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Aliases for MON1B Gene

Aliases for MON1B Gene

  • MON1 Homolog B, Secretory Trafficking Associated 2 3 5
  • MON1 Secretory Trafficking Family Member B 2 3
  • HSV-1 Stimulation-Related Gene 1 Protein 3 4
  • HSV-I Stimulating-Related Protein 3 4
  • HSRG1 3 4
  • SAND2 3 4
  • Vacuolar Fusion Protein MON1 Homolog B 3
  • MON1 Homolog B (Yeast) 2
  • KIAA0872 4
  • SRG1 3

External Ids for MON1B Gene

Previous GeneCards Identifiers for MON1B Gene

  • GC16P075783
  • GC16P062981

Summaries for MON1B Gene

GeneCards Summary for MON1B Gene

MON1B (MON1 Homolog B, Secretory Trafficking Associated) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. An important paralog of this gene is MON1A.

Additional gene information for MON1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON1B Gene

Genomics for MON1B Gene

GeneHancer (GH) Regulatory Elements for MON1B Gene

Promoters and enhancers for MON1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I077190 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.2 +0.5 528 2.7 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MON1B SYCE1L GC16P077193 PIR54148
GH16I077211 Promoter/Enhancer 1.4 Ensembl ENCODE 17.9 +22.4 22360 2.9 PKNOX1 ATF1 SIN3A GLI4 GLIS2 ZNF213 FOS SP3 YY2 REST SYCE1L MON1B VN2R10P ENSG00000261707 ENSG00000261063
GH16I077287 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +98.6 98599 3.4 RFX1 JUN MAX USF2 SIN3A CEBPB REST EP300 SP1 JUND SYCE1L ENSG00000260922 MON1B ADAMTS18 ENSG00000261063 ENSG00000260701
GH16I077219 Enhancer 0.5 ENCODE 12.4 +28.8 28839 0.8 SP1 JUND ATF3 ZBTB33 FOSL2 VN2R10P SYCE1L MON1B ENSG00000261063
GH16I077281 Enhancer 0.5 dbSUPER 7.5 +91.9 91858 2.7 MAFF ZNF316 MAFK EMSY SYCE1L ENSG00000260922 MON1B ADAMTS18 ENSG00000261063 ENSG00000260701
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MON1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MON1B gene promoter:

Genomic Locations for MON1B Gene

Genomic Locations for MON1B Gene
11,571 bases
Plus strand

Genomic View for MON1B Gene

Genes around MON1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1B Gene

Proteins for MON1B Gene

  • Protein details for MON1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vacuolar fusion protein MON1 homolog B
    Protein Accession:
    Secondary Accessions:
    • B4DDZ0
    • O94949

    Protein attributes for MON1B Gene

    547 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    • Interacts with CCNT2; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection.

    Alternative splice isoforms for MON1B Gene


neXtProt entry for MON1B Gene

Post-translational modifications for MON1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MON1B Gene

Domains & Families for MON1B Gene

Gene Families for MON1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MON1B Gene

Suggested Antigen Peptide Sequences for MON1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON1/SAND family.
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1B: view

Function for MON1B Gene

Molecular function for MON1B Gene

UniProtKB/Swiss-Prot Induction:
Induced in fibroblast KMB17 cells by HSV-1.

Phenotypes From GWAS Catalog for MON1B Gene

Gene Ontology (GO) - Molecular Function for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20434987
genes like me logo Genes that share ontologies with MON1B: view
genes like me logo Genes that share phenotypes with MON1B: view

Animal Model Products

CRISPR Products

miRNA for MON1B Gene

miRTarBase miRNAs that target MON1B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON1B Gene

Localization for MON1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON1B gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21509660
GO:0012505 endomembrane system IBA --
GO:0035658 Mon1-Ccz1 complex IDA 29038162
genes like me logo Genes that share ontologies with MON1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON1B Gene

Pathways & Interactions for MON1B Gene

genes like me logo Genes that share pathways with MON1B: view

Pathways by source for MON1B Gene

Gene Ontology (GO) - Biological Process for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
GO:0019085 early viral transcription IDA 21509660
GO:0019086 late viral transcription IDA 21509660
genes like me logo Genes that share ontologies with MON1B: view

No data available for SIGNOR curated interactions for MON1B Gene

Drugs & Compounds for MON1B Gene

No Compound Related Data Available

Transcripts for MON1B Gene

Unigene Clusters for MON1B Gene

MON1 homolog B (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for MON1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MON1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MON1B Gene

Protein differential expression in normal tissues from HIPED for MON1B Gene

This gene is overexpressed in Breast (33.0) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MON1B Gene

Protein tissue co-expression partners for MON1B Gene

NURSA nuclear receptor signaling pathways regulating expression of MON1B Gene:


SOURCE GeneReport for Unigene cluster for MON1B Gene:


Evidence on tissue expression from TISSUES for MON1B Gene

  • Nervous system(4.9)
  • Eye(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MON1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MON1B Gene

Orthologs for MON1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MON1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MON1B 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia MON1B 33 34
  • 88.34 (n)
(Rattus norvegicus)
Mammalia Mon1b 33
  • 85.46 (n)
(Mus musculus)
Mammalia Mon1b 33 16 34
  • 85.04 (n)
(Bos Taurus)
Mammalia MON1B 34
  • 77 (a)
(Monodelphis domestica)
Mammalia MON1B 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MON1B 34
  • 48 (a)
(Anolis carolinensis)
Reptilia MON1B 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11528 33
(Danio rerio)
Actinopterygii wu:fc54b10 33
  • 63.14 (n)
MON1B (1 of 2) 34
  • 51 (a)
MON1B (2 of 2) 34
  • 46 (a)
Dr.26940 33
fruit fly
(Drosophila melanogaster)
Insecta CG11926 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea sand-1 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 34
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G28390 33
  • 44.72 (n)
(Oryza sativa)
Liliopsida Os01g0976000 33
  • 43.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for MON1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON1B Gene

Gene Tree for MON1B (if available)
Gene Tree for MON1B (if available)

Paralogs for MON1B Gene

Paralogs for MON1B Gene

(1) SIMAP similar genes for MON1B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MON1B: view

Variants for MON1B Gene

Sequence variations from dbSNP and Humsavar for MON1B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000393159 -- 77,197,799(+) G/T intron_variant
rs1000504055 -- 77,188,939(+) G/C upstream_transcript_variant
rs1000767676 -- 77,197,590(+) A/G intron_variant
rs1001071007 -- 77,196,602(+) C/G intron_variant
rs1001121038 -- 77,199,112(+) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MON1B Gene

Variant ID Type Subtype PubMed ID
dgv125n111 CNV duplication 26073780
dgv3027n100 CNV gain 25217958
esv25858 CNV loss 19812545
esv3639162 CNV gain 21293372
nsv1055234 CNV gain 25217958
nsv1056676 CNV loss 25217958
nsv1065048 CNV gain 25217958
nsv1115510 CNV duplication 24896259
nsv523187 CNV loss 19592680
nsv827756 CNV gain 20364138

Variation tolerance for MON1B Gene

Residual Variation Intolerance Score: 3.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MON1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON1B Gene

Disorders for MON1B Gene

Additional Disease Information for MON1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MON1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON1B Gene

Publications for MON1B Gene

  1. Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding. (PMID: 12828340) Dong S … Li Q (Acta virologica 2003) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. (PMID: 21509660) Wu W … Li Q (Science China. Life sciences 2011) 3 4 58
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58

Products for MON1B Gene

Sources for MON1B Gene

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