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MPC2 (Mitochondrial Pyruvate Carrier 2) is a Protein Coding gene. Diseases associated with MPC2 include Colon Mucinous Adenocarcinoma. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include pyruvate transmembrane transporter activity. An important paralog of this gene is MPC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32296183 |
GO:0042802 | identical protein binding | IPI | 32296183 |
GO:0050833 | pyruvate transmembrane transporter activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005743 | mitochondrial inner membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006850 | mitochondrial pyruvate transmembrane transport | IEA,IBA | 21873635 |
GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | IEA | -- |
GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
UK 5099 | Pharma | MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport | 0 |
Compound | Action | Cas Number |
---|---|---|
UK-5099 | MCTs and MPC inhibitor | 56396-35-1 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BRP44 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MPC2 31 |
|
OneToOne | |
BRP44 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | MPC2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MPC2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mpc2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MPC2 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mpc2 30 |
|
||
Chicken (Gallus gallus) |
Aves | BRP44 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MPC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mpc2 30 |
|
||
Str.6574 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15887 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mpc2 30 31 |
|
OneToMany | |
MPC2 (2 of 2) 31 |
|
OneToMany | |||
wufb22g07 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8373 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9399 30 31 |
|
OneToMany | |
CG9396 31 |
|
OneToMany | |||
CG32832 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F53F10.3 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A05500g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL210C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToMany | |
FMP43 31 |
|
OneToMany | |||
MPC3 33 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G22310 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os07g0449100 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC24B11.09 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1905 31 |
|
OneToMany | |
CSA.932 31 |
|
OneToMany | |||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03155 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2572362 | CNV | deletion | 19546169 |
esv32660 | CNV | loss | 17666407 |
nsv1078878 | OTHER | inversion | 25765185 |
Disorder | Aliases | PubMed IDs |
---|---|---|
colon mucinous adenocarcinoma |
|
|