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Aliases for MOXD1 Gene

Aliases for MOXD1 Gene

  • Monooxygenase DBH Like 1 2 3 5
  • Monooxygenase X 3 4
  • MOX 3 4
  • DBH-Like Monooxygenase Protein 1 3
  • Monooxygenase, DBH-Like 1 2
  • Dopamine-Oxygenase 3
  • EC 1.14.17.- 4
  • EC 1.14.17 56
  • DJ248E1.1 3
  • PRO5780 3

External Ids for MOXD1 Gene

Previous GeneCards Identifiers for MOXD1 Gene

  • GC06M132553
  • GC06M132597
  • GC06M132658
  • GC06M130192

Summaries for MOXD1 Gene

GeneCards Summary for MOXD1 Gene

MOXD1 (Monooxygenase DBH Like 1) is a Protein Coding gene. Diseases associated with MOXD1 include Mesenteric Lymphadenitis. Gene Ontology (GO) annotations related to this gene include copper ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is DBH.

Gene Wiki entry for MOXD1 Gene

Additional gene information for MOXD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOXD1 Gene

Genomics for MOXD1 Gene

GeneHancer (GH) Regulatory Elements for MOXD1 Gene

Promoters and enhancers for MOXD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I132400 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 558.1 +0.4 391 2.2 PKNOX1 MZF1 FEZF1 ZNF2 ZNF335 GLIS2 ZNF366 EGR2 ZNF202 REST MOXD1 MED23 SNORA33 PIR45153
GH06I132399 Enhancer 0.7 ENCODE 550.8 +1.7 1668 0.2 PKNOX1 ZNF449 FEZF1 BATF BCL11B HIC1 ZNF664 CTBP1 ZNF366 GLI2 MOXD1 PIR45153
GH06I132365 Enhancer 0.8 ENCODE 17.3 +35.7 35720 0.8 PKNOX1 SMAD1 BMI1 FEZF1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 MOXD1 PIR45153
GH06I132493 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -95.9 -95853 7.6 HDGF PKNOX1 SMAD1 RB1 MZF1 BMI1 BATF IRF4 ZNF207 ATF7 MOXD1 STX7 ENPP1
GH06I132369 Enhancer 0.6 Ensembl ENCODE 21.8 +31.8 31807 1 JUND POLR2A MOXD1 PIR45153
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOXD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOXD1 gene promoter:

Genomic Locations for MOXD1 Gene

Genomic Locations for MOXD1 Gene
chr6:132,296,055-132,401,545
(GRCh38/hg38)
Size:
105,491 bases
Orientation:
Minus strand
chr6:132,617,194-132,722,684
(GRCh37/hg19)

Genomic View for MOXD1 Gene

Genes around MOXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD1 Gene

Proteins for MOXD1 Gene

  • Protein details for MOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVY6-MOXD1_HUMAN
    Recommended name:
    DBH-like monooxygenase protein 1
    Protein Accession:
    Q6UVY6
    Secondary Accessions:
    • Q5THU6
    • Q8NC97
    • Q8WV49
    • Q9H4M6
    • Q9Y4U3

    Protein attributes for MOXD1 Gene

    Size:
    613 amino acids
    Molecular mass:
    69652 Da
    Cofactor:
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11263.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MOXD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOXD1 Gene

Selected DME Specific Peptides for MOXD1 Gene

Q6UVY6:
  • MTWGGLSTR
  • STVRVIWA

Post-translational modifications for MOXD1 Gene

Other Protein References for MOXD1 Gene

Domains & Families for MOXD1 Gene

Gene Families for MOXD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MOXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UVY6

UniProtKB/Swiss-Prot:

MOXD1_HUMAN :
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
Family:
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
genes like me logo Genes that share domains with MOXD1: view

Function for MOXD1 Gene

Molecular function for MOXD1 Gene

UniProtKB/Swiss-Prot Induction:
By replicative senescence.

Enzyme Numbers (IUBMB) for MOXD1 Gene

Phenotypes From GWAS Catalog for MOXD1 Gene

Gene Ontology (GO) - Molecular Function for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0004500 dopamine beta-monooxygenase activity IBA --
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MOXD1: view
genes like me logo Genes that share phenotypes with MOXD1: view

Animal Models for MOXD1 Gene

MGI Knock Outs for MOXD1:

Animal Model Products

CRISPR Products

miRNA for MOXD1 Gene

miRTarBase miRNAs that target MOXD1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOXD1 Gene

Localization for MOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOXD1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOXD1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
peroxisome 3
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 15337741
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Pathways & Interactions for MOXD1 Gene

SuperPathways for MOXD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006589 octopamine biosynthetic process IBA --
GO:0042420 dopamine catabolic process IBA --
GO:0042421 norepinephrine biosynthetic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MOXD1: view

No data available for Pathways by source and SIGNOR curated interactions for MOXD1 Gene

Drugs & Compounds for MOXD1 Gene

(2) Drugs for MOXD1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 202
Nepicastat (SYN-117) HCl Pharma Dopamine-β-hydroxylase inhibitor 0

(1) ApexBio Compounds for MOXD1 Gene

Compound Action Cas Number
Nepicastat (SYN-117) HCl Dopamine-β-hydroxylase inhibitor 170151-24-3
genes like me logo Genes that share compounds with MOXD1: view

Drug Products

Transcripts for MOXD1 Gene

Unigene Clusters for MOXD1 Gene

Monooxygenase, DBH-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD1 Gene

No ASD Table

Relevant External Links for MOXD1 Gene

GeneLoc Exon Structure for
MOXD1
ECgene alternative splicing isoforms for
MOXD1

Expression for MOXD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOXD1 Gene

This gene is overexpressed in Uterus (x4.7).

