MOK Gene (Protein Coding)

MOK Protein Kinase

GCID:: GC14M102224

GIFtS:: 35

Genes Participants

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants enc... See more...

Aliases for MOK Gene

MOK Protein Kinase ² ³ ⁴ ⁵
RAGE1 ² ³ ⁴
MAPK/MAK/MRK Overlapping Kinase ³ ⁴
Renal Tumor Antigen 1 ³ ⁴
RAGE-1 ³ ⁴

STK30 ² ³
RAGE ³ ⁴
Renal Cell Carcinoma Antigen ³
Renal Tumor Antigen ²
EC 2.7.11.22 ⁴
MOK ⁵

External Ids for MOK Gene

HGNC: 9833
Entrez Gene: 5891
Ensembl: ENSG00000080823
OMIM: 605762
UniProtKB: Q9UQ07

Previous HGNC Symbols for MOK Gene

RAGE

Previous GeneCards Identifiers for MOK Gene

GC14M102690

Search aliases for MOK gene in PubMed and other databases

Summaries for MOK Gene

Entrez Gene Summary for MOK Gene

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for MOK Gene

MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include Endocrine-Cerebroosteodysplasia and Somatization Disorder. Among its related pathways are IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CILK1.

UniProtKB/Swiss-Prot Summary for MOK Gene

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
- MOK_HUMAN,Q9UQ07

Gene Wiki entry for MOK Gene

Additional gene information for MOK Gene

Search for MOK at DataMed
Search for MOK at HumanCyc

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOK Gene

Genomics for MOK Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

Request up-to-date GeneHancer data

Promoters and enhancers for MOK Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH14J102303	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	607.2	+0.5	537	2.9	SP1 GATAD2A REST RFX1 IKZF1 ZNF692 ZHX2 FOXA1 LARP7 PRDM1	MOK lnc-CINP-2 WDR20 HSP90AA1 ENSG00000271780 RCOR1 CDC42BPB ZNF839 piR-50129-078
GH14J102239	Promoter/Enhancer	1.3	EPDnew Ensembl ENCODE dbSUPER	621.1	+65.5	65450	3.5	ZIC2 GATA3 CTCF EGR2	MOK HSP90AA1 WDR20 ZNF839 piR-51267-007 lnc-HSP90AA1-14 lnc-MOK-1
GH14J102306	Enhancer	0.3	ENCODE	600.7	-1.4	-1372	0.1	ZNF384	MOK lnc-CINP-2 RF00951-039 ZNF839
GH14J102262	Enhancer	1.4	Ensembl ENCODE CraniofacialAtlas dbSUPER	27.2	+41.3	41313	3.4	GATAD2A ZNF692 RCOR2 ZIC2 RBFOX2 RXRB PATZ1 SP1 ZNF600 ZNF561	MOK WDR20 TECPR2 CINP HSP90AA1 lnc-CINP-1 piR-53063-071 lnc-CINP-2
GH14J102234	Promoter/Enhancer	1.4	Ensembl ENCODE dbSUPER	24.3	+70.0	70042	1.5	ARHGAP35 GATAD2A CTCF IKZF1 ZHX2 ZNF143 RXRB REST RAD21 IRF2	MOK DYNC1H1 ENSG00000271780 ENSG00000272444 HSP90AA1 WDR20 RCOR1 lnc-MOK-1 piR-51267-007 lnc-HSP90AA1-14

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOK

Genomic Locations for MOK Gene

chr14:102,224,441-102,305,191: (GRCh38/hg38)

Size:: 80,751 bases
Orientation:: Minus strand

chr14:102,690,837-102,771,537: (GRCh37/hg19)

Size:: 80,701 bases
Orientation:: Minus strand

Genomic View for MOK Gene

Genes around MOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

14q32.31 by HGNC
14q32.31 by Entrez Gene
14q32.31 by Ensembl

MOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for MOK Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MOK Gene

