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Aliases for MOS Gene

Aliases for MOS Gene

  • MOS Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog 2 3
  • Oocyte Maturation Factor Mos 3 4
  • Proto-Oncogene C-Mos 3 4
  • Proto-Oncogene Serine/Threonine-Protein Kinase Mos 3
  • Oncogene MOS, Moloney Murine Sarcoma Virus 3
  • EC 4
  • C-Mos 3
  • MSV 3

External Ids for MOS Gene

Previous GeneCards Identifiers for MOS Gene

  • GC08M056208
  • GC08M056964
  • GC08M056748
  • GC08M057075
  • GC08M057188
  • GC08M057025
  • GC08M052492

Summaries for MOS Gene

Entrez Gene Summary for MOS Gene

  • MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

GeneCards Summary for MOS Gene

MOS (MOS Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with MOS include Sarcoma. Among its related pathways are Preimplantation Embryo and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K21.

Gene Wiki entry for MOS Gene

Additional gene information for MOS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOS Gene

Genomics for MOS Gene

GeneHancer (GH) Regulatory Elements for MOS Gene

Promoters and enhancers for MOS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J056093 Enhancer 0.7 ENCODE 11.6 +20.2 20155 0.2 CTCF RB1 BMI1 ZNF2 RAD21 CC2D1A CTBP1 FOXK2 ZNF143 SMC3 MOS NPM1P21 CERNA3 GC08P056003
GH08J056061 Enhancer 0.7 Ensembl 10 +53.5 53481 0.2 HDGF CTCF USF1 ARNT ZSCAN4 RAD21 CC2D1A ZFHX2 ARID2 ZNF143 MOS PSMC6P1 PIR52236 GC08P056003
GH08J056173 Enhancer 0.5 ENCODE 11.2 -59.9 -59898 1.2 JUND JUN CREB1 FOSL2 FOS MAFK PLAG1 CHCHD7 MOS GC08M056160 ENSG00000221093 GC08M056122
GH08J056168 Enhancer 0.4 UCNEbase 10.8 -54.2 -54231 0.4 PLAG1 CHCHD7 MOS GC08M056160 GC08M056122 ENSG00000221093
GH08J056167 Enhancer 0.3 ENCODE 10.9 -53.3 -53315 0.2 SCRT2 MOS PLAG1 CHCHD7 GC08M056160 GC08M056122 ENSG00000221093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOS gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • CUTL1
  • ATF
  • STAT5A

Genomic Locations for MOS Gene

Genomic Locations for MOS Gene
1,041 bases
Minus strand
1,041 bases
Minus strand

Genomic View for MOS Gene

Genes around MOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOS Gene

Proteins for MOS Gene

  • Protein details for MOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos
    Protein Accession:
    Secondary Accessions:
    • Q3KPG9
    • Q3KPH0

    Protein attributes for MOS Gene

    346 amino acids
    Molecular mass:
    37820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOS Gene

Post-translational modifications for MOS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOS Gene

Domains & Families for MOS Gene

Gene Families for MOS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MOS Gene

Suggested Antigen Peptide Sequences for MOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MOS: view

Function for MOS Gene

Molecular function for MOS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
GENATLAS Biochemistry:
Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase)

Enzyme Numbers (IUBMB) for MOS Gene

Phenotypes From GWAS Catalog for MOS Gene

Gene Ontology (GO) - Molecular Function for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,ISS --
GO:0004709 MAP kinase kinase kinase activity ISS --
GO:0004871 obsolete signal transducer activity IBA --
genes like me logo Genes that share ontologies with MOS: view
genes like me logo Genes that share phenotypes with MOS: view

Animal Models for MOS Gene

MGI Knock Outs for MOS:
  • Mos Mos<tm1Sia>
  • Mos Mos<tm1Ev>
  • Mos Mos<tm1Gvw>

Animal Model Products

Clone Products

  • Addgene plasmids for MOS

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MOS Gene

Localization for MOS Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOS gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MOS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MOS Gene

Pathways & Interactions for MOS Gene

genes like me logo Genes that share pathways with MOS: view

Gene Ontology (GO) - Biological Process for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity ISS --
GO:0000187 activation of MAPK activity ISS --
GO:0000212 meiotic spindle organization ISS --
GO:0006325 chromatin organization ISS --
genes like me logo Genes that share ontologies with MOS: view

No data available for SIGNOR curated interactions for MOS Gene

Drugs & Compounds for MOS Gene

(7) Drugs for MOS Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for MOS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MOS: view

Transcripts for MOS Gene

mRNA/cDNA for MOS Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOS Gene

V-mos Moloney murine sarcoma viral oncogene homolog:
Representative Sequences:

Clone Products

  • Addgene plasmids for MOS

Alternative Splicing Database (ASD) splice patterns (SP) for MOS Gene

No ASD Table

Relevant External Links for MOS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOS Gene

This gene is overexpressed in Testis (x21.4), Brain - Hippocampus (x6.8), and Brain - Amygdala (x5.9).

Protein differential expression in normal tissues from HIPED for MOS Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOS Gene

Protein tissue co-expression partners for MOS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOS Gene:


SOURCE GeneReport for Unigene cluster for MOS Gene:


mRNA Expression by UniProt/SwissProt for MOS Gene:

Tissue specificity: Expressed specifically in testis during spermatogenesis.
genes like me logo Genes that share expression patterns with MOS: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOS Gene

Orthologs for MOS Gene

This gene was present in the common ancestor of animals.

Orthologs for MOS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOS 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia MOS 34 33
  • 80.43 (n)
(Rattus norvegicus)
Mammalia Mos 33
  • 77.06 (n)
(Mus musculus)
Mammalia Mos 16 34 33
  • 76.47 (n)
(Bos Taurus)
Mammalia MOS 33
  • 76 (n)
C-MOS 34
  • 73 (a)
(Monodelphis domestica)
Mammalia MOS 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
(Gallus gallus)
Aves MOS 34 33
  • 64.92 (n)
(Anolis carolinensis)
Reptilia MOS 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489962 33
  • 59.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397924 33
(Danio rerio)
Actinopterygii mos 34 33
  • 57.16 (n)
Dr.12572 33
(Caenorhabditis elegans)
Secernentea Y105C5A.24 34
  • 15 (a)
mom-4 34
  • 14 (a)
Species where no ortholog for MOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOS Gene

Gene Tree for MOS (if available)
Gene Tree for MOS (if available)
Evolutionary constrained regions (ECRs) for MOS: view image

Paralogs for MOS Gene

genes like me logo Genes that share paralogs with MOS: view

Variants for MOS Gene

Sequence variations from dbSNP and Humsavar for MOS Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
VAR_040815 A lung adenocarcinoma sample p.Ala123Thr
rs1001479929 -- 56,114,753(-) C/T upstream_transcript_variant
rs1001553591 -- 56,114,532(-) A/T upstream_transcript_variant
rs1003224361 -- 56,112,802(-) A/G downstream_transcript_variant
rs1003699574 -- 56,112,787(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MOS Gene

Variant ID Type Subtype PubMed ID
nsv524526 CNV loss 19592680
nsv831319 CNV gain 17160897

Variation tolerance for MOS Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOS Gene

Disorders for MOS Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOS Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search MOS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOS

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOS Gene

Publications for MOS Gene

  1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  2. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PMID: 20186124) Vitale I … Kroemer G (The EMBO journal 2010) 3 22 58
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  4. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PMID: 18246541) Prasad CK … MacNicol AM (Molecular reproduction and development 2008) 3 22 58
  5. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PMID: 18550795) Tang W … Kornbluth S (Molecular biology of the cell 2008) 3 22 58

Products for MOS Gene

Sources for MOS Gene

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