Aliases for MPC2 Gene
Aliases for MPC2 Gene
External Ids for MPC2 Gene
- HGNC: 24515
- Entrez Gene: 25874
- Ensembl: ENSG00000143158
- OMIM: 614737
- UniProtKB: O95563
Previous HGNC Symbols for MPC2 Gene
- BRP44
Summaries for MPC2 Gene
GeneCards Summary for MPC2 Gene
MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Among its related pathways are Metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include pyruvate transmembrane transporter activity.
UniProtKB/Swiss-Prot for MPC2 Gene
-
Mediates the uptake of pyruvate into mitochondria.
Additional gene information for MPC2 Gene
- Monarch Initiative
- Search for MPC2 at DataMed
- Search for MPC2 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPC2 Gene
Genomics for MPC2 Gene
GeneHancer (GH) Regulatory Elements for MPC2 Gene
Promoters and enhancers for MPC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MPC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MPC2 Gene
Genomic Locations for MPC2 Gene
- chr1:167,916,675-167,937,069
- (GRCh38/hg38)
- Size:
- 20,395 bases
- Orientation:
- Minus strand
- chr1:167,885,913-167,906,307
- (GRCh37/hg19)
- Size:
- 20,395 bases
- Orientation:
- Minus strand
Genomic View for MPC2 Gene
Genes around MPC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q24.2 by Entrez Gene
- 1q24.2 by HGNC
- 1q24.2 by Ensembl
MPC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MPC2 Gene
Proteins for MPC2 Gene
-
Protein details for MPC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95563-MPC2_HUMAN
- Recommended name:
- Mitochondrial pyruvate carrier 2
- Protein Accession:
- O95563
- A8K261
- Q3SXR6
- Q6FIF3
Protein attributes for MPC2 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14279 Da
- Quaternary structure:
-
- The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.
Protein Expression for MPC2 Gene
Post-translational modifications for MPC2 Gene
Other Protein References for MPC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MPC2
- Novus Biologicals Antibodies for MPC2
- Invitrogen Antibodies for MPC2 (AFLGC-MPC2)
- GeneTex MPC2 Antibody for MPC2
Protein Products
-
OriGene Purified Proteins for MPC2
- Search Origene for MassSpec and Protein Over-expression Lysates for MPC2
- Origene Custom Protein Services for MPC2
- antibodies-online: Search results for 4 available MPC2 Proteins ranked by validation data
- Compare Top MPC2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for MPC2
Assay Products
- antibodies-online: Search results for available MPC2 related products ranked by validation data
No data available for DME Specific Peptides for MPC2 Gene
Domains & Families for MPC2 Gene
Gene Families for MPC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for MPC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MPC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95563UniProtKB/Swiss-Prot:
MPC2_HUMAN :- Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
- Family:
-
- Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
Function for MPC2 Gene
Molecular function for MPC2 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the uptake of pyruvate into mitochondria.
Phenotypes From GWAS Catalog for MPC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0050833 | pyruvate transmembrane transporter activity | IBA | -- |
Phenotypes for MPC2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MPC2
-
CRISPR Products
-
OriGene CRISPR knockouts for MPC2
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- genomics-online: gRNA clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- Applied Biological Materials CRISPR for MPC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPC2
- GenScript: Design CRISPR guide RNA sequences for MPC2
miRNA for MPC2 Gene
- miRTarBase miRNAs that target MPC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPC2
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- Overview of 111 available MPC2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MPC2
- Addgene plasmids for MPC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPC2
- Applied Biological Materials Clones for MPC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MPC2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPC2 Gene
Localization for MPC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MPC2 Gene
- Mitochondrion inner membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005739 | mitochondrion | IEA,IDA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MPC2 Gene
Pathways & Interactions for MPC2 Gene
Pathways by source for MPC2 Gene
1 BioSystems pathway for MPC2 Gene
4 Reactome pathways for MPC2 Gene
1 Cell Signaling Technology pathway for MPC2 Gene
Interacting Proteins for MPC2 Gene
GPS-Prot Interaction Network for MPC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006850 | mitochondrial pyruvate transmembrane transport | IEA | -- |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | IEA | -- |
| GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate | IEA | -- |
No data available for SIGNOR curated interactions for MPC2 Gene
Drugs & Compounds for MPC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| UK 5099 | Pharma | MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport | 0 |
Drug Products
Transcripts for MPC2 Gene
mRNA/cDNA for MPC2 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (314) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000367846 2177 bps (uc001ges.4)
- ENST00000271373 798 bps (uc001get.4)
- ENST00000458574 645 bps (uc057ncl.1)
Unigene Clusters for MPC2 Gene
- Mitochondrial pyruvate carrier 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MPC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPC2
- genomics-online: gRNA clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- Applied Biological Materials CRISPR for MPC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MPC2
- GenScript: Design CRISPR guide RNA sequences for MPC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MPC2
