Aliases for MON1B Gene

Aliases for MON1B Gene

  • MON1 Homolog B, Secretory Trafficking Associated 2 3 5
  • HSRG1 2 3 4
  • SAND2 2 3 4
  • MON1 Secretory Trafficking Family Member B 2 3
  • HSV-1 Stimulation-Related Gene 1 Protein 3 4
  • Vacuolar Fusion Protein MON1 Homolog B 3 4
  • HSV-I Stimulating-Related Protein 3 4
  • KIAA0872 2 4
  • MON1 Homolog B (Yeast) 2
  • MON1B 5
  • SRG1 3

External Ids for MON1B Gene

Previous GeneCards Identifiers for MON1B Gene

  • GC16P075783
  • GC16P077224
  • GC16P062981

Summaries for MON1B Gene

GeneCards Summary for MON1B Gene

MON1B (MON1 Homolog B, Secretory Trafficking Associated) is a Protein Coding gene. Diseases associated with MON1B include Joubert Syndrome 31 and Brugada Syndrome 9. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. An important paralog of this gene is MON1A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MON1B Gene

Genomics for MON1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MON1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J077190 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 262.1 +0.4 366 3.2 BCLAF1 SP1 MYC IKZF1 SSRP1 ZNF580 POLR2A CEBPA ATF3 NFIC MON1B piR-43500 SYCE1L
GH16J077199 Promoter 0.4 EPDnew 250.4 +8.7 8714 0.1 POLR2A SYCE1L NONHSAG020037.2 MON1B piR-44063 ADAMTS18
GH16J077211 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 17.9 +22.3 22340 2.9 SP1 MYC JUND NFIC POLR2A ZIC2 ZBTB10 SMAD5 ZNF639 ZNF341 lnc-ADAMTS18-12 SYCE1L MON1B VN2R10P ENSG00000261707 piR-55985-066 NONHSAG020037.2 ENSG00000261063 ADAMTS18
GH16J077224 Enhancer 0.8 Ensembl 27.7 +33.9 33865 1.4 ZNF580 ATF2 ZNF10 FEZF1 ZNF639 KLF9 ZNF623 TAL1 ZNF843 KLF16 SYCE1L MON1B VN2R10P WWOX lnc-SYCE1L-3 HSALNG0112821 ENSG00000261063 ADAMTS18
GH16J077237 Enhancer 0.5 Ensembl 24.6 +48.0 47966 2.8 ZNF366 PATZ1 CREB1 KLF8 EP300 ZNF335 SYCE1L MON1B ENSG00000260922 ENSG00000261063 ADAMTS18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MON1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MON1B

Top Transcription factor binding sites by QIAGEN in the MON1B gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • CHOP-10
  • CUTL1
  • E47
  • FOXO1
  • FOXO1a
  • NRSF form 1
  • NRSF form 2

Genomic Locations for MON1B Gene

Latest Assembly
11,564 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
11,209 bases
Plus strand

(GRCh37/hg19 by Ensembl)
11,571 bases
Plus strand

Genomic View for MON1B Gene

Genes around MON1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1B Gene

Proteins for MON1B Gene

  • Protein details for MON1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vacuolar fusion protein MON1 homolog B
    Protein Accession:
    Secondary Accessions:
    • B4DDZ0
    • O94949

    Protein attributes for MON1B Gene

    547 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    • Interacts with CCNT2; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection (PubMed:21509660). Found in a complex with RMC1, CCZ1 MON1A and MON1B (PubMed:29038162).

    Alternative splice isoforms for MON1B Gene


neXtProt entry for MON1B Gene

Post-translational modifications for MON1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MON1B Gene

Domains & Families for MON1B Gene

Gene Families for MON1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MON1B Gene

  • Saccharomyces cerevisiae 73.5kDa hypothetical protein signature

Suggested Antigen Peptide Sequences for MON1B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58793, highly similar to Homo sapiens MON1 homolog B (MON1B), mRNA (B4DDZ0_HUMAN)
  • HSV-I stimulating-related protein (MON1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON1/SAND family.
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1B: view

Function for MON1B Gene

Molecular function for MON1B Gene

UniProtKB/Swiss-Prot Induction:
Induced in fibroblast KMB17 cells by HSV-1.

