Aliases for MOXD1 Gene

Aliases for MOXD1 Gene

  • Monooxygenase DBH Like 1 2 3 5
  • DBH-Like Monooxygenase Protein 1 3 4
  • Monooxygenase X 3 4
  • MOX 3 4
  • Monooxygenase, DBH-Like 1 2
  • Dopamine-Oxygenase 3
  • EC 1.14.17.- 4
  • EC 1.14.17 52
  • DJ248E1.1 3
  • PRO5780 3

External Ids for MOXD1 Gene

Previous GeneCards Identifiers for MOXD1 Gene

  • GC06M132553
  • GC06M132597
  • GC06M132658
  • GC06M130192

Summaries for MOXD1 Gene

GeneCards Summary for MOXD1 Gene

MOXD1 (Monooxygenase DBH Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include copper ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is DBH.

Gene Wiki entry for MOXD1 Gene

Additional gene information for MOXD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOXD1 Gene

Genomics for MOXD1 Gene

GeneHancer (GH) Regulatory Elements for MOXD1 Gene

Promoters and enhancers for MOXD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J132399 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 508 +0.7 733 3.6 JUND ZNF10 ZIC2 ZBTB10 ZBTB26 ZNF341 POLR2A CTCF KLF9 ZBTB17 MOXD1 lnc-TAAR9-3 piR-51154-014
GH06J132366 Enhancer 1 Ensembl ENCODE 21.4 +36.2 36226 1.8 SIN3A SP1 EP300 TRIM28 JUND RELA MEF2C RCOR1 TRIM22 EZH2 MOXD1 piR-51154-014
GH06J132354 Enhancer 0.8 Ensembl ENCODE 22.2 +45.5 45534 4.4 ZNF316 NFIC FOS MEF2B SPI1 NFE2 JUND EBF1 MAFG NFIB MOXD1 piR-51154-014
GH06J132333 Enhancer 1 Ensembl ENCODE 12.2 +67.1 67060 1.8 TCF12 NCOR1 JUND FOS REST KDM6A TGIF2 SKI TEAD1 FOXA2 MED23 MOXD1 piR-51154-014 RF00017-5778
GH06J132493 Enhancer 1 ENCODE dbSUPER 11.1 -95.9 -95864 7.6 EP300 ZNF623 RELA MEF2C RCOR1 TRIM22 RBM25 BCL11A ZNF282 ZNF384 MOXD1 STX7 ENPP1 HSALNG0053540 lnc-MOXD1-2 lnc-TAAR9-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOXD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOXD1

Top Transcription factor binding sites by QIAGEN in the MOXD1 gene promoter:
  • c-Myc
  • E4BP4
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • LCR-F1
  • Max1
  • STAT1

Genomic Locations for MOXD1 Gene

Genomic Locations for MOXD1 Gene
105,480 bases
Minus strand
105,491 bases
Minus strand

Genomic View for MOXD1 Gene

Genes around MOXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD1 Gene

Proteins for MOXD1 Gene

  • Protein details for MOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DBH-like monooxygenase protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5THU6
    • Q8NC97
    • Q8WV49
    • Q9H4M6
    • Q9Y4U3

    Protein attributes for MOXD1 Gene

    613 amino acids
    Molecular mass:
    69652 Da
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Quaternary structure:
    No Data Available
    • [Isoform 1]: Major.
    • Sequence=BAC11263.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MOXD1 Gene


neXtProt entry for MOXD1 Gene

Selected DME Specific Peptides for MOXD1 Gene


Post-translational modifications for MOXD1 Gene

Other Protein References for MOXD1 Gene

Domains & Families for MOXD1 Gene

Gene Families for MOXD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MOXD1 Gene

  • Copper type II, ascorbate-dependent monooxygenase
  • Dopamine-beta-monooxygenase signature

Suggested Antigen Peptide Sequences for MOXD1 Gene

GenScript: Design optimal peptide antigens:
  • Monooxygenase X (MOXD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
genes like me logo Genes that share domains with MOXD1: view

Function for MOXD1 Gene

Molecular function for MOXD1 Gene

UniProtKB/Swiss-Prot Induction:
By replicative senescence.

Enzyme Numbers (IUBMB) for MOXD1 Gene

Phenotypes From GWAS Catalog for MOXD1 Gene

Gene Ontology (GO) - Molecular Function for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0004500 dopamine beta-monooxygenase activity IBA 21873635
GO:0005507 copper ion binding IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MOXD1: view
genes like me logo Genes that share phenotypes with MOXD1: view

Animal Models for MOXD1 Gene

MGI Knock Outs for MOXD1:
  • Moxd1 Moxd1<tm2b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for MOXD1

CRISPR Products

miRNA for MOXD1 Gene

miRTarBase miRNAs that target MOXD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOXD1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOXD1 Gene

Localization for MOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOXD1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOXD1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
plasma membrane 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 15337741
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Pathways & Interactions for MOXD1 Gene

PathCards logo

SuperPathways for MOXD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006589 octopamine biosynthetic process IBA 21873635
GO:0042420 dopamine catabolic process IBA 21873635
GO:0042421 norepinephrine biosynthetic process IBA 21873635
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MOXD1: view

