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This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016] See more...
Aliases for MORC3 Gene
Aliases for MORC3 Gene
External Ids for MORC3 Gene
- HGNC: 23572
- NCBI Entrez Gene: 23515
- Ensembl: ENSG00000159256
- OMIM®: 610078
- UniProtKB/Swiss-Prot: Q14149
Previous HGNC Symbols for MORC3 Gene
- ZCWCC3
Previous GeneCards Identifiers for MORC3 Gene
- GC21P036615
- GC21P037692
- GC21P023168
Summaries for MORC3 Gene
-
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for MORC3 Gene
MORC3 (MORC Family CW-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with MORC3 include Adult Dermatomyositis and Childhood Type Dermatomyositis. Among its related pathways are Interactome of polycomb repressive complex 2 (PRC2). An important paralog of this gene is MORC4.
UniProtKB/Swiss-Prot Summary for MORC3 Gene
-
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).
Additional gene information for MORC3 Gene
- HGNC (23572)
- NCBI Entrez Gene (23515)
- Ensembl (ENSG00000159256)
- OMIM® (610078)
- UniProtKB/Swiss-Prot (Q14149)
- Open Targets Platform(ENSG00000159256)
- Search for MORC3 at DataMed
- Search for MORC3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MORC3 Gene
Genomics for MORC3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MORC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MORC3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MORC3
- Top Transcription factor binding sites by QIAGEN in the MORC3 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Egr-1
- NCX
- Nkx2-2
- p300
Genomic Locations for MORC3 Gene
Latest Assembly
- chr21:36,320,189-36,386,148
- (GRCh38/hg38)
- Size:
- 65,960 bases
- Orientation:
- Plus strand
Previous Assembly
- chr21:37,692,495-37,748,930
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 56,436 bases
- Orientation:
- Plus strand
- chr21:37,692,487-37,758,446
- (GRCh37/hg19 by Ensembl)
- Size:
- 65,960 bases
- Orientation:
- Plus strand
Genomic View for MORC3 Gene
Genes around MORC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.12 by HGNC
- 21q22.12 by Entrez Gene
- 21q22.12 by Ensembl
MORC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MORC3 Gene
Proteins for MORC3 Gene
-
Protein details for MORC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14149-MORC3_HUMAN
- Recommended name:
- MORC family CW-type zinc finger protein 3
- Protein Accession:
- Q14149
- A8KA92
- Q9UEZ2
Protein attributes for MORC3 Gene
- Size:
- 939 amino acids
- Molecular mass:
- 107113 Da
- Quaternary structure:
-
- Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233).
- (Microbial infection) Interacts with influenza A virus PA and PB1 polymerase subunits during infection.
- SequenceCaution:
-
- Sequence=BAA09485.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA89432.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MORC3 Gene
Post-translational modifications for MORC3 Gene
- Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.
-
Ubiquitination at Lys280, Lys293, Lys377, Lys404, Lys432, Lys710, Lys825, and Lys891
- NX_Q14149 (NX_Q14149-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MORC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NXP2 / MORC3 Antibody
- Novus Biologicals Antibodies for MORC3
-
Abcam antibodies for MORC3
- Invitrogen Antibodies for MORC3 (AFLGC-MORC3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MORC3
- Sino Biological Antibodies for MORC3
Protein products for research
-
OriGene Purified Proteins for MORC3
- Search Origene for MassSpec and Protein Over-expression Lysates for MORC3
- Origene Custom Protein Services for MORC3
-
Abcam proteins for MORC3
Assay products for research
No data available for DME Specific Peptides for MORC3 Gene
Domains & Families for MORC3 Gene
Gene Families for MORC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MORC3 Gene
- InterPro:
- Blocks:
-
- ATP-binding region, ATPase-like
- CW-type Zn-finger
- ProtoNet:
Suggested Antigen Peptide Sequences for MORC3 Gene
- GenScript: Design optimal peptide antigens:
-
- MORC3 protein (A2RU29_HUMAN)
- Zinc finger CW-type coiled-coil domain protein 3 (MORC3_HUMAN)
- MORC family CW-type zinc finger 3 (Q4VBZ9_HUMAN)
- MORC3 protein (Q86YD6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14149UniProtKB/Swiss-Prot:
MORC3_HUMAN :- The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
- Domain:
-
- The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
Function for MORC3 Gene
Molecular function for MORC3 Gene
- UniProtKB/Swiss-Prot Function:
- Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).
