Aliases for MORN4 Gene

Aliases for MORN4 Gene

  • MORN Repeat Containing 4 2 3 5
  • MORN Repeat-Containing Protein 4 3 4
  • Protein 44050 3 4
  • 44050 Protein 2 3
  • C10orf83 3 4
  • Chromosome 10 Open Reading Frame 83 2
  • Retinophilin Homolog (Drosophila) 2
  • Retinophilin Homolog 3
  • Retinophilin 4
  • BA548K23.4 3
  • UTA 3
  • Rtp 3

External Ids for MORN4 Gene

Previous HGNC Symbols for MORN4 Gene

  • C10orf83

Previous GeneCards Identifiers for MORN4 Gene

  • GC10M099365
  • GC10M093000

Summaries for MORN4 Gene

GeneCards Summary for MORN4 Gene

MORN4 (MORN Repeat Containing 4) is a Protein Coding gene. Diseases associated with MORN4 include Deafness, Autosomal Recessive 30.

UniProtKB/Swiss-Prot Summary for MORN4 Gene

  • Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Additional gene information for MORN4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MORN4 Gene

Genomics for MORN4 Gene

GeneHancer (GH) Regulatory Elements for MORN4 Gene

Promoters and enhancers for MORN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MORN4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MORN4

Top Transcription factor binding sites by QIAGEN in the MORN4 gene promoter:
  • FOXO1
  • FOXO1a
  • Pax-4a
  • RORalpha1
  • Sox9

Genomic Locations for MORN4 Gene

Genomic Locations for MORN4 Gene
chr10:97,614,553-97,634,156
(GRCh38/hg38)
Size:
19,604 bases
Orientation:
Minus strand
chr10:99,374,310-99,393,913
(GRCh37/hg19)
Size:
19,604 bases
Orientation:
Minus strand

Genomic View for MORN4 Gene

Genes around MORN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORN4 Gene

Proteins for MORN4 Gene

  • Protein details for MORN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDC4-MORN4_HUMAN
    Recommended name:
    MORN repeat-containing protein 4
    Protein Accession:
    Q8NDC4
    Secondary Accessions:
    • Q86Y54

    Protein attributes for MORN4 Gene

    Size:
    146 amino acids
    Molecular mass:
    16236 Da
    Quaternary structure:
    • Interacts with MYO3A.

    Alternative splice isoforms for MORN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORN4 Gene

Post-translational modifications for MORN4 Gene

No Post-translational modifications

Other Protein References for MORN4 Gene

No data available for DME Specific Peptides for MORN4 Gene

Domains & Families for MORN4 Gene

Gene Families for MORN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MORN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MORN4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76368 (A6XB87_HUMAN)
  • Protein 44050 (MORN4_HUMAN)
genes like me logo Genes that share domains with MORN4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MORN4 Gene

Function for MORN4 Gene

Molecular function for MORN4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Gene Ontology (GO) - Molecular Function for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MORN4: view
genes like me logo Genes that share phenotypes with MORN4: view

Animal Model Products

CRISPR Products

miRNA for MORN4 Gene

miRTarBase miRNAs that target MORN4

Clone Products

  • Addgene plasmids for MORN4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORN4 Gene

Localization for MORN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORN4 Gene

Cytoplasm. Cell projection, filopodium tip. Cell projection, stereocilium. Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. {ECO:0000269 PubMed:25822849}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORN4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25822849
GO:0032420 stereocilium IEA --
GO:0032426 stereocilium tip ISS --
GO:0032433 filopodium tip IEA,IDA 25822849
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with MORN4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MORN4 Gene

Pathways & Interactions for MORN4 Gene

PathCards logo

SuperPathways for MORN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048678 response to axon injury ISS --
genes like me logo Genes that share ontologies with MORN4: view

No data available for Pathways by source and SIGNOR curated interactions for MORN4 Gene

Drugs & Compounds for MORN4 Gene

No Compound Related Data Available

Transcripts for MORN4 Gene

mRNA/cDNA for MORN4 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for MORN4

Alternative Splicing Database (ASD) splice patterns (SP) for MORN4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for MORN4 Gene

GeneLoc Exon Structure for
MORN4

Expression for MORN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MORN4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MORN4

SOURCE GeneReport for Unigene cluster for MORN4 Gene:

Hs.217409

Evidence on tissue expression from TISSUES for MORN4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MORN4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORN4 Gene

Orthologs for MORN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORN4 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MORN4 31 30
  • 94.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MORN4 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MORN4 31 30
  • 92.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Morn4 17 31 30
  • 91.78 (n)
rat
(Rattus norvegicus)
Mammalia Morn4 30
  • 91.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MORN4 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORN4 31 30
  • 78.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MORN4 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morn4 30
  • 71 (n)
Str.13968 30
zebrafish
(Danio rerio)
Actinopterygii morn4 31 30
  • 69.41 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6686 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003547 30
  • 52.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta rtp 31 30
  • 52.58 (n)
OneToOne
Species where no ortholog for MORN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MORN4 Gene

ENSEMBL:
Gene Tree for MORN4 (if available)
TreeFam:
Gene Tree for MORN4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MORN4: view image

Paralogs for MORN4 Gene

(13) SIMAP similar genes for MORN4 Gene using alignment to 3 proteins:

  • MORN4_HUMAN
  • G3V1L7_HUMAN
  • Q8WVZ3_HUMAN
genes like me logo Genes that share paralogs with MORN4: view

No data available for Paralogs for MORN4 Gene

Variants for MORN4 Gene

Additional dbSNP identifiers (rs#s) for MORN4 Gene

Structural Variations from Database of Genomic Variants (DGV) for MORN4 Gene

Variant ID Type Subtype PubMed ID
nsv1110852 OTHER inversion 24896259

Variation tolerance for MORN4 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MORN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MORN4 Gene

Disorders for MORN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MORN4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 30
  • dfnb30
- elite association - COSMIC cancer census association via MalaCards
Search MORN4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MORN4

genes like me logo Genes that share disorders with MORN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORN4 Gene

Publications for MORN4 Gene

  1. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins. (PMID: 25822849) Mecklenburg KL … O'Tousa JE (PloS one 2015) 2 3 4 54
  2. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. (PMID: 22496551) Bhattacharya MR … DiAntonio A (The Journal of neuroscience : the official journal of the Society for Neuroscience 2012) 2 3 54
  3. Drosophila retinophilin contains MORN repeats and is conserved in humans. (PMID: 17285308) Mecklenburg KL (Molecular genetics and genomics : MGG 2007) 3 4 54
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for MORN4 Gene

Sources for MORN4 Gene