NC_000014.9

Proteins for MOK Gene

Protein details for MOK Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q9UQ07-MOK_HUMAN

Recommended name:

MAPK/MAK/MRK overlapping kinase

Protein Accession:

Q9UQ07

Secondary Accessions:
- B2R6Z4
- B7Z7P6
- E7ER76
- E7ERR8
- Q92790
- Q93067
Protein attributes for MOK Gene
Size:

419 amino acids

Molecular mass:

48014 Da

Cofactor:

Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Quaternary structure:

No Data Available

SequenceCaution:
Sequence=AAB38087.1; Type=Frameshift; Evidence={ECO:0000305};
Alternative splice isoforms for MOK Gene
UniProtKB/Swiss-Prot:
Q9UQ07-1

Q9UQ07-2

Q9UQ07-3

Q9UQ07-4

Q9UQ07-5

Q9UQ07-6

neXtProt entry for MOK Gene

Post-translational modifications for MOK Gene

Autophosphorylated.
- Q9UQ07-MOK_HUMAN
Modification sites at PhosphoSitePlus
- Q9UQ07
Modification sites at neXtProt
- NX_Q9UQ07

Other Protein References for MOK Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

G Biosciences Immunotag™ RAGE Antibody and Immunotag™ MOK Antibody

Creative Diagnostics Anti-RAGE monoclonal antibody, clone 2D6

Creative Biolabs Recombinant Anti-Human MOK Antibody scFv Fragment and Recombinant Anti-Human MOK Antibody

OriGene Antibodies for MOK
- AP14180PU-N
- AP17699PU-N
- AP20575PU-N
- CF810801
- CF810865
- CF810869
- TA314416
- TA314417
- TA336884
- TA337674
- TA345115
- TA345116
- TA347785
- TA810801
- TA810801S
- TA810865
- TA810865S
- TA810869
- TA810869S
Custom Antibody Services

Novus Biologicals Antibodies for MOK

Abcam antibodies for MOK
- MOK protein kinase

Invitrogen Antibodies for MOK (AFLGC-MOK)

antibodies-online: Show 34 available MOK Antibodies ranked by validation data
Compare Top MOK Antibodies
Quality Products:

Biorbyt antibodies for MOK

Boster Bio Antibodies for MOK

Browse Santa Cruz Biotechnology (SCBT) Antibodies

Browse Sino Biological Antibodies

Protein Products

OriGene Purified Proteins for MOK
Search Origene for MassSpec and Protein Over-expression Lysates for MOK
Origene Custom Protein Services for MOK

Novus Biologicals proteins and lysates for MOK

Browse ProSpec Recombinant Proteins

antibodies-online: Show 6 available MOK Proteins ranked by validation data
Compare Top MOK Proteins
Quality Products:

Search for MOK Proteins at ProSci

Abcam proteins for MOK
- MOK protein kinase

Assay Products

RayBiotech Human RAGE ELISA

OriGene ELISA Kits for MOK
- EA100521
Custom Assay Services

antibodies-online: Show 11 available MOK Elisa Kits ranked by validation data
Compare Top MOK Elisa Kits
Quality Products:

Browse Boster Bio ELISA Kits

Signalway ELISA kits for MOK
- EK7806
- EK7805
- EK16360

Browse Sino Biological Assays

No data available for DME Specific Peptides for MOK Gene

Domains & Families for MOK Gene

Gene Families for MOK Gene

IUPHAR :

RCK family

Human Protein Atlas (HPA):

Enzymes
Predicted intracellular proteins

Protein Domains for MOK Gene

InterPro:

ProtoNet:

Q9UQ07

Suggested Antigen Peptide Sequences for MOK Gene

GenScript: Design optimal peptide antigens:

Soluble RAGE variant 1 (B5A978_HUMAN)
Soluble RAGE variant 2 (B5A979_HUMAN)
Soluble RAGE variant 3 (B5A980_HUMAN)
Soluble RAGE variant 4 (B5A981_HUMAN)
Renal tumor antigen 1 (MOK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQ07

UniProtKB/Swiss-Prot:

MOK_HUMAN :

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Family:

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Function for MOK Gene

Molecular function for MOK Gene

UniProtKB/Swiss-Prot Function:

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

MOK_HUMAN,Q9UQ07

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000250|UniProtKB:Q9WVS4};.