Phenotypes From GWAS Catalog for MORC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0035064 | methylated histone binding | IDA | 26933034 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for MORC3 Gene
- MGI mutant phenotypes for MORC3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MORC3:
-
- Increased vaccinia virus (VACV) infection
- Increased viability
- no effect
- Decreased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased G2M DNA content, increased 8N DNA content
- Increased NF-kappaB reporter expression
- Decreased shRNA abundance
- Synthetic lethal with imatinib mesylate
- Decreased viability
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for MORC3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MORC3 - Starting at $85 >
- * MORC3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MORC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MORC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MORC3
miRNA for MORC3 Gene
- miRTarBase miRNAs that target MORC3
-
- hsa-miR-155-5p (MIRT020644)
- hsa-miR-101-3p (MIRT027287)
- hsa-miR-32-5p (MIRT028275)
- hsa-miR-21-5p (MIRT030797)
- hsa-miR-197-3p (MIRT048085)
- hsa-miR-30a-3p (MIRT085314)
- hsa-miR-30d-3p (MIRT085316)
- hsa-miR-218-2-3p (MIRT085317)
- hsa-miR-30e-3p (MIRT085318)
- hsa-miR-545-5p (MIRT085320)
- hsa-miR-584-5p (MIRT085321)
- hsa-miR-622 (MIRT085322)
- hsa-miR-758-5p (MIRT085323)
- hsa-miR-92a-3p (MIRT155523)
- hsa-miR-92b-3p (MIRT155532)
- hsa-miR-144-3p (MIRT556092)
- hsa-miR-5700 (MIRT556093)
- hsa-miR-153-3p (MIRT556094)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MORC3
- Browse OriGene Inhibitory RNA Products For MORC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORC3
Clone products for research
- Applied Biological Materials (abm): Clones for MORC3 - Starting at $45 >
- * MORC3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MORC3
- Addgene plasmids for MORC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MORC3
Cell Lines for research
-
Horizon Cell Lines for MORC3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MORC3 Gene
Localization for MORC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MORC3 Gene
- Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000269 PubMed:20501696}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
- Mitochondria (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IEA,IDA | -- |
| GO:0016363 | nuclear matrix | IEA | -- |
| GO:0016605 | PML body | IDA | 17332504 |
Pathways & Interactions for MORC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Interactome of polycomb repressive complex 2 (PRC2) | ||
Pathways by source for MORC3 Gene
1 BioSystems pathway for MORC3 Gene
Interacting Proteins for MORC3 Gene
Selected Interacting proteins:
Q14149-MORC3_HUMAN
ENSP00000383333
for MORC3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MORC3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 17332504 |
| GO:0007569 | cell aging | IDA | 17332504 |
| GO:0009791 | post-embryonic development | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IDA | 17332504 |
No data available for SIGNOR curated interactions for MORC3 Gene
Transcripts for MORC3 Gene
mRNA/cDNA for MORC3 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000400485 4224 nts (view in UCSC)
- ENST00000484028 688 nts (view in UCSC)
- ENST00000485299 687 nts (view in UCSC)
- ENST00000485933 417 nts (view in UCSC)
- ENST00000487909 4131 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MORC3 - Starting at $85 >
- * MORC3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MORC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MORC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MORC3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MORC3
- Browse OriGene Inhibitory RNA Products For MORC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORC3
Clone products for research
- Applied Biological Materials (abm): Clones for MORC3 - Starting at $45 >
- * MORC3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MORC3
- Addgene plasmids for MORC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MORC3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for MORC3 Gene
- GeneLoc Exon Structure for
- MORC3
Expression for MORC3 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (15.9), Plasma (8.7), and Monocytes (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MORC3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MORC3
SOURCE GeneReport for Unigene cluster for MORC3 Gene:
Hs.421150mRNA Expression by UniProt/SwissProt for MORC3 Gene:
Q14149-MORC3_HUMAN
Tissue specificity:
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
Evidence on tissue expression from TISSUES for MORC3 Gene
- Bone marrow(4.3)
- Muscle(2.8)