No data available for Pathways by source and SIGNOR curated interactions for MOXD1 Gene

Drugs & Compounds for MOXD1 Gene

(2) Drugs for MOXD1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 236
Nepicastat (SYN-117) HCl Pharma Dopamine-β-hydroxylase inhibitor 0

(1) ApexBio Compounds for MOXD1 Gene

Compound Action Cas Number
Nepicastat (SYN-117) HCl Dopamine-β-hydroxylase inhibitor 170151-24-3
genes like me logo Genes that share compounds with MOXD1: view

Drug Products

Transcripts for MOXD1 Gene

mRNA/cDNA for MOXD1 Gene

8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOXD1

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD1 Gene

No ASD Table

Relevant External Links for MOXD1 Gene

GeneLoc Exon Structure for

Expression for MOXD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOXD1 Gene

This gene is overexpressed in Uterus (x4.7).

Protein differential expression in normal tissues from HIPED for MOXD1 Gene

This gene is overexpressed in Uterus (16.0), Fetal gut (7.8), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOXD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOXD1

SOURCE GeneReport for Unigene cluster for MOXD1 Gene:


mRNA Expression by UniProt/SwissProt for MOXD1 Gene:

Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord.

Evidence on tissue expression from TISSUES for MOXD1 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Liver(4)
  • Kidney(2.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with MOXD1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOXD1 Gene

Orthologs for MOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOXD1 31 30
  • 99.46 (n)
(Canis familiaris)
Mammalia MOXD1 31 30
  • 89.46 (n)
(Bos Taurus)
Mammalia MOXD1 31 30
  • 89.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
-- 31
  • 80 (a)
(Mus musculus)
Mammalia Moxd1 17 31 30
  • 84.14 (n)
(Rattus norvegicus)
Mammalia Moxd1 30
  • 84.02 (n)
(Monodelphis domestica)
Mammalia MOXD1 31
  • 81 (a)
(Gallus gallus)
Aves -- 31
  • 78 (a)
LOC777223 30
  • 76.97 (n)
MOXD1 31
  • 75 (a)
(Anolis carolinensis)
Reptilia MOXD1 31
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia moxd1 30
  • 68.36 (n)
(Danio rerio)
Actinopterygii moxd1 31 30
  • 62.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011613 30
  • 48.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta olf413 31 30
  • 45.37 (n)
CG5235 31
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
Species where no ortholog for MOXD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOXD1 Gene

Gene Tree for MOXD1 (if available)
Gene Tree for MOXD1 (if available)
Evolutionary constrained regions (ECRs) for MOXD1: view image

Paralogs for MOXD1 Gene

Paralogs for MOXD1 Gene

(2) SIMAP similar genes for MOXD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOXD1: view

Variants for MOXD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOXD1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17851680 - p.Lys539Glu
rs36075540 - p.Glu488Gln

Additional dbSNP identifiers (rs#s) for MOXD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MOXD1 Gene

Variant ID Type Subtype PubMed ID
dgv10936n54 CNV loss 21841781
dgv10937n54 CNV loss 21841781
dgv10938n54 CNV loss 21841781
dgv10939n54 CNV loss 21841781
dgv10940n54 CNV loss 21841781
dgv10941n54 CNV loss 21841781
dgv10942n54 CNV loss 21841781
dgv3393n106 CNV deletion 24896259
esv1005349 CNV deletion 20482838
esv1048627 CNV deletion 17803354
esv2257358 CNV deletion 18987734
esv23627 CNV loss 19812545
esv2422115 CNV deletion 20811451
esv2669946 CNV deletion 23128226
esv2672404 CNV deletion 23128226
esv2674189 CNV deletion 23128226
esv2732715 CNV deletion 23290073
esv2732716 CNV deletion 23290073
esv2791 CNV loss 18987735
esv3400807 CNV insertion 20981092
esv3540481 CNV deletion 23714750
esv3540483 CNV deletion 23714750
esv3610837 CNV loss 21293372
esv5479 CNV loss 19470904
esv9597 CNV gain 19470904
nsv1074962 CNV deletion 25765185
nsv1125422 OTHER inversion 24896259
nsv1144148 CNV deletion 24896259
nsv442008 CNV loss 18776908
nsv499756 CNV loss 21111241
nsv514389 CNV loss 21397061
nsv5480 CNV deletion 18451855
nsv604668 CNV loss 21841781
nsv604669 CNV loss 21841781
nsv818455 CNV loss 17921354
nsv830811 CNV gain 17160897

Variation tolerance for MOXD1 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOXD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOXD1 Gene

Disorders for MOXD1 Gene

Additional Disease Information for MOXD1

No disorders were found for MOXD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOXD1 Gene

Publications for MOXD1 Gene

  1. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PMID: 15337741) Xin X … Eipper BA (The Journal of biological chemistry 2004) 3 4 23 54
  2. Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. (PMID: 9751809) Chambers KJ … Funk WD (Gene 1998) 2 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. (PMID: 30561431) Van Quickelberghe E … Gevaert K (Scientific data 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for MOXD1 Gene

Sources for MOXD1 Gene