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The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
MPLKIP (M-Phase Specific PLK1 Interacting Protein) is a Protein Coding gene. Diseases associated with MPLKIP include Trichothiodystrophy 4, Nonphotosensitive and Trichothiodystrophy 1, Photosensitive.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17310276 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 17310276 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 17310276 |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005813 | centrosome | IDA | 17310276 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007049 | cell cycle | IEA | -- |
GO:0051301 | cell division | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MPLKIP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mplkip 30 |
|
||
Dog (Canis familiaris) |
Mammalia | MPLKIP 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mplkip 30 17 31 |
|
OneToMany | |
Gm7102 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | C4H7ORF11 31 |
|
OneToOne | |
MPLKIP 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | MPLKIP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | C7ORF11 30 |
|
||
MPLKIP 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | MPLKIP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mplkip 30 |
|
||
MGC76001 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.29095 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mplkip 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718761 | Likely Benign: not provided | 40,133,176(-) | C/T | SYNONYMOUS_VARIANT | |
722260 | Likely Benign: not provided | 40,134,277(-) | G/A | SYNONYMOUS_VARIANT | |
734604 | Likely Benign: not provided | 40,134,216(-) | CTAT/C | SPLICE_DONOR_VARIANT | |
734605 | Likely Benign: not provided | 40,134,442(-) | T/G | SYNONYMOUS_VARIANT | |
740590 | Likely Benign: not provided | 40,134,448(-) | G/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759525 | CNV | gain | 17122850 |
esv34547 | CNV | gain | 17911159 |
esv3612920 | CNV | gain | 21293372 |
nsv1024735 | CNV | gain | 25217958 |
nsv1032278 | CNV | gain | 25217958 |
nsv464437 | CNV | gain | 19166990 |
nsv606709 | CNV | gain | 21841781 |
nsv824080 | CNV | gain | 20364138 |
nsv971193 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
trichothiodystrophy 4, nonphotosensitive |
|
|
trichothiodystrophy 1, photosensitive |
|
|
trichothiodystrophy |
|
|
nonphotosensitive trichothiodystrophy |
|
|
ciliary dyskinesia, primary, 6 |
|
|