
- Browse OriGene Inhibitory RNA Products For MPO
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPO
Clone Products
- Applied Biological Materials (abm): Clones for MPO - Select products 50% OFF >
- * MPO as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MPO
- Addgene plasmids for MPO
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPO
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for MPO Gene
- GeneLoc Exon Structure for
- MPO
Expression for MPO Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Bone (Muscoskeletal System)
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for MPO Gene
This gene is overexpressed in Whole Blood (x38.6) and Spleen (x4.6).
This gene is overexpressed in Neutrophil (37.9), Monocytes (10.5), and Nasal epithelium (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MPO Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPO
SOURCE GeneReport for Unigene cluster for MPO Gene:
Hs.458272Evidence on tissue expression from TISSUES for MPO Gene
- Blood(5)
- Bone marrow(4.8)
- Liver(4.7)
- Saliva(4.4)
- Nervous system(4.3)
- Intestine(3.6)
- Heart(3.3)
- Lung(3.3)
- Kidney(3.1)
- Spleen(3.1)
- Lymph node(2.9)
- Skin(2.9)
- Muscle(2.7)
- Pancreas(2.6)
- Urine(2.6)
- Eye(2.4)
- Stomach(2.3)
- Bone(2.2)
- Adrenal gland(2.2)
- Gall bladder(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MPO Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- lymphatic
Regions:
Thorax:
- thymus
Abdomen:
- liver
- spleen
General:
- blood
- bone marrow
- coagulation system
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MPO
-
OriGene qPCR primer pairs and template standards for MPO
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for MPO Gene
Orthologs for MPO Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MPO 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MPO 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MPO 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mpo 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MPO 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MPO 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MPO 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100496213 30 |
|
||
| Str.11704 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | mpo-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mpx 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5873 32 |
|
|
|
| CG10211 32 |
|
|
|||
| CG6969 32 |
|
|
|||
| CG6879 32 |
|
|
|||
| pxt 32 |
|
|
|||
| CG4009 32 |
|
|
|||
| Pxd 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | C46A5.4 32 |
|
|
|
| ZK430.8 32 |
|
|
|||
| F09F3.5 32 |
|
|
|||
| R08F11.7 32 |
|
|
|||
| mlt-7 31 |
|
ManyToMany | |||
| K10B4.1 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for MPO was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MPO Gene
- ENSEMBL:
- Gene Tree for MPO (if available)
- TreeFam:
- Gene Tree for MPO (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MPO: view image
Paralogs for MPO Gene
Variants for MPO Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPO Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710279 | Benign: not provided | 58,270,761(-) | G/A | SYNONYMOUS_VARIANT | |
| 714561 | Likely Benign: not provided | 58,279,948(-) | C/T | SYNONYMOUS_VARIANT | |
| 718104 | Likely Benign: not provided | 58,273,656(-) | C/T | MISSENSE_VARIANT | |
| 726909 | Likely Benign: not provided | 58,275,535(-) | G/A | INTRON_VARIANT | |
| 727047 | Likely Benign: not provided | 58,271,875(-) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.98;
74.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MPO Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPO Gene
Disorders for MPO Gene
(169) MalaCards diseases for MPO Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloperoxidase deficiency |
|
|
| alzheimer disease |
|
|
| myeloid sarcoma |
|
|
| churg-strauss syndrome |
|
|
| rapidly progressive glomerulonephritis |
|
Search MPO in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PERM_HUMAN- Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269 PubMed:7904599, ECO:0000269 PubMed:8142659, ECO:0000269 PubMed:8621627, ECO:0000269 PubMed:9354683, ECO:0000269 PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for MPO Gene
infections,recurrent,with disseminated candidiasis
Additional Disease Information for MPO
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for MPO Gene
- Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. (PMID: 19651119) Wainstein RV … Polanczyk CA (Clinical biochemistry 2010) 3 23 41
- Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions. (PMID: 19897513) Wenten M … Gilliland FD (American journal of epidemiology 2009) 3 23 41
- Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. (PMID: 19731237) Nahon P … Beaugrand M (Hepatology (Baltimore, Md.) 2009) 3 23 41
- Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. (PMID: 19255063) Li Y … Hong CC (Carcinogenesis 2009) 3 23 41
- A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function. (PMID: 19735726) Rudolph V … Baldus S (Free radical biology & medicine 2009) 3 23 41
ExternalLinks
Products for MPO Gene
- View all 14 R&D Systems MPO (Myeloperoxidase/MPO) Products
- View all R&D Systems MPO (Myeloperoxidase/MPO) Proteins and Enzymes
- View all 5 R&D Systems MPO (Myeloperoxidase/MPO) Primary Antibodies
- View all 3 R&D Systems MPO (Myeloperoxidase/MPO) ELISAs
- View all R&D Systems MPO (Myeloperoxidase/MPO) Simple Plex Assays
- View all R&D Systems MPO (Myeloperoxidase/MPO) Luminex Assays
- View all 3 R&D Systems MPO (Myeloperoxidase/MPO) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom MPO antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MPO
- 4M43-16E3
- 4M43-17G2
- 4M43-18B7
- 4M43-19G8
- 4M43-4A4
- 4M43-4B3
- AM05455PU-N
- AM05456PU-N
- AM26163BT-N
- AM26163FC-N
- AM26163PU-N
- AM26227BT-N
- AM26227PU-N
- AM26325BT-N
- AM26325FC-N
- AM26325PU-N
- AM26774FC-N
- AM26774PU-N
- AM32277PU-N
- AM39035FC-N
- AM39035PU-N
- AP02121SU-N
- AP02121SU-S
- AP07604SU-N
- AP23272PU-N
- AP23566PU-N
- AP31673PU-N
- AP32134PU-N
- AP52737PU-N
- AP52788PU-N
- BP2067
- R1537P
- SM1475F
- SM1475P
- SM1475PT
- SM1475R
- TA318973
- TA319305
- TA327707
- TA343091
- TA349402
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MPO
- Origene Custom Protein Services for MPO
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPO
- Browse OriGene Inhibitory RNA Products For MPO
- OriGene qPCR primer pairs for MPO
- OriGene qPCR primer pairs and template standards for MPO
- OriGene CRISPR knockouts for MPO
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MPO
- Sino Biological Human cDNA Clone for MPO
- Sino Biological Recombinant Proteins for MPO
- Sino Biological Cell Lysates for MPO
- Sino Biological Antibodies for MPO
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MPO
- Novus Biologicals proteins and lysates for MPO
- Novus Biologicals ELISA Kits for MPO
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MPO
- Abcam proteins for MPO
- Abcam assays for MPO
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for MPO (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MPO (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MPO (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MPO CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MPO
- Addgene plasmids for MPO
- antibodies-online: Show 206 available Myeloperoxidase Antibodies ranked by validation data
- Compare Top Myeloperoxidase Antibodies
- Recommended
- 344 WB Antibodies (anti-human)
- 47 FACS Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 59 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 4 IHC (fro) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 3 IA Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 43 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 IF Antibodies (anti-rat)
- 5 IHC (fro) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 128 available Myeloperoxidase Elisa Kits ranked by validation data
- Compare Top Myeloperoxidase Elisa Kits
- Quality Products:
- ABIN411400
- ABIN414471
- ABIN366561
- ABIN492079
- ABIN455939
- ABIN2685015
- ABIN1029344
- ABIN1380041
- ABIN5564581
- ABIN1305167
- ABIN6574172
- ABIN1672855
- ABIN415435
- ABIN2506963
- ABIN367676
- ABIN1979442
- ABIN5521261
- ABIN492080
- ABIN1116079
- ABIN3198471
- ABIN416157
- ABIN368087
- ABIN1571313
- ABIN1116081
- ABIN5521262
- ABIN627285
- ABIN492081
- ABIN5592411
- ABIN5657063
- ABIN577535
- ABIN628448
- ABIN2092945
- antibodies-online: Show 43 available Myeloperoxidase Proteins ranked by validation data
- Compare Top Myeloperoxidase Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MPO
- Search Santa Cruz Biotechnology (SCBT) for MPO siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MPO
- Horizon Cell Lines for MPO
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPO
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPO
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MPO
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPO
Sources for MPO Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB