Aliases for MORF4L1 Gene
External Ids for MORF4L1 Gene
Previous GeneCards Identifiers for MORF4L1 Gene
GeneCards Summary for MORF4L1 Gene
MORF4L1 (Mortality Factor 4 Like 1) is a Protein Coding gene. Diseases associated with MORF4L1 include Primary Hyperoxaluria. Among its related pathways are Chromatin organization and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.
UniProtKB/Swiss-Prot Summary for MORF4L1 Gene
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.