- Blood(2.6)
- Nervous system(2.3)
- Spleen(2.2)
- Skin(2.1)
- Lung(2.1)
- Heart(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MORC3
-
OriGene qPCR primer pairs and template standards for MORC3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORC3 Gene
Orthologs for MORC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MORC3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Morc3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Morc3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MORC3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MORC3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MORC3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MORC3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | morc3 30 |
|
||
| Str.11041 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4065 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | morc3a 30 31 |
|
OneToMany | |
| morc3b 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | morc-1 31 |
|
OneToMany |
- Species where no ortholog for MORC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MORC3 Gene
- ENSEMBL:
- Gene Tree for MORC3 (if available)
- TreeFam:
- Gene Tree for MORC3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MORC3: view image
Paralogs for MORC3 Gene
Variants for MORC3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MORC3 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs532768592 | Benign: not provided | 36,369,252(+) |
A/G NM_015358.3(MORC3):c.1884A>G (p.Ser628=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2659831 | CNV | deletion | 23128226 |
| esv2671533 | CNV | deletion | 23128226 |
| esv33578 | CNV | loss | 17666407 |
| esv3646969 | CNV | loss | 21293372 |
| nsv3505 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.37;
27.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MORC3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MORC3
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC3 Gene
Disorders for MORC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adult dermatomyositis |
|
|
| childhood type dermatomyositis |
|
|
| influenza |
|
|
| orbital plasma cell granuloma |
|
|
| antisynthetase syndrome |
|
|
Search MORC3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MORC3
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MORC3 Gene
Publications for MORC3 Gene
- Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. (PMID: 26933034) Liu Y … Min J (The Journal of biological chemistry 2016) 3 4
- The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication. (PMID: 26202233) Ver LS … Ortín J (Journal of virology 2015) 3 4
- Two-step colocalization of MORC3 with PML nuclear bodies. (PMID: 20501696) Mimura Y … Inoue N (Journal of cell science 2010) 3 4
- Dynamic regulation of p53 subnuclear localization and senescence by MORC3. (PMID: 17332504) Takahashi K … Inoue N (Molecular biology of the cell 2007) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for MORC3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for MORC3
- Origene Custom Protein Services for MORC3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MORC3
- Browse OriGene Inhibitory RNA Products For MORC3
- OriGene qPCR primer pairs for MORC3
- OriGene qPCR primer pairs and template standards for MORC3
- OriGene CRISPR knockouts for MORC3
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- Sino Biological Antibodies for MORC3
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for MORC3
- Browse Antibodies
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- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MORC3 (AFLGC-MORC3)
- VectorBuilder Custom and pre-made DNA vectors for MORC3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MORC3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MORC3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MORC3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MORC3
- Addgene plasmids for MORC3
- antibodies-online: Show 9 available MORC3 Antibodies ranked by validation data
- Compare Top MORC3 Antibodies
- antibodies-online: Search results for available MORC3 related products ranked by validation data
- antibodies-online: Show 4 available MORC3 Proteins ranked by validation data
- Compare Top MORC3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MORC3
- Search Santa Cruz Biotechnology (SCBT) for MORC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MORC3
- Horizon Cell Lines for MORC3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MORC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MORC3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MORC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MORC3
Sources for MORC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB