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Aliases for MOSPD2 Gene

Aliases for MOSPD2 Gene

  • Motile Sperm Domain Containing 2 2 3 5

External Ids for MOSPD2 Gene

Previous GeneCards Identifiers for MOSPD2 Gene

  • GC0XP014253
  • GC0XP014651
  • GC0XP014801
  • GC0XP012649

Summaries for MOSPD2 Gene

GeneCards Summary for MOSPD2 Gene

MOSPD2 (Motile Sperm Domain Containing 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for MOSPD2 Gene

  • Promotes migration of primary monocytes and neutrophils, in response to various chemokines.

Additional gene information for MOSPD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD2 Gene

Genomics for MOSPD2 Gene

GeneHancer (GH) Regulatory Elements for MOSPD2 Gene

Promoters and enhancers for MOSPD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI014872 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 595.4 +0.2 176 2.4 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 ZNF48 YY1 MOSPD2 FANCB GC0XM014977
GH0XI014673 Enhancer 1 Ensembl ENCODE 27.7 -199.5 -199485 0.8 SMAD1 INSM2 KLF17 BATF IRF4 RFX5 ZNF366 ATF7 FOS IKZF2 MOSPD2 PIR55145 PIR53411 GLRA2
GH0XI014851 Enhancer 0.3 Ensembl 51.3 -21.5 -21504 1 RUNX3 MOSPD2 FANCB NPM1P9
GH0XI014963 Enhancer 0.7 Ensembl ENCODE 17.4 +90.6 90572 1.4 CTCF JUND POLR2A RAD21 MOSPD2 GC0XM014977
GH0XI014899 Enhancer 0.9 FANTOM5 Ensembl 9.4 +26.5 26496 0.6 JUN NR2F1 JUNB BATF ATF2 IRF4 NR2F2 JUND BCL11A BCL6B MOSPD2 PIGA GC0XM014977
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOSPD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOSPD2 gene promoter:

Genomic Locations for MOSPD2 Gene

Genomic Locations for MOSPD2 Gene
chrX:14,873,405-14,922,327
(GRCh38/hg38)
Size:
48,923 bases
Orientation:
Plus strand
chrX:14,891,527-14,940,449
(GRCh37/hg19)

Genomic View for MOSPD2 Gene

Genes around MOSPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD2 Gene

Proteins for MOSPD2 Gene

  • Protein details for MOSPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHP6-MSPD2_HUMAN
    Recommended name:
    Motile sperm domain-containing protein 2
    Protein Accession:
    Q8NHP6
    Secondary Accessions:
    • Q8N3H2
    • Q8NA83

    Protein attributes for MOSPD2 Gene

    Size:
    518 amino acids
    Molecular mass:
    59746 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOSPD2 Gene

Post-translational modifications for MOSPD2 Gene

Other Protein References for MOSPD2 Gene

No data available for DME Specific Peptides for MOSPD2 Gene

Domains & Families for MOSPD2 Gene

Gene Families for MOSPD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MOSPD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOSPD2: view

No data available for UniProtKB/Swiss-Prot for MOSPD2 Gene

Function for MOSPD2 Gene

Molecular function for MOSPD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes migration of primary monocytes and neutrophils, in response to various chemokines.

Phenotypes From GWAS Catalog for MOSPD2 Gene

Phenotypes for MOSPD2 Gene

genes like me logo Genes that share phenotypes with MOSPD2: view

Animal Model Products

miRNA for MOSPD2 Gene

miRTarBase miRNAs that target MOSPD2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD2 Gene

Localization for MOSPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOSPD2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOSPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 28137892
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with MOSPD2: view

Pathways & Interactions for MOSPD2 Gene

genes like me logo Genes that share pathways with MOSPD2: view

Pathways by source for MOSPD2 Gene

3 Reactome pathways for MOSPD2 Gene

Gene Ontology (GO) - Biological Process for MOSPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0090023 positive regulation of neutrophil chemotaxis IDA 28137892
GO:0090026 positive regulation of monocyte chemotaxis IDA 28137892
genes like me logo Genes that share ontologies with MOSPD2: view

