Aliases for MOGAT3 Gene
External Ids for MOGAT3 Gene
Previous GeneCards Identifiers for MOGAT3 Gene
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 188.8.131.52) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]
GeneCards Summary for MOGAT3 Gene
MOGAT3 (Monoacylglycerol O-Acyltransferase 3) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diacylglycerol O-acyltransferase activity. An important paralog of this gene is DGAT2.
UniProtKB/Swiss-Prot Summary for MOGAT3 Gene
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).