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Aliases for MOSPD3 Gene

Aliases for MOSPD3 Gene

  • Motile Sperm Domain Containing 3 2 3 5
  • Motile Sperm Domain-Containing Protein 3 3
  • NET30 3
  • CDS3 3

External Ids for MOSPD3 Gene

Previous GeneCards Identifiers for MOSPD3 Gene

  • GC07P099822
  • GC07P099854
  • GC07P100048
  • GC07P100209
  • GC07P094841

Summaries for MOSPD3 Gene

Entrez Gene Summary for MOSPD3 Gene

  • This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOSPD3 Gene

MOSPD3 (Motile Sperm Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is MOSPD1.

Additional gene information for MOSPD3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD3 Gene

Genomics for MOSPD3 Gene

GeneHancer (GH) Regulatory Elements for MOSPD3 Gene

Promoters and enhancers for MOSPD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100611 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 699.1 +0.1 122 2.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B MOSPD3 AP4M1 ZSCAN25 MEPCE SRRT RN7SL416P RN7SL750P PPP1R35 FBXO24 C7orf43
GH07J100894 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 32 +284.3 284305 4.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 SP3 REST ZNF592 ACHE MOSPD3 ENSG00000242798 PPP1R35 SRRT MEPCE SLC12A9 MUC3A TRIP6 ZNF3
GH07J100538 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.1 -67.5 -67489 12.6 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 AGFG2 SRRT PPP1R35 ZSCAN25 SAP25 GIGYF1 MEPCE AP4M1 LRCH4 ENSG00000242798
GH07J100602 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.1 -8.1 -8117 3.9 HDGF FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF213 E2F8 PCOLCE-AS1 PCOLCE MOSPD3 GIGYF1 ZSCAN25 TRIM4 SRRT PPP1R35 ZNF3 PILRB
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 21.4 -178.9 -178903 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOSPD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOSPD3 gene promoter:
  • Sp1
  • PPAR-gamma2
  • Nkx2-5
  • PPAR-gamma1

Genomic Locations for MOSPD3 Gene

Genomic Locations for MOSPD3 Gene
3,283 bases
Plus strand
3,283 bases
Plus strand

Genomic View for MOSPD3 Gene

Genes around MOSPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD3 Gene

Proteins for MOSPD3 Gene

  • Protein details for MOSPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motile sperm domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D2D1
    • A6NG17
    • C9JE89
    • D6W5W1
    • O75423
    • O75424

    Protein attributes for MOSPD3 Gene

    235 amino acids
    Molecular mass:
    25519 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD3 Gene


neXtProt entry for MOSPD3 Gene

Post-translational modifications for MOSPD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOSPD3 Gene

Domains & Families for MOSPD3 Gene

Gene Families for MOSPD3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MOSPD3 Gene

Suggested Antigen Peptide Sequences for MOSPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOSPD3: view

No data available for UniProtKB/Swiss-Prot for MOSPD3 Gene

Function for MOSPD3 Gene

Phenotypes From GWAS Catalog for MOSPD3 Gene

genes like me logo Genes that share phenotypes with MOSPD3: view

Animal Model Products

CRISPR Products

miRNA for MOSPD3 Gene

miRTarBase miRNAs that target MOSPD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD3 Gene

Localization for MOSPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOSPD3 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 3
plasma membrane 2
nucleus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOSPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOSPD3: view

Pathways & Interactions for MOSPD3 Gene

SuperPathways for MOSPD3 Gene

No Data Available

Interacting Proteins for MOSPD3 Gene

Gene Ontology (GO) - Biological Process for MOSPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with MOSPD3: view

No data available for Pathways by source and SIGNOR curated interactions for MOSPD3 Gene

Drugs & Compounds for MOSPD3 Gene

No Compound Related Data Available

Transcripts for MOSPD3 Gene

Unigene Clusters for MOSPD3 Gene

Motile sperm domain containing 3:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP4: -
SP5: - - - -

Relevant External Links for MOSPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOSPD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOSPD3 Gene

Protein differential expression in normal tissues from HIPED for MOSPD3 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOSPD3 Gene

Protein tissue co-expression partners for MOSPD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOSPD3 Gene:


SOURCE GeneReport for Unigene cluster for MOSPD3 Gene:


Evidence on tissue expression from TISSUES for MOSPD3 Gene

  • Eye(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with MOSPD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOSPD3 Gene

Orthologs for MOSPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOSPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOSPD3 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia MOSPD3 34 33
  • 91.31 (n)
(Bos Taurus)
Mammalia MOSPD3 34 33
  • 89.5 (n)
(Mus musculus)
Mammalia Mospd3 16 34 33
  • 87.38 (n)
(Rattus norvegicus)
Mammalia Mospd3 33
  • 86.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd3 33
  • 54.26 (n)
(Caenorhabditis elegans)
Secernentea C34D10.1 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for MOSPD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MOSPD3 Gene

Gene Tree for MOSPD3 (if available)
Gene Tree for MOSPD3 (if available)
Evolutionary constrained regions (ECRs) for MOSPD3: view image

Paralogs for MOSPD3 Gene

Paralogs for MOSPD3 Gene

(1) SIMAP similar genes for MOSPD3 Gene using alignment to 3 proteins:

  • C9J3M4_HUMAN
  • F8WF07_HUMAN
genes like me logo Genes that share paralogs with MOSPD3: view

Variants for MOSPD3 Gene

Sequence variations from dbSNP and Humsavar for MOSPD3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001512454 -- 100,610,368(+) A/G upstream_transcript_variant
rs1001616084 -- 100,612,764(+) C/G 5_prime_UTR_variant
rs1001962147 -- 100,612,453(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002209069 -- 100,615,738(+) C/T downstream_transcript_variant
rs1003022370 -- 100,614,028(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOSPD3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv5868 CNV deletion 18451855
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for MOSPD3 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOSPD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD3 Gene

Disorders for MOSPD3 Gene

Additional Disease Information for MOSPD3

No disorders were found for MOSPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD3 Gene

Publications for MOSPD3 Gene

  1. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. (PMID: 15533722) Pall GS … Forrester LM (Genomics 2004) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Glöckner G … Rosenthal A (Genome research 1998) 3 4 58
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh SK … Lin JP (Nature genetics 2009) 44 58

Products for MOSPD3 Gene

Sources for MOSPD3 Gene

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