Phenotypes From GWAS Catalog for MON1B Gene

Gene Ontology (GO) - Molecular Function for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20434987
genes like me logo Genes that share ontologies with MON1B: view
genes like me logo Genes that share phenotypes with MON1B: view

miRNA for MON1B Gene

miRTarBase miRNAs that target MON1B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MON1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON1B Gene

Localization for MON1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON1B gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 2
peroxisome 1
lysosome 1
golgi apparatus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21509660
GO:0035658 Mon1-Ccz1 complex IDA 29038162
genes like me logo Genes that share ontologies with MON1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON1B Gene

Pathways & Interactions for MON1B Gene

genes like me logo Genes that share pathways with MON1B: view

Pathways by source for MON1B Gene

Gene Ontology (GO) - Biological Process for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0019085 early viral transcription IDA 21509660
GO:0019086 late viral transcription IDA 21509660
genes like me logo Genes that share ontologies with MON1B: view

No data available for SIGNOR curated interactions for MON1B Gene

Drugs & Compounds for MON1B Gene

No Compound Related Data Available

Transcripts for MON1B Gene

mRNA/cDNA for MON1B Gene

12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MON1B

Alternative Splicing Database (ASD) splice patterns (SP) for MON1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for MON1B Gene

GeneLoc Exon Structure for

Expression for MON1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MON1B Gene

Protein differential expression in normal tissues from HIPED for MON1B Gene

This gene is overexpressed in Breast (33.0) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MON1B Gene

Protein tissue co-expression partners for MON1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MON1B

SOURCE GeneReport for Unigene cluster for MON1B Gene:


Evidence on tissue expression from TISSUES for MON1B Gene

  • Nervous system(4.9)
  • Lung(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MON1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MON1B Gene

Orthologs for MON1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MON1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MON1B 29 30
  • 99.45 (n)
(Canis familiaris)
Mammalia MON1B 29 30
  • 88.34 (n)
(Rattus norvegicus)
Mammalia Mon1b 29
  • 85.46 (n)
(Mus musculus)
Mammalia Mon1b 29 16 30
  • 85.04 (n)
(Bos Taurus)
Mammalia MON1B 30
  • 77 (a)
(Monodelphis domestica)
Mammalia MON1B 30
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MON1B 30
  • 48 (a)
(Anolis carolinensis)
Reptilia MON1B 30
  • 50 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11528 29
(Danio rerio)
Actinopterygii wu:fc54b10 29
  • 63.14 (n)
MON1B (1 of 2) 30
  • 51 (a)
MON1B (2 of 2) 30
  • 46 (a)
Dr.26940 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG11926 30
  • 33 (a)
(Caenorhabditis elegans)
Secernentea sand-1 30
  • 26 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 30
  • 18 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G28390 29
  • 44.72 (n)
(Oryza sativa)
Liliopsida Os01g0976000 29
  • 43.6 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 42 (a)
Species where no ortholog for MON1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MON1B Gene

Gene Tree for MON1B (if available)
Gene Tree for MON1B (if available)
Evolutionary constrained regions (ECRs) for MON1B: view image
Alliance of Genome Resources:
Additional Orthologs for MON1B

Paralogs for MON1B Gene

Paralogs for MON1B Gene

(1) SIMAP similar genes for MON1B Gene using alignment to 9 proteins:

  • E7EW32_HUMAN
  • H3BQ73_HUMAN
  • H3BR21_HUMAN
  • H3BU99_HUMAN
genes like me logo Genes that share paralogs with MON1B: view

Variants for MON1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MON1B Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs112674196 Benign/Likely Benign: Non-obstructive azoospermia; not provided 77,199,473(+) C/G

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MON1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MON1B Gene

Variant ID Type Subtype PubMed ID
dgv125n111 CNV duplication 26073780
dgv3027n100 CNV gain 25217958
esv25858 CNV loss 19812545
esv3639162 CNV gain 21293372
nsv1055234 CNV gain 25217958
nsv1056676 CNV loss 25217958
nsv1065048 CNV gain 25217958
nsv1115510 CNV duplication 24896259
nsv523187 CNV loss 19592680
nsv827756 CNV gain 20364138

Variation tolerance for MON1B Gene

Residual Variation Intolerance Score: 3.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MON1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON1B Gene

Disorders for MON1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MON1B Gene - From: COP

Disorder Aliases PubMed IDs
joubert syndrome 31
  • jbts31
brugada syndrome 9
  • brgda9
- elite association - COSMIC cancer census association via MalaCards
Search MON1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MON1B

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MON1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MON1B Gene

Publications for MON1B Gene

  1. Identification of a novel human sand family protein in human fibroblasts induced by herpes simplex virus 1 binding. (PMID: 12828340) Dong S … Li Q (Acta virologica 2003) 3 4 22
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  3. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. (PMID: 29038162) Vaites LP … Harper JW (Molecular and cellular biology 2018) 3 4
  4. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. (PMID: 21509660) Wu W … Li Q (Science China. Life sciences 2011) 3 4
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 40

Products for MON1B Gene

Sources for MON1B Gene