Aliases for MOK Gene
Aliases for MOK Gene
External Ids for MOK Gene
- HGNC: 9833
- Entrez Gene: 5891
- Ensembl: ENSG00000080823
- OMIM: 605762
- UniProtKB: Q9UQ07
Previous HGNC Symbols for MOK Gene
- RAGE
Previous GeneCards Identifiers for MOK Gene
- GC14M102690
Summaries for MOK Gene
-
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for MOK Gene
MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include Renal Cell Carcinoma, Nonpapillary. Among its related pathways are IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ICK.
UniProtKB/Swiss-Prot for MOK Gene
-
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOK Gene
Genomics for MOK Gene
GeneHancer (GH) Regulatory Elements for MOK Gene
Promoters and enhancers for MOK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MOK on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MOK Gene
Genomic Locations for MOK Gene
- chr14:102,224,450-102,305,200
- (GRCh38/hg38)
- Size:
- 80,751 bases
- Orientation:
- Minus strand
- chr14:102,690,837-102,771,537
- (GRCh37/hg19)
- Size:
- 80,701 bases
- Orientation:
- Minus strand
Genomic View for MOK Gene
Genes around MOK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.31 by Entrez Gene
- 14q32.31 by HGNC
- 14q32.31 by Ensembl
MOK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MOK Gene
Proteins for MOK Gene
-
Protein details for MOK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UQ07-MOK_HUMAN
- Recommended name:
- MAPK/MAK/MRK overlapping kinase
- Protein Accession:
- Q9UQ07
- B2R6Z4
- B7Z7P6
- E7ER76
- E7ERR8
- Q92790
- Q93067
Protein attributes for MOK Gene
- Size:
- 419 amino acids
- Molecular mass:
- 48014 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB38087.1; Type=Frameshift; Positions=299; Evidence={ECO:0000305};
Post-translational modifications for MOK Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MOK Gene
- ENSEMBL proteins:
-
- ENSP00000355304
- ENSP00000428206
- ENSP00000429570
- ENSP00000429672
- ENSP00000428957
- ENSP00000454829
- ENSP00000453401
- ENSP00000429511
- ENSP00000427884
- ENSP00000429348
- ENSP00000428942
- ENSP00000453449
- ENSP00000454203
- ENSP00000430775
- ENSP00000453224
- ENSP00000453950
- ENSP00000452978
- ENSP00000429428
- ENSP00000430416
- ENSP00000454098
- ENSP00000453762
- ENSP00000453799
- ENSP00000429469
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MOK
- Novus Biologicals Antibodies for MOK
-
Abcam antibodies for MOK
- Invitrogen Antibodies for MOK (AFLGC-MOK)
- GeneTex MOK Antibody for MOK
Protein Products
-
OriGene Purified Proteins for MOK
- Search Origene for MassSpec and Protein Over-expression Lysates for MOK
- Origene Custom Protein Services for MOK
- antibodies-online: Search results for 2 available MOK Proteins ranked by validation data
- Compare Top MOK Proteins
-
Quality Products:
- Search GeneTex for Proteins for MOK
-
Abcam proteins for MOK
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for MOK
- antibodies-online: Search results for available MOK related products ranked by validation data
No data available for DME Specific Peptides for MOK Gene
Domains & Families for MOK Gene
Gene Families for MOK Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MOK Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MOK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UQ07UniProtKB/Swiss-Prot:
MOK_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Function for MOK Gene
Molecular function for MOK Gene
- UniProtKB/Swiss-Prot Function:
- Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylation appears to increase the enzymatic activity.
