Aliases for MPG Gene

Aliases for MPG Gene

  • N-Methylpurine DNA Glycosylase 2 3 5
  • DNA-3-Methyladenine Glycosylase 3 4
  • 3-Methyladenine DNA Glycosidase 3 4
  • 3-Alkyladenine DNA Glycosylase 3 4
  • ADPG 3 4
  • AAG 3 4
  • MDG 2 3
  • 3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p 3
  • CRA36.1 (3-Methyl-Adenine DNA Glycosylase) 3
  • N-Methylpurine-DNA Glycosylase, MPG 3
  • Proliferation-Inducing Protein 11 3
  • Proliferation-Inducing Protein 16 3
  • N-Methylpurine-DNA Glycosylase 4
  • Alkyladenine DNA Glycosylase 2
  • EC 3.2.2.21 4
  • CRA36.1 3
  • PIG11 3
  • PIG16 3
  • APNG 3
  • Mid1 3
  • Anpg 3
  • ANPG 4
  • MID1 4
  • MPG 5

External Ids for MPG Gene

Previous GeneCards Identifiers for MPG Gene

  • GC16P000148
  • GC16P000067
  • GC16P000069
  • GC16P000068
  • GC16P000127
  • GC16P000046
  • GC16P000087
  • GC16P000097
  • GC16P000448
  • GC16P000528
  • GC16P000600
  • GC16P001209
  • GC16P000108
  • GC16P000116
  • GC16P000123
  • GC16P000129
  • GC16P000133
  • GC16P000193
  • GC16P000429
  • GC16P000423
  • GC16P001366
  • GC16P001553

Summaries for MPG Gene

GeneCards Summary for MPG Gene

MPG (N-Methylpurine DNA Glycosylase) is a Protein Coding gene. Diseases associated with MPG include Familial Adenomatous Polyposis 2. Among its related pathways are DNA Double-Strand Break Repair and Busulfan Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and DNA-3-methyladenine glycosylase activity.

UniProtKB/Swiss-Prot Summary for MPG Gene

  • Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Gene Wiki entry for MPG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPG Gene

Genomics for MPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MPG

Top Transcription factor binding sites by QIAGEN in the MPG gene promoter:
  • STAT3

Genomic Locations for MPG Gene

Latest Assembly
chr16:77,007-85,851
(GRCh38/hg38)
Size:
8,845 bases
Orientation:
Plus strand

Previous Assembly
chr16:127,006-135,845
(GRCh37/hg19 by Entrez Gene)
Size:
8,840 bases
Orientation:
Plus strand

chr16:127,006-135,852
(GRCh37/hg19 by Ensembl)
Size:
8,847 bases
Orientation:
Plus strand

Genomic View for MPG Gene

Genes around MPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPG Gene

Proteins for MPG Gene

  • Protein details for MPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29372-3MG_HUMAN
    Recommended name:
    DNA-3-methyladenine glycosylase
    Protein Accession:
    P29372
    Secondary Accessions:
    • G5E9E2
    • Q13770
    • Q15275
    • Q15961
    • Q5J9I4
    • Q96BZ6
    • Q96S33
    • Q9NNX5

    Protein attributes for MPG Gene

    Size:
    298 amino acids
    Molecular mass:
    32869 Da
    Quaternary structure:
    • Binds MBD1. Binds SSBP1.

    Three dimensional structures from OCA and Proteopedia for MPG Gene

    Alternative splice isoforms for MPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPG Gene

Post-translational modifications for MPG Gene

  • Ubiquitination at Lys80 and Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for MPG Gene

No data available for DME Specific Peptides for MPG Gene

Domains & Families for MPG Gene

Gene Families for MPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MPG Gene

InterPro:
Blocks:
  • Methylpurine-DNA glycosylase (MPG)

Suggested Antigen Peptide Sequences for MPG Gene

GenScript: Design optimal peptide antigens:
  • N-methylpurine-DNA glycosylase (3MG_HUMAN)
  • N-methylpurine-DNA glycosylase, isoform CRA_c (Q1W6H1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P29372

UniProtKB/Swiss-Prot:

3MG_HUMAN :
  • Belongs to the DNA glycosylase MPG family.
Family:
  • Belongs to the DNA glycosylase MPG family.
genes like me logo Genes that share domains with MPG: view

Function for MPG Gene

Molecular function for MPG Gene

UniProtKB/Swiss-Prot Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.
GENATLAS Biochemistry:
DNA glycosylase,3-methyl-adenine,base excision repair

Enzyme Numbers (IUBMB) for MPG Gene

Phenotypes From GWAS Catalog for MPG Gene

Gene Ontology (GO) - Molecular Function for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding TAS 10854423
GO:0003824 catalytic activity IEA --
GO:0003905 alkylbase DNA N-glycosylase activity IBA 21873635
GO:0005515 protein binding IPI 18482256
genes like me logo Genes that share ontologies with MPG: view
genes like me logo Genes that share phenotypes with MPG: view

Animal Models for MPG Gene

MGI Knock Outs for MPG:
  • Mpg Mpg<tm1a(EUCOMM)Wtsi>
  • Mpg Mpg<tm1Lds>
  • Mpg Mpg<tm1Rhe>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MPG Gene

Localization for MPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPG Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPG gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MPG: view