Protein differential expression in normal tissues from HIPED for MOXD1 Gene

This gene is overexpressed in Uterus (16.0), Fetal gut (7.8), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOXD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MOXD1 Gene:

MOXD1

SOURCE GeneReport for Unigene cluster for MOXD1 Gene:

Hs.6909

mRNA Expression by UniProt/SwissProt for MOXD1 Gene:

Q6UVY6-MOXD1_HUMAN
Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord.

Evidence on tissue expression from TISSUES for MOXD1 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Liver(4)
  • Kidney(2.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with MOXD1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOXD1 Gene

Orthologs for MOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOXD1 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia MOXD1 33 34
  • 89.46 (n)
cow
(Bos Taurus)
Mammalia MOXD1 33 34
  • 89.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Moxd1 33 16 34
  • 84.14 (n)
rat
(Rattus norvegicus)
Mammalia Moxd1 33
  • 84.02 (n)
oppossum
(Monodelphis domestica)
Mammalia MOXD1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 78 (a)
OneToMany
LOC777223 33
  • 76.97 (n)
MOXD1 34
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MOXD1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia moxd1 33
  • 68.36 (n)
zebrafish
(Danio rerio)
Actinopterygii moxd1 33 34
  • 62.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011613 33
  • 48.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta olf413 33 34
  • 45.37 (n)
CG5235 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for MOXD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOXD1 Gene

ENSEMBL:
Gene Tree for MOXD1 (if available)
TreeFam:
Gene Tree for MOXD1 (if available)

Paralogs for MOXD1 Gene

Paralogs for MOXD1 Gene

(2) SIMAP similar genes for MOXD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOXD1: view

Variants for MOXD1 Gene

Sequence variations from dbSNP and Humsavar for MOXD1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000000881 -- 132,333,063(-) G/A intron_variant
rs1000012224 -- 132,356,731(-) C/T intron_variant
rs1000027647 -- 132,338,426(-) A/T intron_variant
rs1000067716 -- 132,392,563(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000080956 -- 132,350,577(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOXD1 Gene

Variant ID Type Subtype PubMed ID
nsv830811 CNV gain 17160897
nsv818455 CNV loss 17921354
nsv604669 CNV loss 21841781
nsv604668 CNV loss 21841781
nsv5480 CNV deletion 18451855
nsv514389 CNV loss 21397061
nsv499756 CNV loss 21111241
nsv442008 CNV loss 18776908
nsv1144148 CNV deletion 24896259
nsv1125422 OTHER inversion 24896259
nsv1074962 CNV deletion 25765185
esv9597 CNV gain 19470904
esv5479 CNV loss 19470904
esv3610837 CNV loss 21293372
esv3540483 CNV deletion 23714750
esv3540481 CNV deletion 23714750
esv3400807 CNV insertion 20981092
esv2791 CNV loss 18987735
esv2732716 CNV deletion 23290073
esv2732715 CNV deletion 23290073
esv2674189 CNV deletion 23128226
esv2672404 CNV deletion 23128226
esv2669946 CNV deletion 23128226
esv2422115 CNV deletion 20811451
esv23627 CNV loss 19812545
esv2257358 CNV deletion 18987734
esv1048627 CNV deletion 17803354
esv1005349 CNV deletion 20482838
dgv3393n106 CNV deletion 24896259
dgv10942n54 CNV loss 21841781
dgv10941n54 CNV loss 21841781
dgv10940n54 CNV loss 21841781
dgv10939n54 CNV loss 21841781
dgv10938n54 CNV loss 21841781
dgv10937n54 CNV loss 21841781
dgv10936n54 CNV loss 21841781

Variation tolerance for MOXD1 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOXD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOXD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOXD1 Gene

Disorders for MOXD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOXD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mesenteric lymphadenitis
  • mesenteric adenitis
- elite association - COSMIC cancer census association via MalaCards
Search MOXD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOXD1

genes like me logo Genes that share disorders with MOXD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOXD1 Gene

Publications for MOXD1 Gene

  1. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PMID: 15337741) Xin X … Eipper BA (The Journal of biological chemistry 2004) 3 4 22 58
  2. Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. (PMID: 9751809) Chambers KJ … Funk WD (Gene 1998) 2 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MOXD1 Gene

Sources for MOXD1 Gene

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