Aliases for MON2 Gene

Aliases for MON2 Gene

  • MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking 2 3 5
  • Protein MON2 Homolog 3 4
  • KIAA1040 2 4
  • MON2 Regulator Of Endosome-To-Golgi Trafficking 3
  • MON2 Homolog (S. Cerevisiae) 2
  • MON2 Homolog (Yeast) 2
  • Protein SF21 4
  • MON2 5
  • SF21 4

External Ids for MON2 Gene

Previous GeneCards Identifiers for MON2 Gene

  • GC12P061147
  • GC12P062860
  • GC12P059911

Summaries for MON2 Gene

GeneCards Summary for MON2 Gene

MON2 (MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking) is a Protein Coding gene. Diseases associated with MON2 include Robinow Syndrome, Autosomal Dominant 2 and Robinow Syndrome. Gene Ontology (GO) annotations related to this gene include binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is GBF1.

UniProtKB/Swiss-Prot Summary for MON2 Gene

  • May be required for traffic between late Golgi and early endosomes.

Gene Wiki entry for MON2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MON2 Gene

Genomics for MON2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MON2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MON2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MON2

Top Transcription factor binding sites by QIAGEN in the MON2 gene promoter:
  • AREB6
  • Arnt
  • En-1
  • MAZR
  • p300
  • p53
  • POU2F1
  • POU2F1a
  • STAT3
  • TGIF

Genomic Locations for MON2 Gene

Latest Assembly
133,660 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
133,651 bases
Plus strand

(GRCh37/hg19 by Ensembl)
130,767 bases
Plus strand

Genomic View for MON2 Gene

Genes around MON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON2 Gene

Proteins for MON2 Gene

  • Protein details for MON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MON2 homolog
    Protein Accession:
    Secondary Accessions:
    • A5D8U7
    • A7E2Y0
    • B9EGP5
    • F8VWA6
    • F8W1Z6
    • Q86TA2
    • Q8N3I5
    • Q8NAI0
    • Q8NHE2
    • Q9UPW1

    Protein attributes for MON2 Gene

    1717 amino acids
    Molecular mass:
    190359 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA82992.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON2 Gene


neXtProt entry for MON2 Gene

Post-translational modifications for MON2 Gene

  • Ubiquitination at Lys281 and Lys288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MON2 Gene

Domains & Families for MON2 Gene

Gene Families for MON2 Gene

Protein Domains for MON2 Gene

  • HEAT repeat

Suggested Antigen Peptide Sequences for MON2 Gene

GenScript: Design optimal peptide antigens:
  • MON2 protein (B7ZM73_HUMAN)
  • Protein SF21 (MON2_HUMAN)
  • MON2 protein (Q6P148_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON2 family.
  • Belongs to the MON2 family.
genes like me logo Genes that share domains with MON2: view

Function for MON2 Gene

Molecular function for MON2 Gene

UniProtKB/Swiss-Prot Function:
May be required for traffic between late Golgi and early endosomes.

Phenotypes From GWAS Catalog for MON2 Gene

Gene Ontology (GO) - Molecular Function for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18418388
genes like me logo Genes that share ontologies with MON2: view
genes like me logo Genes that share phenotypes with MON2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MON2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON2 Gene

Localization for MON2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON2 gene
Compartment Confidence
extracellular 4
cytosol 3
nucleus 2
endosome 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MON2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON2 Gene

Pathways & Interactions for MON2 Gene

PathCards logo

SuperPathways for MON2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MON2: view

No data available for Pathways by source and SIGNOR curated interactions for MON2 Gene

Drugs & Compounds for MON2 Gene

No Compound Related Data Available

Transcripts for MON2 Gene

mRNA/cDNA for MON2 Gene

17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MON2

Alternative Splicing Database (ASD) splice patterns (SP) for MON2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP4: - - - - -
SP8: -

ExUns: 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b
SP2: - - -
SP3: - - - -
SP5: -
SP10: - -

Relevant External Links for MON2 Gene

GeneLoc Exon Structure for

Expression for MON2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MON2 Gene

Protein differential expression in normal tissues from HIPED for MON2 Gene

This gene is overexpressed in Bone (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MON2 Gene

Protein tissue co-expression partners for MON2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MON2

SOURCE GeneReport for Unigene cluster for MON2 Gene:


Evidence on tissue expression from TISSUES for MON2 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MON2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MON2 Gene

Orthologs for MON2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MON2 29 30
  • 99.77 (n)
(Canis familiaris)
Mammalia MON2 29 30
  • 94.2 (n)
(Monodelphis domestica)
Mammalia MON2 30
  • 94 (a)
(Bos Taurus)
Mammalia MON2 29 30
  • 93.71 (n)
(Ornithorhynchus anatinus)
Mammalia MON2 30
  • 92 (a)
(Rattus norvegicus)
Mammalia Mon2 29
  • 87.42 (n)
(Mus musculus)
Mammalia Mon2 29 16 30
  • 85.96 (n)
(Gallus gallus)
Aves MON2 29 30
  • 83.53 (n)
(Anolis carolinensis)
Reptilia MON2 30
  • 92 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mon2 29
  • 78.2 (n)
(Danio rerio)
Actinopterygii mon2 30
  • 83 (a)
LOC100334806 29
  • 71.34 (n)
wufc16c07 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.391 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009972 29
  • 54.94 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mon2 29 30
  • 54.82 (n)
(Caenorhabditis elegans)
Secernentea mon-2 29 30
  • 48.28 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON2 30
  • 20 (a)
Species where no ortholog for MON2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MON2 Gene

Gene Tree for MON2 (if available)
Gene Tree for MON2 (if available)
Evolutionary constrained regions (ECRs) for MON2: view image
Alliance of Genome Resources:
Additional Orthologs for MON2

Paralogs for MON2 Gene

genes like me logo Genes that share paralogs with MON2: view

Variants for MON2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MON2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs145811980 Likely Benign: not provided 62,546,899(+) G/A
NM_015026.3(MON2):c.2580G>A (p.Arg860=)
rs146852110 Benign: not provided 62,543,204(+) TTC/T
rs10219555 -- p.Ala548Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MON2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MON2 Gene

Variant ID Type Subtype PubMed ID
dgv822n106 CNV deletion 24896259
esv2658375 CNV deletion 23128226
esv2745966 CNV deletion 23290073
esv3549302 CNV deletion 23714750
esv3629738 CNV loss 21293372
nsv469418 CNV loss 19166990
nsv559156 CNV loss 21841781
nsv739 CNV insertion 18451855
nsv740 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952196 CNV duplication 24416366

Variation tolerance for MON2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.08; 98.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MON2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON2 Gene

Disorders for MON2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MON2 Gene - From: COP

Disorder Aliases PubMed IDs
robinow syndrome, autosomal dominant 2
  • drs2
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
- elite association - COSMIC cancer census association via MalaCards
Search MON2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MON2

genes like me logo Genes that share disorders with MON2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MON2 Gene

Publications for MON2 Gene

  1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham AK … Munro S (The Journal of biological chemistry 2006) 2 3 4
  2. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase. (PMID: 24285343) Mahajan D … Lu L (Scientific reports 2013) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4
  5. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3

Products for MON2 Gene

Sources for MON2 Gene