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MOK Gene(Protein Coding)

MOK Protein Kinase

GCID:
GC14M102224
GIFtS:
42
Genes Participants
UDN Logo

Aliases for MOK Gene

Aliases for MOK Gene

  • MOK Protein Kinase 2 3 4 5
  • Renal Tumor Antigen 1 3 4
  • RAGE-1 3 4
  • RAGE1 3 4
  • RAGE 3 4
  • MAPK/MAK/MRK Overlapping Kinase 3
  • Renal Cell Carcinoma Antigen 3
  • Renal Tumor Antigen 2
  • EC 2.7.11.22 4
  • STK30 3

External Ids for MOK Gene

Previous HGNC Symbols for MOK Gene

  • RAGE

Previous GeneCards Identifiers for MOK Gene

  • GC14M102690

Summaries for MOK Gene

Entrez Gene Summary for MOK Gene

  • This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for MOK Gene

MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include Kidney Cancer and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ICK.

UniProtKB/Swiss-Prot for MOK Gene

  • Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Gene Wiki entry for MOK Gene

Additional gene information for MOK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOK Gene

Genomics for MOK Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MOK Gene

Promoters and enhancers for MOK Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I102303 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 557.3 +0.3 346 2.5 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 YY1 MOK WDR20 HSP90AA1 ENSG00000271780 RCOR1 CDC42BPB GC14P103295
GH14I102306 Enhancer 0.3 ENCODE 550.8 -1.4 -1363 0.1 ZNF384 MOK TRI-AAT5-4
GH14I102588 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.2 -286.8 -286766 6.8 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B RCOR1 ENSG00000271780 MOK CDC42BPB WDR20 KLC1 DYNC1H1 BAG5 ENSG00000272444 CKB
GH14I103204 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 19.7 -902.2 -902153 6 PKNOX1 ARNT ZNF133 GLI4 BRCA1 ZNF280A TCF12 CBX5 GATA2 ZNF416 ENSG00000270705 ENSG00000278071 XRCC3 CDC42BPB RCOR1 MOK BAG5 PPP1R13B TNFAIP2 LINC00605
GH14I102234 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 24.3 +69.9 69851 1.1 HDAC1 ELF3 HDGF PKNOX1 RB1 ARID4B SIN3A DMAP1 NFXL1 ZNF2 MOK DYNC1H1 ENSG00000271780 ENSG00000272444 WDR20 HSP90AA1 RCOR1 GC14M102234 PIR59893
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOK on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOK Gene

Genomic Locations for MOK Gene
chr14:102,224,450-102,305,200
(GRCh38/hg38)
Size:
80,751 bases
Orientation:
Minus strand
chr14:102,690,837-102,771,537
(GRCh37/hg19)

Genomic View for MOK Gene

Genes around MOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOK Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MOK Gene

Proteins for MOK Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ07-MOK_HUMAN
    Recommended name:
    MAPK/MAK/MRK overlapping kinase
    Protein Accession:
    Q9UQ07
    Secondary Accessions:
    • B2R6Z4
    • B7Z7P6
    • E7ER76
    • E7ERR8
    • Q92790
    • Q93067

    Protein attributes for MOK Gene

    Size:
    419 amino acids
    Molecular mass:
    48014 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB38087.1; Type=Frameshift; Positions=299; Evidence={ECO:0000305};

    Alternative splice isoforms for MOK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOK Gene

Post-translational modifications for MOK Gene

Other Protein References for MOK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOK Gene

Domains & Families for MOK Gene

Gene Families for MOK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MOK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ07

UniProtKB/Swiss-Prot:

MOK_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with MOK: view

Function for MOK Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MOK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation appears to increase the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Enzyme Numbers (IUBMB) for MOK Gene

Phenotypes From GWAS Catalog for MOK Gene

Gene Ontology (GO) - Molecular Function for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA 10421840
GO:0004674 protein serine/threonine kinase activity IEA,TAS 10421840
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MOK: view
genes like me logo Genes that share phenotypes with MOK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MOK

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene

Localization for MOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene

Cytoplasm. Cell projection, cilium. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOK gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 3
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm TAS,IBA --
GO:0005929 cilium ISS --
GO:0042995 cell projection IEA --
GO:0097546 ciliary base ISS --
genes like me logo Genes that share ontologies with MOK: view

Pathways & Interactions for MOK Gene

SuperPathways for MOK Gene

PathCards logo More details on SuperPathways for MOK
SuperPathway Contained pathways
1 IL-2 Pathway
HMGB1 Pathway
.36
genes like me logo Genes that share pathways with MOK: view