Enzyme Numbers (IUBMB) for MOK Gene
Phenotypes From GWAS Catalog for MOK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS,IEA | 10421840 |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | 10421840 |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for MOK Gene
- GenomeRNAi human phenotypes for MOK:
-
- Synthetic lethal with paclitaxel
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cilium length after serum starvation
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased IL-13 protein expression
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased viability
Animal Model Products
-
Taconic Biosciences Mouse Models for MOK
- Cyagen custom Knockout/knockin (KOKI) mouse models for MOK
-
CRISPR Products
-
OriGene CRISPR knockouts for MOK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOK
- genomics-online: gRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- Applied Biological Materials CRISPR for MOK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOK
- GenScript: Design CRISPR guide RNA sequences for MOK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOK
- Browse OriGene Inhibitory RNA Products For MOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOK
- genomics-online: shRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for MOK in any vector
- NM_014226.2
- XM_006720226.2
- XM_011537053.2
- XM_006720225.2
- XM_017021550.1
- XM_017021558.1
- XM_011537052.1
- XM_017021551.1
- NM_001330234.1
- NM_001353827.1
- XM_017021555.1
- XM_017021557.1
- NM_001272011.1
- XM_017021553.1
- XM_017021554.1
- XM_017021559.1
- NM_001353830.1
- NM_001353828.1
- NM_001353832.1
- NM_001353831.1
- XM_017021552.1
- XM_017021556.1
- NM_001353829.1
- Sino Biological Human cDNA Clone for MOK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOK
- Applied Biological Materials Clones for MOK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene
Localization for MOK Gene
Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene
- Cytoplasm. Cell projection, cilium. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| endoplasmic reticulum | 3 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005737 | cytoplasm | IBA,TAS | -- |
| GO:0005929 | cilium | ISS | -- |
| GO:0042995 | cell projection | IEA | -- |
| GO:0097546 | ciliary base | ISS | -- |
Pathways & Interactions for MOK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
.36
|
|
Pathways by source for MOK Gene
1 Qiagen pathway for MOK Gene
Interacting Proteins for MOK Gene
GPS-Prot Interaction Network for MOK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | TAS | 10421840 |
| GO:0010468 | regulation of gene expression | IBA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0035556 | intracellular signal transduction | IBA | -- |
No data available for SIGNOR curated interactions for MOK Gene
Drugs & Compounds for MOK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MOK Gene
mRNA/cDNA for MOK Gene
- (20) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (218) Selected AceView cDNA sequences:
- (40) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000559512 748 bps (uc059flc.1)
- ENST00000559138 2041 bps (uc059fld.1)
- ENST00000559838 643 bps (uc059fle.1)
- ENST00000557823 635 bps (uc059flf.1)
- ENST00000561150 568 bps (uc059flg.1)
Unigene Clusters for MOK Gene
- MOK protein kinase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MOK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOK
- genomics-online: gRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- Applied Biological Materials CRISPR for MOK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOK
- GenScript: Design CRISPR guide RNA sequences for MOK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOK
- Browse OriGene Inhibitory RNA Products For MOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOK
- genomics-online: shRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for MOK in any vector
- NM_014226.2
- XM_006720226.2
- XM_011537053.2
- XM_006720225.2
- XM_017021550.1
- XM_017021558.1
- XM_011537052.1
- XM_017021551.1
- NM_001330234.1
- NM_001353827.1
- XM_017021555.1
- XM_017021557.1
- NM_001272011.1
- XM_017021553.1
- XM_017021554.1
- XM_017021559.1
- NM_001353830.1
- NM_001353828.1
- NM_001353832.1
- NM_001353831.1
- XM_017021552.1
- XM_017021556.1
- NM_001353829.1
- Sino Biological Human cDNA Clone for MOK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOK
- Applied Biological Materials Clones for MOK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
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| SP34: |
| ExUns: | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e | · | 16f | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
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| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP25: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP26: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP28: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP29: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP30: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
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| SP32: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP33: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP34: | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 20c | · | 20d | · | 20e | · | 20f | · | 20g | · | 20h | ^ | 21a | · | 21b | · | 21c | · | 21d | · | 21e | · | 21f | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||
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| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||||||||||||
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Expression for MOK Gene
mRNA differential expression in normal tissues according to GTEx for MOK Gene
This gene is overexpressed in Testis (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of MOK Gene:
MOKSOURCE GeneReport for Unigene cluster for MOK Gene:
Hs.104119mRNA Expression by UniProt/SwissProt for MOK Gene:
Q9UQ07-MOK_HUMAN
Tissue specificity:
Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
Evidence on tissue expression from TISSUES for MOK Gene
- Nervous system(4.6)
- Lung(4.2)
- Liver(2.4)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for MOK
-
OriGene qPCR primer pairs and template standards for MOK
- genomics-online: primer clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOK Gene
Orthologs for MOK Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RAGE 33 |
|
||
| MOK 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Mok 33 |
|
||
| dog (Canis familiaris) |
