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This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
MORC2 (MORC Family CW-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with MORC2 include Charcot-Marie-Tooth Disease, Axonal, Type 2Z and Charcot-Marie-Tooth Disease. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is MORC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 29440755 |
GO:0003682 | chromatin binding | IDA | 23260667 |
GO:0005515 | protein binding | IPI | 28581500 |
GO:0005524 | ATP binding | IEA,IDA | 29440755 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000792 | heterochromatin | IDA | 28581500 |
GO:0005634 | nucleus | IBA,IDA | 23260667 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005694 | chromosome | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 23260667 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006338 | chromatin remodeling | IDA | 23260667 |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006974 | cellular response to DNA damage stimulus | IDA | 23260667 |
GO:0045814 | negative regulation of gene expression, epigenetic | IDA | 28581500 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | |||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MORC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MORC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MORC2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Morc2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Morc2a 30 17 31 |
|
OneToMany | |
Morc2b 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | MORC2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MORC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MORC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | morc2 30 |
|
||
Str.10569 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | morc2 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | morc-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
639064 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2z | 30,934,157(-) | G/T | MISSENSE_VARIANT | |
640804 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2z | 30,932,424(-) | T/C | MISSENSE_VARIANT | |
642355 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2z | 30,941,940(-) | T/C | MISSENSE_VARIANT | |
642427 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2z | 30,928,080(-) | G/A | MISSENSE_VARIANT | |
642714 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2z | 30,936,932(-) | C/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1110864 | OTHER | inversion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
charcot-marie-tooth disease, axonal, type 2z |
|
|
charcot-marie-tooth disease |
|
|
charcot-marie-tooth hereditary neuropathy |
|
|
distal hereditary motor neuropathies |
|
|
charcot-marie-tooth disease/hereditary motor and sensory neuropathy |
|
|