Aliases for MPHOSPH6 Gene

Aliases for MPHOSPH6 Gene

  • M-Phase Phosphoprotein 6 2 3 4 5
  • MPP6 2 3 4
  • MPHOSPH6 5
  • MPP-6 3
  • MPP 3

External Ids for MPHOSPH6 Gene

Previous GeneCards Identifiers for MPHOSPH6 Gene

  • GC16M073023
  • GC16M083142
  • GC16M081920
  • GC16M081961
  • GC16M080739
  • GC16M067936

Summaries for MPHOSPH6 Gene

GeneCards Summary for MPHOSPH6 Gene

MPHOSPH6 (M-Phase Phosphoprotein 6) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for MPHOSPH6 Gene

  • RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Gene Wiki entry for MPHOSPH6 Gene

Additional gene information for MPHOSPH6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPHOSPH6 Gene

Genomics for MPHOSPH6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MPHOSPH6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPHOSPH6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPHOSPH6

Genomic Locations for MPHOSPH6 Gene

Genomic Locations for MPHOSPH6 Gene
chr16:82,147,798-82,170,224
(GRCh38/hg38)
Size:
22,427 bases
Orientation:
Minus strand
chr16:82,181,403-82,203,831
(GRCh37/hg19)
Size:
22,429 bases
Orientation:
Minus strand

Genomic View for MPHOSPH6 Gene

Genes around MPHOSPH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH6 Gene

Proteins for MPHOSPH6 Gene

  • Protein details for MPHOSPH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99547-MPH6_HUMAN
    Recommended name:
    M-phase phosphoprotein 6
    Protein Accession:
    Q99547
    Secondary Accessions:
    • B2RAF0

    Protein attributes for MPHOSPH6 Gene

    Size:
    160 amino acids
    Molecular mass:
    19024 Da
    Quaternary structure:
    • Associates with the RNA exosome complex, probably mediated by EXOSC10 (PubMed:29906447). Interacts with ARHGAP18, EXOSC10 and MTREX.

    Three dimensional structures from OCA and Proteopedia for MPHOSPH6 Gene

neXtProt entry for MPHOSPH6 Gene

Post-translational modifications for MPHOSPH6 Gene

Other Protein References for MPHOSPH6 Gene

No data available for DME Specific Peptides for MPHOSPH6 Gene

Domains & Families for MPHOSPH6 Gene

Gene Families for MPHOSPH6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MPHOSPH6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPHOSPH6 Gene

GenScript: Design optimal peptide antigens:
  • M-phase phosphoprotein 6 (MPH6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99547

UniProtKB/Swiss-Prot:

MPH6_HUMAN :
  • Belongs to the MPP6 family.
Family:
  • Belongs to the MPP6 family.
genes like me logo Genes that share domains with MPHOSPH6: view

Function for MPHOSPH6 Gene

Molecular function for MPHOSPH6 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Phenotypes From GWAS Catalog for MPHOSPH6 Gene

Gene Ontology (GO) - Molecular Function for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 11719186
genes like me logo Genes that share ontologies with MPHOSPH6: view
genes like me logo Genes that share phenotypes with MPHOSPH6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPHOSPH6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH6 Gene

Localization for MPHOSPH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH6 Gene

Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPHOSPH6 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 colocalizes_with nuclear exosome (RNase complex) TAS 11719186
GO:0000178 colocalizes_with exosome (RNase complex) IDA 11719186
GO:0005634 nucleus IEA,IDA 8885239
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with MPHOSPH6: view

Pathways & Interactions for MPHOSPH6 Gene

genes like me logo Genes that share pathways with MPHOSPH6: view

Pathways by source for MPHOSPH6 Gene

Gene Ontology (GO) - Biological Process for MPHOSPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IMP 17412707
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with MPHOSPH6: view

No data available for SIGNOR curated interactions for MPHOSPH6 Gene

Drugs & Compounds for MPHOSPH6 Gene

No Compound Related Data Available

Transcripts for MPHOSPH6 Gene

mRNA/cDNA for MPHOSPH6 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPHOSPH6

