Aliases for MORC3 Gene
External Ids for MORC3 Gene
Previous HGNC Symbols for MORC3 Gene
Previous GeneCards Identifiers for MORC3 Gene
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for MORC3 Gene
MORC3 (MORC Family CW-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with MORC3 include Adult Dermatomyositis and Childhood Type Dermatomyositis. Among its related pathways are Interactome of polycomb repressive complex 2 (PRC2). An important paralog of this gene is MORC4.
UniProtKB/Swiss-Prot Summary for MORC3 Gene
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).