MOK_HUMAN,Q9UQ07

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000250|UniProtKB:Q9WVS4};.

MOK_HUMAN,Q9UQ07

UniProtKB/Swiss-Prot EnzymeRegulation:

Phosphorylation appears to increase the enzymatic activity.

MOK_HUMAN,Q9UQ07

Enzyme Numbers (IUBMB) for MOK Gene

EC 2.7.11.22 ⁴

Phenotypes From GWAS Catalog for MOK Gene

Gene Ontology (GO) - Molecular Function for MOK Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	IEA,TAS	10421840
GO:0004674	protein serine/threonine kinase activity	IEA,TAS	10421840
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEA	--
GO:0004707	MAP kinase activity	IBA	21873635

Phenotypes for MOK Gene

GenomeRNAi human phenotypes for MOK:

Animal Model Products

Taconic Biosciences Mouse Models for MOK
- Mok

CRISPR Products

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OriGene CRISPR knockouts for MOK

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOK

Santa Cruz Biotechnology (SCBT) CRISPR for MOK

miRNA Products

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Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for MOK
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Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOK

Search Santa Cruz Biotechnology (SCBT) for MOK siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for MOK - Select products 50% OFF >
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OriGene clones in human,mouse,rat for MOK
- SC206351
- MC209732
- MC218286
- RN212383
- SC313381
- SC323622
- SC331023
OriGene ORF clones in human,mouse,rat for MOK
- MG202873
- MG223986
- MR202873
- MR202873L3
- MR202873L4
- MR223986
- MR223986L3
- MR223986L4
- RC215365
- RC215365L1
- RC215365L2
- RC215365L3
- RC215365L4
- RC232637
- RG215365
- RG232637
- RR212383
- RR212383L3
- RR212383L4
- MR202873L3V
- MR202873L4V
- MR223986L3V
- MR223986L4V
- RC215365L1V
- RC215365L2V
- RC215365L3V
- RC215365L4V
- RR212383L3V
- RR212383L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for MOK

Search Addgene for plasmids for MOK

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOK

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for MOK

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for MOK

Horizon Cell Lines for MOK

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene

Localization for MOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene

Cytoplasm. Cell projection, cilium. Nucleus.

Q9UQ07-MOK_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	4
cytosol	3
endoplasmic reticulum	2
golgi apparatus	2
plasma membrane	1
extracellular	1
cytoskeleton	1
mitochondrion	1

Subcellular locations from the

Human Protein Atlas (HPA)

Endoplasmic reticulum (3)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOK Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IBA,ISS	--
GO:0005737	cytoplasm	TAS,IBA	21873635
GO:0005929	cilium	ISS	--
GO:0042995	cell projection	IEA	--
GO:0097546	ciliary base	ISS	--

Pathways & Interactions for MOK Gene

SuperPathways for MOK Gene

	SuperPathway	Contained pathways
1	IL-2 Pathway	HMGB1 Pathway .36

Pathways by source for MOK Gene

1 Qiagen pathway for MOK Gene

HMGB1 Pathway

Interacting Proteins for MOK Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q9UQ07-MOK_HUMAN ENSP00000355304 for MOK Gene via MINT STRING IID