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for MPHOSPH6 Gene

GeneLoc Exon Structure for
MPHOSPH6

Expression for MPHOSPH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPHOSPH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPHOSPH6 Gene

This gene is overexpressed in Lung (45.8) and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPHOSPH6 Gene



Protein tissue co-expression partners for MPHOSPH6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPHOSPH6

SOURCE GeneReport for Unigene cluster for MPHOSPH6 Gene:

Hs.344400

Evidence on tissue expression from TISSUES for MPHOSPH6 Gene

  • Muscle(4.5)
  • Nervous system(4.5)
  • Liver(4.3)
  • Blood(4.3)
  • Lung(4.3)
  • Kidney(2.7)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with MPHOSPH6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH6 Gene

Orthologs for MPHOSPH6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MPHOSPH6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MPHOSPH6 30 31
  • 98.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MPHOSPH6 30 31
  • 92.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MPHOSPH6 30 31
  • 91.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mphosph6 30
  • 83.54 (n)
Mouse
(Mus musculus)
Mammalia Mphosph6 30 17 31
  • 82.71 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MPHOSPH6 31
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MPHOSPH6 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MPHOSPH6 30 31
  • 76.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MPHOSPH6 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mphosph6 30
  • 72.12 (n)
Str.6419 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7322 30
Zebrafish
(Danio rerio)
Actinopterygii mphosph6 30 31
  • 66.04 (n)
OneToOne
Dr.15757 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11235 30
Fruit Fly
(Drosophila melanogaster)
Insecta Mpp6 31
  • 32 (a)
OneToOne
Species where no ortholog for MPHOSPH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MPHOSPH6 Gene

ENSEMBL:
Gene Tree for MPHOSPH6 (if available)
TreeFam:
Gene Tree for MPHOSPH6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPHOSPH6: view image

Paralogs for MPHOSPH6 Gene

Pseudogenes.org Pseudogenes for MPHOSPH6 Gene

genes like me logo Genes that share paralogs with MPHOSPH6: view

No data available for Paralogs for MPHOSPH6 Gene

Variants for MPHOSPH6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPHOSPH6 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
777047 Benign: not provided 82,149,368(-) T/C SYNONYMOUS_VARIANT
780163 Benign: not provided 82,148,813(-) T/C MISSENSE_VARIANT
rs2303267 - p.Ile58Val

Additional dbSNP identifiers (rs#s) for MPHOSPH6 Gene

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH6 Gene

Variant ID Type Subtype PubMed ID
dgv3050n100 CNV loss 25217958
dgv3051n100 CNV gain 25217958
dgv5251n54 CNV loss 21841781
dgv5252n54 CNV loss 21841781
dgv5253n54 CNV gain 21841781
esv3639349 CNV gain 21293372
esv3639353 CNV loss 21293372
esv3639354 CNV gain 21293372
esv3639355 CNV loss 21293372
esv7218 CNV gain 19470904
nsv1061288 CNV gain+loss 25217958
nsv1129383 OTHER inversion 24896259
nsv518129 CNV loss 19592680
nsv525467 CNV loss 19592680
nsv573367 CNV gain 21841781
nsv573371 CNV loss 21841781
nsv833302 CNV loss 17160897

Variation tolerance for MPHOSPH6 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPHOSPH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPHOSPH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH6 Gene

Disorders for MPHOSPH6 Gene

Additional Disease Information for MPHOSPH6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for MPHOSPH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH6 Gene

Publications for MPHOSPH6 Gene

  1. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. (PMID: 16396833) Schilders G … Pruijn GJ (Nucleic acids research 2005) 3 4 23
  2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N … Westendorf JM (Molecular biology of the cell 1996) 2 3 4
  3. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. (PMID: 26166824) Yoshikatsu Y … Nagahama M (Biochemical and biophysical research communications 2015) 3 4
  4. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for MPHOSPH6 Gene

Sources for MPHOSPH6 Gene