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Aliases for MPHOSPH9 Gene

Aliases for MPHOSPH9 Gene

  • M-Phase Phosphoprotein 9 2 3 5
  • MPP9 3 4
  • MPP-9 3

External Ids for MPHOSPH9 Gene

Previous GeneCards Identifiers for MPHOSPH9 Gene

  • GC12P122405
  • GC12M123338
  • GC12M123445
  • GC12M122074
  • GC12M122152
  • GC12M123637
  • GC12M120601

Summaries for MPHOSPH9 Gene

GeneCards Summary for MPHOSPH9 Gene

MPHOSPH9 (M-Phase Phosphoprotein 9) is a Protein Coding gene.

Additional gene information for MPHOSPH9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH9 Gene

Genomics for MPHOSPH9 Gene

GeneHancer (GH) Regulatory Elements for MPHOSPH9 Gene

Promoters and enhancers for MPHOSPH9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I123231 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 571.4 +10.5 10497 3.7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MPHOSPH9 C12orf65 ZCCHC8 RSRC2 EIF2B1 DDX55 KNTC1 LOC101927415 CDK2AP1 OGFOD2
GH12I123241 Enhancer 0.9 Ensembl ENCODE dbSUPER 569.3 +1.6 1619 1.3 PRDM6 FEZF1 ZNF843 SPI1 MPHOSPH9 CDK2AP1 C12orf65 GC12P123235
GH12I123243 Enhancer 0.4 dbSUPER 550.8 +0.0 32 0.6 STAT1 RFX1 BMI1 MPHOSPH9 CDK2AP1 GC12P123235 C12orf65
GH12I122978 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 21.4 +260.4 260410 9.7 HDGF HNRNPUL1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ABCB9 ARL6IP4 EIF2B1 ZCCHC8 RSRC2 CDK2AP1 DDX55 KNTC1 MPHOSPH9 ATP6V0A2
GH12I122973 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.2 +268.0 267969 4.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 OGFOD2 GC12M122975 PIR57372 ENSG00000256028 CDK2AP1 MPHOSPH9 ZCCHC8 KNTC1 RSRC2 EIF2B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MPHOSPH9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MPHOSPH9 gene promoter:

Genomic Locations for MPHOSPH9 Gene

Genomic Locations for MPHOSPH9 Gene
chr12:123,152,320-123,244,014
(GRCh38/hg38)
Size:
91,695 bases
Orientation:
Minus strand
chr12:123,636,867-123,728,561
(GRCh37/hg19)

Genomic View for MPHOSPH9 Gene

Genes around MPHOSPH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH9 Gene

Proteins for MPHOSPH9 Gene

  • Protein details for MPHOSPH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99550-MPP9_HUMAN
    Recommended name:
    M-phase phosphoprotein 9
    Protein Accession:
    Q99550
    Secondary Accessions:
    • A1L486
    • A6NEE2
    • B3KR87
    • Q9H976
    • U3KQ28

    Protein attributes for MPHOSPH9 Gene

    Size:
    1183 amino acids
    Molecular mass:
    133024 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14359.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG52299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW98394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MPHOSPH9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPHOSPH9 Gene

Post-translational modifications for MPHOSPH9 Gene

No data available for DME Specific Peptides for MPHOSPH9 Gene

Domains & Families for MPHOSPH9 Gene

Gene Families for MPHOSPH9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MPHOSPH9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPHOSPH9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MPHOSPH9: view

No data available for UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Function for MPHOSPH9 Gene

Phenotypes From GWAS Catalog for MPHOSPH9 Gene

genes like me logo Genes that share phenotypes with MPHOSPH9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH9 Gene

Localization for MPHOSPH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPHOSPH9 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPHOSPH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA,IEA 8885239
GO:0005814 centriole IDA,IEA 23644468
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MPHOSPH9: view

Pathways & Interactions for MPHOSPH9 Gene

SuperPathways for MPHOSPH9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MPHOSPH9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MPHOSPH9 Gene

Drugs & Compounds for MPHOSPH9 Gene

No Compound Related Data Available

Transcripts for MPHOSPH9 Gene

Unigene Clusters for MPHOSPH9 Gene

M-phase phosphoprotein 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -
SP13:
SP14:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for MPHOSPH9 Gene

GeneLoc Exon Structure for
MPHOSPH9
ECgene alternative splicing isoforms for
MPHOSPH9

Expression for MPHOSPH9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPHOSPH9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPHOSPH9 Gene

This gene is overexpressed in Serum (48.3), Liver (10.0), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPHOSPH9 Gene



Protein tissue co-expression partners for MPHOSPH9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MPHOSPH9 Gene:

MPHOSPH9

SOURCE GeneReport for Unigene cluster for MPHOSPH9 Gene:

Hs.577404

Evidence on tissue expression from TISSUES for MPHOSPH9 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with MPHOSPH9: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH9 Gene

Orthologs for MPHOSPH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPHOSPH9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPHOSPH9 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia MPHOSPH9 33 34
  • 88.5 (n)
cow
(Bos Taurus)
Mammalia MPHOSPH9 33 34
  • 87.5 (n)
rat
(Rattus norvegicus)
Mammalia Mphosph9 33
  • 79.76 (n)
mouse
(Mus musculus)
Mammalia Mphosph9 33 16 34
  • 79.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MPHOSPH9 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MPHOSPH9 33 34
  • 68.57 (n)
lizard
(Anolis carolinensis)
Reptilia MPHOSPH9 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph9 33
  • 55.65 (n)
zebrafish
(Danio rerio)
Actinopterygii MPHOSPH9 34
  • 38 (a)
OneToOne
Species where no ortholog for MPHOSPH9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPHOSPH9 Gene

ENSEMBL:
Gene Tree for MPHOSPH9 (if available)
TreeFam:
Gene Tree for MPHOSPH9 (if available)

Paralogs for MPHOSPH9 Gene

Pseudogenes.org Pseudogenes for MPHOSPH9 Gene

genes like me logo Genes that share paralogs with MPHOSPH9: view

No data available for Paralogs for MPHOSPH9 Gene

Variants for MPHOSPH9 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH9 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs886049038 uncertain-significance, Combined oxidative phosphorylation deficiency 123,233,354(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs886049039 uncertain-significance, Combined oxidative phosphorylation deficiency 123,233,432(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000109951 -- 123,159,158(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000144839 -- 123,221,200(-) A/T intron_variant
rs1000147791 -- 123,176,520(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH9 Gene

Variant ID Type Subtype PubMed ID
esv2761773 CNV gain 21179565
esv3581949 CNV gain 25503493
nsv1113532 CNV deletion 24896259
nsv517200 CNV loss 19592680

Variation tolerance for MPHOSPH9 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPHOSPH9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPHOSPH9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH9 Gene

Disorders for MPHOSPH9 Gene

Additional Disease Information for MPHOSPH9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MPHOSPH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH9 Gene

Publications for MPHOSPH9 Gene

  1. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N … Westendorf JM (Molecular biology of the cell 1996) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings. (PMID: 20546594) Goldstein BA … Barcellos LF (BMC genetics 2010) 3 44 58
  4. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PMID: 19879194) De Jager PL … Karlson EW (The Lancet. Neurology 2009) 3 44 58
  5. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PMID: 19525953) De Jager PL … Oksenberg JR (Nature genetics 2009) 3 44 58

Products for MPHOSPH9 Gene

Sources for MPHOSPH9 Gene

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