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Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine DNA Glycosylase 2 3 5
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • Mid1 3 4
  • Anpg 3 4
  • ADPG 3 4
  • AAG 3 4
  • 3 End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • DNA-3-Methyladenine Glycosylase 3
  • N-Methylpurine-DNA Glycosylase 4
  • Alkyladenine DNA Glycosylase 2
  • EC 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3
  • MDG 3

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046
  • GC16P000087
  • GC16P000097
  • GC16P000108
  • GC16P000116
  • GC16P000123
  • GC16P000129
  • GC16P000133

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Depurination. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

UniProtKB/Swiss-Prot for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Gene Wiki entry for MPG Gene

Additional gene information for MPG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPG Gene

Genomics for MPG Gene

GeneHancer (GH) Regulatory Elements for MPG Gene

Promoters and enhancers for MPG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000066 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.1 -3.5 -3505 13.6 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 RHBDF1 MPG GC16P000423 ENSG00000278995 NPRL3 LUC7L ENSG00000268836 WASH4P ENSG00000228779 HBZ
GH16I000981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12.9 +904.4 904394 1.6 ZNF493 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF213 ZNF416 KLF7 ZNF548 ENSG00000260807 LMF1 SOX8 GC16M000982 GC16P001002 GC16M000980 WDR90 CRAMP1 ENSG00000261505 UBE2I
GH16I000586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +514.1 514125 8.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAB40C GC16M000587 WDR90 ENSG00000261505 ENSG00000260051 WFIKKN1 ENSG00000260954 RHOT2 WASH4P JMJD8
GH16I000323 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +249.4 249425 5.3 PKNOX1 CLOCK ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 LUC7L WDR90 ENSG00000228779 RHOT2 UBE2I ENSG00000261505 WDR24 JMJD8 ENSG00000262528 TMEM8A
GH16I000052 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -23.4 -23358 2.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SLC30A9 SNRNP25 POLR3K WDR90 RHOT2 WASH4P AXIN1 JMJD8 WDR24 MPG ENSG00000260022
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MPG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MPG gene promoter:

Genomic Locations for MPG Gene

Genomic Locations for MPG Gene
8,847 bases
Plus strand

Genomic View for MPG Gene

Genes around MPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1.

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene


neXtProt entry for MPG Gene

Post-translational modifications for MPG Gene

  • Ubiquitination at Lys80 and Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

No data available for DME Specific Peptides for MPG Gene

Domains & Families for MPG Gene

Gene Families for MPG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MPG Gene

Suggested Antigen Peptide Sequences for MPG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA glycosylase MPG family.
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Enzyme Numbers (IUBMB) for MPG Gene

Phenotypes From GWAS Catalog for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity IEA --
GO:0003905 alkylbase DNA N-glycosylase activity IBA --
GO:0005515 protein binding IPI 18482256
GO:0008725 DNA-3-methyladenine glycosylase activity IEA --
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:

Animal Model Products

CRISPR Products

miRNA for MPG Gene

miRTarBase miRNAs that target MPG

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytoskeleton 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MPG: view

Pathways & Interactions for MPG Gene

genes like me logo Genes that share pathways with MPG: view

Pathways by source for MPG Gene

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS 10854423
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

No data available for SIGNOR curated interactions for MPG Gene

Drugs & Compounds for MPG Gene

(17) Drugs for MPG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Target Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 2906
Zinc Approved, Investigational Pharma Target 2430
Loperamide Approved Pharma 160
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0

(21) Additional Compounds for MPG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 3-Methyl-Guanine (VAN) (8CI)
  • 3-Methylguanine
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one
  • 7-Dihydro-3-methyl-2-amino-3-6H-Purin-6-one (9CI)
  • N3-Methylguanine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • 2-Amino-6-hydroxy-7-methylpurine
  • 2-Amino-7-methylhypoxanthine
  • 7-Methyl-Guanine
  • 7-Methyl-Guanine (8CI)
  • 6-Amino-7-methylpurine
  • 7-Methyl-7H-purin-6-amine
  • 7-Methyl-7H-purin-6-amine (ACD/Name 4.0)
  • 7-Methyl-7H-purin-6-ylamine (ACD/Name 4.0)
  • 7-Methyl-N7-Methyladenine
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

Unigene Clusters for MPG Gene

N-methylpurine-DNA glycosylase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPG Gene

Protein differential expression in normal tissues from HIPED for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MPG Gene

Protein tissue co-expression partners for MPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPG Gene:


SOURCE GeneReport for Unigene cluster for MPG Gene:


Evidence on tissue expression from TISSUES for MPG Gene

  • Liver(4.4)
  • Pancreas(4.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MPG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MPG 33 34
  • 82.73 (n)
(Pan troglodytes)
Mammalia MPG 34
  • 82 (a)
(Bos Taurus)
Mammalia MPG 33 34
  • 80.75 (n)
(Mus musculus)
Mammalia Mpg 33 16 34
  • 79.36 (n)
(Rattus norvegicus)
Mammalia Mpg 33
  • 77.08 (n)
(Monodelphis domestica)
Mammalia MPG 34
  • 65 (a)
(Gallus gallus)
Aves MPG 33 34
  • 63.76 (n)
(Anolis carolinensis)
Reptilia MPG 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549932 33
  • 58.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 33
(Danio rerio)
Actinopterygii mpg 33 34
  • 59.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for MPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MPG Gene

Gene Tree for MPG (if available)
Gene Tree for MPG (if available)

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations from dbSNP and Humsavar for MPG Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000087335 -- 75,536(+) G/A/C upstream_transcript_variant
rs1000251699 -- 82,400(+) A/G intron_variant
rs1001042935 -- 78,998(+) T/C intron_variant
rs1001470245 -- 79,567(+) G/C coding_sequence_variant, missense_variant
rs1001673947 -- 78,709(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv1240373 CNV deletion 17803354
esv1393228 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv26636 CNV gain+loss 19812545
esv2760065 CNV gain 17122850
esv32706 CNV loss 17666407
esv3637536 CNV loss 21293372
esv3637537 CNV gain 21293372
esv996836 CNV insertion 20482838
nsv1044142 CNV gain 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv570924 CNV loss 21841781
nsv820705 CNV duplication 20802225
nsv9317 CNV gain 18304495

Variation tolerance for MPG Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

Additional Disease Information for MPG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D … Mitra S (The Journal of biological chemistry 1991) 2 3 4 22 58
  2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PMID: 14555760) Watanabe S … Nakao M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 58
  3. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PMID: 9790531) Lau AY … Ellenberger T (Cell 1998) 3 4 22 58
  4. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PMID: 8318735) Kielman MF … Bernini LF (Mammalian genome : official journal of the International Mammalian Genome Society 1993) 3 4 22 58
  5. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PMID: 8475094) Vickers MA … Higgs DR (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58

Products for MPG Gene

  • Addgene plasmids for MPG

Sources for MPG Gene

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