Symbol	External ID(s)	Details
CDK3	ENSP00000410561 ²¹ ENSP00000400088 ²¹ Q00526 ¹²⁶	STRING: ENSP00000410561 STRING: ENSP00000400088 IID: # pred=1
MAPK6	Q16659 ²⁰ ¹²⁶ ENSP00000261845 ²¹	MINT-8261824 STRING: ENSP00000261845 IID: # exp=1 # pred=1
CCNB1	ENSP00000256442 ²¹ P14635 ¹²⁶	STRING: ENSP00000256442 IID: # exp=1 # pred=1
CCNT1	ENSP00000261900 ²¹ O60563 ¹²⁶	STRING: ENSP00000261900 IID: # pred=1
CDC37	ENSP00000222005 ²¹ Q16543 ¹²⁶	STRING: ENSP00000222005 IID: # exp=1

GPS-Prot Interaction Network for MOK

Gene Ontology (GO) - Biological Process for MOK Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	10421840
GO:0010468	regulation of gene expression	IBA	21873635
GO:0016310	phosphorylation	IEA	--
GO:0035556	intracellular signal transduction	IBA	21873635

No data available for SIGNOR curated interactions for MOK Gene

Drugs & Compounds for MOK Gene

(1) Drugs for MOK Gene - From: HMDB

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
ATP	Investigational	MalaCards Medline Plus	Nutra	Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation		0

(1) Additional Compounds for MOK Gene - From: HMDB

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
ADP	5'-Adenylphosphoric acid Adenosine 5'-diphosphate ADENOSINE-5'-diphosphATE H3ADP 5'-Adenylphosphate	Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist	MalaCards Medline Plus	58-64-0	6022

Drug Products

Browse Tocris compounds for MOK

Browse compounds at ApexBio

Transcripts for MOK Gene

mRNA/cDNA for MOK Gene

9 REFSEQ mRNAs :

18 NCBI additional mRNA sequence :

40 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000361847 1909 nts (view in UCSC)
ENST00000517537 837 nts (view in UCSC)
ENST00000517966 1230 nts (view in UCSC)
ENST00000518045 640 nts (view in UCSC)
ENST00000518399 610 nts (view in UCSC)

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for MOK - Select products 50% OFF >
* MOK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for MOK

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOK

Santa Cruz Biotechnology (SCBT) CRISPR for MOK

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for MOK

Browse OriGene miRNA Products For MOK

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for MOK
Browse OriGene Inhibitory RNA Products For MOK

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOK

Search Santa Cruz Biotechnology (SCBT) for MOK siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for MOK - Select products 50% OFF >
* MOK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for MOK
- SC206351
- MC209732
- MC218286
- RN212383
- SC313381
- SC323622
- SC331023
OriGene ORF clones in human,mouse,rat for MOK
- MG202873
- MG223986
- MR202873
- MR202873L3
- MR202873L4
- MR223986
- MR223986L3
- MR223986L4
- RC215365
- RC215365L1
- RC215365L2
- RC215365L3
- RC215365L4
- RC232637
- RG215365
- RG232637
- RR212383
- RR212383L3
- RR212383L4
- MR202873L3V
- MR202873L4V
- MR223986L3V
- MR223986L4V
- RC215365L1V
- RC215365L2V
- RC215365L3V
- RC215365L4V
- RR212383L3V
- RR212383L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for MOK

Search Addgene for plasmids for MOK

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOK

Alternative Splicing Database (ASD) splice patterns (SP) for MOK Gene

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	·	10c	·	10d	^
SP1:															-												-		-						-		-		-		-		-		-		-		-		-
SP2:															-																				-		-		-		-		-		-		-		-		-
SP3:															-												-		-						-		-		-		-		-		-		-		-		-
SP4:															-		-		-								-		-						-		-		-		-		-		-		-		-		-
SP5:
SP6:															-		-		-								-		-
SP7:																																													-		-		-		-
SP8:																																													-		-		-		-
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:																																													-		-		-		-
SP15:																											-		-						-		-		-		-		-		-		-		-		-
SP16:																																													-		-		-		-
SP17:																																													-		-		-		-
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:															-		-		-
SP27:																																					-		-		-		-		-		-		-		-
SP28:																																													-		-		-		-
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:

