Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-lik... See more...

Aliases for MORF4 Gene

Aliases for MORF4 Gene

  • Mortality Factor 4 (Pseudogene) 2 3 5
  • Senescence (Cellular)-Related 1 2 3
  • Mortality Factor 4 Like 1 Pseudogene 3
  • Senescence-Related, Cellular, 1 3
  • Mortality Factor 4 2
  • MORF4 5
  • CSRB 3
  • SEN1 3
  • CSR 3
  • SEN 3

External Ids for MORF4 Gene

Previous HGNC Symbols for MORF4 Gene

  • SEN
  • SEN1

Previous GeneCards Identifiers for MORF4 Gene

  • GC04M175456
  • GC04M175074
  • GC04M175232
  • GC04M174911
  • GC04M174773
  • GC04M174538
  • GC04M170282

Summaries for MORF4 Gene

Entrez Gene Summary for MORF4 Gene

  • Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]

GeneCards Summary for MORF4 Gene

MORF4 (Mortality Factor 4 (Pseudogene)) is a Pseudogene.

Additional gene information for MORF4 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MORF4 Gene

Genomics for MORF4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Top Transcription factor binding sites by QIAGEN in the MORF4 gene promoter:
  • aMEF-2
  • ATF-2
  • COMP1
  • ITF-2
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • POU3F2
  • Tal-1beta

Genomic Locations for MORF4 Gene

Latest Assembly
1,171 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,107 bases
Minus strand

(GRCh37/hg19 by Ensembl)
971 bases
Minus strand

Genomic View for MORF4 Gene

Genes around MORF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORF4 Gene

Proteins for MORF4 Gene

Post-translational modifications for MORF4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MORF4 Gene

Domains & Families for MORF4 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MORF4 Gene

Function for MORF4 Gene

Molecular function for MORF4 Gene

GENATLAS Biochemistry:
mortality factor 4,expressed in keratinocyte lines,in the TSG4C region,not essential for human keratinocyte immortality

Phenotypes From GWAS Catalog for MORF4 Gene

genes like me logo Genes that share phenotypes with MORF4: view

Animal Models for research

CRISPR products for research

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MORF4 Gene

Localization for MORF4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MORF4 Gene

Pathways & Interactions for MORF4 Gene

PathCards logo

SuperPathways for MORF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORF4 Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MORF4 Gene

Drugs & Compounds for MORF4 Gene

No Compound Related Data Available

Transcripts for MORF4 Gene

mRNA/cDNA for MORF4 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORF4

Alternative Splicing Database (ASD) splice patterns (SP) for MORF4 Gene

No ASD Table

Relevant External Links for MORF4 Gene

GeneLoc Exon Structure for

Expression for MORF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MORF4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MORF4

genes like me logo Genes that share expression patterns with MORF4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORF4 Gene

Orthologs for MORF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORF4 Gene

Organism Taxonomy Gene Similarity Type Details
Fruit Fly
(Drosophila melanogaster)
Insecta MRG15 32
  • 50 (a)
Species where no ortholog for MORF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MORF4 Gene

Gene Tree for MORF4 (if available)
Gene Tree for MORF4 (if available)

Paralogs for MORF4 Gene

No data available for Paralogs for MORF4 Gene

Variants for MORF4 Gene

Additional Variant Information for MORF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MORF4 Gene

Disorders for MORF4 Gene

Additional Disease Information for MORF4

No disorders were found for MORF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORF4 Gene

Publications for MORF4 Gene

  1. A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23. (PMID: 12407449) Bryce SD … Parkinson EK (Neoplasia (New York, N.Y.) 2002) 2 3
  2. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PMID: 9891081) Bertram MJ … Pereira-Smith OM (Molecular and cellular biology 1999) 2 3
  3. Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. (PMID: 2062841) Ning Y … Pereira-Smith OM (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3

Products for MORF4 Gene

Sources for MORF4 Gene