Aliases for MPND Gene

Aliases for MPND Gene

  • MPN Domain Containing 2 3 5
  • MPN Domain-Containing Protein 3 4
  • EC 3.4.-.- 4
  • FLJ14981 2
  • MPND 5

External Ids for MPND Gene

Previous GeneCards Identifiers for MPND Gene

  • GC19P004295
  • GC19P004105

Summaries for MPND Gene

GeneCards Summary for MPND Gene

MPND (MPN Domain Containing) is a Protein Coding gene. Diseases associated with MPND include Amyloidosis, Hereditary, Transthyretin-Related. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is MYSM1.

UniProtKB/Swiss-Prot Summary for MPND Gene

  • Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744).

Additional gene information for MPND Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPND Gene

Genomics for MPND Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MPND Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004340 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.7 -684 4.3 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 REST TFE3 LEF1 IKZF1 STAP2 MPND ENSG00000267030 CACTIN-AS1 APBA3 YJU2 ENSG00000269807 DPP9-AS1 ENSG00000267769 CACTIN
GH19J003394 Enhancer 0.3 dbSUPER 5.3 -948.8 -948785 1.3 ZNF280D MPND TLE5 MN297551 NONHSAG024474.2 piR-32214-328 NFIC SMIM24
GH19J004367 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +31.2 31228 14.6 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 PRDM10 ZNF629 ENSG00000267769 CACTIN SEMA6B CHAF1A YJU2 ENSG00000267030 SH3GL1 UBXN6 HDGFL2 CACTIN-AS1
GH19J004347 Enhancer 0.6 Ensembl ENCODE 0.7 +4.0 3974 2.2 ZNF10 ZNF189 FOXM1 EIF1P6 lnc-STAP2-1 STAP2 SH3GL1 FSD1 TMIGD2 SHD CHAF1A MPND ENSG00000269807
GH19J004352 Enhancer 0.8 Ensembl ENCODE 0.4 +9.2 9200 0.7 CTCF ZNF692 PATZ1 REST RAD21 TRIM22 ZNF600 ZNF341 SP2 RUNX3 ENSG00000269807 UBXN6 CHAF1A EIF1P6 MPND SH3GL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPND on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPND

Top Transcription factor binding sites by QIAGEN in the MPND gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT3
  • STAT5A

Genomic Locations for MPND Gene

Genomic Locations for MPND Gene
chr19:4,343,527-4,360,086
(GRCh38/hg38)
Size:
16,560 bases
Orientation:
Plus strand
chr19:4,343,524-4,360,083
(GRCh37/hg19)
Size:
16,560 bases
Orientation:
Plus strand

Genomic View for MPND Gene

Genes around MPND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPND Gene

Proteins for MPND Gene

  • Protein details for MPND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N594-MPND_HUMAN
    Recommended name:
    MPN domain-containing protein
    Protein Accession:
    Q8N594
    Secondary Accessions:
    • Q96SJ0
    • Q9Y2P1
    • Q9Y2P2

    Protein attributes for MPND Gene

    Size:
    471 amino acids
    Molecular mass:
    50662 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MPND Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPND Gene

Post-translational modifications for MPND Gene

  • Degraded following binding to N(6)-methyladenosine methylated DNA (m6A).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MPND Gene

Domains & Families for MPND Gene

Gene Families for MPND Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MPND Gene

InterPro:
Blocks:
  • Mov34 family
ProtoNet:

Suggested Antigen Peptide Sequences for MPND Gene

GenScript: Design optimal peptide antigens:
  • MPN domain-containing protein (MPND_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N594

UniProtKB/Swiss-Prot:

MPND_HUMAN :
  • The RAMA domain recognizes and binds N(6)-methyladenosine methylation on DNA (m6A).
  • Belongs to the peptidase M67 family.
Domain:
  • The RAMA domain recognizes and binds N(6)-methyladenosine methylation on DNA (m6A).
Family:
  • Belongs to the peptidase M67 family.
genes like me logo Genes that share domains with MPND: view

Function for MPND Gene

Molecular function for MPND Gene

UniProtKB/Swiss-Prot Function:
Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744).

Enzyme Numbers (IUBMB) for MPND Gene

Phenotypes From GWAS Catalog for MPND Gene

Gene Ontology (GO) - Molecular Function for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA 21873635
GO:0004843 thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MPND: view
genes like me logo Genes that share phenotypes with MPND: view

Animal Model Products

CRISPR Products

miRNA for MPND Gene

miRTarBase miRNAs that target MPND

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPND

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPND Gene

Localization for MPND Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPND gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016514 SWI/SNF complex IBA --
genes like me logo Genes that share ontologies with MPND: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MPND Gene

Pathways & Interactions for MPND Gene

PathCards logo

SuperPathways for MPND Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA 21873635
GO:0006508 proteolysis IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with MPND: view

No data available for Pathways by source and SIGNOR curated interactions for MPND Gene

Drugs & Compounds for MPND Gene

No Compound Related Data Available

Transcripts for MPND Gene

mRNA/cDNA for MPND Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPND

Alternative Splicing Database (ASD) splice patterns (SP) for MPND Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3:

Relevant External Links for MPND Gene

GeneLoc Exon Structure for
MPND

Expression for MPND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPND Gene

Protein differential expression in normal tissues from HIPED for MPND Gene

This gene is overexpressed in Brain (58.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPND Gene



Protein tissue co-expression partners for MPND Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPND

SOURCE GeneReport for Unigene cluster for MPND Gene:

Hs.321689

Evidence on tissue expression from TISSUES for MPND Gene

  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MPND: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPND Gene

Orthologs for MPND Gene

This gene was present in the common ancestor of animals.

Orthologs for MPND Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MPND 30 31
  • 99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MPND 30 31
  • 87.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MPND 30 31
  • 86.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mpnd 30
  • 84.67 (n)
Mouse
(Mus musculus)
Mammalia Mpnd 30 17 31
  • 84.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MPND 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MPND 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MPND 30 31
  • 68.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MPND 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mpnd 30
  • 65.89 (n)
Zebrafish
(Danio rerio)
Actinopterygii mpnd 30 31
  • 63.64 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008858 30
  • 56.48 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG4751 31
  • 5 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Species where no ortholog for MPND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MPND Gene

ENSEMBL:
Gene Tree for MPND (if available)
TreeFam:
Gene Tree for MPND (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPND: view image

Paralogs for MPND Gene

Paralogs for MPND Gene

genes like me logo Genes that share paralogs with MPND: view

Variants for MPND Gene

Additional dbSNP identifiers (rs#s) for MPND Gene

Structural Variations from Database of Genomic Variants (DGV) for MPND Gene

Variant ID Type Subtype PubMed ID
nsv1138659 CNV deletion 24896259
nsv458328 CNV gain 19166990
nsv477244 CNV novel sequence insertion 20440878
nsv578443 CNV gain 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897
nsv833719 CNV loss 17160897

Variation tolerance for MPND Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPND Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPND

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPND Gene

Disorders for MPND Gene

MalaCards: The human disease database

(1) MalaCards diseases for MPND Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyloidosis, hereditary, transthyretin-related
  • hereditary amyloidosis, transthyretin-related
- elite association - COSMIC cancer census association via MalaCards
Search MPND in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MPND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPND Gene

Publications for MPND Gene

  1. An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing. (PMID: 30982744) Kweon SM … Feldman DE (Molecular cell 2019) 4
  2. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. (PMID: 28786561) Poirson J … Masson M (The FEBS journal 2017) 3
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for MPND Gene

  • Signalway ELISA kits for MPND

Sources for MPND Gene