ExUns:	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	·	14c	·	14d	^	15	^	16a	·	16b	·	16c	·	16d	·	16e	·	16f	^	17a	·	17b	^	18a	·	18b	·	18c	·	18d	^	19a	·	19b	^	20a	·	20b	·
SP1:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-
SP2:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-
SP3:	-		-		-		-		-		-		-		-		-		-		-
SP4:	-		-		-		-		-		-		-		-		-		-		-
SP5:	-		-				-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-
SP6:
SP7:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-
SP8:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-
SP9:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-
SP10:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-		-		-
SP11:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-								-		-
SP12:																			-		-				-		-		-		-		-		-		-
SP13:																			-		-				-		-		-		-		-		-
SP14:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-						-		-
SP15:	-		-		-		-		-		-		-		-		-		-		-
SP16:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-		-		-
SP17:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-
SP18:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-								-		-
SP19:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-
SP20:							-		-		-		-		-		-		-		-				-		-		-		-		-		-										-		-
SP21:																			-		-				-		-		-		-		-		-										-		-
SP22:																			-		-				-		-		-		-		-		-		-								-		-		-		-
SP23:																			-		-						-		-		-		-		-										-		-
SP24:																					-				-		-		-		-		-		-										-		-
SP25:							-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-		-				-		-
SP26:
SP27:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP28:	-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-		-		-		-		-
SP29:											-		-		-		-		-		-
SP30:																			-		-								-		-
SP31:																									-		-		-		-		-		-		-
SP32:																																																	-		-
SP33:
SP34:	-		-		-		-		-		-		-		-		-		-		-

ExUns:	20c	·	20d	·	20e	·	20f	·	20g	·	20h	^	21a	·	21b	·	21c	·	21d	·	21e	·	21f	^	22	^	23a	·	23b	·	23c	^	24
SP1:					-		-		-		-
SP2:					-		-		-		-
SP3:					-		-		-		-
SP4:					-		-		-		-
SP5:					-		-		-		-
SP6:
SP7:
SP8:
SP9:					-		-		-		-
SP10:	-		-		-		-		-		-		-		-		-		-		-		-		-
SP11:					-		-		-		-
SP12:
SP13:
SP14:					-		-		-		-
SP15:
SP16:	-		-		-		-		-		-		-		-		-		-		-		-		-
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:	-		-		-		-		-		-		-		-		-		-		-		-		-
SP23:
SP24:
SP25:
SP26:
SP27:	-		-		-		-		-		-		-		-		-		-		-		-		-
SP28:
SP29:
SP30:
SP31:
SP32:	-		-		-		-		-		-		-		-		-		-		-		-
SP33:
SP34:

Relevant External Links for MOK Gene

GeneLoc Exon Structure for: MOK

Expression for MOK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOK Gene

mRNA expression in normal human tissues for MOK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for MOK Gene

This gene is overexpressed in Testis (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOK

SOURCE GeneReport for Unigene cluster for MOK Gene:

Hs.104119

mRNA Expression by UniProt/SwissProt for MOK Gene:

Q9UQ07-MOK_HUMAN

Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Evidence on tissue expression from TISSUES for MOK Gene

Nervous system(4.7)
Lung(4.3)
Skin(3.1)
Liver(2.9)
Intestine(2.3)
Kidney(2.1)

Primer Products

OriGene qPCR primer pairs for MOK
- HP210712
- MP212611
OriGene qPCR primer pairs and template standards for MOK
- HK210170