- Browse OriGene Inhibitory RNA Products For MPC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPC2
- genomics-online: shRNA clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MPC2
- Addgene plasmids for MPC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPC2
- Applied Biological Materials Clones for MPC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - |
Expression for MPC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
This gene is overexpressed in Nasal epithelium (52.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPC2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MPC2 Gene:
MPC2SOURCE GeneReport for Unigene cluster for MPC2 Gene:
Hs.517768Evidence on tissue expression from TISSUES for MPC2 Gene
- Nervous system(4.7)
- Liver(2.9)
- Pancreas(2.8)
- Kidney(2.2)
- Muscle(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for MPC2
-
OriGene qPCR primer pairs and template standards for MPC2
- genomics-online: primer clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPC2 Gene
Orthologs for MPC2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BRP44 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MPC2 34 |
|
OneToOne | |
| BRP44 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | MPC2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MPC2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mpc2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MPC2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mpc2 33 |
|
||
| chicken (Gallus gallus) |
Aves | BRP44 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MPC2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mpc2 33 |
|
||
| Str.6574 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15887 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mpc2 34 33 |
|
OneToMany | |
| MPC2 (2 of 2) 34 |
|
OneToMany | |||
| wufb22g07 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8373 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9399 34 33 |
|
OneToMany | |
| CG9396 34 |
|
OneToMany | |||
| CG32832 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F53F10.3 34 |
|
OneToOne | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A05500g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL210C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 34 |
|
OneToMany | |
| FMP43 34 |
|
OneToMany | |||
| MPC3 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G22310 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0449100 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC24B11.09 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1905 34 |
|
OneToMany | |
| CSA.932 34 |
|
OneToMany | |||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03155 33 |
|
- Species where no ortholog for MPC2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MPC2 Gene
- ENSEMBL:
- Gene Tree for MPC2 (if available)
- TreeFam:
- Gene Tree for MPC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MPC2: view image
Paralogs for MPC2 Gene
(1) SIMAP similar genes for MPC2 Gene using alignment to 2 proteins:
- MPC2_HUMAN
- Q5R3B4_HUMAN
No data available for Paralogs for MPC2 Gene
Variants for MPC2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000063971 | -- | 167,933,099(-) | A/G | intron_variant | |
| rs1000325636 | -- | 167,930,011(-) | T/A | intron_variant | |
| rs1000331734 | -- | 167,933,456(-) | C/A | intron_variant | |
| rs1000437960 | -- | 167,923,016(-) | C/T | intron_variant | |
| rs1000470560 | -- | 167,918,801(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2572362 | CNV | deletion | 19546169 |
| esv32660 | CNV | loss | 17666407 |
| nsv1078878 | OTHER | inversion | 25765185 |
Residual Variation Intolerance Score:
49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.61;
45.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MPC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MPC2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPC2 Gene
Disorders for MPC2 Gene
Additional Disease Information for MPC2
No disorders were found for MPC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPC2 Gene
Publications for MPC2 Gene
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. (PMID: 22628558) Bricker DK … Rutter J (Science (New York, N.Y.) 2012) 2 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
- Structural characterization of a heterogeneous family of rat brain mRNAs. (PMID: 3022128) Tsou AP … Sutcliffe JG (Molecular and cellular biology 1986) 2 3 58
Products for MPC2 Gene
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- Custom Antibody ServicesOriGene Antibodies for MPC2
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- Invitrogen Antibodies for MPC2 (AFLGC-MPC2)
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- Addgene plasmids for MPC2
- antibodies-online: Search results for 48 available MPC2 Antibodies ranked by validation data
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- antibodies-online: Search results for available MPC2 related products ranked by validation data
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- Quality Products:
- GeneTex MPC2 Antibody for MPC2
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- genomics-online: cdna clones - Search results for 111 available MPC2 gene related products
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- orf clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- genomics-online: gRNA clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- genomics-online: primer clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- genomics-online: shRNA clones - Search results for 111 available MPC2 gene related products
- Overview of 111 available MPC2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MPC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MPC2
- GeneCopoeia miRNA 3'UTR Target clone products for MPC2
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Sources for MPC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
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