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Aliases for MOXD2P Gene

Aliases for MOXD2P Gene

  • Monooxygenase, DBH-Like 2, Pseudogene 2 3 5
  • MOXD2 3 4
  • DBH-Like Monooxygenase Protein 2 Pseudogene 4
  • Dopamine-Beta-Hydroxylase-Like Pseudogene 3
  • Monooxygenase, DBH-Like 2 Pseudogene 2
  • DBH-Like Monooxygenase Protein 2 3
  • EC 1.14.17.- 4

External Ids for MOXD2P Gene

Previous HGNC Symbols for MOXD2P Gene

  • MOXD2

Previous GeneCards Identifiers for MOXD2P Gene

  • GC07M141942

Summaries for MOXD2P Gene

GeneCards Summary for MOXD2P Gene

MOXD2P (Monooxygenase, DBH-Like 2, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include copper ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen.

Additional gene information for MOXD2P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOXD2P Gene

Genomics for MOXD2P Gene

GeneHancer (GH) Regulatory Elements for MOXD2P Gene

Promoters and enhancers for MOXD2P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I142150 Enhancer 0.7 FANTOM5 ENCODE 0.2 +95.2 95202 3.4 CTCF ZNF316 MAFG MAFK EMSY RAD21 WEE2 TAS2R4 OR9A4 TAS2R38 TAS2R5 MGAM2 MOXD2P
GH07I142110 Promoter/Enhancer 1 EPDnew ENCODE 0.1 +134.8 134810 2.6 CTCF ZSCAN4 NFE2 REST MGAM2 MOXD2P
GH07I142138 Enhancer 0.4 ENCODE 0.1 +107.1 107087 3.2 RXRA MAX HNF4A EPHB6 MGAM2 MOXD2P
GH07I142119 Enhancer 0.4 ENCODE 0.1 +126.4 126355 1.7 BACH1 FOS MGAM2 MOXD2P
GH07I142125 Enhancer 0.3 ENCODE 0.1 +121.3 121299 1.2 POLR2A MGAM2 MOXD2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOXD2P on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOXD2P Gene

Genomic Locations for MOXD2P Gene
chr7:142,240,737-142,247,067
(GRCh38/hg38)
Size:
6,331 bases
Orientation:
Minus strand
chr7:141,940,556-141,946,886
(GRCh37/hg19)

Genomic View for MOXD2P Gene

Genes around MOXD2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOXD2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOXD2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD2P Gene

Proteins for MOXD2P Gene

  • Protein details for MOXD2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHM9-MOXD2_HUMAN
    Recommended name:
    Putative DBH-like monooxygenase protein 2
    Protein Accession:
    A6NHM9

    Protein attributes for MOXD2P Gene

    Size:
    499 amino acids
    Molecular mass:
    56320 Da
    Cofactor:
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Quaternary structure:
    No Data Available

neXtProt entry for MOXD2P Gene

Post-translational modifications for MOXD2P Gene

  • Glycosylation at Asn236, Asn250, Asn404, and isoforms=476

No data available for DME Specific Peptides for MOXD2P Gene

Domains & Families for MOXD2P Gene

Suggested Antigen Peptide Sequences for MOXD2P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHM9

UniProtKB/Swiss-Prot:

MOXD2_HUMAN :
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
Family:
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
genes like me logo Genes that share domains with MOXD2P: view

No data available for Gene Families for MOXD2P Gene

Function for MOXD2P Gene

Enzyme Numbers (IUBMB) for MOXD2P Gene

Gene Ontology (GO) - Molecular Function for MOXD2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004500 dopamine beta-monooxygenase activity IBA --
GO:0005507 copper ion binding IBA --
genes like me logo Genes that share ontologies with MOXD2P: view

Animal Model Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOXD2P Gene

Localization for MOXD2P Gene

Gene Ontology (GO) - Cellular Components for MOXD2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0030667 secretory granule membrane IBA --
genes like me logo Genes that share ontologies with MOXD2P: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MOXD2P Gene

Pathways & Interactions for MOXD2P Gene

SuperPathways for MOXD2P Gene

No Data Available

Interacting Proteins for MOXD2P Gene

Gene Ontology (GO) - Biological Process for MOXD2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006589 octopamine biosynthetic process IBA --
GO:0042420 dopamine catabolic process IBA --
GO:0042421 norepinephrine biosynthetic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MOXD2P: view

No data available for Pathways by source and SIGNOR curated interactions for MOXD2P Gene

Drugs & Compounds for MOXD2P Gene

(2) Drugs for MOXD2P Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 202
Nepicastat (SYN-117) HCl Pharma Dopamine-β-hydroxylase inhibitor 0

(1) ApexBio Compounds for MOXD2P Gene

Compound Action Cas Number
Nepicastat (SYN-117) HCl Dopamine-β-hydroxylase inhibitor 170151-24-3
genes like me logo Genes that share compounds with MOXD2P: view

Drug Products

Transcripts for MOXD2P Gene

mRNA/cDNA for MOXD2P Gene

(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOXD2P Gene

Monooxygenase, DBH-like 2, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD2P Gene

No ASD Table

Relevant External Links for MOXD2P Gene

GeneLoc Exon Structure for
MOXD2P
ECgene alternative splicing isoforms for
MOXD2P

Expression for MOXD2P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOXD2P Gene

mRNA differential expression in normal tissues according to GTEx for MOXD2P Gene

This gene is overexpressed in Testis (x34.6) and Whole Blood (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of MOXD2P Gene:

MOXD2P

SOURCE GeneReport for Unigene cluster for MOXD2P Gene:

Hs.641504
genes like me logo Genes that share expression patterns with MOXD2P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOXD2P Gene

Orthologs for MOXD2P Gene

Evolution for MOXD2P Gene

ENSEMBL:
Gene Tree for MOXD2P (if available)
TreeFam:
Gene Tree for MOXD2P (if available)

No data available for Orthologs for MOXD2P Gene

Paralogs for MOXD2P Gene

(2) SIMAP similar genes for MOXD2P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOXD2P: view

No data available for Paralogs for MOXD2P Gene

Variants for MOXD2P Gene

Sequence variations from dbSNP and Humsavar for MOXD2P Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000248519 -- 142,246,467(-) T/G intron_variant
rs1001026126 -- 142,243,042(-) C/T intron_variant
rs1001035242 -- 142,248,263(-) C/A/G upstream_transcript_variant
rs1001409390 -- 142,246,592(-) T/A intron_variant
rs1001419921 -- 142,241,588(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOXD2P Gene

Variant ID Type Subtype PubMed ID
nsv608591 CNV gain 21841781
nsv465131 CNV loss 19166990
nsv1035111 CNV gain 25217958
nsv1018286 CNV gain 25217958
esv33962 CNV gain+loss 17666407

Additional Variant Information for MOXD2P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOXD2P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MOXD2P Gene

Disorders for MOXD2P Gene

Additional Disease Information for MOXD2P

No disorders were found for MOXD2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOXD2P Gene

Publications for MOXD2P Gene

  1. Inactivation of MOXD2 and S100A15A by exon deletion during human evolution. (PMID: 17642472) Hahn Y … Lee B (Molecular biology and evolution 2007) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. (PMID: 19380806) Carpenter AC … Bassing CH (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 58
  5. Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor. (PMID: 19051206) Root-Bernstein R (Journal of molecular recognition : JMR 2009) 3 58

Products for MOXD2P Gene

Sources for MOXD2P Gene

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