No data available for SIGNOR curated interactions for MOSPD2 Gene

Drugs & Compounds for MOSPD2 Gene

No Compound Related Data Available

Transcripts for MOSPD2 Gene

Unigene Clusters for MOSPD2 Gene

Motile sperm domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for MOSPD2 Gene

GeneLoc Exon Structure for
MOSPD2
ECgene alternative splicing isoforms for
MOSPD2

Expression for MOSPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOSPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOSPD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MOSPD2 Gene

This gene is overexpressed in Bone (22.6) and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOSPD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MOSPD2 Gene:

MOSPD2

SOURCE GeneReport for Unigene cluster for MOSPD2 Gene:

Hs.744919

mRNA Expression by UniProt/SwissProt for MOSPD2 Gene:

Q8NHP6-MSPD2_HUMAN
Tissue specificity: Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells.

Evidence on tissue expression from TISSUES for MOSPD2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MOSPD2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOSPD2 Gene

Orthologs for MOSPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOSPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOSPD2 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia MOSPD2 33 34
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia MOSPD2 33 34
  • 89.68 (n)
-- 34
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mospd2 33 16 34
  • 86.94 (n)
rat
(Rattus norvegicus)
Mammalia Mospd2 33
  • 86.79 (n)
oppossum
(Monodelphis domestica)
Mammalia MOSPD2 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOSPD2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOSPD2 33 34
  • 72.42 (n)
lizard
(Anolis carolinensis)
Reptilia MOSPD2 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd2 33
  • 67.73 (n)
Str.3865 33
zebrafish
(Danio rerio)
Actinopterygii mospd2 33 34
  • 61.37 (n)
wufc48a06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9762 33
fruit fly
(Drosophila melanogaster)
Insecta CG33523 33 34
  • 44.99 (n)
CG32407 34
  • 28 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005556 33
  • 44.57 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-28 33 34
  • 46.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSR1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
CSA.9460 34
  • 31 (a)
OneToMany
CSA.3857 34
  • 18 (a)
OneToMany
Species where no ortholog for MOSPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOSPD2 Gene

ENSEMBL:
Gene Tree for MOSPD2 (if available)
TreeFam:
Gene Tree for MOSPD2 (if available)

Paralogs for MOSPD2 Gene

(1) SIMAP similar genes for MOSPD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MOSPD2: view

No data available for Paralogs for MOSPD2 Gene

Variants for MOSPD2 Gene

Sequence variations from dbSNP and Humsavar for MOSPD2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1020271259 uncertain-significance, Fanconi Anemia, X-Linked, VACTERL association with hydrocephalus 14,873,024(+) T/A upstream_transcript_variant
rs149617434 benign, VACTERL association with hydrocephalus, Fanconi Anemia, X-Linked 14,873,023(+) A/C upstream_transcript_variant
rs756766337 likely-benign, VACTERL association with hydrocephalus, Fanconi Anemia, X-Linked 14,873,026(+) C/T upstream_transcript_variant
rs1000451219 -- 14,908,274(+) A/C intron_variant
rs1000475809 -- 14,877,598(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOSPD2 Gene

Variant ID Type Subtype PubMed ID
nsv9934 CNV loss 18304495
esv3372386 CNV insertion 20981092

Variation tolerance for MOSPD2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOSPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOSPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD2 Gene

Disorders for MOSPD2 Gene

Additional Disease Information for MOSPD2

No disorders were found for MOSPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD2 Gene

Publications for MOSPD2 Gene

  1. Identification of Motile Sperm Domain-Containing Protein 2 as Regulator of Human Monocyte Migration. (PMID: 28137892) Mendel I … Breitbart E (Journal of immunology (Baltimore, Md. : 1950) 2017) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel CH … Baumgrass R (The Journal of biological chemistry 2016) 3 58

Products for MOSPD2 Gene

Sources for MOSPD2 Gene

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