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for MOK

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOK Gene

Orthologs for MOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOK Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
Chimpanzee (Pan troglodytes)	Mammalia	RAGE ³⁰	99.36 (n)		453176 XM_510176.3 XP_510176.2
Chimpanzee (Pan troglodytes)	Mammalia	MOK ³¹	99 (a)	OneToOne	14:101932515-102003348
Rat (Rattus norvegicus)	Mammalia	Mok ³⁰	91.13 (n)		362787 NM_001010965.1 NP_001010965.1
Dog (Canis familiaris)	Mammalia	MOK ³⁰ ³¹	87.5 (n)	OneToOne	490863 XM_005623826.1 XP_005623883.1 8:70212746-70270398
Mouse (Mus musculus)	Mammalia	Stk30 ³⁰ ³¹	83.57 (n)	OneToOne	26448 NM_011973.2 NP_036103.1 12:110807798-110840939
Mouse (Mus musculus)	Mammalia	Mok ¹⁷			110807798
Cow (Bos Taurus)	Mammalia	MOK ³⁰ ³¹	83.45 (n)	OneToOne	616277 XM_002696774.2 XP_002696820.2 21:68706703-68736526
Oppossum (Monodelphis domestica)	Mammalia	MOK ³¹	77 (a)	OneToOne	1:314694038-314797126
Platypus (Ornithorhynchus anatinus)	Mammalia	MOK ³¹	64 (a)	OneToOne	Ultra378:7334945-7368764
Chicken (Gallus gallus)	Aves	MOK ³⁰ ³¹	68.75 (n)	OneToOne	428910 XM_004936326.1 XP_004936383.1 5:49456511-49472350
Lizard (Anolis carolinensis)	Reptilia	MOK ³¹	62 (a)	OneToOne	GL343232.1:1812223-1826315
Tropical Clawed Frog (Silurana tropicalis)	Amphibia	mok ³⁰	67.53 (n)		780087 NM_001079163.1 NP_001072631.1
Tropical Clawed Frog (Silurana tropicalis)	Amphibia	Str.2425 ³⁰			AL961377.2
African clawed frog (Xenopus laevis)	Amphibia	Xl.10381 ³⁰			CB592375.1
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP002515 ³⁰	49.12 (n)		1273447 XM_312423.5 XP_312423.5
Baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	IME2 ³¹	18 (a)	OneToMany	X:221390-223327
Wheat (Triticum aestivum)	Liliopsida	Ta.27829 ³⁰			CD867230.1
Sea Squirt (Ciona savignyi)	Ascidiacea	-- ³¹	63 (a)	OneToOne	reftig_37:1609039-1616437

Species where no ortholog for MOK was found in the sources mined by GeneCards:

A. gosspyii yeast (Eremothecium gossypii)
Actinobacteria (Mycobacterium tuberculosis)
Alicante grape (Vitis vinifera)
Alpha proteobacteria (Wolbachia pipientis)
Amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
Barley (Hordeum vulgare)
Beta proteobacteria (Neisseria meningitidis)
Bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
Common water flea (Daphnia pulex)
Corn (Zea mays)
E. coli (Escherichia coli)
Filamentous fungi (Aspergillus nidulans)
Firmicute Bacteria (Streptococcus pneumoniae)
Fission Yeast (Schizosaccharomyces pombe)
Fruit Fly (Drosophila melanogaster)
Green Algae (Chlamydomonas reinhardtii)
Honey Bee (Apis mellifera)
K. Lactis Yeast (Kluyveromyces lactis)
Loblloly Pine (Pinus taeda)
Malaria Parasite (Plasmodium falciparum)
Medicago Trunc (Medicago Truncatula)
Moss (Physcomitrella patens)
Orangutan (Pongo pygmaeus)
Pig (Sus scrofa)
Rainbow Trout (Oncorhynchus mykiss)
Rice (Oryza sativa)
Rice Blast Fungus (Magnaporthe grisea)
Schistosome Parasite (Schistosoma mansoni)
Sea Anemone (Nematostella vectensis)
Sea Vase (Ciona intestinalis)
Sea Urchin (Strongylocentrotus purpuratus)
Sorghum (Sorghum bicolor)
Soybean (Glycine max)
Stem Rust Fungus (Puccinia graminis)
Sugarcane (Saccharum officinarum)
Thale Cress (Arabidopsis thaliana)
Tomato (Lycopersicon esculentum)
Toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
Worm (Caenorhabditis elegans)
Zebrafish (Danio rerio)

