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Aliases for MORC4 Gene

Aliases for MORC4 Gene

  • MORC Family CW-Type Zinc Finger 4 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 2 3 4
  • Zinc Finger, CW Type With Coiled-Coil Domain 2 2 3
  • Zinc Finger CW-Type Domain Protein 4 3 4
  • ZCWCC2 3 4
  • ZCW4 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 2 2
  • MORC Family CW-Type Zinc Finger Protein 4 3
  • DJ75H8.2 3

External Ids for MORC4 Gene

Previous HGNC Symbols for MORC4 Gene

  • ZCWCC2

Previous GeneCards Identifiers for MORC4 Gene

  • GC0XM105992
  • GC0XM106070
  • GC0XM106183
  • GC0XM095811

Summaries for MORC4 Gene

Entrez Gene Summary for MORC4 Gene

  • In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

GeneCards Summary for MORC4 Gene

MORC4 (MORC Family CW-Type Zinc Finger 4) is a Protein Coding gene. An important paralog of this gene is MORC3.

Additional gene information for MORC4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC4 Gene

Genomics for MORC4 Gene

GeneHancer (GH) Regulatory Elements for MORC4 Gene

Promoters and enhancers for MORC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI106998 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.4 424 2 ARNT ARID4B SIN3A ZNF76 FEZF1 RAD21 YY1 ZNF335 HSF1 ZNF143 MORC4 GC0XM106980
GH0XI107708 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 -714.1 -714068 10.9 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 YY1 ZNF143 FOS JUNB TSC22D3 RBM41 MORC4 MID2 LOC101928335 ATG4A GC0XM107728 GC0XM107676
GH0XI107733 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -738.7 -738653 10.9 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 YY1 POLR2B E2F8 ZNF263 TSC22D3 MID2 MORC4 RBM41 GC0XM107728 NCBP2L
GH0XI107672 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 -676.2 -676155 7.7 PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 POLR2B ZNF213 ZNF143 GC0XM107676 TSC22D3 RBM41 MORC4 RNF128 GC0XM107673
GH0XI106927 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.2 +69.4 69378 7.7 ELF3 FOXA2 RAD21 YY1 FOS CREM EGR2 RXRA CEBPB ELF1 PIR48891 CLDN2 RIPPLY1 MYCLP1 TBC1D8B GC0XM106980 MORC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MORC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MORC4 gene promoter:

Genomic Locations for MORC4 Gene

Genomic Locations for MORC4 Gene
chrX:106,813,871-107,000,244
(GRCh38/hg38)
Size:
186,374 bases
Orientation:
Minus strand
chrX:106,057,101-106,243,474
(GRCh37/hg19)

Genomic View for MORC4 Gene

Genes around MORC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC4 Gene

Proteins for MORC4 Gene

  • Protein details for MORC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE76-MORC4_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 4
    Protein Accession:
    Q8TE76
    Secondary Accessions:
    • A1YR23
    • A1YR24
    • H7BXF1
    • Q5JUK7
    • Q96MZ2
    • Q9HAI7

    Protein attributes for MORC4 Gene

    Size:
    937 amino acids
    Molecular mass:
    106348 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13859.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71125.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MORC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC4 Gene

Post-translational modifications for MORC4 Gene

No Post-translational modifications

Other Protein References for MORC4 Gene

No data available for DME Specific Peptides for MORC4 Gene

Domains & Families for MORC4 Gene

Gene Families for MORC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for MORC4 Gene

Suggested Antigen Peptide Sequences for MORC4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORC4: view

No data available for UniProtKB/Swiss-Prot for MORC4 Gene

Function for MORC4 Gene

Phenotypes From GWAS Catalog for MORC4 Gene

Gene Ontology (GO) - Molecular Function for MORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MORC4: view

Phenotypes for MORC4 Gene

genes like me logo Genes that share phenotypes with MORC4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC4 Gene

Localization for MORC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORC4 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MORC4: view

Pathways & Interactions for MORC4 Gene

SuperPathways for MORC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORC4 Gene

Drugs & Compounds for MORC4 Gene

No Compound Related Data Available

Transcripts for MORC4 Gene

Unigene Clusters for MORC4 Gene

MORC family CW-type zinc finger 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b
SP1: - -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for MORC4 Gene

GeneLoc Exon Structure for
MORC4
ECgene alternative splicing isoforms for
MORC4

Expression for MORC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MORC4 Gene

This gene is overexpressed in Fetal gut (41.4), Pancreas (19.1), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MORC4 Gene



Protein tissue co-expression partners for MORC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MORC4 Gene:

MORC4

SOURCE GeneReport for Unigene cluster for MORC4 Gene:

Hs.496544

mRNA Expression by UniProt/SwissProt for MORC4 Gene:

Q8TE76-MORC4_HUMAN
Tissue specificity: Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.
genes like me logo Genes that share expression patterns with MORC4: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORC4 Gene

Orthologs for MORC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC4 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
OneToMany
MORC4 33
  • 91.2 (n)
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MORC4 33 34
  • 90.08 (n)
mouse
(Mus musculus)
Mammalia Morc4 33 16 34
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Morc4 33
  • 85.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MORC4 34
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MORC4 34
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea morc-1 34
  • 19 (a)
OneToMany
Species where no ortholog for MORC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MORC4 Gene

ENSEMBL:
Gene Tree for MORC4 (if available)
TreeFam:
Gene Tree for MORC4 (if available)

Paralogs for MORC4 Gene

Paralogs for MORC4 Gene

(1) SIMAP similar genes for MORC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORC4: view

Variants for MORC4 Gene

Sequence variations from dbSNP and Humsavar for MORC4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000094563 -- 106,973,851(-) C/A intron_variant
rs1000162019 -- 106,957,526(-) CTTTCT/CT intron_variant
rs1000293038 -- 106,984,754(-) C/A intron_variant
rs1000388438 -- 106,984,229(-) T/C intron_variant
rs1000388588 -- 106,967,785(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MORC4 Gene

Variant ID Type Subtype PubMed ID
nsv519484 CNV gain 19592680
nsv477947 CNV novel sequence insertion 20440878
nsv1110096 CNV deletion 24896259
esv2752312 CNV gain 17911159

Variation tolerance for MORC4 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MORC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC4 Gene

Disorders for MORC4 Gene

Additional Disease Information for MORC4

No disorders were found for MORC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORC4 Gene

Publications for MORC4 Gene

  1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. (PMID: 17608765) Liggins AP … Banham AH (British journal of haematology 2007) 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J … Zhao Y (Trends in biochemical sciences 2003) 2 3 58
  5. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. (PMID: 28913878) Campa D … Canzian F (International journal of cancer 2018) 3 58

Products for MORC4 Gene

Sources for MORC4 Gene

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