Pathways by source for MOK Gene

1 Qiagen pathway for MOK Gene

Gene Ontology (GO) - Biological Process for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10421840
GO:0010468 regulation of gene expression IBA --
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with MOK: view

No data available for SIGNOR curated interactions for MOK Gene

Drugs & Compounds for MOK Gene

Products:

  1. Drug

(1) Drugs for MOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for MOK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOK: view

Transcripts for MOK Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MOK Gene

(24) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(218) Selected AceView cDNA sequences:
(40) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOK Gene

MOK protein kinase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - - -
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ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
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SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
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SP28: - - - - - - - - - - - - - - - - - - - - - - -
SP29: - - - - - -
SP30: - - - -
SP31: - - - - - - -
SP32: - -
SP33:
SP34: - - - - - - - - - - -

ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
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SP9: - - - -
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SP22: - - - - - - - - - - - - -
SP23:
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SP27: - - - - - - - - - - - - -
SP28:
SP29:
SP30:
SP31:
SP32: - - - - - - - - - - - -
SP33:
SP34:

Relevant External Links for MOK Gene

GeneLoc Exon Structure for
MOK
ECgene alternative splicing isoforms for
MOK

Expression for MOK Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOK Gene

mRNA expression in normal human tissues for MOK Gene
mRNA expression by BioGPS for MOK GenemRNA expression by GTEx for MOK Gene

mRNA differential expression in normal tissues according to GTEx for MOK Gene

This gene is overexpressed in Testis (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MOK Gene:

MOK

SOURCE GeneReport for Unigene cluster for MOK Gene:

Hs.104119

mRNA Expression by UniProt/SwissProt for MOK Gene:

Q9UQ07-MOK_HUMAN
Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Evidence on tissue expression from TISSUES for MOK Gene

  • Nervous system(4.6)
  • Lung(4.2)
  • Liver(2.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with MOK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOK Gene

Orthologs for MOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RAGE 33
  • 99.36 (n)
MOK 34
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mok 33
  • 91.13 (n)
dog
(Canis familiaris)
 Mammalia MOK 33 34
  • 87.5 (n)
mouse
(Mus musculus)
 Mammalia Stk30 33 34
  • 83.57 (n)
Mok 16
cow
(Bos Taurus)
 Mammalia MOK 33 34
  • 83.45 (n)
oppossum
(Monodelphis domestica)
 Mammalia MOK 34
  • 77 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MOK 34
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MOK 33 34
  • 68.75 (n)
lizard
(Anolis carolinensis)
 Reptilia MOK 34
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mok 33
  • 67.53 (n)
Str.2425 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.10381 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002515 33
  • 49.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes IME2 34
  • 18 (a)
 OneToMany
wheat
(Triticum aestivum)
 Liliopsida Ta.27829 33
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 63 (a)
 OneToOne
Species where no ortholog for MOK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOK Gene

ENSEMBL:
Gene Tree for MOK (if available)
TreeFam:
Gene Tree for MOK (if available)

Paralogs for MOK Gene

Variants for MOK Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MOK Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
VAR_042015 A breast pleomorphic lobular carcinoma sample p.Glu272Asp
rs1000017027 -- 102,257,848(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000043280 -- 102,302,845(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000075652 -- 102,302,970(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000099179 -- 102,265,328(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOK Gene

Variant ID Type Subtype PubMed ID
esv22037 CNV gain 19812545
esv2659155 CNV deletion 23128226
esv3366828 CNV insertion 20981092
esv3635547 CNV gain 21293372
esv3635549 CNV loss 21293372
esv3635550 CNV loss 21293372
esv3635551 CNV loss 21293372
esv3635552 CNV loss 21293372
esv3635553 CNV gain 21293372
esv3635554 CNV loss 21293372
nsv1116755 CNV tandem duplication 24896259
nsv1429 CNV deletion 18451855

Variation tolerance for MOK Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene

Disorders for MOK Gene

MalaCards: The human disease database

(2) MalaCards diseases for MOK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • malignant neoplasm of kidney except pelvis
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards
Search MOK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOK

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MOK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene

Publications for MOK Gene

  1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PMID: 10421840) Miyata Y … Nishida E (Genes to cells : devoted to molecular & cellular mechanisms 1999) 2 3 4 58
  2. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PMID: 8781117) Gaugler B … Van den Eynde BJ (Immunogenetics 1996) 2 3 4 58
  3. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D … Sandbank J (The International journal of biological markers 2007) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PMID: 15327990) Uesaka T … Kageyama N (FEBS letters 2004) 3 22 58

Products for MOK Gene

Sources for MOK Gene

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