Pathways & Interactions for MPG Gene

genes like me logo Genes that share pathways with MPG: view

Pathways by source for MPG Gene

Gene Ontology (GO) - Biological Process for MPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS,IBA 21873635
GO:0006307 DNA dealkylation involved in DNA repair TAS 1645538
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045007 depurination TAS --
genes like me logo Genes that share ontologies with MPG: view

No data available for SIGNOR curated interactions for MPG Gene

Drugs & Compounds for MPG Gene

(22) Drugs for MPG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Target Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3624
Zinc Approved, Investigational Pharma Target 1706
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target, cofactor 0
Zinc sulfate, unspecified form Approved, Experimental Pharma Target, cofactor 0

(19) Additional Compounds for MPG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Methylguanine
  • N(3)-Methylguanine
  • 2-Amino-3,7-dihydro-3-methyl-6H-purin-6-one
  • 3-Methyl-guanine
  • 7-Dihydro-3-methyl-2-amino-3-6H-purin-6-one
  • 7-Dihydro-3-methyl-2-amino-3-6H-purin-6-one (9ci)
2958-98-7
7-Methylguanine
  • 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
  • 2-Amino-7-methylhypoxanthine
  • N(7)-Methylguanine
  • 2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-one
  • 2-Amino-6-hydroxy-7-methylpurine
578-76-7
7-Methyladenine
  • 6-Amino-7-methylpurine
  • 7-Methyl-7H-purin-6-amine
  • 7-Methyl-7H-purin-6-amine (acd/name 4.0)
  • 7-Methyl-7H-purin-6-ylamine (acd/name 4.0)
  • 7-Methyl-N7-methyladenine
935-69-3
genes like me logo Genes that share compounds with MPG: view

Transcripts for MPG Gene

mRNA/cDNA for MPG Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPG

Alternative Splicing Database (ASD) splice patterns (SP) for MPG Gene

No ASD Table

Relevant External Links for MPG Gene

GeneLoc Exon Structure for
MPG

Expression for MPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MPG Gene

Protein differential expression in normal tissues from HIPED for MPG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.3), Blymphocyte (7.0), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPG Gene



Protein tissue co-expression partners for MPG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MPG

SOURCE GeneReport for Unigene cluster for MPG Gene:

Hs.459596

Evidence on tissue expression from TISSUES for MPG Gene

  • Liver(4.4)
  • Pancreas(4.4)
  • Skin(2.5)
  • Intestine(2.2)
  • Nervous system(2.2)
  • Blood(2.1)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MPG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPG Gene

Orthologs for MPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MPG Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia MPG 29 30
  • 82.73 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia MPG 30
  • 82 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MPG 29 30
  • 80.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mpg 29 16 30
  • 79.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mpg 29
  • 77.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia MPG 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MPG 29 30
  • 63.76 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MPG 30
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC549932 29
  • 58.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16168 29
Zebrafish
(Danio rerio)
Actinopterygii mpg 29 30
  • 59.76 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToOne
Species where no ortholog for MPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MPG Gene

ENSEMBL:
Gene Tree for MPG (if available)
TreeFam:
Gene Tree for MPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPG: view image
Alliance of Genome Resources:
Additional Orthologs for MPG

Paralogs for MPG Gene

No data available for Paralogs for MPG Gene

Variants for MPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MPG Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2266605 Benign: not provided 79,493(+) C/T
NM_001015052.3(MPG):c.93C>T (p.Asp31=)
SYNONYMOUS
rs2266606 Benign: not provided 79,589(+) G/A
NM_001015052.3(MPG):c.189G>A (p.Pro63=)
SYNONYMOUS
rs2234949 -- p.Ala298Ser
rs2266607 -- p.Tyr71His
rs2308312 -- p.Arg141Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MPG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MPG Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv1240373 CNV deletion 17803354
esv1393228 CNV insertion 17803354
esv2422427 CNV duplication 17116639
esv26636 CNV gain+loss 19812545
esv2760065 CNV gain 17122850
esv32706 CNV loss 17666407
esv3637536 CNV loss 21293372
esv3637537 CNV gain 21293372
esv996836 CNV insertion 20482838
nsv1044142 CNV gain 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv570924 CNV loss 21841781
nsv820705 CNV duplication 20802225
nsv9317 CNV gain 18304495

Variation tolerance for MPG Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPG Gene

Human Gene Mutation Database (HGMD)
MPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPG
Leiden Open Variation Database (LOVD)
MPG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPG Gene

Disorders for MPG Gene

MalaCards: The human disease database

(1) MalaCards diseases for MPG Gene - From: COP

Disorder Aliases PubMed IDs
familial adenomatous polyposis 2
  • fap2
- elite association - COSMIC cancer census association via MalaCards
Search MPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MPG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MPG Gene

Publications for MPG Gene

  1. Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase. (PMID: 1874728) Chakravarti D … Mitra S (The Journal of biological chemistry 1991) 2 3 4 22
  2. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. (PMID: 14555760) Watanabe S … Nakao M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22
  3. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision. (PMID: 9790531) Lau AY … Ellenberger T (Cell 1998) 3 4 22
  4. Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (PMID: 8475094) Vickers MA … Higgs DR (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22
  5. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. (PMID: 8318735) Kielman MF … Bernini LF (Mammalian genome : official journal of the International Mammalian Genome Society 1993) 3 4 22

Products for MPG Gene

Sources for MPG Gene