Aliases for MPC2 Gene

Aliases for MPC2 Gene

  • Mitochondrial Pyruvate Carrier 2 2 3 4 5
  • Brain Protein 44 2 3 4
  • BRP44 3 4
  • SLC54A2 3

External Ids for MPC2 Gene

Previous HGNC Symbols for MPC2 Gene

  • BRP44

Previous GeneCards Identifiers for MPC2 Gene

  • GC01M167886

Summaries for MPC2 Gene

GeneCards Summary for MPC2 Gene

MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Glucose metabolism. Gene Ontology (GO) annotations related to this gene include pyruvate transmembrane transporter activity. An important paralog of this gene is MPC1.

UniProtKB/Swiss-Prot Summary for MPC2 Gene

Gene Wiki entry for MPC2 Gene

Additional gene information for MPC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MPC2 Gene

Genomics for MPC2 Gene

GeneHancer (GH) Regulatory Elements for MPC2 Gene

Promoters and enhancers for MPC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 759.8 +0.6 562 5.8 SIN3A SP1 ZBTB40 SREBF1 SIX5 LCORL FOXA1 RBPJ SMARCE1 POLR2A MPC2 DCAF6 ADCY10 POU2F1 MPZL1 DPT TIPRL CREG1
GH01J167904 Enhancer 0.9 Ensembl ENCODE 20.2 +31.3 31271 4 SMARCE1 HLF DACH1 SMARCA4 IKZF1 DPF2 CEBPA FOXA2 PKNOX1 ZNF316 MPC2 DCAF6 ENSG00000232194 ENSG00000250762 ADCY10 piR-30876-008 lnc-MPC2-2 RF00017-386
GH01J168134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 -199.1 -199129 3.6 L3MBTL2 ZFX MLLT1 SP7 ZSCAN21 PRDM1 IKZF1 GLIS2 POLR2A ZBTB8A GPR161 lnc-MPC2-1 TIPRL SFT2D2 MPC2
GH01J167925 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.7 +8.6 8599 5.5 CTCF FOXA1 SMARCE1 CTBP1 NR2F6 ZNF217 MIXL1 ZNF362 CC2D1A L3MBTL2 piR-50443-029 GCSHP5 MPC2 MIR378G-001
GH01J168177 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.2 -242.3 -242252 3 ZBTB40 CTCF SIX5 RBPJ SMARCE1 POLR2A ATF1 CREB1 HCFC1 ZNF362 TIPRL POU2F1 MPZL1 ENSG00000272205 GPR161 MPC2 HSALNG0008270
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MPC2 Gene

Genomic Locations for MPC2 Gene
chr1:167,916,675-167,937,072
(GRCh38/hg38)
Size:
20,398 bases
Orientation:
Minus strand
chr1:167,885,913-167,906,307
(GRCh37/hg19)
Size:
20,395 bases
Orientation:
Minus strand

Genomic View for MPC2 Gene

Genes around MPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPC2 Gene

Proteins for MPC2 Gene

  • Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95563-MPC2_HUMAN
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Protein Accession:
    O95563
    Secondary Accessions:
    • A8K261
    • Q3SXR6
    • Q6FIF3

    Protein attributes for MPC2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14279 Da
    Quaternary structure:
    • The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

neXtProt entry for MPC2 Gene

Post-translational modifications for MPC2 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for MPC2 Gene

No data available for DME Specific Peptides for MPC2 Gene

Domains & Families for MPC2 Gene

Gene Families for MPC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for MPC2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MPC2 Gene

GenScript: Design optimal peptide antigens:
  • Brain protein 44 (BR44_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95563

UniProtKB/Swiss-Prot:

MPC2_HUMAN :
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Family:
  • Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
genes like me logo Genes that share domains with MPC2: view

Function for MPC2 Gene

Molecular function for MPC2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the uptake of pyruvate into mitochondria.

Phenotypes From GWAS Catalog for MPC2 Gene

Gene Ontology (GO) - Molecular Function for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050833 pyruvate transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with MPC2: view
genes like me logo Genes that share phenotypes with MPC2: view

Animal Model Products

CRISPR Products

miRNA for MPC2 Gene

miRTarBase miRNAs that target MPC2

Clone Products

  • Addgene plasmids for MPC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPC2 Gene

Localization for MPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPC2 gene
Compartment Confidence
mitochondrion 5
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MPC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MPC2 Gene

Pathways & Interactions for MPC2 Gene

genes like me logo Genes that share pathways with MPC2: view

Pathways by source for MPC2 Gene

Gene Ontology (GO) - Biological Process for MPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006850 mitochondrial pyruvate transmembrane transport IEA,IBA 21873635
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate IEA --
genes like me logo Genes that share ontologies with MPC2: view

No data available for SIGNOR curated interactions for MPC2 Gene

Drugs & Compounds for MPC2 Gene

(1) Drugs for MPC2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UK 5099 Pharma MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport 0

(1) ApexBio Compounds for MPC2 Gene

Compound Action Cas Number
UK-5099 MCTs and MPC inhibitor 56396-35-1
genes like me logo Genes that share compounds with MPC2: view

Drug Products

Transcripts for MPC2 Gene

mRNA/cDNA for MPC2 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for MPC2

Alternative Splicing Database (ASD) splice patterns (SP) for MPC2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for MPC2 Gene

GeneLoc Exon Structure for
MPC2
ECgene alternative splicing isoforms for
MPC2

Expression for MPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MPC2 Gene

This gene is overexpressed in Nasal epithelium (52.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPC2 Gene



Protein tissue co-expression partners for MPC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPC2 Gene:

MPC2

SOURCE GeneReport for Unigene cluster for MPC2 Gene:

Hs.517768

Evidence on tissue expression from TISSUES for MPC2 Gene

  • Nervous system(4.7)
  • Liver(2.9)
  • Pancreas(2.8)
  • Kidney(2.2)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MPC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPC2 Gene

Orthologs for MPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRP44 33 32
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MPC2 33
  • 96 (a)
OneToOne
BRP44 32
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia MPC2 33 32
  • 92.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPC2 33
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpc2 17 33 32
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia MPC2 33
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mpc2 32
  • 88.53 (n)
chicken
(Gallus gallus)
Aves BRP44 33 32
  • 76.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MPC2 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mpc2 32
  • 72.95 (n)
Str.6574 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.15887 32
zebrafish
(Danio rerio)
Actinopterygii mpc2 33 32
  • 71.51 (n)
OneToMany
MPC2 (2 of 2) 33
  • 62 (a)
OneToMany
wufb22g07 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8373 32
fruit fly
(Drosophila melanogaster)
Insecta CG9399 33 32
  • 56.48 (n)
OneToMany
CG9396 33
  • 41 (a)
OneToMany
CG32832 33
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.3 33
  • 46 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05500g 32
  • 58.78 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL210C 32
  • 50.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
  • 35 (a)
OneToMany
FMP43 33
  • 34 (a)
OneToMany
MPC3 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22310 32
  • 55.56 (n)
rice
(Oryza sativa)
Liliopsida Os07g0449100 32
  • 56.3 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.09 32
  • 57.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1905 33
  • 52 (a)
OneToMany
CSA.932 33
  • 43 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03155 32
  • 51.2 (n)
Species where no ortholog for MPC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPC2 Gene

ENSEMBL:
Gene Tree for MPC2 (if available)
TreeFam:
Gene Tree for MPC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MPC2: view image

Paralogs for MPC2 Gene

Paralogs for MPC2 Gene

(1) SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:

  • MPC2_HUMAN
  • Q5R3B4_HUMAN
genes like me logo Genes that share paralogs with MPC2: view

Variants for MPC2 Gene

Sequence variations from dbSNP and Humsavar for MPC2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000063971 -- 167,933,099(-) A/G intron_variant
rs1000325636 -- 167,930,011(-) T/A intron_variant
rs1000331734 -- 167,933,456(-) C/A/T intron_variant
rs1000437960 -- 167,923,016(-) C/T intron_variant
rs1000470560 -- 167,918,801(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MPC2 Gene

Variant ID Type Subtype PubMed ID
esv2572362 CNV deletion 19546169
esv32660 CNV loss 17666407
nsv1078878 OTHER inversion 25765185

Variation tolerance for MPC2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MPC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPC2 Gene

Disorders for MPC2 Gene

Additional Disease Information for MPC2

No disorders were found for MPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPC2 Gene

Publications for MPC2 Gene

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker DK … Rutter J (Science (New York, N.Y.) 2012) 2 3 4 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 56
  5. Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou AP … Sutcliffe JG (Molecular and cellular biology 1986) 2 3 56

Products for MPC2 Gene

Sources for MPC2 Gene