Mammalia | MOK 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stk30 34 33 |
|
OneToOne | |
| Mok 16 |
|
||||
| cow (Bos Taurus) |
Mammalia | MOK 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MOK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MOK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MOK 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MOK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mok 33 |
|
||
| Str.2425 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10381 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002515 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IME2 34 |
|
OneToMany | |
| wheat (Triticum aestivum) |
Liliopsida | Ta.27829 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MOK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for MOK Gene
- ENSEMBL:
- Gene Tree for MOK (if available)
- TreeFam:
- Gene Tree for MOK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MOK: view image
Paralogs for MOK Gene
(63) SIMAP similar genes for MOK Gene using alignment to 13 proteins:
- MOK_HUMAN
- E5RFX9_HUMAN
- E5RHT7_HUMAN
- E5RHY4_HUMAN
- E5RI85_HUMAN
- E7ER76_HUMAN
- E7ERR8_HUMAN
- H0YBV8_HUMAN
- H0YKX6_HUMAN
- H0YLZ5_HUMAN
- H0YM36_HUMAN
- H0YMY9_HUMAN
- H3BNF8_HUMAN
- RAGE
- MAPK8
- NEK9
- MAPK4
- CDK7
- NLK
- MAK
- DYRK1A
- DKFZp564L2416
- FGFR1
- ICK
- CDK17
- CDK16
- CCRK
- MAPK1
- MAPK14
- BRAF
- CDK3
- DYRK4
- CDK11B
- MAPK3
- STK25
- RPS6KA1
- PCTK1
- MAPK7
- GSK3A
- MAPK12
- HUNK
- CDK1
- CDK6
- MAPK10
- NEK6
- DKFZp686L20222
- MAPK11
- DKFZp686O0215
- BRSK2
- RPS6KA2
- CDKL2
- DKFZp686M02159
- MAPK9
- MAPK13
- CDK2
- CDK4
- CDK19
- CDKL1
- CDK5
- PCTK3
- CDK20
- CDK10
- NUAK1
- HIPK1
- CDK14
- CDK12
- CSNK2A3
- CDC2
- CDKL3
- CDKL4
- TYK2
- STK11
- CDKL5
- PIM2
- CSNK2A2
- DKFZp686D0638
Variants for MOK Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042015 | A breast pleomorphic lobular carcinoma sample | p.Glu272Asp | |||
| rs1000017027 | -- | 102,257,848(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000043280 | -- | 102,302,845(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000075652 | -- | 102,302,970(-) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000099179 | -- | 102,265,328(-) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22037 | CNV | gain | 19812545 |
| esv2659155 | CNV | deletion | 23128226 |
| esv3366828 | CNV | insertion | 20981092 |
| esv3635547 | CNV | gain | 21293372 |
| esv3635549 | CNV | loss | 21293372 |
| esv3635550 | CNV | loss | 21293372 |
| esv3635551 | CNV | loss | 21293372 |
| esv3635552 | CNV | loss | 21293372 |
| esv3635553 | CNV | gain | 21293372 |
| esv3635554 | CNV | loss | 21293372 |
| nsv1116755 | CNV | tandem duplication | 24896259 |
| nsv1429 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.38;
90.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MOK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MOK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene
Disorders for MOK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| renal cell carcinoma, nonpapillary |
|
Search MOK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MOK
No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene
Publications for MOK Gene
- Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PMID: 10421840) Miyata Y … Nishida E (Genes to cells : devoted to molecular & cellular mechanisms 1999) 2 3 4 58
- A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PMID: 8781117) Gaugler B … Van den Eynde BJ (Immunogenetics 1996) 2 3 4 58
- Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D … Sandbank J (The International journal of biological markers 2007) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for MOK Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for MOK
- Custom Assay ServicesOriGene ELISA Kits for MOK
- OriGene Purified Proteins for MOK
- Search Origene for MassSpec and Protein Over-expression Lysates for MOK
- Origene Custom Protein Services for MOK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOK
- Browse OriGene Inhibitory RNA Products For MOK
- OriGene qPCR primer pairs for MOK
- OriGene qPCR primer pairs and template standards for MOK
- OriGene CRISPR knockouts for MOK
- OriGene ORF clones in human for MOK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MOK
- GenScript: Next-day shipping of latest version cDNA ORF clones for MOK in any vector
- NM_014226.2
- XM_006720226.2
- XM_011537053.2
- XM_006720225.2
- XM_017021550.1
- XM_017021558.1
- XM_011537052.1
- XM_017021551.1
- NM_001330234.1
- NM_001353827.1
- XM_017021555.1
- XM_017021557.1
- NM_001272011.1
- XM_017021553.1
- XM_017021554.1
- XM_017021559.1
- NM_001353830.1
- NM_001353828.1
- NM_001353832.1
- NM_001353831.1
- XM_017021552.1
- XM_017021556.1
- NM_001353829.1
- GenScript Custom Purified and Recombinant Proteins Services for MOK
- GenScript Custom Assay Services for MOK
- GenScript Custom overexpressing Cell Line Services for MOK
- GenScript: Design CRISPR guide RNA sequences for MOK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MOK
- Sino Biological Human cDNA Clone for MOK
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MOK
- Novus Biologicals proteins and lysates for MOK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MOK
- Abcam proteins for MOK
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for MOK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MOK (AFLGC-MOK)
- Cyagen custom Knockout/knockin (KOKI) mouse models for MOK
- antibodies-online: Search results for 60 available MOK Antibodies ranked by validation data
- Compare Top MOK Antibodies
- antibodies-online: Search results for available MOK related products ranked by validation data
- antibodies-online: Search results for 2 available MOK Proteins ranked by validation data
- Compare Top MOK Proteins
- Quality Products:
- GeneTex MOK Antibody for MOK
- Search GeneTex for Proteins for MOK
- Horizon Cell Lines for MOK
- genomics-online: cdna clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- orf clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- genomics-online: gRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- genomics-online: primer clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- genomics-online: shRNA clones - Search results for 35 available MOK gene related products
- Overview of 35 available MOK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOK
- GeneCopoeia miRNA 3'UTR Target clone products for MOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOK
Sources for MOK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt