MORN3 Gene (Protein Coding)

MORN Repeat Containing 3

GC12M121651
GIFtS:
29
See more...

Aliases for MORN3 Gene

Aliases for MORN3 Gene

  • MORN Repeat Containing 3 2 3 5
  • MORN Repeat-Containing Protein 3 3 4
  • Membrane Occupation And Recognition Nexus Repeat Containing Protein 3
  • MORN3 5

External Ids for MORN3 Gene

Previous GeneCards Identifiers for MORN3 Gene

  • GC12M120553
  • GC12M122089
  • GC12M119101

Summaries for MORN3 Gene

GeneCards Summary for MORN3 Gene

MORN3 (MORN Repeat Containing 3) is a Protein Coding gene. An important paralog of this gene is RSPH10B.

Additional gene information for MORN3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MORN3 Gene

Genomics for MORN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MORN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MORN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MORN3

Genomic Locations for MORN3 Gene

Latest Assembly
chr12:121,648,742-121,672,650
(GRCh38/hg38)
Size:
23,909 bases
Orientation:
Minus strand

Previous Assembly
chr12:122,086,648-122,110,550
(GRCh37/hg19 by Entrez Gene)
Size:
23,903 bases
Orientation:
Minus strand

chr12:122,089,024-122,110,537
(GRCh37/hg19 by Ensembl)
Size:
21,514 bases
Orientation:
Minus strand

Genomic View for MORN3 Gene

Genes around MORN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MORN3 Gene

Proteins for MORN3 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for MORN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF18-MORN3_HUMAN
    Recommended name:
    MORN repeat-containing protein 3
    Protein Accession:
    Q6PF18
    Secondary Accessions:
    • Q86YQ9

    Protein attributes for MORN3 Gene

    Size:
    240 amino acids
    Molecular mass:
    27585 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MORN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORN3 Gene

Post-translational modifications for MORN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MORN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MORN3 Gene

Domains & Families for MORN3 Gene

Gene Families for MORN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MORN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MORN3 Gene

GenScript: Design optimal peptide antigens:
  • MORN repeat-containing protein 3 (MORN3_HUMAN)
genes like me logo Genes that share domains with MORN3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MORN3 Gene

Function for MORN3 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for MORN3 Gene

Gene Ontology (GO) - Molecular Function for MORN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MORN3: view
genes like me logo Genes that share phenotypes with MORN3: view

Animal Models for research

miRNA for MORN3 Gene

miRTarBase miRNAs that target MORN3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORN3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORN3 Gene

Localization for MORN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORN3 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MORN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with MORN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MORN3 Gene

Pathways & Interactions for MORN3 Gene

PathCards logo

SuperPathways for MORN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORN3 Gene

Drugs & Compounds for MORN3 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MORN3 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for MORN3 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORN3

Alternative Splicing Database (ASD) splice patterns (SP) for MORN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for MORN3 Gene

GeneLoc Exon Structure for
MORN3

Expression for MORN3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MORN3 Gene

mRNA expression in normal human tissues for MORN3 Gene
mRNA expression by BioGPS for MORN3 GenemRNA expression by GTEx for MORN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MORN3 Gene

This gene is overexpressed in Testis (x30.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MORN3

SOURCE GeneReport for Unigene cluster for MORN3 Gene:

Hs.434154
genes like me logo Genes that share expression patterns with MORN3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORN3 Gene

Orthologs for MORN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MORN3 30 31
  • 98.89 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MORN3 30 31
  • 88.75 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MORN3 30 31
  • 86.53 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Morn3 30 17 31
  • 84.59 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Morn3 30
  • 84.31 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MORN3 31
  • 68 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MORN3 31
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MORN3 30 31
  • 62.87 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MORN3 31
  • 55 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia morn3 30
  • 61.43 (n)
Zebrafish
(Danio rerio)
 Actinopterygii morn3 30 31
  • 59.52 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG14490 30 31
  • 47.59 (n)
 OneToMany
CG30429 31
  • 23 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 54 (a)
 OneToOne
Species where no ortholog for MORN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MORN3 Gene

ENSEMBL:
Gene Tree for MORN3 (if available)
TreeFam:
Gene Tree for MORN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MORN3: view image

Paralogs for MORN3 Gene

Paralogs for MORN3 Gene

(2) SIMAP similar genes for MORN3 Gene using alignment to 1 proteins:

  • MORN3_HUMAN
genes like me logo Genes that share paralogs with MORN3: view

Variants for MORN3 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MORN3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs139184687 Benign: not provided 121,653,179(-) G/C
NM_173855.5(MORN3):c.544C>G (p.Gln182Glu) 		MISSENSE
rs7965126 Benign: not provided 121,653,265(-) G/A
NM_173855.5(MORN3):c.464-6C>T 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MORN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MORN3 Gene

Variant ID Type Subtype PubMed ID
esv3630952 CNV loss 21293372
nsv1053272 CNV gain 25217958
nsv1145633 CNV deletion 24896259
nsv560458 CNV loss 21841781

Variation tolerance for MORN3 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MORN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORN3 Gene

Disorders for MORN3 Gene

Additional Disease Information for MORN3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MORN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORN3 Gene

Publications for MORN3 Gene

  1. Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells. (PMID: 25248657) Zhang L … Zhang ZB (Asian journal of andrology 2015) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for MORN3 gene in Mastermind

Products for MORN3 Gene

Sources for MORN3 Gene