Evolution for MOK Gene

ENSEMBL:: Gene Tree for MOK (if available)
TreeFam:: Gene Tree for MOK (if available)
Aminode:: Evolutionary constrained regions (ECRs) for MOK: view image

Paralogs for MOK Gene

CILK1 ⁵
MAK ⁵
MAPK6 ⁵
MAPK15 ⁵
MAPK10 ⁵
MAPK7 ⁵
MAPK9 ⁵
MAPK8 ⁵
MAPK4 ⁵
MAPK1 ⁵
MAPK12 ⁵
MAPK13 ⁵
MAPK3 ⁵
MAPK11 ⁵
NLK ⁵
MAPK14 ⁵
SRPK2 ⁵
SRPK3 ⁵
SRPK1 ⁵

(63) SIMAP similar genes for MOK Gene using alignment to 13 proteins:

MOK_HUMAN
E5RFX9_HUMAN
E5RHT7_HUMAN
E5RHY4_HUMAN
E5RI85_HUMAN
E7ER76_HUMAN
E7ERR8_HUMAN
H0YBV8_HUMAN
H0YKX6_HUMAN
H0YLZ5_HUMAN
H0YM36_HUMAN
H0YMY9_HUMAN
H3BNF8_HUMAN

Variants for MOK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOK Gene

SNP ID	Clinical significance and condition	Chr 14 pos	Variation	Type
727122	Benign: not provided	102,251,756(-)	C/G	MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
746396	Likely Benign: not provided	102,250,916(-)	G/A	NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
rs769431982	Uncertain Significance: Mucopolysaccharidosis, MPS-III-D	102,233,748(-)	A/ATT	FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
VAR_042015	A breast pleomorphic lobular carcinoma sample		p.Glu272Asp
rs148360666	-		p.Val217Ile

Additional dbSNP identifiers (rs#s) for MOK Gene

Structural Variations from Database of Genomic Variants (DGV) for MOK Gene

Variant ID	Type	Subtype	PubMed ID
esv22037	CNV	gain	19812545
esv2659155	CNV	deletion	23128226
esv3366828	CNV	insertion	20981092
esv3635547	CNV	gain	21293372
esv3635549	CNV	loss	21293372
esv3635550	CNV	loss	21293372
esv3635551	CNV	loss	21293372
esv3635552	CNV	loss	21293372
esv3635553	CNV	gain	21293372
esv3635554	CNV	loss	21293372
nsv1116755	CNV	tandem duplication	24896259
nsv1429	CNV	deletion	18451855

Variation tolerance for MOK Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: MOK

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for MOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene

Disorders for MOK Gene

(4) MalaCards diseases for MOK Gene - From: DISEASES and Novoseek

Disorder	Aliases	PubMed IDs
endocrine-cerebroosteodysplasia	eco
somatization disorder	briquet's disorder
renal cell carcinoma, nonpapillary	rcc	9865739
ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension	icpps

- elite association - COSMIC cancer census association via MalaCards

Search MOK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOK

: ATLAS of Genetics and Cytogenetics in Oncology and Haematology
: Open Targets Platform

Search disorders for MOK gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene

Publications for MOK Gene

Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PMID: 10421840) Miyata Y … Nishida E (Genes to cells : devoted to molecular & cellular mechanisms 1999) ² ³ ⁴
A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PMID: 8781117) Gaugler B … Van den Eynde BJ (Immunogenetics 1996) ² ³ ⁴
Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D … Sandbank J (The International journal of biological markers 2007) ³ ²³
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) ³ ⁴
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) ³ ⁴