Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
MORC3 (MORC Family CW-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with MORC3 include Adult Dermatomyositis and Childhood Type Dermatomyositis. Among its related pathways are Interactome of polycomb repressive complex 2 (PRC2). An important paralog of this gene is MORC4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IEA,IDA | -- |
GO:0016363 | nuclear matrix | IEA | -- |
GO:0016605 | PML body | IDA | 17332504 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interactome of polycomb repressive complex 2 (PRC2) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IDA | 17332504 |
GO:0007569 | cell aging | IDA | 17332504 |
GO:0009791 | post-embryonic development | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0018105 | peptidyl-serine phosphorylation | IDA | 17332504 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Morc3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Morc3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MORC3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MORC3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MORC3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MORC3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | morc3 30 |
|
||
Str.11041 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4065 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | morc3a 30 31 |
|
OneToMany | |
morc3b 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | morc-1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
773090 | Benign: not provided | 36,369,252(+) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2659831 | CNV | deletion | 23128226 |
esv2671533 | CNV | deletion | 23128226 |
esv33578 | CNV | loss | 17666407 |
esv3646969 | CNV | loss | 21293372 |
nsv3505 | CNV | deletion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult dermatomyositis |
|
|
childhood type dermatomyositis |
|
|
influenza |
|
|
orbital plasma cell granuloma |
|
|
interstitial lung disease |
|
|